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GT201300267A - Isoxazolinas como agentes terapéuticos - Google Patents

Isoxazolinas como agentes terapéuticos

Info

Publication number
GT201300267A
GT201300267A GT201300267A GT201300267A GT201300267A GT 201300267 A GT201300267 A GT 201300267A GT 201300267 A GT201300267 A GT 201300267A GT 201300267 A GT201300267 A GT 201300267A GT 201300267 A GT201300267 A GT 201300267A
Authority
GT
Guatemala
Prior art keywords
therapeutic agents
isoxazolins
metaloproteinasa
matríz
isoxazolinas
Prior art date
Application number
GT201300267A
Other languages
English (en)
Inventor
David J Calderwood
Eric C Breinlinger
Steven L Swann
Subhendu Mukherjee
Venkata Srikanth Chitty
Siva Sanjeeva Rao Thunuguntla
Subramanyah Seetharama Shastry Hosahalli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47108012&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT201300267(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT201300267A publication Critical patent/GT201300267A/es

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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
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    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

LA PRESENTE INVENCIÓN SE REFIERE A ISOXAZOLINAS COMO AGENTES TERAPÉUTICOS LOS CUALES SE CONSTITUYEN COMO INHIBIDORES SELECTIVOS DE METALOPROTEINASA DE MATRÍZ, MMP-13, Y DE LAS CUALES SE HA INFORMADO QUE MEDIAN EN LA DEGRADACIÓN DEL TEJIDO CONECTIVO EN PROCESOS FISIOLÓGICOS NORMALES
GT201300267A 2011-04-30 2013-10-30 Isoxazolinas como agentes terapéuticos GT201300267A (es)

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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX368078B (es) * 2012-11-21 2019-09-17 Zoetis Llc Sintesis de derivados de isoxazolina espirociclicos.
US20150065724A1 (en) * 2013-09-05 2015-03-05 Abbvie Inc. Diastereoselective methods for synthesizing compounds
EP3325465B1 (en) * 2015-07-17 2022-05-18 Syngenta Participations AG Pesticidally active pyrazole derivatives
EP3145168A1 (en) 2015-09-17 2017-03-22 Thomson Licensing An apparatus and a method for generating data representing a pixel beam
WO2019036407A1 (en) * 2017-08-14 2019-02-21 Merial, Inc. PYRAZOLE-ISOXAZOLINE COMPOUNDS WITH PESTICIDE AND PARASITICIDE ACTIVITY
US11639352B2 (en) * 2018-09-04 2023-05-02 Hoffman-La Roche Inc. Benzothiazole compounds for the treatment of autoimmune diseases
JP2024518377A (ja) 2021-05-03 2024-05-01 カトリック ユニヴェルシテット ルーヴェン 薬剤耐性癲癇の治療

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
CO5170501A1 (es) 1999-04-14 2002-06-27 Novartis Ag AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO
ECSP003448A (es) 2000-04-27 2000-05-25 Azoles sustituidos
EP1536790A2 (en) 2002-08-09 2005-06-08 AstraZeneca AB Oxadiazoles as modulators of metabotropic glutamate receptor-5
US20040067985A1 (en) 2002-10-04 2004-04-08 Fortuna Haviv Method of inhibiting angiogenesis
US7166609B2 (en) * 2002-11-02 2007-01-23 Sanofi-Aventis Deutschland Gmbh Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases
ES2298621T3 (es) 2002-11-02 2008-05-16 Sanofi-Aventis Deutschland Gmbh Nuevas diamidas del acido pirimidin-4,6-dicarboxilico para la inhibicion selectiva de colagenasas.
WO2004043349A2 (en) 2002-11-06 2004-05-27 Bristol-Myers Squibb Company Isoxazoline derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme
US20050004111A1 (en) * 2003-01-03 2005-01-06 Aventis Pharma Deutschland Gmbh Selective MMP-13 inhibitors
EP1694655A2 (en) 2003-11-26 2006-08-30 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
UA86614C2 (ru) 2004-01-23 2009-05-12 Амген Инк Соединение, которое имеет активность ингибитора киназ, фармацевтическая композиция, которая включает указанное соединение, и их применение для приготовления лекарственного препарата
BRPI0508140B1 (pt) 2004-03-05 2015-03-17 Nissan Chemical Ind Ltd Composto benzamida substituída por isoxazolina da fórmula (1); da fórmula (2) substituído por 3,5-bis (aril substituído); da fórmula (4) substituída por alquinibenzeno ou um sal do mesmo; "pesticida, agroquímico, inseticida, parasiticida contendo como ingrediente ativo um ou mais composto benzamida substituída por isoxazolina e sal do mesmo"
DE102004023635A1 (de) 2004-05-10 2006-04-13 Grünenthal GmbH Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
CA2595855C (en) * 2005-01-25 2017-07-04 Synta Pharmaceuticals Corp. Pyrazine compounds for inflammation and immune-related uses
JP4987871B2 (ja) 2005-08-15 2012-07-25 エフ.ホフマン−ラ ロシュ アーゲー P2x3アンタゴニストとしてのピペリジン及びピペラジン誘導体
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
JP2009519937A (ja) * 2005-12-14 2009-05-21 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 無脊椎有害生物防除用イソオキサゾリン
CN101330828A (zh) * 2005-12-14 2008-12-24 杜邦公司 用于防治无脊椎害虫的异噁唑啉
WO2007069773A1 (en) 2005-12-15 2007-06-21 Shionogi & Co., Ltd. A pharmaceutical composition comprising an amide derivative
US20070155739A1 (en) * 2005-12-30 2007-07-05 Alantos Pharmaceuticals, Inc. Substituted bis-amide metalloprotease inhibitors
TWI412322B (zh) * 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
MX2008013307A (es) 2006-04-20 2008-10-27 Du Pont Pirazolinas para controlar plagas de invertebrados.
EP2114873B1 (en) 2006-12-26 2013-02-20 Lantheus Medical Imaging, Inc. N-[3-bromo-4-(3- [18f]fluoropropoxy)-benzyl]-guanidine for imaging cardiac innervation
EP2155701B1 (en) * 2007-06-13 2013-12-11 E. I. Du Pont de Nemours and Company Isoxazoline insecticides
US20090035381A1 (en) 2007-08-01 2009-02-05 Stankus John J Electrospraying method for fabrication of particles and coatings and treatment methods thereof
CA2695304A1 (en) 2007-08-02 2009-02-05 Pfizer Inc. Pyrimidine and pyridine derivatives and their pharmaceutical use and compositions
EP2186804B1 (en) 2007-08-10 2015-06-17 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic compound and pest control agent
US8168114B2 (en) 2007-09-12 2012-05-01 University Of Washington Through Its Center For Commercialization Methods for blow molding solid-state cellular thermoplastic articles
ES2553412T3 (es) 2007-10-31 2015-12-09 Merck Sharp & Dohme Corp. Antagonistas del receptor P2X3 para el tratamiento del dolor
TWI411395B (zh) * 2007-12-24 2013-10-11 Syngenta Participations Ag 殺蟲化合物
JP2009286773A (ja) 2008-03-14 2009-12-10 Bayer Cropscience Ag 殺虫性縮環式アリール類
TW200946520A (en) 2008-05-01 2009-11-16 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
RU2015105591A (ru) 2008-06-10 2015-08-10 Эббви Инк. Новые трициклические соединения
WO2010010187A1 (en) 2008-07-25 2010-01-28 Galapagos Nv Novel compounds useful for the treatment of degenerative and inflammatory diseases
WO2010020522A1 (en) 2008-08-22 2010-02-25 Syngenta Participations Ag Insecticidal compounds
WO2010045191A2 (en) 2008-10-13 2010-04-22 Vuelogic, Llc Methods and systems for customer performance scoring
EP2344480A1 (en) 2008-10-15 2011-07-20 Boehringer Ingelheim International GmbH Fused heteroaryl diamide compounds useful as mmp-13 inhibitors
WO2010051188A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
EP2379537B9 (en) * 2008-12-19 2017-07-12 Novartis AG Isoxazoline derivatives and their use as pesticide
BRPI1007310A2 (pt) 2009-01-22 2015-08-25 Syngenta Participations Ag Compostos inseticidas.
JP2012522750A (ja) 2009-04-01 2012-09-27 ビーエーエスエフ ソシエタス・ヨーロピア 無脊椎動物害虫を駆除するためのイソキサゾリン化合物
CA2756250A1 (en) 2009-04-10 2010-10-14 Pfizer Inc. 4,5-dihydro-1h-pyrazole compounds and their pharmaceutical uses
GB0910003D0 (en) 2009-06-11 2009-07-22 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases
FR2948939B1 (fr) 2009-08-05 2013-03-22 Pf Medicament Derives de 2h pyridazin-3-ones, leur preparation et leur application en therapeutique humaine
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
GB2481118A (en) 2010-06-09 2011-12-14 Syngenta Participations Ag Pesticidal mixtures comprising enantiomerically enriched isoxazoline derivatives
ES2555260T3 (es) * 2010-06-15 2015-12-30 Bayer Intellectual Property Gmbh Derivados de diamida de ácido antranílico
DK178277B1 (da) * 2010-06-18 2015-10-26 Novartis Tiergesundheit Ag Diaryloxazolinforbindelser til bekæmpelse af fiskelus
AU2012215440B2 (en) * 2011-02-10 2015-08-27 Novartis Tiergesundheit Ag Isoxazoline derivatives for controlling invertebrate pests

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AR086113A1 (es) 2013-11-20
PH12016500838A1 (en) 2016-09-26
PE20141190A1 (es) 2014-10-12
RU2013152961A (ru) 2015-06-10
TW201247657A (en) 2012-12-01
AU2012250979B2 (en) 2015-07-30
CL2013003125A1 (es) 2014-04-25
DOP2013000251A (es) 2014-02-28
MX2013012686A (es) 2013-12-02
CO6801765A2 (es) 2013-11-29
US20130023526A1 (en) 2013-01-24
JP6101250B2 (ja) 2017-03-22
KR20140041512A (ko) 2014-04-04
MY163870A (en) 2017-10-31
ECSP13013026A (es) 2014-01-31
MX355996B (es) 2018-05-08
WO2012151158A1 (en) 2012-11-08
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IL229081A0 (en) 2013-12-31
SG194696A1 (en) 2013-12-30
AU2015246181A1 (en) 2015-11-12
CA2834237A1 (en) 2012-11-08
AU2012250979A1 (en) 2013-04-18
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