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HK1006855A1 - T-cell receptor-specific for antigen polypeptides and related polynucleotides - Google Patents

T-cell receptor-specific for antigen polypeptides and related polynucleotides Download PDF

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Publication number
HK1006855A1
HK1006855A1 HK98105909A HK98105909A HK1006855A1 HK 1006855 A1 HK1006855 A1 HK 1006855A1 HK 98105909 A HK98105909 A HK 98105909A HK 98105909 A HK98105909 A HK 98105909A HK 1006855 A1 HK1006855 A1 HK 1006855A1
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HK
Hong Kong
Prior art keywords
sequence
dna
cell
sequences
region
Prior art date
Application number
HK98105909A
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English (en)
French (fr)
Chinese (zh)
Other versions
HK1006855B (en
Inventor
M Davis Mark
M Hedrick Stephen
Original Assignee
The Board Of Trustees Of The Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27079355&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1006855(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Board Of Trustees Of The Leland Stanford Junior University filed Critical The Board Of Trustees Of The Leland Stanford Junior University
Publication of HK1006855B publication Critical patent/HK1006855B/en
Publication of HK1006855A1 publication Critical patent/HK1006855A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Claims (10)

1. DNA-Sequenz mit wenigstens 15 Nucleotiden , die für eine Sequenz kodiert, die einzigartig für eine ß-Subeinheit von T-Zellen-Antigen-Rezeptoren ist.
2. DNA-Sequenz nach Anspruch 1, bei der die genannte Sequenz für wenigstens einen Abschnitt des konstanten Bereiches der ß-Subeinheit kodiert.
3. DNA-Sequenz nach Anspruch 1 oder 2, die an Nicht-Wildtyp-DNA angefügt ist, um Hybrid-DNA zu bilden, die ein Replikationssystem enthält, das von einem Mikroorganismus erkannt wird.
4. DNA-Sequenz nach einem der Ansprüche 1 bis 3, bei der die genannte DNA-Sequenz eine cDNA-Sequenz von 15 -2.000 Nucleotiden ist, die für wenigstens eine spezifische Domäne der genannten ß-Einheit kodiert.
5. DNA-Sequenz nach Anspruch 4, bei der die cDNA-Sequenz an regulatorische Transkriptions- und Translationssignale für die Expression angefügt ist.
6. DNA-Sequenz nach Anspruch 5, bei der die genannte, für den konstanten Bereich kodierende DNA und die genannte DNA des Nicht-Wildtyps durch eine Sequenz getrennt sind, die für einen J-Bereich kodiert.
7. Klonierungsvektor zum Klonen in einem prokaryotischen Wirt enthaltend eine cDNA-Sequenz nach Anspruch 5 oder 6 und einer Markierung für eine Selektion.
8. Expressionsvektor enthaltend Transkriptions- und Translationssignale und eine cDNA-Sequenz nach Anspruch 5 oder 6 unter der Transkriptions- und Translationssteuerung der genannten Signale.
9. DNA-Sequenz mit wenigstens etwa 15 Nucleotiden , die in der Sequenz von 86T1 in Fig. 2 vorliegt und an DNA des Nicht-Wildtyps angefügt ist.
10. DNA-Sequenz mit wenigstens etwa 15 Nucleotiden, die in der Sequenz von TT11 in Fig. 3 vorliegt und an DNA des Nicht-Wildtyps angefügt ist.
HK98105909A 1984-03-01 1985-02-28 T-cell receptor-specific for antigen polypeptides and related polynucleotides HK1006855A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US58533384A 1984-03-01 1984-03-01
US66380984A 1984-10-22 1984-10-22
US585333 1984-10-22
US663809 1984-10-22
US8503947 1985-02-28

Publications (2)

Publication Number Publication Date
HK1006855B HK1006855B (en) 1999-03-19
HK1006855A1 true HK1006855A1 (en) 1999-03-19

Family

ID=27079355

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98105909A HK1006855A1 (en) 1984-03-01 1985-02-28 T-cell receptor-specific for antigen polypeptides and related polynucleotides

Country Status (8)

Country Link
US (3) US5316925A (de)
EP (3) EP0174366B1 (de)
JP (7) JPH06225765A (de)
AT (1) ATE188251T1 (de)
DE (3) DE570027T1 (de)
HK (1) HK1006855A1 (de)
SG (1) SG70553A1 (de)
WO (1) WO1985003947A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713332A (en) * 1984-01-13 1987-12-15 The Ontario Cancer Institute T cell specific CDNA clone
HK1006855A1 (en) 1984-03-01 1999-03-19 The Board Of Trustees Of The Leland Stanford Junior University T-cell receptor-specific for antigen polypeptides and related polynucleotides
US4873190A (en) * 1984-06-13 1989-10-10 Massachusetts Institute Of Technology Heterodimeric T lymphocyte receptor
US4874845A (en) * 1984-06-13 1989-10-17 Massachusetts Institute Of Technology T lymphocyte receptor subunit
US5189147A (en) * 1984-06-13 1993-02-23 Massachusetts Institute Of Technology Meterodimeric T lymphocyte receptor antibody
ES2093606T3 (es) * 1987-06-23 1997-01-01 Univ Leland Stanford Junior Gen del receptor de celulas t localizado en el locus alfa y estructuras artificiales de adn.
US6710169B2 (en) 1987-10-02 2004-03-23 Genentech, Inc. Adheson variants
US5336603A (en) * 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
US6464978B1 (en) 1989-03-21 2002-10-15 The Immune Response Corporation Vaccination and methods against multiple sclerosis resulting from pathogenic responses by specific T cell populations
US6413516B1 (en) * 1989-03-21 2002-07-02 The Immune Response Corporation Peptides and methods against psoriasis
US5614192A (en) * 1989-07-19 1997-03-25 Connective Therapeutics, Inc. T cell receptor peptides as therapeutics for immune-related disease
US5776459A (en) * 1989-07-19 1998-07-07 Connetics Corporation TCR V beta 5 peptides
US6416971B1 (en) * 1990-05-15 2002-07-09 E.R. Squibb & Sons, Inc. Soluble single chain T cell receptors
US7294712B2 (en) * 1990-06-04 2007-11-13 Aventis Pharma S.A. Nucleotide sequences coding for variable regions of β chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses
IE920447A1 (en) * 1991-02-12 1992-08-12 Roussel Uclaf NUCLEOTIDE SEQUENCES CODING FOR ß-CHAIN VARIABLE REGIONS OF¹HUMAN T-LYMPHOCYTE RECEPTORS, CORRESPONDING PEPTIDE SEGMENTS¹AND DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
US5552300A (en) * 1994-01-13 1996-09-03 T Cell Sciences, Inc. T cell antigen receptor V region proteins and methods of preparation thereof
US6451571B1 (en) 1994-05-02 2002-09-17 University Of Washington Thymidine kinase mutants
US5688690A (en) * 1994-09-16 1997-11-18 The Wistar Institute Of Anatomy And Biology Human cytotoxic lymphocyte signal transduction surface protein (P38) and monoclonal antibodies thereto
US6087096A (en) * 1995-11-13 2000-07-11 Dau; Peter C. Method of intrafamily fragment analysis of the T cell receptor α and β chain CDR3 regions
AU9186598A (en) * 1997-09-26 1999-04-23 Kyowa Hakko Kogyo Co. Ltd. Killer t cell receptor recognizing human immunodeficiency virus
US6759243B2 (en) 1998-01-20 2004-07-06 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
DE19816129A1 (de) * 1998-04-09 1999-10-14 Dolores Schendel T-Zellrezeptor-Expressionskassette
AU2002220275A1 (en) * 2000-12-08 2002-06-18 The Board Of Trustees Of The University Of Illinois Mutated class ii major histocompatibility proteins
DE10109855A1 (de) * 2001-03-01 2002-09-12 Stanislawski Thomas Polypeptide eines p53-Protein-spezifischen murinen alpha/beta T-Zell Rezeptors, diese kodierende Nukleinsäuren und deren Verwendung
US20030199092A1 (en) * 2002-01-11 2003-10-23 The Regents Of The University Of California Methods for increasing mRNA half-life in eukaryotic cells
ATE414718T1 (de) 2005-01-05 2008-12-15 F Star Biotech Forsch & Entw Synthetische immunoglobulindomänen mit in regionen des moleküls, die sich von den die komplementarität bestimmenden bereichen unterscheiden, modifizierten bindeeigenschaften
US20080064631A1 (en) * 2006-01-13 2008-03-13 Jeffrey Molldrem T-cell receptors for use in diagnosis and therapy of cancers and autoimmune disease
AT503889B1 (de) 2006-07-05 2011-12-15 Star Biotechnologische Forschungs Und Entwicklungsges M B H F Multivalente immunglobuline
AT503861B1 (de) * 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw Verfahren zur manipulation von t-zell-rezeptoren
WO2008097926A2 (en) * 2007-02-02 2008-08-14 Yale University Transient transfection with rna
US9249423B2 (en) 2007-02-02 2016-02-02 Yale University Method of de-differentiating and re-differentiating somatic cells using RNA
US10155038B2 (en) 2007-02-02 2018-12-18 Yale University Cells prepared by transient transfection and methods of use thereof
WO2009045898A2 (en) * 2007-09-28 2009-04-09 Mayo Foundation For Medical Education And Research Assessing t cell repertoires
EP2098536A1 (de) 2008-03-05 2009-09-09 4-Antibody AG Isolation und Identifikation antigen- oder ligandenspezifischer Bindungsproteine
EP2113255A1 (de) 2008-05-02 2009-11-04 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Zytotoxisches Immunglobulin
WO2011008502A2 (en) * 2009-06-29 2011-01-20 California Institute Of Technology Isolation of unknown rearranged t-cell receptors from single cells
CA2955984A1 (en) 2014-07-22 2016-01-28 The University Of Notre Dame Du Lac Molecular constructs and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468464A (en) * 1974-11-04 1984-08-28 The Board Of Trustees Of The Leland Stanford Junior University Biologically functional molecular chimeras
US4363877B1 (en) * 1977-09-23 1998-05-26 Univ California Recombinant dna transfer vectors
US4356270A (en) * 1977-11-08 1982-10-26 Genentech, Inc. Recombinant DNA cloning vehicle
US4394443A (en) * 1980-12-18 1983-07-19 Yale University Method for cloning genes
US4446235A (en) * 1982-03-22 1984-05-01 Genentech, Inc. Method for cloning human growth hormone varient genes
US4550086A (en) * 1983-02-16 1985-10-29 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies that recognize human T cells
US4713332A (en) * 1984-01-13 1987-12-15 The Ontario Cancer Institute T cell specific CDNA clone
US4923799A (en) * 1984-02-06 1990-05-08 The Ontario Cancer Institute T cell specific cDNA clone
HK1006855A1 (en) * 1984-03-01 1999-03-19 The Board Of Trustees Of The Leland Stanford Junior University T-cell receptor-specific for antigen polypeptides and related polynucleotides
US4874845A (en) * 1984-06-13 1989-10-17 Massachusetts Institute Of Technology T lymphocyte receptor subunit
US4873190A (en) * 1984-06-13 1989-10-10 Massachusetts Institute Of Technology Heterodimeric T lymphocyte receptor

Also Published As

Publication number Publication date
EP0570027B1 (de) 1999-12-29
ATE188251T1 (de) 2000-01-15
DE3588219D1 (de) 2000-02-03
HK1013844A1 (en) 1999-09-10
EP0174366A1 (de) 1986-03-19
EP0609901A1 (de) 1994-08-10
DE3584209T2 (de) 1995-05-04
US5840304A (en) 1998-11-24
EP0174366B1 (de) 1994-10-26
JPH07274976A (ja) 1995-10-24
US5316925A (en) 1994-05-31
EP0174366A4 (de) 1987-03-26
WO1985003947A1 (en) 1985-09-12
EP0570027A1 (de) 1993-11-18
JPH1067675A (ja) 1998-03-10
JPH06225765A (ja) 1994-08-16
JPH10114672A (ja) 1998-05-06
SG70553A1 (en) 2000-02-22
JPH1146779A (ja) 1999-02-23
US6180104B1 (en) 2001-01-30
DE570027T1 (de) 1994-11-17
DE3584209D1 (de) 1994-12-01
JPH09121871A (ja) 1997-05-13
DE3588219T2 (de) 2000-05-18
JPH10210992A (ja) 1998-08-11

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)