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HRP20180262T1 - Monoklonska anti-gt468 protutijela za liječenje karcinoma - Google Patents

Monoklonska anti-gt468 protutijela za liječenje karcinoma Download PDF

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Publication number
HRP20180262T1
HRP20180262T1 HRP20180262TT HRP20180262T HRP20180262T1 HR P20180262 T1 HRP20180262 T1 HR P20180262T1 HR P20180262T T HRP20180262T T HR P20180262TT HR P20180262 T HRP20180262 T HR P20180262T HR P20180262 T1 HRP20180262 T1 HR P20180262T1
Authority
HR
Croatia
Prior art keywords
cancer
antibody
conjugate
antibodies
cell
Prior art date
Application number
HRP20180262TT
Other languages
English (en)
Inventor
Ugur Sahin
Özlem TÜRECI
Michael Koslowski
Rita Mitnacht-Kraus
Original Assignee
Ganymed Pharmaceuticals Gmbh
Johannes Gutenberg-Universität Mainz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ganymed Pharmaceuticals Gmbh, Johannes Gutenberg-Universität Mainz filed Critical Ganymed Pharmaceuticals Gmbh
Publication of HRP20180262T1 publication Critical patent/HRP20180262T1/hr

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (8)

1. Protutijelo koje se bira iz skupine koju čini: (i) protutijela koje je proizvedeno ili koje se može dobiti iz klona dpohranjenog pod pristupnim br. DSM ACC2944 (51-1A-1), (ii) protutijela koje je kimerizirani ili humanizirani oblikprotutijela pod (i), i (iii) protutijela koje sadrži dio koji se veže za antigen ili mjesto koje se veže za antigen protutijela pod (i), pri čemu se navedeno protutijela veže za polipeptid koji se sastoji od aminokiselinske sekvence od SEQ ID NO: 2 iz listinga sekvenci i inhibira proliferaciju stanica koje eksprimiraju navedeni polipeptid.
2. Hibridom odabran iz skupine koju čine: (i) hibridoma koji proizvodi protutijela sukladno patentnom zahtjevu 1, i (ii) hibridoma deponiranog pod pristupnim br. DSM ACC2944 (51-1A-1).
3. Konjugat koji sadrži protutijelo sukladno patentnom zahtjevu 1 povezano s terapijskim sredstvom, poželjno toksinom, radioizotopom, lijekom ili citotoksičnim sredstvom.
4. Farmaceutski pripravak koja sadrži protutijelo sukladno patentnom zahtjevu 1 i/ili konjugat sukladno patentnom zahtjevu 3, i farmaceutski prihvatljiv nosač.
5. Protutijelo sukladno patentnom zahtjevu 1 i/ili konjugat 3, naznačeno time da se koristi u postupku liječenja bolesti povezane s tumorom ili poremećajem povezanog s tumorom, naznačeno stanicama koje eksprimiraju polipeptid koji se sastoji od aminokiselinske sekvence prema SEQ ID NO: 2 iz listinga sekvenci i/ili karakteriziranje vezivanjem navedenog polipeptida s svojom površinom stanice subjekta.
6. Protutijelo ili konjugat za uporabu sukladno patentnom zahtjevu 5, pri čemu navedeni postupak liječenja je (i) postupak za inhibiranje rasta spomenute stanice, (ii) postupak za ubijanje spomenute stanice ili (iii) postupak za inhibiranje metastatskog širenja navedene stanice.
7. Protutijelo ili konjugat za uporabu sukladno patentnom zahtjevu 5 ili 6, pri čemu, bolest ili poremećaj je karcinom.
8. Protutijelo ili konjugat za uporabu sukladno patentnom zahtjevu 7, pri čemu, karacinom je odabran iz skupine koju čine karcinom dojke, karcinom pluća, karcinom želuca, karcinom jajnika, hepatocelularni karcinom, karcinom debelog crijeva, karcinom pankreasa, karcinom jednjaka, karcinom glave i vrata, karcinom bubrega, osobito karcinoma stanica bubrega, karcinom prostate, karcinom jetre, melanoma, sarkoma, mijeloma, neuroblastoma, placentalnog koriokarcinoma, karcinom grlića maternice, i tiroidnog karcinom, i njihovih metastatskih oblika, i metastatskog karcinoma pluća.
HRP20180262TT 2008-09-16 2018-02-13 Monoklonska anti-gt468 protutijela za liječenje karcinoma HRP20180262T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9745308P 2008-09-16 2008-09-16
EP08016277A EP2166021A1 (en) 2008-09-16 2008-09-16 Monoclonal antibodies for treatment of cancer
PCT/EP2009/006704 WO2010031551A2 (en) 2008-09-16 2009-09-16 Monoclonal antibodies for treatment of cancer
EP09778564.6A EP2342234B1 (en) 2008-09-16 2009-09-16 Monoclonal anti-gt468 antibodies for treatment of cancer

Publications (1)

Publication Number Publication Date
HRP20180262T1 true HRP20180262T1 (hr) 2018-03-23

Family

ID=40589589

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20180262TT HRP20180262T1 (hr) 2008-09-16 2018-02-13 Monoklonska anti-gt468 protutijela za liječenje karcinoma

Country Status (26)

Country Link
US (1) US8946388B2 (hr)
EP (3) EP2166021A1 (hr)
JP (1) JP2012502938A (hr)
KR (1) KR101818741B1 (hr)
CN (3) CN104628858B (hr)
AU (1) AU2009294896B2 (hr)
BR (1) BRPI0918178B8 (hr)
CA (1) CA2732594C (hr)
CY (1) CY1119956T1 (hr)
DK (1) DK2342234T3 (hr)
ES (1) ES2659718T3 (hr)
HK (1) HK1253579A1 (hr)
HR (1) HRP20180262T1 (hr)
HU (1) HUE036477T2 (hr)
IL (2) IL211010A (hr)
LT (1) LT2342234T (hr)
MX (2) MX357010B (hr)
NO (1) NO2342234T3 (hr)
NZ (2) NZ596490A (hr)
PL (1) PL2342234T3 (hr)
PT (1) PT2342234T (hr)
RS (1) RS56937B1 (hr)
SI (1) SI2342234T1 (hr)
TR (1) TR201802090T4 (hr)
WO (1) WO2010031551A2 (hr)
ZA (1) ZA201100835B (hr)

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Also Published As

Publication number Publication date
NZ596490A (en) 2013-05-31
JP2012502938A (ja) 2012-02-02
HK1253579A1 (zh) 2019-06-21
EP3312198A1 (en) 2018-04-25
NO2342234T3 (hr) 2018-04-14
CN104628858B (zh) 2018-11-16
AU2009294896A1 (en) 2010-03-25
EP2342234B1 (en) 2017-11-15
ES2659718T3 (es) 2018-03-19
LT2342234T (lt) 2018-03-12
IL242204B (en) 2020-09-30
CN104628858A (zh) 2015-05-20
BRPI0918178A8 (pt) 2020-05-19
NZ591004A (en) 2012-03-30
MX357010B (es) 2018-06-22
EP2342234A2 (en) 2011-07-13
CN102164963A (zh) 2011-08-24
US8946388B2 (en) 2015-02-03
TR201802090T4 (tr) 2018-03-21
CN102164963B (zh) 2015-07-29
PL2342234T3 (pl) 2018-07-31
HUE036477T2 (hu) 2018-07-30
ZA201100835B (en) 2014-04-30
DK2342234T3 (en) 2018-02-26
BRPI0918178A2 (pt) 2015-12-01
IL242204A0 (en) 2015-11-30
WO2010031551A3 (en) 2010-09-16
KR20110055699A (ko) 2011-05-25
RS56937B1 (sr) 2018-05-31
IL211010A (en) 2015-11-30
CA2732594A1 (en) 2010-03-25
MX2011002856A (es) 2011-06-28
BRPI0918178B8 (pt) 2021-05-25
PT2342234T (pt) 2018-02-21
US20110223182A1 (en) 2011-09-15
CY1119956T1 (el) 2018-12-12
EP2166021A1 (en) 2010-03-24
SI2342234T1 (en) 2018-04-30
KR101818741B1 (ko) 2018-01-15
CN105753988A (zh) 2016-07-13
IL211010A0 (en) 2011-04-28
AU2009294896B2 (en) 2015-04-30
CA2732594C (en) 2019-05-28
WO2010031551A2 (en) 2010-03-25
BRPI0918178B1 (pt) 2021-04-06

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