FI844544A0 - Syntes av fibrinolytiska aemnen med jaest. - Google Patents

Syntes av fibrinolytiska aemnen med jaest.

Info

Publication number: FI844544A0
Authority: FI; Finland
Prior art keywords: jaest; fibrinolytiska; syntes; aemnen; med
Prior art date: 1983-11-21

Application number

FI844544A

Other languages

English (en)

Other versions

FI844544L (fi

FI86746C (fi

FI86746B (fi

Inventor

Bernd Meyhack

Albert Hinnen

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-11-21

Filing date

1984-11-19

Publication date

1984-11-19

1983-11-21 Priority claimed from GB838331045A external-priority patent/GB8331045D0/en

1984-11-19 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1984-11-19 Publication of FI844544A0 publication Critical patent/FI844544A0/fi

1985-05-22 Publication of FI844544L publication Critical patent/FI844544L/fi

1992-06-30 Application granted granted Critical

1992-06-30 Publication of FI86746B publication Critical patent/FI86746B/fi

1992-10-12 Publication of FI86746C publication Critical patent/FI86746C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/69—Increasing the copy number of the vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Mycology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)

FI844544A 1983-11-21 1984-11-19 Foerfarande foer framstaellning av maensklig vaevnads-plasminogenaktivator (tpa) med hjaelp av saccharomyces cerevisiae -jaest och i foerfarandet anvaenda hybridvektorer FI86746C (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB838331045A GB8331045D0 (en)	1983-11-21	1983-11-21	Synthesis of fibrinolytic agents by yeast
GB8331045		1983-11-21
GB848423112A GB8423112D0 (en)	1983-11-21	1984-09-13	Synthesis of fibrino lytic agents by yeast
GB8423112		1984-09-13

Publications (4)

Publication Number	Publication Date
FI844544A0 true FI844544A0 (fi)	1984-11-19
FI844544L FI844544L (fi)	1985-05-22
FI86746B FI86746B (fi)	1992-06-30
FI86746C FI86746C (fi)	1992-10-12

Family

ID=26287024

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI844544A FI86746C (fi)	1983-11-21	1984-11-19	Foerfarande foer framstaellning av maensklig vaevnads-plasminogenaktivator (tpa) med hjaelp av saccharomyces cerevisiae -jaest och i foerfarandet anvaenda hybridvektorer

Country Status (17)

Country	Link
EP (1)	EP0143081B1 (fi)
JP (1)	JPS6119489A (fi)
KR (1)	KR930002889B1 (fi)
AU (1)	AU595478B2 (fi)
DD (1)	DD229151A5 (fi)
DE (1)	DE3479520D1 (fi)
DK (1)	DK164941C (fi)
ES (1)	ES8609471A1 (fi)
FI (1)	FI86746C (fi)
GR (1)	GR80966B (fi)
HU (1)	HU201115B (fi)
IE (1)	IE57699B1 (fi)
IL (1)	IL73568A (fi)
NO (1)	NO844618L (fi)
NZ (1)	NZ210266A (fi)
PH (1)	PH22337A (fi)
PT (1)	PT79518B (fi)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL68366A (en) *	1982-04-15	1990-08-31	Genentech Inc	Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture
US7138505B1 (en)	1984-01-12	2006-11-21	Novartis Vaccines And Diagnostics, Inc.	Factor VIII:C nucleic acid molecules
JPS61502655A (ja) *	1984-07-09	1986-11-20	インテグレ−テッド・ジェネティックス・インコ−ポレ−テッド	酵母クロ−ニングビヒクル
DE3588149T2 (de) *	1984-10-01	1997-10-09	Genzyme Corp	Rekombinante DNS-Verfahren und dadurch hergestellte Produkte
JPS624233A (ja) *	1985-07-01	1987-01-10	Toyobo Co Ltd	組織性プラスミノ−ゲン活性化因子の製造法
JPS6229975A (ja) *	1985-08-01	1987-02-07	Mitsui Toatsu Chem Inc	粗ｔＰＡの精製法
GB8521496D0 (en) *	1985-08-29	1985-10-02	Ciba Geigy Ag	Repressible yeast promoters
DE3675724D1 (de) *	1985-09-18	1991-01-03	Green Cross Corp	Hefe-promotor und verfahren zur herstellung von heterologen proteinen.
USH2055H1 (en) *	1985-09-20	2002-12-03	Zymogenetics, Inc.	Expression of tissue-type plasminogen activator in bacteria
GB8530631D0 (en)	1985-12-12	1986-01-22	Ciba Geigy Ag	Thrombin inhibitors
MY101203A (en) *	1985-12-12	1991-08-17	Ucp Gen Pharma Ag	Production of thrombin iinhibitors.
US5106741A (en) *	1985-12-20	1992-04-21	The Upjohn Company	Tissue plasminogen activator (TPA) analogs
US4898825A (en) *	1986-05-07	1990-02-06	Mitsui Toatsu Chemicals, Incorporated	Methods for purification of single-chain and double-chain tissue plasminogen activator
ZA872534B (en) *	1986-05-08	1987-11-25	Phillips Petroleum Co	Yeast production of streptokinase
IL82746A (en) *	1986-06-06	1994-10-07	Genentech Inc	A process for producing a biologically active tissue plasminogen activator
JPS6463378A (en) *	1986-08-11	1989-03-09	Mitsui Toatsu Chemicals	Separation of single stranded tpa and double standard tpa
GB8621118D0 (en) *	1986-09-01	1986-10-08	Whitbread & Co Plc	Stabilised polypeptides
ES2052602T3 (es)	1986-10-03	1994-07-16	Ciba Geigy Ag	Nuevos peptidos afines a las linfocinas.
PT86162B (pt) *	1986-11-21	1990-11-20	Smithkline Beecham Corp	Expressao de proteina recombinante
ZA879286B (en)	1986-12-16	1988-10-26	Smith Kline Rit	New plasminogen activators
US5149533A (en) *	1987-06-04	1992-09-22	Zymogenetics, Inc.	Modified t-PA with kringle-/replaced by another kringle
US5089409A (en) *	1989-09-28	1992-02-18	Monsanto Company	Method of increasing specific activity of t-pa
US5326700A (en) *	1990-11-06	1994-07-05	Eli Lilly And Company	DNA sequences encoding t-PA derivatives with cleavable sites
CA2144523A1 (en) *	1993-08-04	1995-02-16	Hugo Grossenbacher	High molecular weight desulphatohirudin
ATE207538T1 (de)	1995-02-09	2001-11-15	Behringwerke Ag	Verfahren zur produktion von proteinen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4775622A (en) *	1982-03-08	1988-10-04	Genentech, Inc.	Expression, processing and secretion of heterologous protein by yeast
IL68561A (en) *	1982-05-05	1991-01-31	Genentech Inc	Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
GB2125047B (en) *	1982-08-09	1986-02-19	Ciba Geigy Ag	Yeast hybrid vectors and their use for the production of polypeptides
EP0174835A1 (en) *	1984-09-11	1986-03-19	The Upjohn Company	Human tissue plasminogen activator and recombinant DNA compounds
DE3588149T2 (de) *	1984-10-01	1997-10-09	Genzyme Corp	Rekombinante DNS-Verfahren und dadurch hergestellte Produkte

1984
- 1984-11-19 DE DE8484810564T patent/DE3479520D1/de not_active Expired
- 1984-11-19 GR GR80966A patent/GR80966B/el unknown
- 1984-11-19 PH PH31460A patent/PH22337A/en unknown
- 1984-11-19 DD DD84269628A patent/DD229151A5/de not_active IP Right Cessation
- 1984-11-19 EP EP84810564A patent/EP0143081B1/en not_active Expired
- 1984-11-19 FI FI844544A patent/FI86746C/fi not_active IP Right Cessation
- 1984-11-19 PT PT79518A patent/PT79518B/pt not_active IP Right Cessation
- 1984-11-20 AU AU35719/84A patent/AU595478B2/en not_active Ceased
- 1984-11-20 IL IL73568A patent/IL73568A/xx unknown
- 1984-11-20 NO NO844618A patent/NO844618L/no unknown
- 1984-11-20 NZ NZ210266A patent/NZ210266A/xx unknown
- 1984-11-20 IE IE2965/84A patent/IE57699B1/en not_active IP Right Cessation
- 1984-11-20 JP JP59243529A patent/JPS6119489A/ja active Pending
- 1984-11-20 DK DK551084A patent/DK164941C/da not_active IP Right Cessation
- 1984-11-20 HU HU844309A patent/HU201115B/hu not_active IP Right Cessation
- 1984-11-21 ES ES537828A patent/ES8609471A1/es not_active Expired
- 1984-11-21 KR KR1019840007284A patent/KR930002889B1/ko active IP Right Grant

Also Published As

Publication number	Publication date
PH22337A (en)	1988-08-12
AU595478B2 (en)	1990-04-05
IE842965L (en)	1985-05-21
HUT36185A (en)	1985-08-28
KR850003733A (ko)	1985-06-26
IL73568A (en)	1992-07-15
DK551084D0 (da)	1984-11-20
FI844544L (fi)	1985-05-22
IE57699B1 (en)	1993-03-10
DD229151A5 (de)	1985-10-30
NO844618L (no)	1985-05-22
FI86746C (fi)	1992-10-12
ES537828A0 (es)	1986-07-16
HU201115B (en)	1990-09-28
DE3479520D1 (en)	1989-09-28
EP0143081B1 (en)	1989-08-23
DK164941C (da)	1993-02-01
PT79518A (en)	1984-12-01
DK551084A (da)	1985-05-22
NZ210266A (en)	1988-11-29
KR930002889B1 (ko)	1993-04-12
EP0143081A3 (en)	1987-01-07
PT79518B (pt)	1986-12-12
ES8609471A1 (es)	1986-07-16
GR80966B (en)	1985-03-15
EP0143081A2 (en)	1985-05-29
FI86746B (fi)	1992-06-30
DK164941B (da)	1992-09-14
JPS6119489A (ja)	1986-01-28
AU3571984A (en)	1986-03-20
IL73568A0 (en)	1985-02-28

Publication	Publication Date	Title
FI841622A (fi)	1984-10-26	Komplex av teknetium-99m med alkylenaminoximer.
FI841839A0 (fi)	1984-05-08	Medellastkraftverk med en integrerad kolfoergasningsanlaeggning.
FI850240A0 (fi)	1985-01-18	Roerformig behaollare med rivningsoeppningsorgan.
FI844544L (fi)	1985-05-22	Syntes av fibrinolytiska aemnen med jaest.
FI851810L (fi)	1986-11-09	Reformering av kolvaeteaonga med anvaendning av serier av aongoeverhettare.
FI841729A0 (fi)	1984-05-02	Hoegtalarenhet med integrerat akustiskt bandpassfilter.
FI841630A0 (fi)	1984-04-25	Foerfarande foer aostadkommande av en projektionsbild med minskad kaenslighet foer objektets roerelser.
FI842713A0 (fi)	1984-07-05	Informationsbehandlingssystem med reglering av loepande bandtyp.
FI843197A0 (fi)	1984-08-14	Foerbaettrat n-paraffin-isoparaffin- separationsfoerfarande med tvaettning av aotercirkulerad reningsgas.
FI841901A (fi)	1984-11-12	Ingaongskrets med aotminstone tvao ingaongar.
FI833010A (fi)	1985-02-24	Byggnadselement eller -skiva foersett med aongspaerr.
FI841108A0 (fi)	1984-03-20	Hisskorg med upphaengda vaeggfogar.
FI833962A (fi)	1985-04-29	Med rotationsmaskineri foersedd tryckmediedriven slagborrmaskin.
FI843075A0 (fi)	1984-08-03	Rullningsmaskin med dubbla understoedsvalsar.
FI842008A (fi)	1984-11-19	Stenkol-vattenblandning med bestaemd partikelstorleksfoerdelning.
FI841173A (fi)	1984-09-25	Regleringsmekanism med fyra pelare foer kalander.
FI845079A0 (fi)	1984-12-20	Eldning av mesaombraenningsugn med fast braensle.
FI843331A (fi)	1985-02-26	Foerfarande foer avskiljande av lipoproteiner med hjaelp av derivatiserad polyhydroximetylen.
FI843854A0 (fi)	1984-10-01	Anordning foer tillverkning av med sprundflikar foersedda dragkedjor.
FI834814A (fi)	1984-08-08	Hopfaellbar kniv foersedd med bladlaos.
FI841747A (fi)	1984-11-10	Avfyrningsmekanism med en kontrollerad serieavfyrningsanordning foer eldvapen.
FI840705A (fi)	1984-08-23	Med sigillfoerslutning foersedd flaska.
FI833006A (fi)	1985-02-24	Halvmask foersedd med en filterbrygga.
FI830219L (fi)	1984-07-25	Foerfarande foer oxidering av staerkelse med en kontinuerlig reaktor.
FI833236A (fi)	1985-03-10	Foerfarande foer formning av katetrar med hoegfrekvensuppvaermare.

Legal Events

Date	Code	Title	Description
1994-06-08	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: CIBA-GEIGY AG