HK1055111A1 - Process for the purification of a salt of clavulanic acid. - Google Patents
Process for the purification of a salt of clavulanic acid.Info
- Publication number
- HK1055111A1 HK1055111A1 HK03106008A HK03106008A HK1055111A1 HK 1055111 A1 HK1055111 A1 HK 1055111A1 HK 03106008 A HK03106008 A HK 03106008A HK 03106008 A HK03106008 A HK 03106008A HK 1055111 A1 HK1055111 A1 HK 1055111A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- salt
- clavulanic acid
- purification
- exposed
- typically
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0011521A GB0011521D0 (en) | 2000-05-13 | 2000-05-13 | Process |
GB0011519A GB0011519D0 (en) | 2000-05-13 | 2000-05-13 | Process |
PCT/GB2001/002025 WO2001087891A1 (en) | 2000-05-13 | 2001-05-09 | Process for the purification of a salt of clavulanic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1055111A1 true HK1055111A1 (en) | 2003-12-24 |
Family
ID=26244256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK03106008A HK1055111A1 (en) | 2000-05-13 | 2003-08-21 | Process for the purification of a salt of clavulanic acid. |
Country Status (24)
Country | Link |
---|---|
US (1) | US7767823B2 (zh) |
EP (1) | EP1284978B2 (zh) |
JP (1) | JP4954421B2 (zh) |
KR (1) | KR100827898B1 (zh) |
CN (1) | CN1222528C (zh) |
AT (1) | ATE273982T1 (zh) |
AU (1) | AU776184B2 (zh) |
BR (1) | BRPI0110774B8 (zh) |
CA (1) | CA2408853C (zh) |
CZ (1) | CZ304775B6 (zh) |
DE (1) | DE60105016T3 (zh) |
DK (1) | DK1284978T4 (zh) |
ES (1) | ES2225524T5 (zh) |
HK (1) | HK1055111A1 (zh) |
HU (1) | HU228593B1 (zh) |
IL (2) | IL152643A0 (zh) |
MX (1) | MXPA02011192A (zh) |
NO (1) | NO328528B1 (zh) |
NZ (1) | NZ522414A (zh) |
PL (1) | PL206316B1 (zh) |
PT (1) | PT1284978E (zh) |
SI (1) | SI1284978T2 (zh) |
WO (1) | WO2001087891A1 (zh) |
ZA (1) | ZA200209141B (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001087891A1 (en) | 2000-05-13 | 2001-11-22 | Smithkline Beecham P.L.C. | Process for the purification of a salt of clavulanic acid |
CN105384758B (zh) * | 2015-12-01 | 2018-05-01 | 国药集团威奇达药业有限公司 | 克拉维酸胺盐的制备方法 |
JP2019527214A (ja) | 2016-07-14 | 2019-09-26 | アカオジェン インコーポレイテッド | 細菌感染症の処置における使用のためのセフチブテンとクラブラン酸の組み合わせ |
CN109305978A (zh) * | 2017-07-26 | 2019-02-05 | 山东睿鹰先锋制药有限公司 | 一种制备克拉维酸盐的新方法 |
CN109535184B (zh) * | 2017-09-21 | 2020-11-20 | 联邦制药(内蒙古)有限公司 | 一种克拉维酸叔辛胺制备克拉维酸钾的方法 |
CN108558909B (zh) * | 2018-05-17 | 2019-09-17 | 国药集团威奇达药业有限公司 | 综合回收克拉维酸叔丁胺盐结晶母液中有效成分的方法 |
WO2021004912A1 (en) | 2019-07-05 | 2021-01-14 | Glaxosmithkline Intellectual Property (No.2) Limited | Streptomyces clavuligerus |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1299883A (fr) | 1961-09-06 | 1962-07-27 | Pfizer & Co C | Perfectionnements apportés aux procédés pour séparer des amino-acides amphotères de leurs solutions aqueuses |
GB1508977A (en) | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
GB2003863B (en) | 1977-09-01 | 1982-03-31 | Beecham Group Ltd | Chemical process |
DE3063683D1 (en) | 1979-08-24 | 1983-07-14 | Beecham Group Plc | Amine salt of clavulanic acid, its preparation and use |
US4449182A (en) * | 1981-10-05 | 1984-05-15 | Digital Equipment Corporation | Interface between a pair of processors, such as host and peripheral-controlling processors in data processing systems |
MX7417E (es) | 1984-10-27 | 1988-10-14 | Antibioticos Sa | Metodo para la preparacion de acido clavulanico y sus derivados |
GR1000035B (el) | 1987-01-29 | 1990-03-12 | Beecham Group Plc | Κλαβουλανικο καλιο. |
GB2204944B (en) | 1987-05-18 | 1991-10-02 | Frederick John Anderson | Rechargeable light |
DE3729338A1 (de) | 1987-09-02 | 1989-03-23 | Biotechnolog Forschung Gmbh | Verfahren zur abtrennung von penicillin g aus einem fermentationsmedium durch extraktion |
US5318896A (en) | 1991-09-11 | 1994-06-07 | Merck & Co., Inc. | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) |
CZ288721B6 (cs) | 1991-10-15 | 2001-08-15 | Dsm Gist B. V. | Biologický způsob výroby kyseliny 7-aminodeacetylcefalosporanové |
AT400033B (de) * | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
SI9300296B (sl) | 1992-06-11 | 1998-06-30 | Smithkline Beecham P.L.C. | Postopek in intermedianti za pripravo klavulanske kisline |
KR100200239B1 (ko) * | 1992-10-21 | 1999-06-15 | 김충환 | 클라불란산 칼륨염의 제조방법 |
GB9305565D0 (en) | 1993-03-18 | 1993-05-05 | Smithkline Beecham Plc | Novel compounds and processes |
US5821364A (en) * | 1993-03-26 | 1998-10-13 | Gist-Brocades N.V. | Diamine salts of clavulanic acid |
CN1103814C (zh) | 1993-07-30 | 2003-03-26 | 吉斯特·布罗卡迪斯公司 | 通过2-(羧乙硫基)乙酰-7-adca和3-(羧甲硫基)丙酰-7-adca有效生产7-adca的方法 |
AT400846B (de) | 1994-02-25 | 1996-03-25 | Fermic S A De C V | Verfahren zur gewinnung und reinigung von alkalimetallsalzen der clavulansäure |
SI9400107A (en) | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
GB9426261D0 (en) | 1994-12-24 | 1995-02-22 | Spurcourt Ltd | Clavulanic acid salts |
SI9500074A (en) | 1995-03-10 | 1996-10-31 | Lek Tovarna Farmacevtskih | Process for preparation of alkani salts of clavulanic acid. |
SI9500134B (sl) | 1995-04-20 | 2004-04-30 | Lek, | Postopek za pripravo čistih alkalijskih soli klavulanske kisline |
KR100200242B1 (ko) | 1995-05-16 | 1999-06-15 | 김충환 | 클라불란산염의 제조 방법 |
WO1997005143A1 (fr) * | 1995-07-25 | 1997-02-13 | Asahi Kasei Kogyo Kabushiki Kaisha | Nouveaux composes a base de metaux de transition du groupe 4 |
GB9515809D0 (en) * | 1995-08-02 | 1995-10-04 | Smithkline Beecham Plc | Process |
CN1238776A (zh) * | 1996-11-11 | 1999-12-15 | 吉斯特-布罗卡迪斯有限公司 | 制备棒酸盐和酯的方法 |
AT404728B (de) * | 1996-11-27 | 1999-02-25 | Biochemie Gmbh | Verfahren zur herstellung von clavulansäure-aminsalzen |
WO1998042858A1 (en) | 1997-03-24 | 1998-10-01 | Cipan-Companhia Industrial Produtora De Antibióticos, S.A. | Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid |
PT918878E (pt) * | 1997-04-22 | 2005-05-31 | Dsm Ip Assets Bv | Processo melhorado para a producao fermentativa de cefalosporina |
EP1095046A1 (en) * | 1998-07-16 | 2001-05-02 | Dsm N.V. | Improved process for the preparation of salts and esters of clavulanic acid |
WO2001087891A1 (en) | 2000-05-13 | 2001-11-22 | Smithkline Beecham P.L.C. | Process for the purification of a salt of clavulanic acid |
-
2001
- 2001-05-09 WO PCT/GB2001/002025 patent/WO2001087891A1/en active Application Filing
- 2001-05-09 CN CNB018094236A patent/CN1222528C/zh not_active Expired - Lifetime
- 2001-05-09 PT PT01925753T patent/PT1284978E/pt unknown
- 2001-05-09 CZ CZ2002-3723A patent/CZ304775B6/cs not_active IP Right Cessation
- 2001-05-09 HU HU0300869A patent/HU228593B1/hu unknown
- 2001-05-09 DK DK01925753T patent/DK1284978T4/da active
- 2001-05-09 SI SI200130207T patent/SI1284978T2/sl unknown
- 2001-05-09 US US10/275,852 patent/US7767823B2/en active Active
- 2001-05-09 PL PL358368A patent/PL206316B1/pl unknown
- 2001-05-09 EP EP01925753A patent/EP1284978B2/en not_active Expired - Lifetime
- 2001-05-09 IL IL15264301A patent/IL152643A0/xx unknown
- 2001-05-09 KR KR1020027015169A patent/KR100827898B1/ko active IP Right Grant
- 2001-05-09 NZ NZ522414A patent/NZ522414A/en not_active IP Right Cessation
- 2001-05-09 DE DE60105016T patent/DE60105016T3/de not_active Expired - Lifetime
- 2001-05-09 JP JP2001584285A patent/JP4954421B2/ja not_active Expired - Lifetime
- 2001-05-09 CA CA2408853A patent/CA2408853C/en not_active Expired - Lifetime
- 2001-05-09 MX MXPA02011192A patent/MXPA02011192A/es active IP Right Grant
- 2001-05-09 AU AU52432/01A patent/AU776184B2/en not_active Expired
- 2001-05-09 AT AT01925753T patent/ATE273982T1/de active
- 2001-05-09 BR BRPI0110774A patent/BRPI0110774B8/pt not_active IP Right Cessation
- 2001-05-09 ES ES01925753T patent/ES2225524T5/es not_active Expired - Lifetime
-
2002
- 2002-11-04 IL IL152643A patent/IL152643A/en active IP Right Grant
- 2002-11-11 ZA ZA2002/09141A patent/ZA200209141B/en unknown
- 2002-11-12 NO NO20025422A patent/NO328528B1/no not_active IP Right Cessation
-
2003
- 2003-08-21 HK HK03106008A patent/HK1055111A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE | Patent expired |
Effective date: 20210508 |