HK1206753A1 - Antibody purification by cation exchange chromatography - Google Patents

Antibody purification by cation exchange chromatography

Info

Publication number: HK1206753A1
Authority: HK; Hong Kong
Prior art keywords: cation exchange; exchange chromatography; antibody purification; antibody; purification
Prior art date: 2007-10-30

Application number

HK15107237.1A

Other languages

English (en)

Chinese (zh)

Inventor

Benedicte Andree Lebreton

Deborah Ann Oconnor

Aurelia Safta

Mandakini Sharma

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-30

Filing date

2015-07-28

Publication date

2016-01-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40262967&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1206753(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2015-07-28 Application filed by Genentech Inc filed Critical Genentech Inc

2016-01-15 Publication of HK1206753A1 publication Critical patent/HK1206753A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Analytical Chemistry (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

HK15107237.1A 2007-10-30 2015-07-28 Antibody purification by cation exchange chromatography HK1206753A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US98382507P	2007-10-30	2007-10-30

Publications (1)

Publication Number	Publication Date
HK1206753A1 true HK1206753A1 (en)	2016-01-15

Family

ID=40262967

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
HK13109765.9A HK1182401A1 (zh)	2007-10-30	2010-10-28	通過陽離子交換色譜法提純抗體
HK10110121.9A HK1143821A1 (en)	2007-10-30	2010-10-28	Antibody purification by cation exchange chromatography
HK15107237.1A HK1206753A1 (en)	2007-10-30	2015-07-28	Antibody purification by cation exchange chromatography
HK16109407.0A HK1221234A1 (zh)	2007-10-30	2016-08-08	通過陽離子交換層析進行的抗體純化

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
HK13109765.9A HK1182401A1 (zh)	2007-10-30	2010-10-28	通過陽離子交換色譜法提純抗體
HK10110121.9A HK1143821A1 (en)	2007-10-30	2010-10-28	Antibody purification by cation exchange chromatography

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
HK16109407.0A HK1221234A1 (zh)	2007-10-30	2016-08-08	通過陽離子交換層析進行的抗體純化

Country Status (32)

Country	Link
US (3)	US20090148435A1 (xx)
EP (4)	EP3441402A1 (xx)
JP (5)	JP5237382B2 (xx)
KR (3)	KR101241486B1 (xx)
CN (3)	CN105315323A (xx)
AR (2)	AR069097A1 (xx)
AU (1)	AU2008318865B2 (xx)
BR (1)	BRPI0817182A2 (xx)
CA (1)	CA2703279C (xx)
CL (1)	CL2008003218A1 (xx)
CO (1)	CO6280422A2 (xx)
CY (1)	CY1116129T1 (xx)
DK (3)	DK2565206T3 (xx)
ES (3)	ES2533266T5 (xx)
HK (4)	HK1182401A1 (xx)
HR (2)	HRP20150282T4 (xx)
HU (3)	HUE037409T2 (xx)
IL (4)	IL205310A0 (xx)
ME (1)	ME02101B (xx)
MX (1)	MX2010004740A (xx)
NZ (1)	NZ584839A (xx)
PE (1)	PE20091434A1 (xx)
PH (1)	PH12013501128A1 (xx)
PL (3)	PL2565206T3 (xx)
PT (1)	PT2215117E (xx)
RS (1)	RS53850B2 (xx)
RU (1)	RU2498991C2 (xx)
SG (2)	SG10201401690XA (xx)
SI (3)	SI2215117T2 (xx)
TW (2)	TWI448330B (xx)
WO (1)	WO2009058812A1 (xx)
ZA (2)	ZA201002850B (xx)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2380911B1 (en)	2003-11-05	2018-05-09	Roche Glycart AG	Antigen binding molecules with increased Fc receptor binding affinity and effector function
JO3000B1 (ar)	2004-10-20	2016-09-05	Genentech Inc	مركبات أجسام مضادة .
UA94899C2 (ru) *	2005-01-21	2011-06-25	Дженентек, Инк.	Фиксированное дозирование антител к her
ES2440481T3 (es)	2005-02-23	2014-01-29	Genentech, Inc.	Prolongación del tiempo hasta la progresión de la enfermedad o supervivencia en pacientes de cáncer de ovario usando pertuzumab
MX346523B (es)	2006-09-13	2017-03-23	Abbvie Inc	Mejoras de cultivos celulares.
US8911964B2 (en)	2006-09-13	2014-12-16	Abbvie Inc.	Fed-batch method of making human anti-TNF-alpha antibody
CA2677108A1 (en)	2007-03-02	2008-09-12	Genentech, Inc.	Predicting response to a her inhibitor
KR101241486B1 (ko) *	2007-10-30	2013-03-15	제넨테크, 인크.	양이온 교환 크로마토그래피에 의한 항체 정제
TWI472339B (zh)	2008-01-30	2015-02-11	Genentech Inc	包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物
BRPI0812682A2 (pt)	2008-06-16	2010-06-22	Genentech Inc	tratamento de cáncer de mama metastático
AR073295A1 (es)	2008-09-16	2010-10-28	Genentech Inc	Metodos para tratar la esclerosis multiple progresiva. articulo de fabricacion.
US8268314B2 (en)	2008-10-08	2012-09-18	Hoffmann-La Roche Inc.	Bispecific anti-VEGF/anti-ANG-2 antibodies
JP5856845B2 (ja)	2008-10-20	2016-02-10	アッヴィ・インコーポレイテッド	抗体精製中におけるウイルスの不活性化
NZ592095A (en)	2008-10-20	2013-01-25	Abbott Lab	Isolation and purification of il-12 and tnf-alpha antibodies using protein a affinity chromatography
AR078161A1 (es) *	2009-09-11	2011-10-19	Hoffmann La Roche	Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
EP2480561B1 (en) *	2009-09-23	2016-07-13	E. R. Squibb & Sons, L.L.C.	Cation exchange chromatography
EP3696194A1 (en) *	2010-02-23	2020-08-19	F. Hoffmann-La Roche AG	Anti-angiogenesis therapy for the treatment of ovarian cancer
TWI426920B (zh)	2010-03-26	2014-02-21	Hoffmann La Roche	雙專一性、雙價抗－ｖｅｇｆ／抗－ａｎｇ－２抗體
JP5887337B2 (ja) *	2010-03-30	2016-03-16	ヤンセンバイオテツク，インコーポレーテツド	ヒト化ｉｌ−２５抗体
PT3351636T (pt)	2010-05-14	2020-09-24	Univ Oregon Health & Science	Vectores de hcmv e rhcmv recombinantes codificadores de um antigénio heterólogo isolado a partir de um vírus paramyxoviridae e seus usos
CA3209878A1 (en) *	2010-05-25	2011-12-01	Genentech, Inc.	Methods of purifying polypeptides
GB201012603D0 (en)	2010-07-27	2010-09-08	Ucb Pharma Sa	Protein purification
WO2012084829A1 (en) *	2010-12-21	2012-06-28	F. Hoffmann-La Roche Ag	Isoform enriched antibody preparation and method for obtaining it
ES2784628T3 (es)	2011-03-29	2020-09-29	Glaxosmithkline Llc	Sistema de tampón para purificación de proteína
WO2012160530A1 (en) *	2011-05-26	2012-11-29	Dr. Reddy's Laboratories Limited	Purification of antibodies
EP2691530B1 (en)	2011-06-10	2018-03-07	Oregon Health & Science University	Cmv glycoproteins and recombinant vectors
WO2013054250A1 (en) *	2011-10-10	2013-04-18	Dr Reddy's Laboratories Limited	Purification method
SI2766040T1 (sl)	2011-10-14	2019-08-30	F. Hoffmann-La Roche Ag	Pertuzumab, Trastuzumab, Docetaxel in Carboplatin za zdravljenje zgodnjega raka dojke
RU2478646C1 (ru) *	2011-11-28	2013-04-10	Федеральное государственное бюджетное учреждение науки Институт молекулярной биологии им.В.А.Энгельгардта Российской академии наук (ИМБ РАН)	Способ получения высокоаффинных поликлональных антител
RU2648999C2 (ru)	2011-12-22	2018-03-29	Дженентек, Инк.	Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии
HRP20211641T1 (hr)	2012-07-13	2022-02-04	Roche Glycart Ag	Bispecifična protutijela anti-vegf/anti-ang-2 i njihova primjena u liječenju vaskularnih očnih bolesti
JP6253584B2 (ja) *	2012-08-27	2017-12-27	旭化成メディカル株式会社	温度応答性クロマトグラフィーによる抗体の精製方法
CN103217499B (zh) *	2013-01-15	2015-12-02	珠海市丽珠单抗生物技术有限公司	一种测定免疫球蛋白电荷异构体的糖基化和末端修饰情况的方法
RU2662929C2 (ru)	2013-03-08	2018-07-31	Джензим Корпорейшн	Интегрированное непрерывное производство терапевтических белковых лекарственных веществ
UY35517A (es) *	2013-04-04	2014-10-31	Mabxience S A	Un procedimiento para aumentar la formación de ácido piroglutamico de una proteína
SG10201706045RA (en)	2013-04-16	2017-08-30	Genentech Inc	Pertuzumab variants and evaluation thereof
KR101700580B1 (ko)	2013-10-30	2017-02-13	(주)셀트리온	양이온 교환 크로마토그래피를 이용한 항체의 아형 분리 방법
CN104628846B (zh) *	2013-11-06	2019-12-06	三生国健药业（上海）股份有限公司	重组蛋白质的纯化方法
WO2015077605A1 (en) *	2013-11-25	2015-05-28	Seattle Genetics, Inc.	Preparing antibodies from cho cell cultures for conjugation
TWI709570B (zh)	2014-01-17	2020-11-11	美商健臻公司	無菌層析法及製法
TWI709569B (zh)	2014-01-17	2020-11-11	美商健臻公司	無菌層析樹脂及其用於製造方法的用途
US20160347787A1 (en)	2014-02-04	2016-12-01	Biogen Ma Inc.	Use of cation-exchange chromatography in the flow-through mode to enrich post-translational modifications
HUE048782T2 (hu)	2014-03-10	2020-08-28	Richter Gedeon Nyrt	Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával
CN105017418B (zh) *	2014-03-27	2021-02-23	上海药明康德新药开发有限公司	单克隆抗体纯化工艺方法
EP3134440A1 (en)	2014-04-25	2017-03-01	F. Hoffmann-La Roche AG	Methods of treating early breast cancer with trastuzumab-mcc-dm1 and pertuzumab
AU2015289560B2 (en)	2014-07-16	2018-09-27	Oregon Health & Science University	Human cytomegalovirus comprising exogenous antigens
CN105315369B (zh) *	2014-07-25	2020-03-13	山东博安生物技术有限公司	利用阳离子交换层析纯化蛋白质
US10695693B2 (en) *	2015-03-13	2020-06-30	Bristol-Myers Squibb Company	Use of alkaline washes during chromatography to remove impurities
US11406715B2 (en)	2015-05-30	2022-08-09	Genentech, Inc.	Methods of treating HER2-positive metastatic breast cancer
KR101657690B1 (ko) *	2015-06-05	2016-09-19	주식회사 녹십자홀딩스	혈장 유래 b형 간염 사람 면역글로불린 제제의 제조방법
WO2017087280A1 (en)	2015-11-16	2017-05-26	Genentech, Inc.	Methods of treating her2-positive cancer
JP7133468B2 (ja)	2015-11-20	2022-09-08	オレゴン・ヘルス・アンド・サイエンス・ユニバーシティ	マイクロｒｎａ認識エレメントを含むｃｍｖベクター
GB201600512D0 (en)	2016-01-12	2016-02-24	Univ York	Recombinant protein production
AU2017248731B2 (en)	2016-04-15	2024-08-29	The Trustees Of The University Of Pennsylvania	Compositions for treatment of wet age-related macular degeneration
CN109310756B (zh) *	2016-05-13	2022-06-28	奥美药业有限公司	新型血管生成素2，vegf双特异性拮抗剂
SG11201811553UA (en) *	2016-07-15	2019-01-30	Hoffmann La Roche	Method for purifying pegylated erythropoietin
CN106222222B (zh) *	2016-08-08	2019-10-29	湖北医药学院	一种重组人白血病抑制因子的制备方法
WO2018045587A1 (zh) *	2016-09-12	2018-03-15	广东东阳光药业有限公司	一种抗vegf类单克隆抗体的纯化方法
CN106380519B (zh) *	2016-10-17	2019-11-01	深圳万乐药业有限公司	一种单克隆抗体的纯化方法
EP3529363A4 (en)	2016-10-18	2020-05-06	Oregon Health & Science University	CYTOMEGALOVIRUS VECTORS, CALLING OUT T-CELLS, RESTRICTED BY A LARGE HISTOCOMPATIBILITY COMPLEX E-MOLECULE
US11021530B2 (en) *	2016-10-31	2021-06-01	Hexal Ag	Antibody preparation
WO2018125589A1 (en)	2016-12-28	2018-07-05	Genentech, Inc.	Treatment of advanced her2 expressing cancer
MY189536A (en)	2017-01-17	2022-02-16	Hoffmann La Roche	Subcutaneous her2 antibody formulations
KR102417583B1 (ko)	2017-03-02	2022-07-07	제넨테크, 인크.	Her2-양성 유방암 어쥬번트 치료
BE1025090B1 (fr) *	2017-03-30	2018-10-29	Univercells Sa	Procede et kit de purification de proteines
KR102140693B1 (ko) *	2017-04-14	2020-08-05	에이치케이이노엔 주식회사	양이온 교환 크로마토그래피를 이용한 유사항체 정제 방법
WO2018200505A1 (en)	2017-04-24	2018-11-01	Genentech, Inc.	Erbb2/her2 mutations in the transmbrane or juxtamembrane domain
US11426706B2 (en)	2017-06-21	2022-08-30	Cephalon, Inc.	Cation exchange chromatography wash buffer
CN111163804A (zh) *	2017-09-22	2020-05-15	伊缪诺金公司	使用阳离子交换色谱法分离三轻链抗体
CN110272491B (zh) *	2018-03-13	2023-01-24	江苏恒瑞医药股份有限公司	一种抗pd-1抗体的纯化工艺
EP3774882A1 (en) *	2018-03-29	2021-02-17	Bristol-Myers Squibb Company	Methods of purifying monomeric monoclonal antibodies
EP3791172B1 (en) *	2018-05-08	2023-06-28	Waters Technologies Corporation	Methods, compositions and kits useful for ph gradient cation exchange chromatography
WO2020046602A1 (en)	2018-08-31	2020-03-05	Genzyme Corporation	Sterile chromatography resin and use thereof in manufacturing processes
EP3643322A1 (en) *	2018-10-26	2020-04-29	Mabion SA	Low aggregate anti cd20 ligand formulation
CN109320611B (zh) *	2018-10-31	2022-06-03	鼎康(武汉)生物医药有限公司	一种人鼠嵌合单克隆抗体生物类似药的纯化方法
CN112206327A (zh) *	2019-07-12	2021-01-12	上海药明生物技术有限公司	一种抗体偶联药物的制备及其高通量筛选方法
WO2021076489A1 (en) *	2019-10-14	2021-04-22	Pierce Biotechnology, Inc.	Peptide purification formulations and methods
EP4067387A4 (en) *	2019-11-25	2023-12-27	Akeso Biopharma, Inc.	BISPECIFIC ANTI-PD-1 ANTI-VEGFA NTIBODY, PHARMACEUTICAL COMPOSITION AND USE THEREOF
KR102153258B1 (ko) *	2020-02-21	2020-09-07	프레스티지바이오로직스 주식회사	베바시주맙 정제의 최적화된 방법
US11416468B2 (en) *	2020-07-21	2022-08-16	International Business Machines Corporation	Active-active system index management
CN114591438B (zh) *	2022-04-25	2023-12-05	达石药业(广东)有限公司	一种采用阳离子交换层析法纯化双特异性抗体的方法
WO2024090489A1 (ja) *	2022-10-26	2024-05-02	日本メジフィジックス株式会社	放射性医薬組成物の製造方法
CN115850493B (zh) *	2022-11-08	2024-03-12	江苏耀海生物制药有限公司	一种二价纳米抗体Cablivi的分离纯化方法
CN117756878A (zh) *	2023-12-26	2024-03-26	康日百奥生物科技(苏州)有限公司	抗体层析分离方法及应用

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3773919A (en)	1969-10-23	1973-11-20	Du Pont	Polylactide-drug mixtures
USRE30985E (en)	1978-01-01	1982-06-29		Serum-free cell culture media
US4515893A (en)	1979-04-26	1985-05-07	Ortho Pharmaceutical Corporation	Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells
GB2070818A (en)	1980-02-04	1981-09-09	Philips Electronic Associated	Regulated power supply for an image intensifier
WO1984002129A1 (en)	1982-11-22	1984-06-07	Takeda Chemical Industries Ltd	Human immune interferon protein and process for its preparation
US4560655A (en)	1982-12-16	1985-12-24	Immunex Corporation	Serum-free cell culture medium and process for making same
US4657866A (en)	1982-12-21	1987-04-14	Sudhir Kumar	Serum-free, synthetic, completely chemically defined tissue culture media
US4816567A (en)	1983-04-08	1989-03-28	Genentech, Inc.	Recombinant immunoglobin preparations
DD266710A3 (de)	1983-06-06	1989-04-12	Ve Forschungszentrum Biotechnologie	Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
US4767704A (en)	1983-10-07	1988-08-30	Columbia University In The City Of New York	Protein-free culture medium
US6054561A (en)	1984-02-08	2000-04-25	Chiron Corporation	Antigen-binding sites of antibody molecules specific for cancer antigens
US5169774A (en)	1984-02-08	1992-12-08	Cetus Oncology Corporation	Monoclonal anti-human breast cancer antibodies
US4753894A (en)	1984-02-08	1988-06-28	Cetus Corporation	Monoclonal anti-human breast cancer antibodies
WO1986002068A1 (en)	1984-09-26	1986-04-10	Takeda Chemical Industries, Ltd.	Mutual separation of proteins
US4879231A (en)	1984-10-30	1989-11-07	Phillips Petroleum Company	Transformation of yeasts of the genus pichia
US5196323A (en)	1985-04-27	1993-03-23	Boehringer Ingelheim International Gmbh	Process for preparing and purifying alpha-interferon
GB8516415D0 (en)	1985-06-28	1985-07-31	Celltech Ltd	Culture of animal cells
US5525338A (en)	1992-08-21	1996-06-11	Immunomedics, Inc.	Detection and therapy of lesions with biotin/avidin conjugates
US5091178A (en)	1986-02-21	1992-02-25	Oncogen	Tumor therapy with biologically active anti-tumor antibodies
US4927762A (en)	1986-04-01	1990-05-22	Cell Enterprises, Inc.	Cell culture medium with antioxidant
GB8610600D0 (en)	1986-04-30	1986-06-04	Novo Industri As	Transformation of trichoderma
CA1283072C (en) *	1986-12-01	1991-04-16	Timothy Durance	Process for the isolation and separation of lysozyme and avidin from eggwhite
IL85035A0 (en)	1987-01-08	1988-06-30	Int Genetic Eng	Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5451662A (en)	1987-10-23	1995-09-19	Schering Corporation	Method of purifying protein
US5118796A (en)	1987-12-09	1992-06-02	Centocor, Incorporated	Efficient large-scale purification of immunoglobulins and derivatives
US5091313A (en)	1988-08-05	1992-02-25	Tanox Biosystems, Inc.	Antigenic epitopes of IgE present on B cell but not basophil surface
WO1989006692A1 (en)	1988-01-12	1989-07-27	Genentech, Inc.	Method of treating tumor cells by inhibiting growth factor receptor function
US5720937A (en)	1988-01-12	1998-02-24	Genentech, Inc.	In vivo tumor detection assay
IT1219874B (it)	1988-03-18	1990-05-24	Fidia Farmaceutici	Utilizzazione del fattore di crescita nervoso umano e sue composizioni farmaceutiche
US5115101A (en)	1988-06-08	1992-05-19	Miles Inc.	Removal of protein A from antibody preparations
JP2749167B2 (ja)	1988-06-21	1998-05-13	ジェネンテク，インコーポレイテッド	心筋梗塞の処置のための方法および治療用組成物
AU632065B2 (en)	1988-09-23	1992-12-17	Novartis Vaccines And Diagnostics, Inc.	Cell culture medium for enhanced cell growth, culture longevity and product expression
US5530101A (en)	1988-12-28	1996-06-25	Protein Design Labs, Inc.	Humanized immunoglobulins
EP0402226A1 (en)	1989-06-06	1990-12-12	Institut National De La Recherche Agronomique	Transformation vectors for yeast yarrowia
DE3920358A1 (de)	1989-06-22	1991-01-17	Behringwerke Ag	Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5112951A (en) *	1989-07-28	1992-05-12	Hybritech Incorporated	Separation of anti-metal chelate antibodies
US5110913A (en)	1990-05-25	1992-05-05	Miles Inc.	Antibody purification method
EP0467466A1 (en) *	1990-07-16	1992-01-22	Eastman Kodak Company	Method for the purification of immunoreactive labeled thyroxine conjugates
US5122469A (en)	1990-10-03	1992-06-16	Genentech, Inc.	Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
LU91067I2 (fr)	1991-06-14	2004-04-02	Genentech Inc	Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines
AU2498192A (en)	1991-08-14	1993-03-16	Genentech Inc.	Immunoglobulin variants for specific fc epsilon receptors
JP3951062B2 (ja)	1991-09-19	2007-08-01	ジェネンテック・インコーポレーテッド	少なくとも遊離のチオールとして存在するシステインを有する抗体フラグメントの大腸菌での発現、２官能性Ｆ（ａｂ’）２抗体の産生のための使用
ATE297465T1 (de)	1991-11-25	2005-06-15	Enzon Inc	Verfahren zur herstellung von multivalenten antigenbindenden proteinen
JPH05202098A (ja)	1992-01-29	1993-08-10	Snow Brand Milk Prod Co Ltd	乳質原料から生理活性物質の製造法
DE69334351D1 (de)	1992-02-06	2011-05-12	Novartis Vaccines & Diagnostic	Biosynthetisches Bindeprotein für Tumormarker
US5279823A (en)	1992-06-08	1994-01-18	Genentech, Inc.	Purified forms of DNASE
ATE161192T1 (de)	1992-08-21	1998-01-15	Genentech Inc	Verfahren zur behandlung einer durch lfa-1 vermittelten störung
DE69303494T2 (de)	1992-11-13	1997-01-16	Idec Pharma Corp	Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma
US5736137A (en)	1992-11-13	1998-04-07	Idec Pharmaceuticals Corporation	Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5595721A (en)	1993-09-16	1997-01-21	Coulter Pharmaceutical, Inc.	Radioimmunotherapy of lymphoma using anti-CD20
EP0733207B1 (en)	1993-12-10	1997-08-27	Genentech, Inc.	Methods for diagnosis of allergy and screening of anti-allergy therapeutics
AP660A (en)	1994-01-18	1998-08-18	Genentech Inc	A method of treatment of parasitic infection using IgE antagonists.
US5429746A (en) *	1994-02-22	1995-07-04	Smith Kline Beecham Corporation	Antibody purification
CA2181787A1 (en)	1994-03-03	1995-09-08	Claire M. Doerschuk	Anti-il-8 monoclonal antibodies for treatment of inflammatory disorders
US5534615A (en)	1994-04-25	1996-07-09	Genentech, Inc.	Cardiac hypertrophy factor and uses therefor
IL117645A (en)	1995-03-30	2005-08-31	Genentech Inc	Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
US5641870A (en)	1995-04-20	1997-06-24	Genentech, Inc.	Low pH hydrophobic interaction chromatography for antibody purification
US5714583A (en)	1995-06-07	1998-02-03	Genetics Institute, Inc.	Factor IX purification methods
JPH11507535A (ja)	1995-06-07	1999-07-06	イムクローンシステムズインコーポレイテッド	腫瘍の成長を抑制する抗体および抗体フラグメント類
US6267958B1 (en)	1995-07-27	2001-07-31	Genentech, Inc.	Protein formulation
PT877626E (pt)	1996-01-23	2003-01-31	Univ Vermont And State Agric C	Anticorpos anti-cd1s para utilizacao contra icto
US7147851B1 (en)	1996-08-15	2006-12-12	Millennium Pharmaceuticals, Inc.	Humanized immunoglobulin reactive with α4β7 integrin
TR199901734T2 (xx)	1996-11-15	2000-01-21	Genentech, Inc.	N�rotrofinlerin ar�t�lmas�.
CA2272842C (en)	1996-11-27	2012-05-15	Genentech, Inc.	Humanized anti-cd11a antibodies
PT1900751E (pt)	1996-11-27	2010-02-23	Genentech Inc	Purificação por afinidade de um polipéptido numa matriz de proteína a
US20020032315A1 (en)	1997-08-06	2002-03-14	Manuel Baca	Anti-vegf antibodies
EP1325932B9 (en)	1997-04-07	2006-07-19	Genentech, Inc.	Anti-vegf antibodies
SI1787999T1 (sl)	1997-04-07	2010-12-31	Genentech Inc	Anti-VEGF protitelesa
PT1860187E (pt)	1997-05-15	2011-10-04	Genentech Inc	Receptor apo-2
US5994511A (en)	1997-07-02	1999-11-30	Genentech, Inc.	Anti-IgE antibodies and methods of improving polypeptides
KR101036414B1 (ko)	1998-05-06	2011-05-23	제넨테크, 인크.	이온 교환 크로마토그래피에 의한 단백질 정제 방법
DK1084136T3 (da)	1998-06-01	2005-01-03	Genentech Inc	Adskillelse af monomere af et antistof fra dets multimere ved anvendelse af ionbytterchromatografi
EP1493751A1 (en)	1998-06-09	2005-01-05	Statens Serum Institut	Process for producing immunoglobulins for intravenous administration and other immunoglobulin products
PT1189641E (pt)	1999-06-25	2009-11-04	Genentech Inc	Anticorpos anti-erbb2 humanizados e tratamento com anticorpos anti-erbb2
IL149116A0 (en)	1999-10-29	2002-11-10	Genentech Inc	Anti-prostate stem cell antigen (psca) antibody compositions and methods of use
UA83458C2 (uk)	2000-09-18	2008-07-25	Байоджен Айдек Ма Інк.	Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
US6417355B1 (en)	2001-04-11	2002-07-09	The United States Of America As Represented By The Secretary Of The Navy	Geminal-dinitro-1-5 diazocine derivatives
GB0113179D0 (en) *	2001-05-31	2001-07-25	Novartis Ag	Organic compounds
US7321026B2 (en)	2001-06-27	2008-01-22	Skytech Technology Limited	Framework-patched immunoglobulins
US6770027B2 (en) *	2001-10-05	2004-08-03	Scimed Life Systems, Inc.	Robotic endoscope with wireless interface
EP1507793A4 (en)	2001-10-17	2006-02-01	Human Genome Sciences Inc	NEUTROKIN ALPHA AND NEUTROKIN ALPHA SPLICE VERSION
US20040093621A1 (en)	2001-12-25	2004-05-13	Kyowa Hakko Kogyo Co., Ltd	Antibody composition which specifically binds to CD20
RU2004127458A (ru)	2002-02-14	2005-10-27	Иммуномедикс, Инк. (Us)	Анти-cd20 антитела, их гибридные белки и способы их использования
NZ537687A (en) *	2002-06-21	2008-04-30	Biogen Idec Inc	Buffered formulations for concentrating antibodies and methods of use thereof
EP2332996B1 (en) *	2002-09-11	2014-10-15	Genentech, Inc.	Purification of anti-Her2 antibodies
EP1558648B1 (en)	2002-10-17	2012-01-11	Genmab A/S	Human monoclonal antibodies against cd20
AU2003287131B2 (en)	2002-12-13	2008-07-24	Mitra Medical Technology Ab	Antilymphoma targeting agents with effector and affinity functions linked by a trifunctional reagent
PL212899B1 (pl)	2002-12-16	2012-12-31	Genentech Inc	Humanizowane przeciwcialo, kompozycja zawierajaca to przeciwcialo, wyrób fabryczny, przeciwcialo lub jego fragment do zastosowania w sposobie indukowania apoptozy, izolowany kwas nukleinowy, wektor ekspresji, komórka gospodarza, sposób wytwarzania przeciwciala lub jego fragmentu, plynny preparat i zastosowanie przeciwciala do wytwarzania leku
BR0317896A (pt)	2002-12-31	2005-12-06	Altus Pharmaceuticals Inc	Complexos de cristais de proteìna e polìmeros iÈnicos
EP1614693A4 (en) *	2003-03-31	2006-07-19	Kirin Brewery	PURIFICATION OF A HUMAN MONOCLONAL ANTIBODY AND A HUMAN POLYCLONAL ANTIBODY
CA2897608C (en)	2003-05-09	2018-07-31	Duke University	Cd20-specific antibodies and methods employing same
AR044388A1 (es)	2003-05-20	2005-09-07	Applied Molecular Evolution	Moleculas de union a cd20
CA2534898A1 (en)	2003-08-08	2005-02-17	Immunomedics, Inc.	Bispecific antibodies for inducing apoptosis of tumor and diseased cells
US8147832B2 (en)	2003-08-14	2012-04-03	Merck Patent Gmbh	CD20-binding polypeptide compositions and methods
KR100524074B1 (ko)	2003-10-01	2005-10-26	삼성전자주식회사	베젤 구조를 가지는 전자기기
TW200533357A (en) †	2004-01-08	2005-10-16	Millennium Pharm Inc	2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases
CN101022829A (zh) *	2004-04-16	2007-08-22	健泰科生物技术公司	用抗cd20抗体治疗多软骨炎和多发性单神经炎
AU2005247303A1 (en) *	2004-04-16	2005-12-08	Genentech, Inc.	Treatment of polychondritis and mononeuritis multiplex with anti-CD20 antibodies
EP2290086A3 (en) *	2004-12-22	2011-10-19	Genentech, Inc.	Methods for producing soluble multi-membrane-spanning proteins
KR101482791B1 (ko) *	2005-03-11	2015-01-21	와이어쓰 엘엘씨	약한 분배성 크로마토그래피법
ZA200710331B (en) *	2005-06-17	2009-04-29	Elan Pharma Int Ltd	Methods of purifying anti A Beta antibodies
US8246983B2 (en) *	2005-09-02	2012-08-21	Northwestern University	Encapsulated arsenic drugs
AU2007227700A1 (en) *	2006-03-20	2007-09-27	Medarex, Inc.	Protein purification
NZ571479A (en) †	2006-04-05	2012-10-26	Abbott Biotech Ltd	Antibody purification
HUE045898T2 (hu) *	2006-08-28	2020-01-28	Ares Trading Sa	Eljárás Fc-t tartalmazó proteinek tisztítására
US8620738B2 (en)	2006-08-31	2013-12-31	Visa U.S.A. Inc	Loyalty program incentive determination
EP2703007A1 (en) *	2007-03-30	2014-03-05	MedImmune, LLC	Antibodies with decreased deamidation profiles
KR101241486B1 (ko)	2007-10-30	2013-03-15	제넨테크, 인크.	양이온 교환 크로마토그래피에 의한 항체 정제
JP5731726B1 (ja)	2014-06-26	2015-06-10	楽天株式会社	情報処理装置、情報処理方法及び情報処理プログラム

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Publication number	Publication date
EP2565206B1 (en)	2016-03-30
AU2008318865A1 (en)	2009-05-07
CA2703279A1 (en)	2009-05-07
TW201512216A (zh)	2015-04-01
IL205310A0 (en)	2010-12-30
EP2215117B2 (en)	2018-01-10
RS53850B1 (en)	2015-08-31
KR101241486B1 (ko)	2013-03-15
ZA201102169B (en)	2012-12-27
EP2215117B1 (en)	2014-12-31
JP5237382B2 (ja)	2013-07-17
HK1143821A1 (en)	2011-01-14
CA2703279C (en)	2014-04-22
EP2565206A3 (en)	2013-11-06
HUE037409T2 (hu)	2018-08-28
DK2565206T3 (en)	2016-06-06
HK1221234A1 (zh)	2017-05-26
RU2010121816A (ru)	2011-12-10
US9896478B2 (en)	2018-02-20
JP2015145371A (ja)	2015-08-13
EP3441402A1 (en)	2019-02-13
JP2015155406A (ja)	2015-08-27
IL234902A0 (en)	2014-11-30
CN101889025A (zh)	2010-11-17
PL2840090T3 (pl)	2018-07-31
AU2008318865B2 (en)	2012-06-28
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PL2215117T5 (pl)	2018-06-29

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