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ES8401006A1 - Un procedimiento para la preparacion de 1-(3-benciloxifenil)-1,1-dimetilheptano. - Google Patents

Un procedimiento para la preparacion de 1-(3-benciloxifenil)-1,1-dimetilheptano.

Info

Publication number
ES8401006A1
ES8401006A1 ES517002A ES517002A ES8401006A1 ES 8401006 A1 ES8401006 A1 ES 8401006A1 ES 517002 A ES517002 A ES 517002A ES 517002 A ES517002 A ES 517002A ES 8401006 A1 ES8401006 A1 ES 8401006A1
Authority
ES
Spain
Prior art keywords
benzyloxyphenyl
dimethylheptane
making
intermediates therefor
methylheptane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517002A
Other languages
English (en)
Other versions
ES517002A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES517002A0 publication Critical patent/ES517002A0/es
Publication of ES8401006A1 publication Critical patent/ES8401006A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/205—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/24—Preparation of ethers by reactions not forming ether-oxygen bonds by elimination of halogens, e.g. elimination of HCl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 1-(3-BENCILOXIFENIL)-1,1-DIMETILHEPTANO.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE BENCILA LA 3-HIDROXIACETOFENONA PARA PRODUCIR 3-BENCILOXIACETOFENONA; SEGUNDA, DICHA 3-BENCILOXIACETOFENONA SE CONVIERTE EN 1-(3-BENCILOXIFENIL)-1-METILHEPTAN-1-OL MEDIANTE UNA REACCION DE GRIGNARD CON BROMURO DE N-HEXILMAGNESIO; Y POR ULTIMO, SE CLORA EL CITADO HEPTANOL POR REACCION CON CLORURO DE HIDROGENO, SEGUIDO DE METILACION DE 1-(3-BENCILOXIFENIL)-1-CLORO-METILHEPTANO PRODUCIDO CON TRIMETILALUMINIO.DE APLICACION COMO PRODUCTO INTERMEDIO EN LA PREPARACIONDE AGENTES ANALGESICOS.
ES517002A 1981-11-02 1982-10-30 Un procedimiento para la preparacion de 1-(3-benciloxifenil)-1,1-dimetilheptano. Expired ES8401006A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/317,223 US4360700A (en) 1981-11-02 1981-11-02 Intermediates for making 1-(3-benzyloxyphenyl)-1,1-dimethylheptane

Publications (2)

Publication Number Publication Date
ES517002A0 ES517002A0 (es) 1983-12-01
ES8401006A1 true ES8401006A1 (es) 1983-12-01

Family

ID=23232676

Family Applications (1)

Application Number Title Priority Date Filing Date
ES517002A Expired ES8401006A1 (es) 1981-11-02 1982-10-30 Un procedimiento para la preparacion de 1-(3-benciloxifenil)-1,1-dimetilheptano.

Country Status (28)

Country Link
US (1) US4360700A (es)
EP (1) EP0079168B1 (es)
JP (1) JPS5888335A (es)
KR (1) KR850001471B1 (es)
AR (1) AR231966A1 (es)
AT (1) ATE9088T1 (es)
AU (1) AU535034B2 (es)
CA (1) CA1198450A (es)
CS (1) CS241129B2 (es)
DD (1) DD208606A5 (es)
DE (1) DE3260609D1 (es)
DK (1) DK483782A (es)
ES (1) ES8401006A1 (es)
FI (1) FI823721L (es)
GR (1) GR77726B (es)
GT (1) GT198277940A (es)
HU (1) HU187796B (es)
IE (1) IE54030B1 (es)
IL (1) IL67144A (es)
IN (1) IN158311B (es)
NO (1) NO156008C (es)
NZ (1) NZ202321A (es)
PH (1) PH18275A (es)
PL (1) PL137947B1 (es)
PT (1) PT75771B (es)
SU (1) SU1250168A3 (es)
YU (1) YU242882A (es)
ZA (1) ZA826792B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56702B1 (en) * 1982-12-01 1991-11-06 Usv Pharma Corp Antiinflammatory antiallergic compounds
US4778931A (en) * 1982-12-01 1988-10-18 Usv Pharmaceutical Corporation Certain [3-(1-hydroxy hexyl-tetrahydro)naphthalenes], the corresponding naphthalenes having anti-inflammatory and anti-allergic activity
US4794188A (en) * 1982-12-01 1988-12-27 Usv Pharmaceutical Corporation Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
DE3617183A1 (de) * 1985-11-16 1987-05-27 Bayer Ag Substituierte benzylether
DE3644798A1 (de) * 1986-12-31 1988-07-14 Hoechst Ag Neue nitrohaloalkoxybenzole, verfahren zu ihrer herstellung und ihre verwendung
KR101057546B1 (ko) * 2007-06-05 2011-08-17 주식회사 엘지화학 광학 이방성 화합물 및 이를 포함하는 수지 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US831323A (en) * 1905-09-28 1906-09-18 Concave And Convex Printing Company Printing-machine.
US3883012A (en) * 1971-10-21 1975-05-13 Transfer Systems Dry cask handling system for shipping nuclear fuel
US3765549A (en) * 1971-10-21 1973-10-16 Transfer Systems Apparatus and method for loading nuclear fuel into a shipping cask without immersion in a pool
US3910006A (en) * 1973-06-07 1975-10-07 Westinghouse Electric Corp Fuel element handling arrangement and method
US4284829A (en) * 1977-09-13 1981-08-18 Pfizer Inc. Hydroxyalkyl and oxoalkyl substituted phenols as analgesics and sedatives
US4285867A (en) * 1980-09-19 1981-08-25 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor

Also Published As

Publication number Publication date
FI823721L (fi) 1983-05-03
AU9004482A (en) 1983-05-12
CS241129B2 (en) 1986-03-13
PT75771B (en) 1985-12-09
GR77726B (es) 1984-09-25
NO156008B (no) 1987-03-30
CS770482A2 (en) 1985-06-13
KR850001471B1 (ko) 1985-10-10
NZ202321A (en) 1984-11-09
US4360700A (en) 1982-11-23
YU242882A (en) 1985-03-20
KR840002340A (ko) 1984-06-25
IL67144A0 (en) 1983-03-31
ES517002A0 (es) 1983-12-01
AU535034B2 (en) 1984-03-01
IE822609L (en) 1983-05-02
GT198277940A (es) 1984-04-21
PL238735A1 (en) 1983-06-06
PH18275A (en) 1985-05-14
DE3260609D1 (en) 1984-09-27
IN158311B (es) 1986-10-18
JPS6212773B2 (es) 1987-03-20
FI823721A0 (fi) 1982-11-01
DK483782A (da) 1983-05-03
EP0079168A1 (en) 1983-05-18
NO156008C (no) 1987-07-08
ZA826792B (en) 1983-07-27
SU1250168A3 (ru) 1986-08-07
EP0079168B1 (en) 1984-08-22
NO823618L (no) 1983-05-03
DD208606A5 (de) 1984-04-04
ATE9088T1 (de) 1984-09-15
HU187796B (en) 1986-02-28
CA1198450A (en) 1985-12-24
IE54030B1 (en) 1989-05-24
AR231966A1 (es) 1985-04-30
PT75771A (en) 1982-11-01
IL67144A (en) 1985-10-31
PL137947B1 (en) 1986-08-30
JPS5888335A (ja) 1983-05-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603