Nothing Special   »   [go: up one dir, main page]

HRP940701B1 - 2,4- and 2,5-substituted pyridine-n-oxydes, process for their preparation and utilization - Google Patents

2,4- and 2,5-substituted pyridine-n-oxydes, process for their preparation and utilization

Info

Publication number
HRP940701B1
HRP940701B1 HRP-1133/91A HRP940701A HRP940701B1 HR P940701 B1 HRP940701 B1 HR P940701B1 HR P940701 A HRP940701 A HR P940701A HR P940701 B1 HRP940701 B1 HR P940701B1
Authority
HR
Croatia
Prior art keywords
substituted pyridine
oxydes
utilization
preparation
collagen
Prior art date
Application number
HRP-1133/91A
Other languages
English (en)
Inventor
Volkmar Guenzler-Pukall
Original Assignee
Volkmar Guenzler-Pukall
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Volkmar Guenzler-Pukall filed Critical Volkmar Guenzler-Pukall
Publication of HRP940701A2 publication Critical patent/HRP940701A2/xx
Publication of HRP940701B1 publication Critical patent/HRP940701B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HRP-1133/91A 1990-06-28 1994-10-19 2,4- and 2,5-substituted pyridine-n-oxydes, process for their preparation and utilization HRP940701B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4020570A DE4020570A1 (de) 1990-06-28 1990-06-28 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung
YU113391A YU113391A (sh) 1990-06-28 1991-06-27 2,4 i 2,5 substituirani piridin-n oksidi i postupak za njihovu proizvodnju

Publications (2)

Publication Number Publication Date
HRP940701A2 HRP940701A2 (en) 1997-02-28
HRP940701B1 true HRP940701B1 (en) 1999-08-31

Family

ID=6409247

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP-1133/91A HRP940701B1 (en) 1990-06-28 1994-10-19 2,4- and 2,5-substituted pyridine-n-oxydes, process for their preparation and utilization

Country Status (27)

Country Link
EP (1) EP0463592B1 (es)
JP (1) JPH0832687B2 (es)
KR (1) KR920000724A (es)
CN (1) CN1038585C (es)
AT (1) ATE110059T1 (es)
AU (1) AU636990B2 (es)
BR (1) BR9102699A (es)
CA (1) CA2045868A1 (es)
CZ (1) CZ283782B6 (es)
DE (2) DE4020570A1 (es)
DK (1) DK0463592T3 (es)
EG (1) EG19851A (es)
ES (1) ES2061118T3 (es)
FI (1) FI101070B (es)
HR (1) HRP940701B1 (es)
HU (1) HU214627B (es)
IE (1) IE65300B1 (es)
IL (1) IL98629A (es)
LT (1) LT3918B (es)
MA (1) MA22191A1 (es)
MX (1) MX26415A (es)
MY (1) MY107573A (es)
NO (1) NO178026C (es)
NZ (1) NZ238701A (es)
PT (1) PT98108B (es)
YU (1) YU113391A (es)
ZA (1) ZA914958B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU9492A (sh) * 1991-02-05 1995-03-27 Hoechst Ag. 2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanje
CA2085954A1 (en) * 1991-12-24 1993-06-25 Klaus Weidmann Substituted pyridine n-oxides, processes for their preparation, and their use
TW352384B (en) * 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
TW222585B (es) * 1992-09-11 1994-04-21 Hoechst Ag
DE4233124A1 (de) * 1992-10-02 1994-04-07 Hoechst Ag Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6451816B1 (en) 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
DE19624704A1 (de) * 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalkansäureamide
DE19624659A1 (de) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalken- und Pyridylalkinsäureamide
FR2766187B1 (fr) 1997-07-17 2000-06-02 Rhone Poulenc Rorer Sa Derives de pyrazine, leur preparation et les medicaments les contenant
DE19756261A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
DE19756212A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
DE19756235A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
US6903118B1 (en) 1997-12-17 2005-06-07 Klinge Pharma Gmbh Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
EP1031564A1 (en) 1999-02-26 2000-08-30 Klinge Pharma GmbH Inhibitors of cellular nicotinamide mononucleotide formation and their use in cancer therapy
DOP2002000332A (es) 2001-02-14 2002-08-30 Warner Lambert Co Inhibidores de piridina de metaloproteinasas de la matriz
DOP2002000333A (es) 2001-02-14 2002-09-30 Warner Lambert Co Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
DE60236851D1 (en) 2001-02-14 2010-08-12 Warner Lambert Co Pyrimidinmatrixmetalloproteinaseinhibitoren
US6924276B2 (en) 2001-09-10 2005-08-02 Warner-Lambert Company Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
CA2462442A1 (en) 2001-10-12 2003-04-24 Warner-Lambert Company Llc Alkyne matrix metalloproteinase inhibitors
US6933298B2 (en) 2001-12-08 2005-08-23 Aventis Pharma Deutschland Gmbh Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides and the use thereof for selectively inhibiting collagenases
DE10160357A1 (de) * 2001-12-08 2003-06-18 Aventis Pharma Gmbh Verwendung von Pyridin-2,4-dicarbonsäurediamiden und Pyrimidin-4,6-dicarbonsäurediamiden zur selektiven Inhibierung von Kollagenasen

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5623987B2 (es) * 1972-02-04 1981-06-03
JPS6052702B2 (ja) 1976-08-27 1985-11-20 中外製薬株式会社 ピリジン誘導体およびその製造方法
JPS57109792A (en) * 1980-12-26 1982-07-08 Banyu Pharmaceut Co Ltd Penicillin derivative and salt thereof
DE3432094A1 (de) 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase
JP2512924B2 (ja) * 1987-01-21 1996-07-03 萬有製薬株式会社 育毛剤
DE3703959A1 (de) 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3703963A1 (de) * 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben, sowie arzneimittel auf basis dieser verbindungen
DE3703962A1 (de) 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
JP2600786B2 (ja) * 1988-04-12 1997-04-16 萬有製薬株式会社 育毛剤
DE3826471A1 (de) 1988-08-04 1990-02-22 Hoechst Ag Verbessertes verfahren zur herstellung von n,n'-bis(alkoxyalkyl)-pyridin-2,4-dicarbonsaeurediamiden
DE3924093A1 (de) 1989-07-20 1991-02-07 Hoechst Ag N,n'-bis(alkoxy-alkyl)-pyridin-2,4-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
ZA91291B (en) 1990-01-16 1991-09-25 Hoechst Ag Di(nitroxyalkyl)amides of pyridine-2,4-and-2,5-dicarboxylic acids,a process for the preparation thereof,and the use thereof

Also Published As

Publication number Publication date
MA22191A1 (fr) 1991-12-31
MX26415A (es) 1993-05-01
JPH04230264A (ja) 1992-08-19
DE59102547D1 (de) 1994-09-22
NO178026B (no) 1995-10-02
HUT59104A (en) 1992-04-28
DK0463592T3 (da) 1994-12-19
IL98629A (en) 1996-05-14
CA2045868A1 (en) 1991-12-29
PT98108A (pt) 1993-06-30
CS195991A3 (en) 1992-02-19
ZA914958B (en) 1992-03-25
MY107573A (en) 1996-04-30
HRP940701A2 (en) 1997-02-28
FI913118A (fi) 1991-12-29
AU7935691A (en) 1992-01-02
LTIP1464A (en) 1995-05-25
CN1057649A (zh) 1992-01-08
CZ283782B6 (cs) 1998-06-17
LT3918B (en) 1996-04-25
NO178026C (no) 1996-01-10
EG19851A (en) 1996-10-31
NO912541L (no) 1991-12-30
JPH0832687B2 (ja) 1996-03-29
ATE110059T1 (de) 1994-09-15
CN1038585C (zh) 1998-06-03
HU214627B (hu) 1998-04-28
IL98629A0 (en) 1992-07-15
ES2061118T3 (es) 1994-12-01
NO912541D0 (no) 1991-06-27
IE65300B1 (en) 1995-10-18
IE912253A1 (en) 1992-01-01
AU636990B2 (en) 1993-05-13
EP0463592A1 (de) 1992-01-02
DE4020570A1 (de) 1992-01-02
KR920000724A (ko) 1992-01-29
FI913118A0 (fi) 1991-06-26
YU113391A (sh) 1995-10-03
BR9102699A (pt) 1992-02-04
HU912158D0 (en) 1991-12-30
FI101070B (fi) 1998-04-15
EP0463592B1 (de) 1994-08-17
PT98108B (pt) 1998-12-31
NZ238701A (en) 1994-06-27

Similar Documents

Publication Publication Date Title
HRP940701A2 (en) 2,4- and 2,5-substituted pyridine-n-oxydes, process for their preparation and utilization
TW263423B (es)
HU9301314D0 (en) Quinazoline derivatves for improving anto-tumouric activity
AU588826B2 (en) Esters of pyridine-2,4- and 2,5-dicarboxylic acid as medicaments for the inhibition of proline hydroxylase and lysine hydroxylase
BG101748A (en) Heterocyclic condensated pyridines
ZA914580B (en) Process for the preparation of dialkyl,pyridine-2,3-dicarboxylates and derivatives thereof from dialkyl dichlorosucciante
AU7903091A (en) N-substituted-1,2,4-triazolone compounds for treatment of cardiovascular disorders
DE3763215D1 (de) Aushaengbares verschwindscharnier fuer schaltschraenke.
AU1384688A (en) 1,5-substituted 1H-imidazoles
EP0630383A4 (en) METHODS FOR TREATING DIABETIS.
HUT47794A (en) Insecticide, acaricide and nematocide compositions containing pyridazinone derivatives as active components and process for producing the active components
AU7842191A (en) Process for the preparation of dialkyl pyridine-2,3,-dicarboxylates and derivatives thereof from dialakyl dichloromaleate
FR2659652B1 (fr) Procede de preparation de n-phenyl benzoquinone-imine.
EP0303232A3 (en) Use of benzylpyridine derivatives for the treatment of dementia
EP0466042A3 (en) Microbiological process for the oxidation of methyl groups
ZA927035B (en) Process for the microbial oxidation of sulphidic wastes.
IL107849A (en) Process for the preparation of 2, 3, 5, 6- tetrachloropyridine
Steno The eclipsing companion of Epsilon Aurigae
CS394590A3 (en) Material for sliding surfaces, particularly of bearings
GR3033536T3 (en) 2,4- and 2,5-bis-(tetrazolyl)pyridines, process for their preparation and their use as medicines.
HU906204D0 (en) Process for enzyme purfication
ZA914582B (en) Process for the preparation of dialkyl,pyridine-2,3-dicarboxylates and derivatives thereof from dialkyl dichloromaleate
HU9501757D0 (en) Bridle of bearing, especially for treating spine ailment
HU913368D0 (en) Process for the production of sydnonimine derivatives substituted in the 4-position, and of medical preparations containing them

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20000627

Year of fee payment: 10

PBON Lapse due to non-payment of renewal fee

Effective date: 20010628