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BR0110774A - Processo para purificação de um sal de ácido clavulânico - Google Patents

Processo para purificação de um sal de ácido clavulânico

Info

Publication number
BR0110774A
BR0110774A BR0110774-7A BR0110774A BR0110774A BR 0110774 A BR0110774 A BR 0110774A BR 0110774 A BR0110774 A BR 0110774A BR 0110774 A BR0110774 A BR 0110774A
Authority
BR
Brazil
Prior art keywords
acid salt
clavulanic acid
purification
salt
exposed
Prior art date
Application number
BR0110774-7A
Other languages
English (en)
Other versions
BRPI0110774B1 (pt
BRPI0110774B8 (pt
Inventor
Guo Zhang
John Mcknight
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26244256&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0110774(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0011521A external-priority patent/GB0011521D0/en
Priority claimed from GB0011519A external-priority patent/GB0011519D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of BR0110774A publication Critical patent/BR0110774A/pt
Publication of BRPI0110774B1 publication Critical patent/BRPI0110774B1/pt
Publication of BRPI0110774B8 publication Critical patent/BRPI0110774B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)

Abstract

"PROCESSO PARA PURIFICAçãO DE UM SAL DE áCIDO CLAVULâNICO". Trata-se de um processo pelo qual um sal de ácido clavulânico, tipicamente um sal de amina ou um sal de metal alcalino é exposto a condições particularmente, a um pH menor que 6,0, que reduz a quantidade de impurezas contaminantes. O processo pode ser um processo de lavagem, um processo de recristalização ou um processo preparativo.
BRPI0110774A 2000-05-13 2001-05-09 processo para purificação de um sal de ácido clavulânico BRPI0110774B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0011521A GB0011521D0 (en) 2000-05-13 2000-05-13 Process
GB0011519A GB0011519D0 (en) 2000-05-13 2000-05-13 Process
PCT/GB2001/002025 WO2001087891A1 (en) 2000-05-13 2001-05-09 Process for the purification of a salt of clavulanic acid

Publications (3)

Publication Number Publication Date
BR0110774A true BR0110774A (pt) 2003-05-13
BRPI0110774B1 BRPI0110774B1 (pt) 2015-07-07
BRPI0110774B8 BRPI0110774B8 (pt) 2021-05-25

Family

ID=26244256

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0110774A BRPI0110774B8 (pt) 2000-05-13 2001-05-09 processo para purificação de um sal de ácido clavulânico

Country Status (24)

Country Link
US (1) US7767823B2 (pt)
EP (1) EP1284978B2 (pt)
JP (1) JP4954421B2 (pt)
KR (1) KR100827898B1 (pt)
CN (1) CN1222528C (pt)
AT (1) ATE273982T1 (pt)
AU (1) AU776184B2 (pt)
BR (1) BRPI0110774B8 (pt)
CA (1) CA2408853C (pt)
CZ (1) CZ304775B6 (pt)
DE (1) DE60105016T3 (pt)
DK (1) DK1284978T4 (pt)
ES (1) ES2225524T5 (pt)
HK (1) HK1055111A1 (pt)
HU (1) HU228593B1 (pt)
IL (2) IL152643A0 (pt)
MX (1) MXPA02011192A (pt)
NO (1) NO328528B1 (pt)
NZ (1) NZ522414A (pt)
PL (1) PL206316B1 (pt)
PT (1) PT1284978E (pt)
SI (1) SI1284978T2 (pt)
WO (1) WO2001087891A1 (pt)
ZA (1) ZA200209141B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087891A1 (en) 2000-05-13 2001-11-22 Smithkline Beecham P.L.C. Process for the purification of a salt of clavulanic acid
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法
JP2019527214A (ja) 2016-07-14 2019-09-26 アカオジェン インコーポレイテッド 細菌感染症の処置における使用のためのセフチブテンとクラブラン酸の組み合わせ
CN109305978A (zh) * 2017-07-26 2019-02-05 山东睿鹰先锋制药有限公司 一种制备克拉维酸盐的新方法
CN109535184B (zh) * 2017-09-21 2020-11-20 联邦制药(内蒙古)有限公司 一种克拉维酸叔辛胺制备克拉维酸钾的方法
CN108558909B (zh) * 2018-05-17 2019-09-17 国药集团威奇达药业有限公司 综合回收克拉维酸叔丁胺盐结晶母液中有效成分的方法
WO2021004912A1 (en) 2019-07-05 2021-01-14 Glaxosmithkline Intellectual Property (No.2) Limited Streptomyces clavuligerus

Family Cites Families (31)

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FR1299883A (fr) 1961-09-06 1962-07-27 Pfizer & Co C Perfectionnements apportés aux procédés pour séparer des amino-acides amphotères de leurs solutions aqueuses
GB1508977A (en) 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB2003863B (en) 1977-09-01 1982-03-31 Beecham Group Ltd Chemical process
DE3063683D1 (en) 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
US4449182A (en) * 1981-10-05 1984-05-15 Digital Equipment Corporation Interface between a pair of processors, such as host and peripheral-controlling processors in data processing systems
MX7417E (es) 1984-10-27 1988-10-14 Antibioticos Sa Metodo para la preparacion de acido clavulanico y sus derivados
GR1000035B (el) 1987-01-29 1990-03-12 Beecham Group Plc Κλαβουλανικο καλιο.
GB2204944B (en) 1987-05-18 1991-10-02 Frederick John Anderson Rechargeable light
DE3729338A1 (de) 1987-09-02 1989-03-23 Biotechnolog Forschung Gmbh Verfahren zur abtrennung von penicillin g aus einem fermentationsmedium durch extraktion
US5318896A (en) 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
CZ288721B6 (cs) 1991-10-15 2001-08-15 Dsm Gist B. V. Biologický způsob výroby kyseliny 7-aminodeacetylcefalosporanové
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9300296B (sl) 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9305565D0 (en) 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
US5821364A (en) * 1993-03-26 1998-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid
CN1103814C (zh) 1993-07-30 2003-03-26 吉斯特·布罗卡迪斯公司 通过2－(羧乙硫基)乙酰－7－adca和3－(羧甲硫基)丙酰－7－adca有效生产7－adca的方法
AT400846B (de) 1994-02-25 1996-03-25 Fermic S A De C V Verfahren zur gewinnung und reinigung von alkalimetallsalzen der clavulansäure
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
SI9500074A (en) 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
WO1997005143A1 (fr) * 1995-07-25 1997-02-13 Asahi Kasei Kogyo Kabushiki Kaisha Nouveaux composes a base de metaux de transition du groupe 4
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
CN1238776A (zh) * 1996-11-11 1999-12-15 吉斯特-布罗卡迪斯有限公司 制备棒酸盐和酯的方法
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
WO1998042858A1 (en) 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
PT918878E (pt) * 1997-04-22 2005-05-31 Dsm Ip Assets Bv Processo melhorado para a producao fermentativa de cefalosporina
EP1095046A1 (en) * 1998-07-16 2001-05-02 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid
WO2001087891A1 (en) 2000-05-13 2001-11-22 Smithkline Beecham P.L.C. Process for the purification of a salt of clavulanic acid

Also Published As

Publication number Publication date
ATE273982T1 (de) 2004-09-15
US20060079676A1 (en) 2006-04-13
CN1429227A (zh) 2003-07-09
PL206316B1 (pl) 2010-07-30
EP1284978B2 (en) 2008-09-10
JP4954421B2 (ja) 2012-06-13
CA2408853A1 (en) 2001-11-22
DE60105016T3 (de) 2009-06-25
CA2408853C (en) 2012-01-10
IL152643A (en) 2012-12-31
PL358368A1 (en) 2004-08-09
WO2001087891A1 (en) 2001-11-22
AU776184B2 (en) 2004-09-02
AU5243201A (en) 2001-11-26
NO20025422D0 (no) 2002-11-12
EP1284978B1 (en) 2004-08-18
NZ522414A (en) 2004-05-28
BRPI0110774B1 (pt) 2015-07-07
IL152643A0 (en) 2003-06-24
EP1284978A1 (en) 2003-02-26
KR20030014222A (ko) 2003-02-15
DK1284978T3 (da) 2004-12-13
DK1284978T4 (da) 2009-01-05
PT1284978E (pt) 2004-12-31
HUP0300869A3 (en) 2003-10-28
CZ304775B6 (cs) 2014-10-15
HU228593B1 (en) 2013-04-29
MXPA02011192A (es) 2003-03-10
JP2003533529A (ja) 2003-11-11
HUP0300869A2 (hu) 2003-08-28
US7767823B2 (en) 2010-08-03
DE60105016D1 (de) 2004-09-23
ZA200209141B (en) 2003-12-31
ES2225524T5 (es) 2009-03-01
DE60105016T2 (de) 2005-08-18
NO20025422L (no) 2003-01-07
HK1055111A1 (en) 2003-12-24
SI1284978T1 (en) 2005-02-28
ES2225524T3 (es) 2005-03-16
BRPI0110774B8 (pt) 2021-05-25
NO328528B1 (no) 2010-03-08
SI1284978T2 (sl) 2008-12-31
CZ20023723A3 (cs) 2003-05-14
CN1222528C (zh) 2005-10-12
KR100827898B1 (ko) 2008-05-07

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Legal Events

Date Code Title Description
B15K Others concerning applications: alteration of classification

Free format text: PARA.INT.CI. C07D 498/04, A61P 31/00

Ipc: C07D 498/04 (2006.01)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

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