FR2665453B1 - Polylactides purifies, procede pour leur preparation et compositions pharmaceutiques les contenant. - Google Patents

Polylactides purifies, procede pour leur preparation et compositions pharmaceutiques les contenant.

Info

Publication number: FR2665453B1
Authority: FR; France
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; polylactides; purified
Prior art date: 1990-08-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

FR9109673A

Other languages

English (en)

Other versions

FR2665453A1 (fr

Inventor

Prikoszovich

Walter

Langeweg

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sandoz AG

Original Assignee

Sandoz AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-01

Filing date

1991-07-30

Publication date

1995-01-27

1990-08-01 Priority claimed from GB909016882A external-priority patent/GB9016882D0/en

1990-08-01 Priority claimed from GB909016840A external-priority patent/GB9016840D0/en

1991-07-30 Application filed by Sandoz AG filed Critical Sandoz AG

1992-02-07 Publication of FR2665453A1 publication Critical patent/FR2665453A1/fr

1995-01-27 Application granted granted Critical

1995-01-27 Publication of FR2665453B1 publication Critical patent/FR2665453B1/fr

2011-07-30 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/88—Post-polymerisation treatment
- C08G63/90—Purification; Drying
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Polyesters Or Polycarbonates (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

FR9109673A 1990-08-01 1991-07-30 Polylactides purifies, procede pour leur preparation et compositions pharmaceutiques les contenant. Expired - Fee Related FR2665453B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB909016882A GB9016882D0 (en)	1990-08-01	1990-08-01	Improvements in or relating to organic compounds
GB909016840A GB9016840D0 (en)	1990-08-01	1990-08-01	Improvements in or relating to organic compounds

Publications (2)

Publication Number	Publication Date
FR2665453A1 FR2665453A1 (fr)	1992-02-07
FR2665453B1 true FR2665453B1 (fr)	1995-01-27

Family

ID=26297417

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR9109673A Expired - Fee Related FR2665453B1 (fr)	1990-08-01	1991-07-30	Polylactides purifies, procede pour leur preparation et compositions pharmaceutiques les contenant.

Country Status (27)

Country	Link
EP (2)	EP0816413B1 (fr)
JP (1)	JP3137368B2 (fr)
KR (1)	KR100255904B1 (fr)
AT (1)	AT402503B (fr)
AU (1)	AU650277B2 (fr)
CA (1)	CA2048200C (fr)
CH (1)	CH683772A5 (fr)
CY (1)	CY1986A (fr)
DE (1)	DE4124468B4 (fr)
DK (2)	DK0816413T3 (fr)
ES (2)	ES2112259T3 (fr)
FI (2)	FI108040B (fr)
FR (1)	FR2665453B1 (fr)
GB (1)	GB2246573B (fr)
GR (1)	GR3026322T3 (fr)
HK (1)	HK11797A (fr)
HU (1)	HUT59837A (fr)
IE (1)	IE66185B1 (fr)
IL (1)	IL99007A (fr)
IT (1)	IT1252944B (fr)
LU (1)	LU87985A1 (fr)
MY (1)	MY108621A (fr)
NO (1)	NO912960D0 (fr)
NZ (1)	NZ239184A (fr)
PH (1)	PH31047A (fr)
PT (1)	PT98491B (fr)
TW (2)	TW282477B (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5527524A (en) *	1986-08-18	1996-06-18	The Dow Chemical Company	Dense star polymer conjugates
US5560929A (en) *	1986-08-18	1996-10-01	The Dow Chemical Company	Structured copolymers and their use as absorbents, gels and carriers of metal ions
US5225521A (en) *	1991-12-31	1993-07-06	E. I. Du Pont De Nemours And Company	Star-shaped hydroxyacid polymers
US5405919A (en) *	1992-08-24	1995-04-11	The United States Of America As Represented By The Secretary Of Health And Human Services	Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US5525357A (en) *	1992-08-24	1996-06-11	The United States Of America As Represented By The Department Of Health And Human Services	Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US6200558B1 (en)	1993-09-14	2001-03-13	The United States Of America As Represented By The Department Of Health And Human Services	Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
JPH06116381A (ja) *	1992-10-09	1994-04-26	Mitsui Toatsu Chem Inc	ポリヒドロキシカルボン酸の精製方法
DE4412317A1 (de) *	1993-04-21	1994-10-27	Basf Ag	Polylactid mit verbreiterter Molmassenverteilung
US5359026A (en)	1993-07-30	1994-10-25	Cargill, Incorporated	Poly(lactide) copolymer and process for manufacture thereof
US5496923A (en) *	1993-09-20	1996-03-05	Mitsui Toatsu Chemicals, Inc.	Purification process of aliphatic polyester
EP0729357B1 (fr)	1993-11-19	2005-02-02	Janssen Pharmaceutica N.V.	1,2-benzazole microencapsules
KR100357839B1 (ko) *	1994-03-07	2003-08-02	더 다우 케미칼 캄파니	생체활성및/또는표적화된덴드리머콘쥬게이트
CA2350638C (fr)	1998-09-11	2009-11-24	Gerhard Schmidmaier	Implants biologiquement actifs recouverts d'un polymere biodegradable
US6362308B1 (en)	2000-08-10	2002-03-26	Alkermes Controlled Therapeutics Inc. Ii	Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
EP1404738B1 (fr) *	2001-07-10	2008-03-05	Kureha Corporation	Acide polyhydroxycarboxylique et son procede de production
FR2830448B1 (fr) *	2001-10-10	2004-03-19	Pf Medicament	Microspheres biodegradables a liberation prolongee et leur procede de preparation
JP2005509611A (ja)	2001-10-10	2005-04-14	ピエール、ファーブル、メディカマン	徐放型生物分解性微小球およびその製造方法
GB0226993D0 (en) *	2002-11-19	2002-12-24	Novartis Ag	Organic compounds
US20040097419A1 (en) *	2002-11-19	2004-05-20	Holger Petersen	Organic compounds
AU2013204972B2 (en) *	2002-11-19	2016-04-21	Novartis Ag	Pharmaceutical composition comprising octreotide microparticles
SI1787658T1 (sl)	2005-11-10	2012-07-31	Chemi Spa	Formulacije z trajnim sproščanjem somatostatin analognih inhibitorjev rastnega hormona
CN101193531B (zh)	2006-11-29	2010-12-01	富准精密工业(深圳)有限公司	散热装置
RU2459840C2 (ru) *	2007-12-31	2012-08-27	Самъянг Корпорейшн	АМФИФИЛЬНЫЙ СОПОЛИМЕР ВЫСОКОЙ ЧИСТОТЫ, СОДЕРЖАЩИЙ ГИДРОФОБНЫЙ БЛОК ИЗ α-ГИДРОКСИКИСЛОТЫ, И СПОСОБ ЕГО ПОЛУЧЕНИЯ
US20100256746A1 (en) *	2009-03-23	2010-10-07	Micell Technologies, Inc.	Biodegradable polymers
JP5594996B2 (ja)	2009-09-14	2014-09-24	三菱重工業株式会社	航空機の操縦システム
EP2583990B2 (fr) *	2010-06-21	2020-08-19	LG Chem, Ltd.	Résine polylactide remarquablement résistante à la chaleur et son procédé de production
EP2455415A1 (fr) *	2010-11-17	2012-05-23	Evonik Röhm GmbH	Procédé de fabrication de polyesters sous-moléculaires et résorbables, polyesters sous-moléculaires et résorbables fabriqués selon le procédé et leur utilisation
EP2455414A1 (fr) *	2010-11-17	2012-05-23	Evonik Röhm GmbH	Procédé pour la production des polyésters resorbables
CN105820332B (zh) *	2015-01-09	2018-06-29	北京化工大学	一种星形聚氨基酸和星形聚氨基酸载药纳米胶束及制备方法
EP3408305B1 (fr)	2016-01-29	2024-03-06	Tolmar Inc.	Purification et décoloration de polymères
US11261293B2 (en)	2017-08-31	2022-03-01	Evonik Corporation	Resorbable polymer purification process
GR1009392B (el) *	2017-09-19	2018-10-25	Φαρματεν Αβεε	Φαρμακευτικο σκευασμα που περιλαμβανει ενα πεπτιδικο φαρμακο και μεθοδος για την παρασκευη αυτου
GB2568526A (en) *	2017-11-20	2019-05-22	Rebio Tech Oy	Composition
CN112940234B (zh) *	2021-01-28	2022-05-03	广东粤港澳大湾区黄埔材料研究院	一种高纯度聚乙丙交酯的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1467970A (en) *	1975-05-02	1977-03-23	Ici Ltd	Purification of polyethers
US4273920A (en) *	1979-09-12	1981-06-16	Eli Lilly And Company	Polymerization process and product
CH656884A5 (de) *	1983-08-26	1986-07-31	Sandoz Ag	Polyolester, deren herstellung und verwendung.
CA1256638A (fr) *	1984-07-06	1989-06-27	Motoaki Tanaka	Polymere, et sa production
EP0181621B1 (fr) *	1984-11-13	1991-09-04	Asahi Kasei Kogyo Kabushiki Kaisha	Procédé de purification d'éther de polyalkylène
JP2551756B2 (ja) *	1985-05-07	1996-11-06	武田薬品工業株式会社	ポリオキシカルボン酸エステルおよびその製造法
JPH0610252B2 (ja) *	1985-08-21	1994-02-09	和光純薬工業株式会社	重合体の製造法
DE3641692A1 (de) *	1986-12-06	1988-06-09	Boehringer Ingelheim Kg	Katalysatorfreie resorbierbare homopolymere und copolymere
DE3708916A1 (de) *	1987-03-19	1988-09-29	Boehringer Ingelheim Kg	Verfahren zur reinigung resorbierbarer polyester
JP2714454B2 (ja) *	1988-11-07	1998-02-16	三井東圧化学株式会社	生体吸収性ポリエステルの製造方法
DE69129770T2 (de) *	1990-04-13	1998-11-19	Takeda Chemical Industries Ltd	Biologisch abbaubare hochmolekulare Polymere, ihre Herstellung und ihre Verwendung

1991
- 1991-07-17 MY MYPI91001289A patent/MY108621A/en unknown
- 1991-07-22 HU HU912452A patent/HUT59837A/hu unknown
- 1991-07-23 IT ITRM910553A patent/IT1252944B/it active IP Right Grant
- 1991-07-24 DE DE4124468A patent/DE4124468B4/de not_active Expired - Fee Related
- 1991-07-29 ES ES91112725T patent/ES2112259T3/es not_active Expired - Lifetime
- 1991-07-29 EP EP97202586A patent/EP0816413B1/fr not_active Expired - Lifetime
- 1991-07-29 DK DK97202586T patent/DK0816413T3/da active
- 1991-07-29 ES ES97202586T patent/ES2243966T3/es not_active Expired - Lifetime
- 1991-07-29 CH CH2264/91A patent/CH683772A5/de not_active IP Right Cessation
- 1991-07-29 DK DK91112725T patent/DK0469520T3/da active
- 1991-07-29 EP EP91112725A patent/EP0469520B1/fr not_active Expired - Lifetime
- 1991-07-30 NZ NZ239184A patent/NZ239184A/en not_active IP Right Cessation
- 1991-07-30 FI FI913641A patent/FI108040B/fi active
- 1991-07-30 PT PT98491A patent/PT98491B/pt not_active IP Right Cessation
- 1991-07-30 GB GB9116396A patent/GB2246573B/en not_active Expired - Fee Related
- 1991-07-30 AT AT0151591A patent/AT402503B/de not_active IP Right Cessation
- 1991-07-30 NO NO912960A patent/NO912960D0/no unknown
- 1991-07-30 IL IL9900791A patent/IL99007A/en not_active IP Right Cessation
- 1991-07-30 AU AU81430/91A patent/AU650277B2/en not_active Ceased
- 1991-07-30 PH PH42864A patent/PH31047A/en unknown
- 1991-07-30 LU LU87985A patent/LU87985A1/fr unknown
- 1991-07-30 FR FR9109673A patent/FR2665453B1/fr not_active Expired - Fee Related
- 1991-07-31 JP JP03191781A patent/JP3137368B2/ja not_active Expired - Fee Related
- 1991-07-31 IE IE269791A patent/IE66185B1/en not_active IP Right Cessation
- 1991-07-31 KR KR1019910013171A patent/KR100255904B1/ko not_active IP Right Cessation
- 1991-07-31 CA CA002048200A patent/CA2048200C/fr not_active Expired - Lifetime
- 1991-08-02 TW TW082100731A patent/TW282477B/zh not_active IP Right Cessation
- 1991-08-02 TW TW080106046A patent/TW218025B/zh not_active IP Right Cessation
1997
- 1997-02-05 HK HK11797A patent/HK11797A/xx not_active IP Right Cessation
- 1997-09-05 CY CY198697A patent/CY1986A/xx unknown
1998
- 1998-03-11 GR GR980400513T patent/GR3026322T3/el unknown
2001
- 2001-06-05 FI FI20011189A patent/FI111268B/fi active

Also Published As

Publication number	Publication date
NO912960D0 (no)	1991-07-30
CA2048200A1 (fr)	1992-02-02
FR2665453A1 (fr)	1992-02-07
IL99007A (en)	1994-12-29
FI108040B (fi)	2001-11-15
IL99007A0 (en)	1992-07-15
IT1252944B (it)	1995-07-05
DK0469520T3 (da)	1998-09-23
KR920003990A (ko)	1992-03-27
EP0816413B1 (fr)	2005-06-08
GB9116396D0 (en)	1991-09-11
GB2246573B (en)	1994-05-11
DK0816413T3 (da)	2005-08-29
PH31047A (en)	1998-02-03
JPH0641279A (ja)	1994-02-15
LU87985A1 (fr)	1993-02-15
AT402503B (de)	1997-06-25
HU912452D0 (en)	1991-12-30
AU8143091A (en)	1992-02-27
FI913641A (fi)	1992-02-02
EP0469520A3 (en)	1992-10-07
CA2048200C (fr)	1999-06-29
FI913641A0 (fi)	1991-07-30
AU650277B2 (en)	1994-06-16
CY1986A (en)	1997-09-05
TW218025B (fr)	1993-12-21
ES2112259T3 (es)	1998-04-01
EP0469520B1 (fr)	1998-02-25
ITRM910553A0 (it)	1991-07-23
PT98491B (pt)	1997-12-31
GB2246573A (en)	1992-02-05
TW282477B (fr)	1996-08-01
ATA151591A (de)	1996-10-15
HUT59837A (en)	1992-07-28
DE4124468A1 (de)	1992-02-06
JP3137368B2 (ja)	2001-02-19
CH683772A5 (de)	1994-05-13
EP0816413A2 (fr)	1998-01-07
IE912697A1 (en)	1992-02-12
EP0816413A3 (fr)	1998-11-11
IE66185B1 (en)	1995-12-13
ITRM910553A1 (it)	1993-01-23
DE4124468B4 (de)	2010-10-28
PT98491A (pt)	1992-06-30
NZ239184A (en)	1994-09-27
GR3026322T3 (en)	1998-06-30
EP0469520A2 (fr)	1992-02-05
KR100255904B1 (ko)	2000-05-01
FI111268B (fi)	2003-06-30
ES2243966T3 (es)	2005-12-01
HK11797A (en)	1997-02-14
FI20011189A (fi)	2001-06-05
MY108621A (en)	1996-10-31

Publication	Publication Date	Title
FR2665453B1 (fr)	1995-01-27	Polylactides purifies, procede pour leur preparation et compositions pharmaceutiques les contenant.
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Legal Events

Date	Code	Title	Description
1997-11-14	TP	Transmission of property
2011-04-22	ST	Notification of lapse	Effective date: 20110331