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AR073295A1 - Metodos para tratar la esclerosis multiple progresiva. articulo de fabricacion. - Google Patents

Metodos para tratar la esclerosis multiple progresiva. articulo de fabricacion.

Info

Publication number
AR073295A1
AR073295A1 ARP090103528A ARP090103528A AR073295A1 AR 073295 A1 AR073295 A1 AR 073295A1 AR P090103528 A ARP090103528 A AR P090103528A AR P090103528 A ARP090103528 A AR P090103528A AR 073295 A1 AR073295 A1 AR 073295A1
Authority
AR
Argentina
Prior art keywords
seq
multiple sclerosis
antibody
treatment
patient
Prior art date
Application number
ARP090103528A
Other languages
English (en)
Inventor
Craig Smith
Peter Scott Chin
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41571287&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR073295(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR073295A1 publication Critical patent/AR073295A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
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Abstract

Reivindicacion 1: Un método de tratamiento de la esclerosis multiple progresiva en un paciente que compende administrar al paciente una cantidad efectiva de un anticuerpo anti-CD20, en el cual el tratamiento se basa en que el paciente tenga una o más características seleccionadas del grupo que consiste de (a) edad menor que alrededor de 55 anos, (b) una o más lesiones con tincion con gadolinio, (c) un aumento de al menos alrededor de un punto en la Escala de Estatus de Discapacidad Expandida (EDSS) durante dos anos antes de comenzar el tratamiento, y (d) un Puntaje de Gravedad de Esclerosis Multiple (MSSS) superior a alrededor de 5 puntos. Reivindicacion 21: El método de la reivindicacion 1, en el cual el anticuerpo anti-CD20 comprende: a) una region variable de la cadena pesada que comprende tres regiones CDR que constan de SEQ ID Ns: 10, SEQ ID Ns: 11 y SEQ lD Ns: 12, y b) una region variable de la cadena liviana que comprende tres regiones CDR que constan de SEQ ID Ns: 4, SEQ ID Ns: 5 y SEQ ID Ns: 6. Reivindicacion 22: El método de la reivindicacion 1, en el cual el anticuerpo anti-CD20 no es ocrelizumab. Reivindicacion 37: Un articulo de fabricacion que comprende, envasados en conjunto, una composicion farmacéutica que incluye un anticuerpo anti-CD20 y un portador aceptable desde el punto de vista farmacéutico y una etiqueta que denota que el anticuerpo anti-CD20 o la composicion farmacéutica están indicados para el tratamiento de pacientes con esclerosis multiple que tengan una o más características seleccionadas del grupo que consiste de (a) edad menor que alrededor de 55 anos, (b) una o más lesiones con tincion con gadolinio, (c) un aumento de al menos alrededor de un punto en la Escala de Estatus de Discapacidad Expandida (EDSS) durante dos anos antes de comenzar el tratamiento, y (d) un Puntaje de Gravedad de Esclerosis Multiple (MSSS) superior a alrededor de 5 puntos.
ARP090103528A 2008-09-16 2009-09-15 Metodos para tratar la esclerosis multiple progresiva. articulo de fabricacion. AR073295A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9746408P 2008-09-16 2008-09-16

Publications (1)

Publication Number Publication Date
AR073295A1 true AR073295A1 (es) 2010-10-28

Family

ID=41571287

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP090103528A AR073295A1 (es) 2008-09-16 2009-09-15 Metodos para tratar la esclerosis multiple progresiva. articulo de fabricacion.
ARP190103089A AR116859A2 (es) 2008-09-16 2019-10-25 Métodos para tratar la esclerosis múltiple progresiva

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP190103089A AR116859A2 (es) 2008-09-16 2019-10-25 Métodos para tratar la esclerosis múltiple progresiva

Country Status (26)

Country Link
US (11) US20100158903A1 (es)
EP (4) EP3095463B1 (es)
JP (5) JP2012502919A (es)
CN (2) CN102215868B (es)
AR (2) AR073295A1 (es)
AU (1) AU2009293363B2 (es)
BR (1) BRPI0918604A2 (es)
CA (1) CA2737074C (es)
CL (1) CL2011000553A1 (es)
DK (2) DK3747464T3 (es)
EA (1) EA034369B1 (es)
ES (1) ES2830255T3 (es)
FI (1) FI3747464T3 (es)
HK (1) HK1210596A1 (es)
HR (1) HRP20201740T1 (es)
HU (1) HUE051206T2 (es)
IL (3) IL211710A0 (es)
LT (2) LT3095463T (es)
MX (2) MX2011002627A (es)
PL (2) PL3095463T3 (es)
PT (2) PT3095463T (es)
SG (2) SG10201913368UA (es)
SI (2) SI3747464T1 (es)
TW (2) TW201014605A (es)
WO (1) WO2010033587A2 (es)
ZA (1) ZA201101854B (es)

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