HK1062637A1 - Use of cd26/dpp iv in the preparation of medicament for treating and/or diagnosing disease - Google Patents

Use of cd26/dpp iv in the preparation of medicament for treating and/or diagnosing disease

Info

Publication number: HK1062637A1
Authority: HK; Hong Kong
Prior art keywords: dpp; medicament; treating; preparation; diagnosing disease
Prior art date: 1997-09-29

Application number

HK04105182A

Other languages

English (en)

Inventor

Paul Proost

Sofie Struyf

Damme Jo Van

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-29

Filing date

2001-04-25

Publication date

2004-11-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8227408&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1062637(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-04-25 Application filed by Applied Research Systems filed Critical Applied Research Systems

2004-11-19 Publication of HK1062637A1 publication Critical patent/HK1062637A1/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Cardiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Virology (AREA)
AIDS & HIV (AREA)
Diabetes (AREA)
Tropical Medicine & Parasitology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

HK04105182A 1997-09-29 2001-04-25 Use of cd26/dpp iv in the preparation of medicament for treating and/or diagnosing disease HK1062637A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP97116863A EP0906954A1 (en)	1997-09-29	1997-09-29	Amino-terminal truncated c-c chemokines as chemokine antagonist
EP97122471A EP0905240A1 (en)	1997-09-29	1997-12-19	Amino-terminally truncated c-c chemokines as chemokine antagonists
EP98104216A EP0905241A1 (en)	1997-09-29	1998-03-10	Amino-terminally truncated c-c chemokines as chemokine antagonists

Publications (1)

Publication Number	Publication Date
HK1062637A1 true HK1062637A1 (en)	2004-11-19

Family

ID=8227408

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
HK04105182A HK1062637A1 (en)	1997-09-29	2001-04-25	Use of cd26/dpp iv in the preparation of medicament for treating and/or diagnosing disease
HK01102962A HK1032426A1 (en)	1997-09-29	2001-04-25	Amino-terminally truncated rantes as chemokine antagonists
HK01102961A HK1032425A1 (en)	1997-09-29	2001-04-25	Amino-terminally truncated mcp-2 as chemokine antagonists

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
HK01102962A HK1032426A1 (en)	1997-09-29	2001-04-25	Amino-terminally truncated rantes as chemokine antagonists
HK01102961A HK1032425A1 (en)	1997-09-29	2001-04-25	Amino-terminally truncated mcp-2 as chemokine antagonists

Country Status (29)

Country	Link
US (5)	US6977071B2 (zh)
EP (6)	EP0906954A1 (zh)
JP (2)	JP4230659B2 (zh)
KR (2)	KR100560275B1 (zh)
CN (3)	CN1233415C (zh)
AR (2)	AR013529A1 (zh)
AT (3)	ATE263242T1 (zh)
AU (2)	AU750341B2 (zh)
BG (2)	BG64679B1 (zh)
BR (2)	BR9812394A (zh)
CA (2)	CA2304827A1 (zh)
CY (1)	CY1110927T1 (zh)
CZ (2)	CZ299479B6 (zh)
DE (3)	DE69838188T2 (zh)
DK (3)	DK1021541T3 (zh)
EA (2)	EA003942B1 (zh)
EE (2)	EE200000151A (zh)
ES (3)	ES2218860T3 (zh)
HK (3)	HK1062637A1 (zh)
HU (2)	HU226414B1 (zh)
IL (2)	IL135352A (zh)
NO (2)	NO20001584L (zh)
NZ (3)	NZ503235A (zh)
PL (2)	PL196427B1 (zh)
PT (3)	PT1019507E (zh)
SK (2)	SK286439B6 (zh)
UA (2)	UA73080C2 (zh)
WO (2)	WO1999016877A1 (zh)
ZA (2)	ZA988676B (zh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7067117B1 (en)	1997-09-11	2006-06-27	Cambridge University Technical Services, Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US6989435B2 (en)	1997-09-11	2006-01-24	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
WO1999028474A2 (en) *	1997-12-01	1999-06-10	The Government Of The United States Of America, Represented By The Secretary Of Health And Human Services	Chemokine variants and methods of use
US7238711B1 (en)	1999-03-17	2007-07-03	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
WO2001031016A2 (en) *	1999-10-25	2001-05-03	Euroscreen S.A.	Processed human chemokines phc-1 and phc-2
EP1167527A1 (en) *	2000-06-22	2002-01-02	Euroscreen S.A.	Processed human chemokines PHC-1 and PHC-2
AU2505601A (en) *	1999-11-15	2001-05-30	Wolf-Georg Forssmann	Novel use of hcc-2
CA2316405A1 (en) *	2000-05-26	2001-11-26	Ian Clark-Lewis	Modulation of inflammation by protease products
EP1176200A3 (de)	2000-06-20	2005-01-12	Switch Biotech Aktiengesellschaft	Verwendung von Polypeptiden oder diese kodierende Nukleinsäuren zur Diagnose oder Behandlung von Hauterkrankung oder Wundheilung sowie ihre Verwendung zur Indentifizierung von pharmakologisch aktiven Substanzen
UA77950C2 (en) *	2000-10-04	2007-02-15	Applied Research Systems	Use of mutants of cc chemokines for treatment of multiple sclerosis
GB2373785A (en) *	2001-03-28	2002-10-02	Rega Inst For Medical Res	Truncating chemokines using dipeptidyl peptidase IV
EP1458756B1 (en)	2001-12-17	2009-01-28	Laboratoires Serono SA	Chemokine mutants acting as chemokine antagonists
EP1631680A2 (en) *	2003-05-21	2006-03-08	Bayer HealthCare AG	Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase iv (dpp4)
DE102005049637A1 (de) *	2005-10-14	2007-04-26	Rheinisch-Westfälische Technische Hochschule Aachen	Antagonisten gegen die Interaktion von PF4 und RANTES
CA2695237A1 (en)	2007-08-02	2009-04-30	Novimmune S.A.	Anti-rantes antibodies and methods of use thereof
WO2011097567A1 (en) *	2010-02-08	2011-08-11	Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University	Rantes multiplexed assay, rantes variants related to disease, and rantes variants related to enzymatice activity
CN102884194B (zh)	2010-03-11	2015-07-22	健康研究股份有限公司	含增强免疫应答的Fc融合蛋白的方法和组合物
TW201718851A (zh) *	2015-09-18	2017-06-01	通用醫院公司	具有抗化學排斥(anti-fugetactic)性質之經修飾自然殺手細胞及其用途
CA3101052A1 (en)	2018-05-28	2019-12-05	ORION Biotechnology Switzerland Sarl	Methods of inhibiting cerebral inflammation
US11629196B2 (en)	2020-04-27	2023-04-18	Incelldx, Inc.	Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
US11402391B2 (en)	2020-12-21	2022-08-02	Incelldx, Inc.	Methods of treating a long-hauler subject for chronic COVID-19 by administering a CCR5 or CCL5 antagonist

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0311107A3 (en)	1987-10-08	1990-04-18	Stichting REGA V.Z.W.	Anti-hiv active 3'-fluoro-purine-2',3'-dideoxyribosides
US5739103A (en) *	1993-11-12	1998-04-14	Dana-Farber Cancer Institute	Chemokine N-terminal deletion mutations
BR9509890A (pt) *	1994-12-08	1997-12-30	Glaxo Group Ltd	Polipeptídeo sequencia de dna ou rna vetor célula hospedeira e processo para produzir um polipeptídeo
WO1997025427A1 (en) *	1996-01-12	1997-07-17	Genetics Institute, Inc.	Beta-chemokine, h1305 (mcp-2)
EP0889961A2 (en) *	1996-03-27	1999-01-13	Icos Corporation	Monocyte chemotactic protein-5 materials and methods
FR2748938B1 (fr) *	1996-05-22	1998-07-31	Pasteur Institut	Utilisation de molecules antagonistes de chemokines pour leur activite antivirale notamment contre un retrovirus de type vih
US6168784B1 (en) *	1997-09-03	2001-01-02	Gryphon Sciences	N-terminal modifications of RANTES and methods of use

1997
- 1997-09-29 EP EP97116863A patent/EP0906954A1/en not_active Withdrawn
- 1997-12-19 EP EP97122471A patent/EP0905240A1/en not_active Withdrawn
1998
- 1998-03-10 EP EP98104216A patent/EP0905241A1/en not_active Withdrawn
- 1998-09-22 ZA ZA9808676A patent/ZA988676B/xx unknown
- 1998-09-22 ZA ZA9808675A patent/ZA988675B/xx unknown
- 1998-09-28 CA CA002304827A patent/CA2304827A1/en not_active Abandoned
- 1998-09-28 AT AT98951476T patent/ATE263242T1/de active
- 1998-09-28 JP JP2000513946A patent/JP4230659B2/ja not_active Expired - Fee Related
- 1998-09-28 CA CA002305017A patent/CA2305017A1/en not_active Abandoned
- 1998-09-28 AU AU97474/98A patent/AU750341B2/en not_active Ceased
- 1998-09-28 EP EP98947553A patent/EP1021541B1/en not_active Expired - Lifetime
- 1998-09-28 NZ NZ503235A patent/NZ503235A/xx unknown
- 1998-09-28 PL PL339545A patent/PL196427B1/pl not_active IP Right Cessation
- 1998-09-28 UA UA2000042496A patent/UA73080C2/uk unknown
- 1998-09-28 DE DE69838188T patent/DE69838188T2/de not_active Expired - Lifetime
- 1998-09-28 BR BR9812394-7A patent/BR9812394A/pt not_active Application Discontinuation
- 1998-09-28 CN CNB031492991A patent/CN1233415C/zh not_active Expired - Fee Related
- 1998-09-28 AR ARP980104820A patent/AR013529A1/es active IP Right Grant
- 1998-09-28 CZ CZ20001147A patent/CZ299479B6/cs not_active IP Right Cessation
- 1998-09-28 CN CNB988095696A patent/CN1145693C/zh not_active Expired - Fee Related
- 1998-09-28 PT PT98951476T patent/PT1019507E/pt unknown
- 1998-09-28 ES ES98951476T patent/ES2218860T3/es not_active Expired - Lifetime
- 1998-09-28 DK DK98947553T patent/DK1021541T3/da active
- 1998-09-28 SK SK450-2000A patent/SK286439B6/sk not_active IP Right Cessation
- 1998-09-28 SK SK451-2000A patent/SK286495B6/sk not_active IP Right Cessation
- 1998-09-28 DE DE69823218T patent/DE69823218T2/de not_active Expired - Lifetime
- 1998-09-28 DK DK04007579T patent/DK1439231T3/da active
- 1998-09-28 HU HU0003505A patent/HU226414B1/hu not_active IP Right Cessation
- 1998-09-28 WO PCT/EP1998/006143 patent/WO1999016877A1/en active IP Right Grant
- 1998-09-28 EP EP04007579A patent/EP1439231B1/en not_active Expired - Lifetime
- 1998-09-28 AR ARP980104819A patent/AR013528A1/es active IP Right Grant
- 1998-09-28 EA EA200000378A patent/EA003942B1/ru not_active IP Right Cessation
- 1998-09-28 KR KR1020007003019A patent/KR100560275B1/ko not_active IP Right Cessation
- 1998-09-28 PT PT98947553T patent/PT1021541E/pt unknown
- 1998-09-28 BR BR9812565-6A patent/BR9812565A/pt not_active Application Discontinuation
- 1998-09-28 EP EP98951476A patent/EP1019507B1/en not_active Expired - Lifetime
- 1998-09-28 ES ES98947553T patent/ES2215324T3/es not_active Expired - Lifetime
- 1998-09-28 EE EEP200000151A patent/EE200000151A/xx unknown
- 1998-09-28 ES ES04007579T patent/ES2287601T3/es not_active Expired - Lifetime
- 1998-09-28 PT PT04007579T patent/PT1439231E/pt unknown
- 1998-09-28 JP JP2000513947A patent/JP4233214B2/ja not_active Expired - Fee Related
- 1998-09-28 NZ NZ503234A patent/NZ503234A/en unknown
- 1998-09-28 HU HU0003563A patent/HU226468B1/hu not_active IP Right Cessation
- 1998-09-28 KR KR1020007003020A patent/KR100542934B1/ko not_active IP Right Cessation
- 1998-09-28 DE DE69822856T patent/DE69822856T2/de not_active Expired - Lifetime
- 1998-09-28 EE EEP200000152A patent/EE200000152A/xx unknown
- 1998-09-28 DK DK98951476T patent/DK1019507T3/da active
- 1998-09-28 NZ NZ516027A patent/NZ516027A/en unknown
- 1998-09-28 CZ CZ20001146A patent/CZ299478B6/cs not_active IP Right Cessation
- 1998-09-28 UA UA2000042499A patent/UA73081C2/uk unknown
- 1998-09-28 WO PCT/EP1998/006142 patent/WO1999016876A1/en active IP Right Grant
- 1998-09-28 CN CNB988095726A patent/CN1148447C/zh not_active Expired - Fee Related
- 1998-09-28 AU AU94420/98A patent/AU750606B2/en not_active Ceased
- 1998-09-28 AT AT98947553T patent/ATE264390T1/de active
- 1998-09-28 EA EA200000379A patent/EA003940B1/ru not_active IP Right Cessation
- 1998-09-28 AT AT04007579T patent/ATE368742T1/de active
- 1998-09-28 PL PL339559A patent/PL197569B1/pl not_active IP Right Cessation
2000
- 2000-03-22 BG BG104266A patent/BG64679B1/bg unknown
- 2000-03-22 BG BG104267A patent/BG64757B1/bg unknown
- 2000-03-27 NO NO20001584A patent/NO20001584L/no not_active Application Discontinuation
- 2000-03-28 NO NO20001609A patent/NO20001609D0/no unknown
- 2000-03-28 US US09/537,858 patent/US6977071B2/en not_active Expired - Fee Related
- 2000-03-28 US US09/537,859 patent/US6905676B2/en not_active Expired - Fee Related
- 2000-03-29 IL IL135352A patent/IL135352A/en not_active IP Right Cessation
- 2000-03-29 IL IL135351A patent/IL135351A/en not_active IP Right Cessation
2001
- 2001-04-25 HK HK04105182A patent/HK1062637A1/xx not_active IP Right Cessation
- 2001-04-25 HK HK01102962A patent/HK1032426A1/xx not_active IP Right Cessation
- 2001-04-25 HK HK01102961A patent/HK1032425A1/xx not_active IP Right Cessation
2005
- 2005-03-07 US US11/072,454 patent/US7326411B2/en not_active Expired - Fee Related
- 2005-05-06 US US11/123,089 patent/US7338653B2/en not_active Expired - Fee Related
- 2005-05-18 US US11/131,221 patent/US20050220790A1/en not_active Abandoned
2007
- 2007-10-08 CY CY20071101290T patent/CY1110927T1/el unknown

Also Published As

Publication number	Publication date
EP1439231A3 (en)	2004-12-22
ES2287601T3 (es)	2007-12-16
SK286439B6 (sk)	2008-10-07
JP4230659B2 (ja)	2009-02-25
JP2001518297A (ja)	2001-10-16
CZ20001147A3 (cs)	2000-09-13
HUP0003505A3 (en)	2005-11-28
EE200000152A (et)	2001-02-15
ATE264390T1 (de)	2004-04-15
PL196427B1 (pl)	2008-01-31
US20030124677A1 (en)	2003-07-03
EA200000378A1 (ru)	2000-10-30
AR013529A1 (es)	2000-12-27
EA003942B1 (ru)	2003-10-30
AU9442098A (en)	1999-04-23
CZ20001146A3 (cs)	2000-09-13
BR9812565A (pt)	2000-08-01
PT1019507E (pt)	2004-06-30
AU750341B2 (en)	2002-07-18
EA003940B1 (ru)	2003-10-30
ZA988676B (en)	1999-12-03
DK1439231T3 (da)	2007-11-05
US6977071B2 (en)	2005-12-20
IL135352A (en)	2006-08-20
DE69838188D1 (de)	2007-09-13
US20050164936A1 (en)	2005-07-28
PT1439231E (pt)	2007-08-20
EP1019507B1 (en)	2004-03-31
PT1021541E (pt)	2004-07-30
CN1148447C (zh)	2004-05-05
KR100560275B1 (ko)	2006-03-10
PL339559A1 (en)	2000-12-18
PL197569B1 (pl)	2008-04-30
DE69838188T2 (de)	2007-11-22
CN1490049A (zh)	2004-04-21
DE69823218D1 (de)	2004-05-19
NO20001584D0 (no)	2000-03-27
EE200000151A (et)	2001-02-15
AU750606B2 (en)	2002-07-25
PL339545A1 (en)	2000-12-18
DK1019507T3 (da)	2004-07-19
WO1999016877A1 (en)	1999-04-08
US20050201977A1 (en)	2005-09-15
US6905676B2 (en)	2005-06-14
NO20001584L (no)	2000-03-27
HU226468B1 (en)	2008-12-29
HUP0003563A3 (en)	2005-11-28
WO1999016876A1 (en)	1999-04-08
KR100542934B1 (ko)	2006-01-11
BG64757B1 (bg)	2006-02-28
CZ299478B6 (cs)	2008-08-06
NZ516027A (en)	2003-05-30
CZ299479B6 (cs)	2008-08-06
NO20001609L (no)	2000-03-28
JP2001518296A (ja)	2001-10-16
US7326411B2 (en)	2008-02-05
DE69823218T2 (de)	2004-08-26
EP1439231B1 (en)	2007-08-01
HUP0003505A2 (hu)	2001-02-28
SK4502000A3 (en)	2000-09-12
HK1032426A1 (en)	2001-07-20
UA73080C2 (en)	2005-06-15
CN1271386A (zh)	2000-10-25
HU226414B1 (en)	2008-11-28
BG104266A (en)	2000-11-30
EP1439231A2 (en)	2004-07-21
EP0905240A1 (en)	1999-03-31
JP4233214B2 (ja)	2009-03-04
CN1271385A (zh)	2000-10-25
KR20010024214A (ko)	2001-03-26
HK1032425A1 (en)	2001-07-20
DE69822856T2 (de)	2004-08-19
AU9747498A (en)	1999-04-23
BG104267A (en)	2000-11-30
ATE263242T1 (de)	2004-04-15
BG64679B1 (bg)	2005-11-30
ES2218860T3 (es)	2004-11-16
ZA988675B (en)	1999-11-24
NZ503235A (en)	2002-08-28
EP0906954A1 (en)	1999-04-07
DK1021541T3 (da)	2004-08-02
CA2304827A1 (en)	1999-04-08
US7338653B2 (en)	2008-03-04
CN1145693C (zh)	2004-04-14
SK4512000A3 (en)	2000-09-12
EP1021541B1 (en)	2004-04-14
AR013528A1 (es)	2000-12-27
KR20010024213A (ko)	2001-03-26
IL135351A (en)	2006-08-20
CN1233415C (zh)	2005-12-28
BR9812394A (pt)	2000-09-12
US20030119148A1 (en)	2003-06-26
US20050220790A1 (en)	2005-10-06
NO20001609D0 (no)	2000-03-28
HUP0003563A2 (hu)	2001-02-28
EP0905241A1 (en)	1999-03-31
DE69822856D1 (de)	2004-05-06
EP1021541A1 (en)	2000-07-26
SK286495B6 (sk)	2008-11-06
UA73081C2 (en)	2005-06-15
ATE368742T1 (de)	2007-08-15
NZ503234A (en)	2002-06-28
CY1110927T1 (el)	2015-06-10
CA2305017A1 (en)	1999-04-08
EA200000379A1 (ru)	2000-10-30
EP1019507A1 (en)	2000-07-19
ES2215324T3 (es)	2004-10-01

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HK1062637A1 (en)	2004-11-19	Use of cd26/dpp iv in the preparation of medicament for treating and/or diagnosing disease
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CA2219988A1 (en)	1996-11-07	Cd16-ii variants
KR970701776A (ko)	1997-04-12	형질전환 성장 인자 알파 에이치1(Transforming growth factor alpha H1)
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CA2417207C (en)	2010-04-20	Dental products comprising bone growth enhancing peptide
JP2002522508A5 (zh)	2006-09-21
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CA2284548A1 (en)	1998-10-01	The use of proteins extractable from animal organs for the preparation of medicaments for the treatment of pathological conditions characterized by hyperproduction of tumor necrosis factor (tnf)
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DE69730967D1 (en)	2004-11-04	Human dnase ii
Proost et al.	1997	Amino-terminally truncated cc chemokines as chemokine antagonists
CA2242562A1 (en)	1997-08-07	Human dnase resistant to actin inhibition
JP2002355060A5 (zh)	2005-06-16
BG101847A (en)	1998-07-31	Human dnase i variants
JP2001269184A5 (zh)	2007-09-06

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