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ES8607296A1 - Un metodo para preparar pirrolilaminopiperidinas - Google Patents

Un metodo para preparar pirrolilaminopiperidinas

Info

Publication number
ES8607296A1
ES8607296A1 ES535973A ES535973A ES8607296A1 ES 8607296 A1 ES8607296 A1 ES 8607296A1 ES 535973 A ES535973 A ES 535973A ES 535973 A ES535973 A ES 535973A ES 8607296 A1 ES8607296 A1 ES 8607296A1
Authority
ES
Spain
Prior art keywords
hydrogen
pyrrolylaminopiperidines
medicaments
preparation
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535973A
Other languages
English (en)
Other versions
ES535973A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of ES535973A0 publication Critical patent/ES535973A0/es
Publication of ES8607296A1 publication Critical patent/ES8607296A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SINTESIS DE PIRROLLILAMINOPIPERIDINAS. COMPRENDE: HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) EN UN DISOLVENTE Y UNA BASE, A 25-80JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) EN EL QUE R1 ES -CO-R3; Y B) REDUCIR EL RESULTADO DE (A) PARA TRANSFORMAR R1 EN ALQUILO DE C 1 A 6 O CICLOALQUILO DE C 3 A 7; O C) HACER REACCIONAR EL RESULTADO DE (A) DONDE R1 ES -CO-R3 Y R3 ALQUILO C 1 A 5, CON UN DIMERO DE SULFURO DE P-METOXIFENILTIONOFOSFINA PARA TRANSFORMAR A R1 EN -CS-ALUILO C 1 A 6. SIENDO: R, H, ALQUILO C 1 A 6 Y OTROS; R1, ALQUILO DE C 1 A 8, ALQUIL-CARBONILO DE C 1 A 6 Y OTROS; Y R2, H, HALOGENO, O -CH3.SE UTILIZAN EN FARMACOLOGIA COMO ANALGESICOS.
ES535973A 1983-09-19 1984-09-17 Un metodo para preparar pirrolilaminopiperidinas Expired ES8607296A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/533,677 US4452803A (en) 1983-09-19 1983-09-19 Pyrrolylaminopiperidines

Publications (2)

Publication Number Publication Date
ES535973A0 ES535973A0 (es) 1986-05-16
ES8607296A1 true ES8607296A1 (es) 1986-05-16

Family

ID=24126985

Family Applications (4)

Application Number Title Priority Date Filing Date
ES535973A Expired ES8607296A1 (es) 1983-09-19 1984-09-17 Un metodo para preparar pirrolilaminopiperidinas
ES549953A Expired ES8701754A1 (es) 1983-09-19 1985-12-16 Un metodo para preparar pirrolilaminopiperidinas
ES549954A Expired ES8701755A1 (es) 1983-09-19 1985-12-16 Un metodo para preparar pirrolilaminopiperidinas
ES549952A Expired ES8701753A1 (es) 1983-09-19 1985-12-16 Un metodo para preparar pirrolilaminopiperidinas

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES549953A Expired ES8701754A1 (es) 1983-09-19 1985-12-16 Un metodo para preparar pirrolilaminopiperidinas
ES549954A Expired ES8701755A1 (es) 1983-09-19 1985-12-16 Un metodo para preparar pirrolilaminopiperidinas
ES549952A Expired ES8701753A1 (es) 1983-09-19 1985-12-16 Un metodo para preparar pirrolilaminopiperidinas

Country Status (14)

Country Link
US (1) US4452803A (es)
EP (1) EP0141968B1 (es)
JP (1) JPS6087285A (es)
KR (1) KR880002626B1 (es)
AT (1) ATE34390T1 (es)
AU (1) AU577313B2 (es)
CA (1) CA1262547A (es)
DE (1) DE3471307D1 (es)
DK (1) DK443784A (es)
ES (4) ES8607296A1 (es)
GR (1) GR80385B (es)
HU (2) HU199140B (es)
PT (1) PT79219B (es)
ZA (1) ZA847328B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4546105A (en) * 1984-09-04 1985-10-08 Hoechst-Roussel Pharmaceuticals Inc. Pyrrolylaminopiperidines, compositions thereof and methods of use
US6140349A (en) * 1998-02-02 2000-10-31 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172835A (en) * 1973-06-21 1979-10-30 Sterling Drug Inc. 1-(Phenylamino)pyrrole
GB1476503A (en) * 1973-06-21 1977-06-16 Sterling Drug Inc 1-arylamino-and 1-arylimino-pyrroles and preparation thereof
CH583195A5 (en) * 1974-03-21 1976-12-31 Siegfried Ag Schiff's bases prodn. from 1-amino 3-phenylindole - by reaction with aldehydes, useful as bacteriostats and fungistats
US4348524A (en) * 1980-03-28 1982-09-07 Ciba-Geigy Corporation Amide derivatives of polyalkylpiperidines
US4302455A (en) * 1980-04-14 1981-11-24 Merck & Co., Inc. 2-(4-Aminopiperidino)pyrazines

Also Published As

Publication number Publication date
DE3471307D1 (en) 1988-06-23
AU577313B2 (en) 1988-09-22
ES549953A0 (es) 1986-12-01
AU3325984A (en) 1985-03-28
DK443784D0 (da) 1984-09-18
GR80385B (en) 1985-01-18
JPS6087285A (ja) 1985-05-16
ES8701755A1 (es) 1986-12-01
ES549952A0 (es) 1986-12-01
EP0141968A1 (en) 1985-05-22
ES549954A0 (es) 1986-12-01
PT79219B (en) 1986-09-10
ES8701753A1 (es) 1986-12-01
KR850002266A (ko) 1985-05-10
ES535973A0 (es) 1986-05-16
CA1262547A (en) 1989-10-31
HUT35668A (en) 1985-07-29
US4452803A (en) 1984-06-05
ZA847328B (en) 1985-05-29
KR880002626B1 (ko) 1988-12-07
PT79219A (en) 1984-10-01
EP0141968B1 (en) 1988-05-18
HU199140B (en) 1990-01-29
ATE34390T1 (de) 1988-06-15
HU193903B (en) 1987-12-28
ES8701754A1 (es) 1986-12-01
DK443784A (da) 1985-03-20

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