HRP20160406T1 - Postupci i pripravci za liječenje sa štitnjačom povezanih medicinskih stanja sa sniženiim folatima - Google Patents
Postupci i pripravci za liječenje sa štitnjačom povezanih medicinskih stanja sa sniženiim folatima Download PDFInfo
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- HRP20160406T1 HRP20160406T1 HRP20160406TT HRP20160406T HRP20160406T1 HR P20160406 T1 HRP20160406 T1 HR P20160406T1 HR P20160406T T HRP20160406T T HR P20160406TT HR P20160406 T HRP20160406 T HR P20160406T HR P20160406 T1 HRP20160406 T1 HR P20160406T1
- Authority
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- Croatia
- Prior art keywords
- preparation
- use according
- individual
- vitamin
- folate
- Prior art date
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- 235000019152 folic acid Nutrition 0.000 title claims 8
- 239000000203 mixture Substances 0.000 title claims 5
- 238000000034 method Methods 0.000 title claims 2
- 150000002224 folic acids Chemical class 0.000 title 1
- 210000001685 thyroid gland Anatomy 0.000 title 1
- 229930003779 Vitamin B12 Natural products 0.000 claims 8
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 8
- 235000019163 vitamin B12 Nutrition 0.000 claims 8
- 239000011715 vitamin B12 Substances 0.000 claims 8
- 229940014144 folate Drugs 0.000 claims 7
- 239000011724 folic acid Substances 0.000 claims 7
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 6
- XUIIKFGFIJCVMT-LBPRGKRZSA-N L-thyroxine Chemical compound IC1=CC(C[C@H]([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-LBPRGKRZSA-N 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 claims 4
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 3
- 229930003316 Vitamin D Natural products 0.000 claims 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 3
- 229960005069 calcium Drugs 0.000 claims 3
- 239000011575 calcium Substances 0.000 claims 3
- 229910052791 calcium Inorganic materials 0.000 claims 3
- 229910052742 iron Inorganic materials 0.000 claims 3
- 235000019166 vitamin D Nutrition 0.000 claims 3
- 239000011710 vitamin D Substances 0.000 claims 3
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 3
- 229940046008 vitamin d Drugs 0.000 claims 3
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 claims 2
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 208000003532 hypothyroidism Diseases 0.000 claims 2
- 230000002989 hypothyroidism Effects 0.000 claims 2
- 239000011578 levomefolic acid Substances 0.000 claims 2
- 229950008325 levothyroxine Drugs 0.000 claims 2
- 229960003918 levothyroxine sodium Drugs 0.000 claims 2
- 229960002018 liothyronine sodium Drugs 0.000 claims 2
- SBXXSUDPJJJJLC-YDALLXLXSA-M liothyronine sodium Chemical compound [Na+].IC1=CC(C[C@H](N)C([O-])=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 SBXXSUDPJJJJLC-YDALLXLXSA-M 0.000 claims 2
- 229940034208 thyroxine Drugs 0.000 claims 2
- 229940035722 triiodothyronine Drugs 0.000 claims 2
- 206010002064 Anaemia macrocytic Diseases 0.000 claims 1
- 206010002065 Anaemia megaloblastic Diseases 0.000 claims 1
- 206010016880 Folate deficiency Diseases 0.000 claims 1
- 101000587058 Homo sapiens Methylenetetrahydrofolate reductase Proteins 0.000 claims 1
- LKYWLLWWYBVUPP-XOCLESOZSA-L Liotrix Chemical compound [Na+].[Na+].IC1=CC(C[C@H](N)C([O-])=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1.IC1=CC(C[C@H](N)C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 LKYWLLWWYBVUPP-XOCLESOZSA-L 0.000 claims 1
- 208000000682 Megaloblastic Anemia Diseases 0.000 claims 1
- 102100029684 Methylenetetrahydrofolate reductase Human genes 0.000 claims 1
- -1 liothrix Chemical compound 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 230000005976 liver dysfunction Effects 0.000 claims 1
- 201000006437 macrocytic anemia Diseases 0.000 claims 1
- 231100001016 megaloblastic anemia Toxicity 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (16)
1. Pripravak koji sadrži folat za uporabu u postupku liječenja cerebrospinalne folatne deficijencije u pojedinca s hipotiroidizmom, taj postupak obuhvaća:
a. odabir pojedinca s hipotiroidizmom koji se liječi lijekom, sredstvom, medikamentom ili hormonom izabranim iz skupine koju čine levotiroksin, levotiroksin natrij, liotironin natrij, liotriks, tiroksin i trijodtironin; i
b. primjena pojedincu tog pripravka koji sadrži folat.
2. Pripravak za uporabu prema zahtjevu 1, gdje folat jest sniženi folat.
3. Pripravak za uporabu prema zahtjevu 1, gdje folat jest 6(S)-5-metiltetrahidrofolat.
4. Pripravak za uporabu prema zahtjevima 1 do 3, dalje obuhvaća primjenu vitamina B12 pojedincu.
5. Pripravak za uporabu prema zahtjevu 1, gdje pojedinac ima maskiranu megaloblastičnu anemiju.
6. Pripravak za uporabu prema zahtjevu 1, gdje pojedinac ima maskiranu makrocitnu anemiju.
7. Pripravak za uporabu prema zahtjevu 1, gdje pojedinac ima disfunkciju jetre.
8. Pripravak za uporabu prema zahtjevu 1, gdje pojedinac ima MTHFR polimorfizam.
9. Pripravak za uporabu prema zahtjevima 1 do 3, dalje obuhvaća primjenu vitamina B12 i željeza pojedincu.
10. Pripravak za uporabu prema zahtjevima 1 do 3, dalje obuhvaća primjenu vitamina B12 i L-karnitina pojedincu.
11. Pripravak za uporabu prema zahtjevima 1 do 3, dalje obuhvaća primjenu vitamina B12 i kalcija pojedincu.
12. Pripravak za uporabu prema zahtjevima 1 do 3, dalje obuhvaća primjenu vitamina B12 i vitamina D pojedincu.
13. Pripravak za uporabu prema zahtjevima 1 do 3, gdje pripravak dalje sadrži vitamin B12 i jedno ili više od sljedećeg: željezo, L-karnitin, kalcij ili vitamin D.
14. Pripravak za uporabu prema zahtjevima 1 do 3, dalje obuhvaća primjenu vitamina B12, željeza, L-karnitina, kalcija ili vitamina D.
15. Pripravak koji sadrži (a) lijek, sredstvo, medikament ili hormon izabran iz skupine koju čine levotiroksin, levotiroksin natrij, liotironin natrij, liotriks, tiroksin i trijodtironin i (b) sniženi folat, gdje sniženi folat jest 6(S)-5-metiltetrahidrofolat.
16. Pripravak prema zahtjevu 15, dalje sadrži vitamin B12.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27061509P | 2009-07-10 | 2009-07-10 | |
| US27074109P | 2009-07-13 | 2009-07-13 | |
| PCT/US2010/041631 WO2011006147A1 (en) | 2009-07-10 | 2010-07-09 | Methods and compositions for treating thyroid-related medical conditions with reduced folates |
| EP10797960.1A EP2451299B1 (en) | 2009-07-10 | 2010-07-09 | Methods and compositions for treating thyroid-related medical conditions with reduced folates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20160406T1 true HRP20160406T1 (hr) | 2016-05-20 |
Family
ID=43427658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160406TT HRP20160406T1 (hr) | 2009-07-10 | 2016-04-18 | Postupci i pripravci za liječenje sa štitnjačom povezanih medicinskih stanja sa sniženiim folatima |
Country Status (27)
| Country | Link |
|---|---|
| US (13) | US8343974B2 (hr) |
| EP (2) | EP3053583B1 (hr) |
| JP (6) | JP5940448B2 (hr) |
| KR (1) | KR101850558B1 (hr) |
| CN (2) | CN105476997B (hr) |
| AP (1) | AP2012006124A0 (hr) |
| AU (1) | AU2010271178B2 (hr) |
| BR (1) | BR112012000614B1 (hr) |
| CA (2) | CA2804265C (hr) |
| DK (1) | DK2451299T3 (hr) |
| EA (1) | EA201270160A1 (hr) |
| ES (1) | ES2569238T3 (hr) |
| HK (1) | HK1174798A1 (hr) |
| HR (1) | HRP20160406T1 (hr) |
| HU (1) | HUE027341T2 (hr) |
| IL (3) | IL304064A (hr) |
| IN (1) | IN2012DN01286A (hr) |
| MX (2) | MX350564B (hr) |
| MY (2) | MY189270A (hr) |
| NZ (1) | NZ598171A (hr) |
| PH (1) | PH12019500495A1 (hr) |
| PL (1) | PL2451299T3 (hr) |
| SG (2) | SG10201404000RA (hr) |
| SI (1) | SI2451299T1 (hr) |
| SM (1) | SMT201600110B (hr) |
| WO (1) | WO2011006147A1 (hr) |
| ZA (2) | ZA201201002B (hr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2451299T1 (sl) * | 2009-07-10 | 2016-10-28 | Iii Linzy O. Scott | Metode in sestave za zdravljenje s ščitnico- povezanih zdravstvenih stanj z reduciranimi folati |
| US20140271704A1 (en) * | 2013-03-15 | 2014-09-18 | Jarrow Formulas, Inc. | METHODS OF PRODUCING NUTRITIONAL SUPPLEMENTS USING MUSHROOMS FROM THE SPECIES Poria cocos OR Flammulina velutipes |
| US20160053281A1 (en) * | 2013-08-15 | 2016-02-25 | The University Court Of The University Of Edinburgh | Enhanced Expression Of RNA Vectors |
| CN103705497B (zh) * | 2013-12-11 | 2015-04-01 | 武汉威立得生物医药有限公司 | 碘塞罗宁在制备治疗或预防流感病毒感染的药物中的应用 |
| JP6424078B2 (ja) * | 2014-02-13 | 2018-11-14 | 山洋電気株式会社 | ステータ、ステータの製造方法、およびモータ |
| CN108992458A (zh) * | 2018-06-12 | 2018-12-14 | 中国人民解放军第四军医大学 | 维生素b12用于制备预防和/或治疗术后认知功能障碍药物的应用 |
| CN115916177A (zh) * | 2020-04-22 | 2023-04-04 | 林茨·O·斯科特三世 | 与甲状腺激素相关的疾患的治疗 |
| AU2022249968A1 (en) * | 2021-03-31 | 2023-11-02 | Boggarapu, Shravya | An oral liquid formulation of metformin, teneligliptin, vitamin b12, atorvastatin and levothyroxine for diabetes |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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