HRP20020160A2 - Preserved pharmaceutical formulations - Google Patents

Preserved pharmaceutical formulations Download PDF

Info

Publication number: HRP20020160A2
Authority: HR; Croatia
Prior art keywords: agent; phenoxyethanol; preparation according; benzethonium chloride; preparation
Prior art date: 1999-07-22

Application number

HR20020160A

Other languages

English (en)

Croatian (hr)

Inventor

Atef Gayed

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-22

Filing date

2002-02-21

Publication date

2003-10-31

2002-02-21 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2003-10-31 Publication of HRP20020160A2 publication Critical patent/HRP20020160A2/hr

Links

239000008194 pharmaceutical composition Substances 0.000 title description 38
239000003795 chemical substances by application Substances 0.000 claims description 128
238000002360 preparation method Methods 0.000 claims description 101
239000000203 mixture Substances 0.000 claims description 68
QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 66
229960005323 phenoxyethanol Drugs 0.000 claims description 66
UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims description 56
229960001950 benzethonium chloride Drugs 0.000 claims description 56
239000004480 active ingredient Substances 0.000 claims description 42
238000000034 method Methods 0.000 claims description 37
229940088597 hormone Drugs 0.000 claims description 33
239000005556 hormone Substances 0.000 claims description 33
-1 hypnotic Substances 0.000 claims description 32
239000013543 active substance Substances 0.000 claims description 23
239000002934 diuretic Substances 0.000 claims description 23
239000000739 antihistaminic agent Substances 0.000 claims description 21
239000002831 pharmacologic agent Substances 0.000 claims description 18
102000004169 proteins and genes Human genes 0.000 claims description 18
108090000623 proteins and genes Proteins 0.000 claims description 18
239000002327 cardiovascular agent Substances 0.000 claims description 17
229940125692 cardiovascular agent Drugs 0.000 claims description 17
239000004094 surface-active agent Substances 0.000 claims description 17
230000000573 anti-seizure effect Effects 0.000 claims description 15
239000001961 anticonvulsive agent Substances 0.000 claims description 14
108090000765 processed proteins & peptides Proteins 0.000 claims description 14
230000001003 psychopharmacologic effect Effects 0.000 claims description 14
239000000932 sedative agent Substances 0.000 claims description 14
230000001624 sedative effect Effects 0.000 claims description 14
230000003556 anti-epileptic effect Effects 0.000 claims description 13
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims description 12
230000001387 anti-histamine Effects 0.000 claims description 11
239000004599 antimicrobial Substances 0.000 claims description 11
239000002282 antimigraine agent Substances 0.000 claims description 11
229940125684 antimigraine agent Drugs 0.000 claims description 11
239000003937 drug carrier Substances 0.000 claims description 11
239000000825 pharmaceutical preparation Substances 0.000 claims description 11
239000000843 powder Substances 0.000 claims description 11
208000018522 Gastrointestinal disease Diseases 0.000 claims description 10
230000001882 diuretic effect Effects 0.000 claims description 10
230000002489 hematologic effect Effects 0.000 claims description 10
230000000147 hypnotic effect Effects 0.000 claims description 10
239000000829 suppository Substances 0.000 claims description 10
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 7
239000000935 antidepressant agent Substances 0.000 claims description 7
229940005513 antidepressants Drugs 0.000 claims description 7
239000007788 liquid Substances 0.000 claims description 7
239000000243 solution Substances 0.000 claims description 7
239000000443 aerosol Substances 0.000 claims description 6
235000011187 glycerol Nutrition 0.000 claims description 6
ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical group O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims description 6
229930000680 A04AD01 - Scopolamine Natural products 0.000 claims description 5
STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 claims description 5
STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 claims description 5
229940069428 antacid Drugs 0.000 claims description 5
239000003159 antacid agent Substances 0.000 claims description 5
229920000669 heparin Polymers 0.000 claims description 5
210000004400 mucous membrane Anatomy 0.000 claims description 5
229960002646 scopolamine Drugs 0.000 claims description 5
STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 claims description 5
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 4
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 4
CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical group N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 claims description 4
108090000373 Tissue Plasminogen Activator Proteins 0.000 claims description 4
102000003978 Tissue Plasminogen Activator Human genes 0.000 claims description 4
XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 4
239000006071 cream Substances 0.000 claims description 4
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 4
239000002895 emetic Substances 0.000 claims description 4
RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical group C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims description 4
229960003592 fexofenadine Drugs 0.000 claims description 4
210000005095 gastrointestinal system Anatomy 0.000 claims description 4
239000000499 gel Substances 0.000 claims description 4
229960002897 heparin Drugs 0.000 claims description 4
210000004185 liver Anatomy 0.000 claims description 4
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 4
239000002674 ointment Substances 0.000 claims description 4
230000008569 process Effects 0.000 claims description 4
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 3
LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 claims description 3
229960001138 acetylsalicylic acid Drugs 0.000 claims description 3
229960002576 amiloride Drugs 0.000 claims description 3
XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 claims description 3
239000003866 digestant Substances 0.000 claims description 3
229960005156 digoxin Drugs 0.000 claims description 3
LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 claims description 3
LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 claims description 3
230000002401 inhibitory effect Effects 0.000 claims description 3
229960002695 phenobarbital Drugs 0.000 claims description 3
DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 claims description 3
229960005202 streptokinase Drugs 0.000 claims description 3
239000000725 suspension Substances 0.000 claims description 3
239000003826 tablet Substances 0.000 claims description 3
229960000278 theophylline Drugs 0.000 claims description 3
229960000187 tissue plasminogen activator Drugs 0.000 claims description 3
SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims description 2
102000004882 Lipase Human genes 0.000 claims description 2
108090001060 Lipase Proteins 0.000 claims description 2
239000004367 Lipase Substances 0.000 claims description 2
JEYCTXHKTXCGPB-UHFFFAOYSA-N Methaqualone Chemical compound CC1=CC=CC=C1N1C(=O)C2=CC=CC=C2N=C1C JEYCTXHKTXCGPB-UHFFFAOYSA-N 0.000 claims description 2
229930182555 Penicillin Natural products 0.000 claims description 2
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 2
108010023197 Streptokinase Proteins 0.000 claims description 2
239000004098 Tetracycline Substances 0.000 claims description 2
108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims description 2
102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims description 2
230000001430 anti-depressive effect Effects 0.000 claims description 2
239000000440 bentonite Substances 0.000 claims description 2
229910000278 bentonite Inorganic materials 0.000 claims description 2
235000012216 bentonite Nutrition 0.000 claims description 2
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical group O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
229940064790 dilantin Drugs 0.000 claims description 2
HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical group C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims description 2
229960004166 diltiazem Drugs 0.000 claims description 2
229940008099 dimethicone Drugs 0.000 claims description 2
239000004205 dimethyl polysiloxane Substances 0.000 claims description 2
235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 2
229960003638 dopamine Drugs 0.000 claims description 2
229960003276 erythromycin Drugs 0.000 claims description 2
PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 claims description 2
ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims description 2
229960003883 furosemide Drugs 0.000 claims description 2
ZQDWXGKKHFNSQK-UHFFFAOYSA-N hydroxyzine Chemical compound C1CN(CCOCCO)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZQDWXGKKHFNSQK-UHFFFAOYSA-N 0.000 claims description 2
235000019421 lipase Nutrition 0.000 claims description 2
229960002803 methaqualone Drugs 0.000 claims description 2
229960005181 morphine Drugs 0.000 claims description 2
OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 claims description 2
229960001180 norfloxacin Drugs 0.000 claims description 2
229940049954 penicillin Drugs 0.000 claims description 2
229960002036 phenytoin Drugs 0.000 claims description 2
229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 2
ABTXGJFUQRCPNH-UHFFFAOYSA-N procainamide hydrochloride Chemical compound [H+].[Cl-].CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 ABTXGJFUQRCPNH-UHFFFAOYSA-N 0.000 claims description 2
229960003253 procainamide hydrochloride Drugs 0.000 claims description 2
229960000620 ranitidine Drugs 0.000 claims description 2
VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 claims description 2
235000019364 tetracycline Nutrition 0.000 claims description 2
150000003522 tetracyclines Chemical class 0.000 claims description 2
229960005356 urokinase Drugs 0.000 claims description 2
239000011787 zinc oxide Substances 0.000 claims description 2
235000014692 zinc oxide Nutrition 0.000 claims description 2
238000009512 pharmaceutical packaging Methods 0.000 claims 2
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
108010036949 Cyclosporine Proteins 0.000 claims 1
241000208011 Digitalis Species 0.000 claims 1
NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 1
230000001458 anti-acid effect Effects 0.000 claims 1
230000000561 anti-psychotic effect Effects 0.000 claims 1
229960001265 ciclosporin Drugs 0.000 claims 1
ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims 1
229960003722 doxycycline Drugs 0.000 claims 1
229960000930 hydroxyzine Drugs 0.000 claims 1
229960004194 lidocaine Drugs 0.000 claims 1
229960002180 tetracycline Drugs 0.000 claims 1
229930101283 tetracycline Natural products 0.000 claims 1
238000009472 formulation Methods 0.000 description 59
WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 48
239000003755 preservative agent Substances 0.000 description 34
229940067107 phenylethyl alcohol Drugs 0.000 description 24
235000002639 sodium chloride Nutrition 0.000 description 20
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 19
229940079593 drug Drugs 0.000 description 18
239000003814 drug Substances 0.000 description 18
230000002335 preservative effect Effects 0.000 description 17
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 15
229940030606 diuretics Drugs 0.000 description 12
230000000694 effects Effects 0.000 description 12
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 11
229940125715 antihistaminic agent Drugs 0.000 description 10
210000004369 blood Anatomy 0.000 description 10
239000008280 blood Substances 0.000 description 10
239000011780 sodium chloride Substances 0.000 description 10
239000000654 additive Substances 0.000 description 9
239000000872 buffer Substances 0.000 description 9
230000002496 gastric effect Effects 0.000 description 9
150000003839 salts Chemical class 0.000 description 9
239000000126 substance Substances 0.000 description 9
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 8
UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 8
239000003242 anti bacterial agent Substances 0.000 description 8
230000000845 anti-microbial effect Effects 0.000 description 8
230000002440 hepatic effect Effects 0.000 description 8
239000003921 oil Substances 0.000 description 8
235000019198 oils Nutrition 0.000 description 8
239000003146 anticoagulant agent Substances 0.000 description 7
239000002372 hematologic agent Substances 0.000 description 7
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
239000003463 adsorbent Substances 0.000 description 6
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239000008141 laxative Substances 0.000 description 6
229940125722 laxative agent Drugs 0.000 description 6
230000003204 osmotic effect Effects 0.000 description 6
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239000011734 sodium Substances 0.000 description 6
229910052708 sodium Inorganic materials 0.000 description 6
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230000002195 synergetic effect Effects 0.000 description 6
IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 6
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108010010803 Gelatin Proteins 0.000 description 5
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical class NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 5
241000282414 Homo sapiens Species 0.000 description 5
208000019695 Migraine disease Diseases 0.000 description 5
230000001166 anti-perspirative effect Effects 0.000 description 5
229940088710 antibiotic agent Drugs 0.000 description 5
239000003213 antiperspirant Substances 0.000 description 5
239000003212 astringent agent Substances 0.000 description 5
230000000903 blocking effect Effects 0.000 description 5
239000002552 dosage form Substances 0.000 description 5
229920000159 gelatin Polymers 0.000 description 5
239000008273 gelatin Substances 0.000 description 5
235000019322 gelatine Nutrition 0.000 description 5
235000011852 gelatine desserts Nutrition 0.000 description 5
244000005700 microbiome Species 0.000 description 5
206010027599 migraine Diseases 0.000 description 5
239000000810 peripheral vasodilating agent Substances 0.000 description 5
229960002116 peripheral vasodilator Drugs 0.000 description 5
239000001488 sodium phosphate Substances 0.000 description 5
235000011008 sodium phosphates Nutrition 0.000 description 5
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 5
229940127291 Calcium channel antagonist Drugs 0.000 description 4
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 4
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 4
239000002220 antihypertensive agent Substances 0.000 description 4
239000000480 calcium channel blocker Substances 0.000 description 4
150000001875 compounds Chemical class 0.000 description 4
239000003974 emollient agent Substances 0.000 description 4
230000006870 function Effects 0.000 description 4
229940124562 hematologic agent Drugs 0.000 description 4
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

HR20020160A 1999-07-22 2002-02-21 Preserved pharmaceutical formulations HRP20020160A2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US22881599P	1999-07-22	1999-07-22

Publications (1)

Publication Number	Publication Date
HRP20020160A2 true HRP20020160A2 (en)	2003-10-31

Family

ID=22858657

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20020160A HRP20020160A2 (en)	1999-07-22	2002-02-21	Preserved pharmaceutical formulations

Country Status (21)

Country	Link
US (1)	US7109161B1 (no)
EP (1)	EP1200128A1 (no)
JP (1)	JP2003520777A (no)
KR (2)	KR20070116181A (no)
CN (1)	CN1371287A (no)
AU (1)	AU777410C (no)
BR (1)	BR0012674A (no)
CA (1)	CA2378892C (no)
CZ (1)	CZ2002265A3 (no)
EA (1)	EA007070B1 (no)
EE (1)	EE200200038A (no)
HK (1)	HK1050317A1 (no)
HR (1)	HRP20020160A2 (no)
HU (1)	HUP0202235A3 (no)
IL (1)	IL147756A (no)
NO (1)	NO20020304L (no)
NZ (1)	NZ516736A (no)
PL (1)	PL353026A1 (no)
WO (1)	WO2001007086A1 (no)
YU (1)	YU4602A (no)
ZA (1)	ZA200200743B (no)

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2000
- 2000-07-21 EE EEP200200038A patent/EE200200038A/xx unknown
- 2000-07-21 US US10/031,922 patent/US7109161B1/en not_active Expired - Lifetime
- 2000-07-21 KR KR1020077025804A patent/KR20070116181A/ko not_active Application Discontinuation
- 2000-07-21 CZ CZ2002265A patent/CZ2002265A3/cs unknown
- 2000-07-21 IL IL14775600A patent/IL147756A/xx active IP Right Grant
- 2000-07-21 EA EA200200072A patent/EA007070B1/ru not_active IP Right Cessation
- 2000-07-21 KR KR1020027000952A patent/KR20020032534A/ko not_active Application Discontinuation
- 2000-07-21 BR BR0012674-8A patent/BR0012674A/pt not_active IP Right Cessation
- 2000-07-21 HU HU0202235A patent/HUP0202235A3/hu unknown
- 2000-07-21 CA CA002378892A patent/CA2378892C/en not_active Expired - Lifetime
- 2000-07-21 JP JP2001511969A patent/JP2003520777A/ja not_active Abandoned
- 2000-07-21 AU AU62325/00A patent/AU777410C/en not_active Expired
- 2000-07-21 CN CN00812154A patent/CN1371287A/zh active Pending
- 2000-07-21 PL PL00353026A patent/PL353026A1/xx not_active Application Discontinuation
- 2000-07-21 YU YU4602A patent/YU4602A/sh unknown
- 2000-07-21 NZ NZ516736A patent/NZ516736A/en not_active IP Right Cessation
- 2000-07-21 EP EP00948895A patent/EP1200128A1/en not_active Withdrawn
- 2000-07-21 WO PCT/US2000/020040 patent/WO2001007086A1/en active Search and Examination
2002
- 2002-01-21 NO NO20020304A patent/NO20020304L/no not_active Application Discontinuation
- 2002-01-28 ZA ZA200200743A patent/ZA200200743B/xx unknown
- 2002-02-21 HR HR20020160A patent/HRP20020160A2/hr not_active Application Discontinuation
2003
- 2003-03-24 HK HK03102131.3A patent/HK1050317A1/zh unknown

Also Published As

Publication number	Publication date
CN1371287A (zh)	2002-09-25
HK1050317A1 (zh)	2003-06-20
CA2378892A1 (en)	2001-02-01
IL147756A (en)	2005-12-18
PL353026A1 (en)	2003-10-06
IL147756A0 (en)	2002-08-14
EA200200072A1 (ru)	2003-02-27
JP2003520777A (ja)	2003-07-08
US7109161B1 (en)	2006-09-19
NO20020304L (no)	2002-03-21
EP1200128A1 (en)	2002-05-02
NZ516736A (en)	2004-02-27
CZ2002265A3 (cs)	2002-08-14
AU777410B2 (en)	2004-10-14
KR20020032534A (ko)	2002-05-03
EE200200038A (et)	2003-04-15
AU6232500A (en)	2001-02-13
WO2001007086A1 (en)	2001-02-01
CA2378892C (en)	2008-07-15
NO20020304D0 (no)	2002-01-21
ZA200200743B (en)	2003-06-25
AU777410C (en)	2006-08-17
HUP0202235A2 (hu)	2002-11-28
EA007070B1 (ru)	2006-06-30
YU4602A (sh)	2005-06-10
HUP0202235A3 (en)	2004-05-28
BR0012674A (pt)	2002-09-17
KR20070116181A (ko)	2007-12-06

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HRP20020160A2 (en)	2003-10-31	Preserved pharmaceutical formulations
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FI111130B (fi)	2003-06-13	Menetelmä syklosporiinijohdannaista sisältävän farmaseuttisen koostumuksen valmistamiseksi
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JPH044300B2 (no)	1992-01-27
JPS631923B2 (no)	1988-01-14
AU2018275545B2 (en)	2021-02-04	Rapid-acting insulin compositions
CZ294604B6 (cs)	2005-02-16	Léčivý přípravek pro parenterální podávání z extraktů ze jmelí
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EP0168626B1 (en)	1990-09-12	Composition for the manufacture of a medicament for the therapeutic treatment of trauma of the skin

Legal Events

Date	Code	Title	Description
2003-10-31	A1OB	Publication of a patent application
2004-04-29	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2010-07-14	PPPP	Transfer of rights	Owner name: AVENTISUB II INC., US Owner name: HMR PHARMA INC., US Owner name: AVENTIS HOLDINGS INC., US
2010-07-19	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20100719 Year of fee payment: 11
2012-10-12	ODBI	Application refused