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FR2384770A1 - Nouveaux derives de quinazoline utiles comme medicaments - Google Patents

Nouveaux derives de quinazoline utiles comme medicaments

Info

Publication number
FR2384770A1
FR2384770A1 FR7808316A FR7808316A FR2384770A1 FR 2384770 A1 FR2384770 A1 FR 2384770A1 FR 7808316 A FR7808316 A FR 7808316A FR 7808316 A FR7808316 A FR 7808316A FR 2384770 A1 FR2384770 A1 FR 2384770A1
Authority
FR
France
Prior art keywords
medicinal products
derivatives useful
quinazoline derivatives
new quinazoline
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7808316A
Other languages
English (en)
Other versions
FR2384770B1 (fr
Inventor
Richard Wightman Kierstead
Jefferson Wright Tilley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2384770A1 publication Critical patent/FR2384770A1/fr
Application granted granted Critical
Publication of FR2384770B1 publication Critical patent/FR2384770B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention concerne des composés chimiques nouveaux. Il s'agit de nouveaux dérivés de pyrido-Ø2,1-bõquinazoline de formule genérale :
FR7808316A 1977-03-24 1978-03-22 Nouveaux derives de quinazoline utiles comme medicaments Granted FR2384770A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78093977A 1977-03-24 1977-03-24
US87156478A 1978-01-23 1978-01-23

Publications (2)

Publication Number Publication Date
FR2384770A1 true FR2384770A1 (fr) 1978-10-20
FR2384770B1 FR2384770B1 (fr) 1980-10-24

Family

ID=27119777

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7808317A Granted FR2384771A1 (fr) 1977-03-24 1978-03-22 Derives de quinazoline utiles comme medicament
FR7808316A Granted FR2384770A1 (fr) 1977-03-24 1978-03-22 Nouveaux derives de quinazoline utiles comme medicaments

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7808317A Granted FR2384771A1 (fr) 1977-03-24 1978-03-22 Derives de quinazoline utiles comme medicament

Country Status (23)

Country Link
JP (2) JPS53119896A (fr)
AR (3) AR218060A1 (fr)
AT (2) AT367051B (fr)
AU (2) AU521096B2 (fr)
DE (2) DE2812586A1 (fr)
DK (2) DK128878A (fr)
ES (13) ES468126A1 (fr)
FI (2) FI780917A (fr)
FR (2) FR2384771A1 (fr)
GB (2) GB1601371A (fr)
GR (2) GR72948B (fr)
HU (1) HU180782B (fr)
IE (1) IE46505B1 (fr)
IL (2) IL54328A (fr)
IT (2) IT1093710B (fr)
LU (2) LU79290A1 (fr)
MC (2) MC1186A1 (fr)
NL (2) NL7803122A (fr)
NO (2) NO781053L (fr)
NZ (2) NZ186759A (fr)
PH (2) PH13915A (fr)
PT (2) PT67821B (fr)
SE (2) SE7803418L (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2526023A1 (fr) * 1982-04-30 1983-11-04 Lafarquim Nouvelles 2-isopropyl pyrido (2-1-b)quinazolines et leurs sels non toxiques, procede de fabrication de celles-ci et compositions pharmaceutiques les contenant

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2557425C2 (de) * 1975-12-19 1987-03-19 C.H. Boehringer Sohn, 6507 Ingelheim 11-Oxo-11-H-pyrido[2,1-b]-chinazolin-2-carbonsäure und ihre Salze, Verfahren zu ihrer Herstellung und Arzneimittel
DE2845766A1 (de) * 1978-10-18 1980-04-30 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
US4395549A (en) 1981-10-02 1983-07-26 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 6-Hydrazono-pyrido[2,1-b] quinazoline-11 ones
US4551460A (en) * 1982-05-10 1985-11-05 Hoffmann-La Roche Inc. Pyrido[2,1-b]quinazoline derivatives useful as agents for treatment of allergic conditions and vascular disorders involving thrombosis
DE3300477A1 (de) * 1983-01-08 1984-07-12 Boehringer Ingelheim KG, 6507 Ingelheim Neue heterocyclische verbindungen, ihre herstellung und verwendung
JPS62238264A (ja) * 1986-04-04 1987-10-19 Nippon Tokushu Noyaku Seizo Kk ２−ハロ−５−アセチルピリジン

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4012387A (en) * 1975-09-18 1977-03-15 Warner-Lambert Company Benzo-[g]pyrido[2,1-b]quinazolinones
FR2326924A1 (fr) * 1975-10-07 1977-05-06 Warner Lambert Co Pyrido(2,1-b)quinazolin-ones et leur procede de preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4012387A (en) * 1975-09-18 1977-03-15 Warner-Lambert Company Benzo-[g]pyrido[2,1-b]quinazolinones
FR2326924A1 (fr) * 1975-10-07 1977-05-06 Warner Lambert Co Pyrido(2,1-b)quinazolin-ones et leur procede de preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2526023A1 (fr) * 1982-04-30 1983-11-04 Lafarquim Nouvelles 2-isopropyl pyrido (2-1-b)quinazolines et leurs sels non toxiques, procede de fabrication de celles-ci et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
SE7803419L (sv) 1978-09-25
ES468126A1 (es) 1979-09-01
NZ186759A (en) 1981-03-16
AT367051B (de) 1982-05-25
IL54328A (en) 1982-03-31
SE7803418L (sv) 1978-09-25
ES478329A1 (es) 1979-11-01
GB1601991A (en) 1981-11-04
IL54326A0 (en) 1978-06-15
FI780918A (fi) 1978-09-25
AU521096B2 (en) 1982-03-18
GB1601371A (en) 1981-10-28
ES478333A1 (es) 1979-11-16
DK128878A (da) 1978-09-25
LU79293A1 (de) 1979-05-25
ES478326A1 (es) 1979-11-01
AU3447478A (en) 1979-09-27
PH14130A (en) 1981-02-26
IT7821578A0 (it) 1978-03-23
ES478324A1 (es) 1979-11-01
GR73170B (fr) 1983-02-14
DE2812585A1 (de) 1978-09-28
NZ186760A (en) 1981-03-16
MC1185A1 (fr) 1978-12-22
PT67820A (en) 1978-04-01
IT1093710B (it) 1985-07-26
JPS53119896A (en) 1978-10-19
JPS53119897A (en) 1978-10-19
IL54328A0 (en) 1978-06-15
AR218060A1 (es) 1980-05-15
DE2812586A1 (de) 1978-09-28
DK132778A (da) 1978-09-25
AU3447578A (en) 1979-09-27
PT67821A (en) 1978-04-01
FI780917A (fi) 1978-09-25
NO781053L (no) 1978-09-26
NL7803112A (nl) 1978-09-26
MC1186A1 (fr) 1978-12-22
HU180782B (en) 1983-04-29
FR2384771A1 (fr) 1978-10-20
LU79290A1 (de) 1979-05-25
NL7803122A (nl) 1978-09-26
ES478327A1 (es) 1979-11-01
IE46505B1 (en) 1983-06-29
FR2384770B1 (fr) 1980-10-24
ES468127A1 (es) 1979-09-16
PH13915A (en) 1980-11-04
PT67821B (en) 1980-03-04
IL54326A (en) 1982-04-30
AR225415A1 (es) 1982-03-31
IT1095493B (it) 1985-08-10
ES478325A1 (es) 1979-11-01
ES478331A1 (es) 1979-11-16
GR72948B (fr) 1984-01-17
ES478323A1 (es) 1979-11-01
ES478330A1 (es) 1979-11-01
IE780582L (en) 1978-09-24
ATA210478A (de) 1981-10-15
ES478328A1 (es) 1979-11-01
NO781051L (no) 1978-09-26
AT367050B (de) 1982-05-25
ES478332A1 (es) 1979-11-16
IT7821655A0 (it) 1978-03-24
ATA210278A (de) 1981-10-15
AR218480A1 (es) 1980-06-13
AU521352B2 (en) 1982-04-01
FR2384771B1 (fr) 1980-04-04

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