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FI111730B - Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi - Google Patents

Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi Download PDF

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Publication number
FI111730B
FI111730B FI915135A FI915135A FI111730B FI 111730 B FI111730 B FI 111730B FI 915135 A FI915135 A FI 915135A FI 915135 A FI915135 A FI 915135A FI 111730 B FI111730 B FI 111730B
Authority
FI
Finland
Prior art keywords
meleu
cyclosporin
mebmt
ciclosporin
hydroxy
Prior art date
Application number
FI915135A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI915135A0 (fi
FI915135A (fi
Inventor
Dieter Seebach
Hans Kobel
Roland Wenger
Pietro Bollinger
Soo Young Ko
Brigitte Rosenwirth
Rene P Traber
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27517009&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI111730(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB909023859A external-priority patent/GB9023859D0/en
Priority claimed from GB909023972A external-priority patent/GB9023972D0/en
Priority claimed from GB909023971A external-priority patent/GB9023971D0/en
Priority claimed from GB909023970A external-priority patent/GB9023970D0/en
Priority claimed from GB919116836A external-priority patent/GB9116836D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of FI915135A0 publication Critical patent/FI915135A0/fi
Publication of FI915135A publication Critical patent/FI915135A/fi
Application granted granted Critical
Publication of FI111730B publication Critical patent/FI111730B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI915135A 1990-11-02 1991-10-30 Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi FI111730B (fi)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
GB9023859 1990-11-02
GB909023859A GB9023859D0 (en) 1990-11-02 1990-11-02 Chemical products
GB909023972A GB9023972D0 (en) 1990-11-05 1990-11-05 New use of a cyclosporin derivative
GB9023972 1990-11-05
GB9023970 1990-11-05
GB909023971A GB9023971D0 (en) 1990-11-05 1990-11-05 New use of a cyclosporin derivative
GB9023971 1990-11-05
GB909023970A GB9023970D0 (en) 1990-11-05 1990-11-05 New use of a cyclosporin derivative
GB919116836A GB9116836D0 (en) 1991-08-05 1991-08-05 Organic compounds
GB9116836 1991-08-05

Publications (3)

Publication Number Publication Date
FI915135A0 FI915135A0 (fi) 1991-10-30
FI915135A FI915135A (fi) 1992-05-03
FI111730B true FI111730B (fi) 2003-09-15

Family

ID=27517009

Family Applications (1)

Application Number Title Priority Date Filing Date
FI915135A FI111730B (fi) 1990-11-02 1991-10-30 Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi

Country Status (25)

Country Link
US (3) US5767069A (de)
EP (1) EP0484281B2 (de)
JP (1) JP2740775B2 (de)
KR (1) KR100203556B1 (de)
AT (1) ATE148469T1 (de)
AU (1) AU649277B2 (de)
CA (1) CA2054590C (de)
CY (1) CY2159B1 (de)
CZ (1) CZ280909B6 (de)
DE (1) DE69124459T3 (de)
DK (1) DK0484281T4 (de)
ES (1) ES2095926T5 (de)
FI (1) FI111730B (de)
GR (2) GR3022592T3 (de)
HK (1) HK1005741A1 (de)
HU (1) HU212674B (de)
IE (1) IE913824A1 (de)
IL (1) IL99912A (de)
MX (1) MX9101869A (de)
MY (1) MY134806A (de)
NZ (1) NZ240421A (de)
PL (1) PL168609B1 (de)
PT (1) PT99410B (de)
SA (1) SA92120344B1 (de)
SK (1) SK278808B6 (de)

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ES2065273B1 (es) * 1993-05-25 1995-09-16 Biogal Gyogyszergyar Procedimiento para la purificacion de ciclosporina a.
US5639852A (en) * 1994-09-01 1997-06-17 Wisconsin Alumni Research Foundation Immunostimulatory agents
US5948693A (en) * 1994-09-01 1999-09-07 Wisconsin Alumni Research Foundation Solid phase synthesis of immunosuppressive agents
US6696413B2 (en) 1995-06-16 2004-02-24 Hexal Ag Pharmaceutical preparation with cyclosporin A
US5948884A (en) * 1995-07-17 1999-09-07 C-Chem Ag Cyclosporin derivatives with anti-HIV effect
JP3089350B2 (ja) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤
JP2000510097A (ja) * 1996-03-12 2000-08-08 ザ ピコワー インスティテュート フォー メディカル リサーチ 宿主細胞シクロフィリンレセプター活性を妨げることによるｈｉｖ感染の治療
CN1130373C (zh) * 1996-09-13 2003-12-10 诺瓦蒂斯有限公司 [3'－脱氧－3'－氧代－MeBmt]'环孢菌素制备方法
FR2757520B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
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IL99912A0 (en) 1992-08-18
ATE148469T1 (de) 1997-02-15
GR3022592T3 (en) 1997-05-31
US5981479A (en) 1999-11-09
MX9101869A (es) 1993-04-01
JP2740775B2 (ja) 1998-04-15
AU8692391A (en) 1992-05-07
SA92120344B1 (ar) 2004-01-24
EP0484281A3 (en) 1993-02-24
US6255100B1 (en) 2001-07-03
MY134806A (en) 2007-12-31
DE69124459D1 (de) 1997-03-13
AU649277B2 (en) 1994-05-19
PL168609B1 (pl) 1996-03-29
KR920009390A (ko) 1992-06-25
CS329791A3 (en) 1992-05-13
EP0484281A2 (de) 1992-05-06
ES2095926T3 (es) 1997-03-01
US5767069A (en) 1998-06-16
HU212674B (en) 1996-09-30
KR100203556B1 (ko) 1999-06-15
CZ280909B6 (cs) 1996-05-15
CA2054590C (en) 2003-09-16
HK1005741A1 (en) 1999-01-22
GR3035323T3 (en) 2001-04-30
JPH05208996A (ja) 1993-08-20
DE69124459T2 (de) 1997-07-10
EP0484281B1 (de) 1997-01-29
NZ240421A (en) 1993-04-28
EP0484281B2 (de) 2000-11-22
IL99912A (en) 1996-09-12
CY2159B1 (en) 2002-08-23
DK0484281T4 (da) 2001-02-05
HUT62337A (en) 1993-04-28
DE69124459T3 (de) 2001-05-31
IE913824A1 (en) 1992-05-22
CA2054590A1 (en) 1992-05-03
PL292248A1 (en) 1992-07-27
SK278808B6 (sk) 1998-03-04
DK0484281T3 (de) 1997-02-17
FI915135A0 (fi) 1991-10-30
HU913446D0 (en) 1992-01-28
FI915135A (fi) 1992-05-03
PT99410A (pt) 1992-09-30
PT99410B (pt) 1999-04-30
ES2095926T5 (es) 2001-02-16

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