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ES423178A1 - Penicillins and cephalosporins - Google Patents

Penicillins and cephalosporins

Info

Publication number
ES423178A1
ES423178A1 ES423178A ES423178A ES423178A1 ES 423178 A1 ES423178 A1 ES 423178A1 ES 423178 A ES423178 A ES 423178A ES 423178 A ES423178 A ES 423178A ES 423178 A1 ES423178 A1 ES 423178A1
Authority
ES
Spain
Prior art keywords
see formula
hydrogen
formula
chosen
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES423178A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of ES423178A1 publication Critical patent/ES423178A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Process for the preparation of acylamidomethyl esters of penicillins and cephalosporins and particularly acylamidomethyl esters derived from 6-aminopenicyllanic acid (6-APA), 7-aminocephalosporanic acid (7-ACA) and 7-aminodecetoxycephalosporic acid (7-ADCA) from formula I and I': **(See formula)** where R and R1 are the same or different and represent hydrogen and a lower alkyl radical with 1 to 4 carbon atoms; R2 is chosen from the group consisting of hydrogen, a linear or branched alkyl radical and a cycloalkyl radical with at most 10 carbon atoms, a mononuclear phenyl and naphthyl radical heterocyclic chosen from the group consisting of pyrrolyl, thienyl, furyl, pyridyl; R3 is hydrogen or methoxy; R4 is chosen from the group consisting of the following radicals: **(See formula)** (see formula) and its derivatives of the amine function; (see formula) where X is hydrogen, hydroxyl, amino, chlorine and fluorine; **(See formula)** R5 is chosen from the group consisting of hydrogen and by the following results: **(See formula)** characterized in that a compound of the formula is reacted (see formula) with a compound of the formula **(See formula)** where Z indicates the radicals **(See formula)** and where R, R1, R2, R3, R4 and R5 have the same meaning as indicated above, Y is hydrogen or a cation such as an alkali metal or tertiary amine and X is a halogen atom, preferably chlorine or bromine, a hydroxyl, an acyloxy radical or an alkyl or arylsulfonic moiety and why the acylamidomethyl esters thus formed are isolated or purified as such or transformed into salts with pharmaceutically acceptable acids. (Machine-translation by Google Translate, not legally binding)
ES423178A 1973-02-14 1974-02-13 Penicillins and cephalosporins Expired ES423178A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2035873 1973-02-14

Publications (1)

Publication Number Publication Date
ES423178A1 true ES423178A1 (en) 1976-05-01

Family

ID=11166010

Family Applications (1)

Application Number Title Priority Date Filing Date
ES423178A Expired ES423178A1 (en) 1973-02-14 1974-02-13 Penicillins and cephalosporins

Country Status (9)

Country Link
JP (1) JPS5418277B2 (en)
AT (1) AT329179B (en)
BE (1) BE810969A (en)
CH (1) CH592670A5 (en)
DE (1) DE2406817A1 (en)
ES (1) ES423178A1 (en)
FR (1) FR2216995B1 (en)
GB (1) GB1421526A (en)
NL (1) NL7401782A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4428935A (en) * 1982-05-24 1984-01-31 Pfizer Inc. Penicillanic acid dioxide prodrug
GB8300295D0 (en) * 1983-01-06 1983-02-09 Erba Farmitalia Penem esters

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1491583A (en) * 1965-07-22 1967-08-11 Bristol Myers Co Production of new activated esters of 6-aminopenicillanic acid
US3873521A (en) * 1970-09-17 1975-03-25 Astra Laekemedel Ab Esters of {60 -amino penicillins
GB1425933A (en) * 1972-03-13 1976-02-25 Astra Laekemedel Ab Cephalosporins
GB1426869A (en) * 1972-03-13 1976-03-03 Astra Laekemedel Ab Penicillins

Also Published As

Publication number Publication date
BE810969A (en) 1974-08-13
CH592670A5 (en) 1977-10-31
DE2406817A1 (en) 1974-08-22
JPS5418277B2 (en) 1979-07-06
FR2216995B1 (en) 1978-07-28
GB1421526A (en) 1976-01-21
FR2216995A1 (en) 1974-09-06
ATA105874A (en) 1975-07-15
AT329179B (en) 1976-04-26
NL7401782A (en) 1974-08-16
JPS49116093A (en) 1974-11-06

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