ES2570856T3 - Composiciones oftálmicas que contienen una combinación sinérgica de dos polímeros - Google Patents
Composiciones oftálmicas que contienen una combinación sinérgica de dos polímerosInfo
- Publication number
- ES2570856T3 ES2570856T3 ES12173896T ES12173896T ES2570856T3 ES 2570856 T3 ES2570856 T3 ES 2570856T3 ES 12173896 T ES12173896 T ES 12173896T ES 12173896 T ES12173896 T ES 12173896T ES 2570856 T3 ES2570856 T3 ES 2570856T3
- Authority
- ES
- Spain
- Prior art keywords
- polymers
- compositions containing
- synergistic combination
- ophthalmic compositions
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 229920000642 polymer Polymers 0.000 title abstract 3
- 239000011885 synergistic combination Substances 0.000 title 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract 1
- 206010013774 Dry eye Diseases 0.000 abstract 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 abstract 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 abstract 1
- 229920002674 hyaluronan Polymers 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una composición acuosa para su uso en el tratamiento del ojo seco mediante administración oftálmica tópica, que comprende una cantidad que mejora la viscosidad de una combinación de dos polímeros que tiene un efecto sinérgico sobre la viscosidad de la composición y en donde la combinación de dos polímeros se selecciona del grupo que consiste en hidroxipropilmetilcelulosa y ácido hialurónico o hidroxietilcelulosa, en donde la concentración de hidroxipropil metilcelulosa oscila entre el 0,05-0,5 % (p/v).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47825303P | 2003-06-13 | 2003-06-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2570856T3 true ES2570856T3 (es) | 2016-05-20 |
Family
ID=33539082
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES11163662T Expired - Lifetime ES2410505T3 (es) | 2003-06-13 | 2004-06-08 | Composiciones oftálmicas que contienen una combinación sinérgica de dos polímeros |
ES12173896T Expired - Lifetime ES2570856T3 (es) | 2003-06-13 | 2004-06-08 | Composiciones oftálmicas que contienen una combinación sinérgica de dos polímeros |
ES09168920T Expired - Lifetime ES2415738T3 (es) | 2003-06-13 | 2004-06-08 | Composiciones oftálmicas que contienen una combinación sinérgica de dos polímeros |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES11163662T Expired - Lifetime ES2410505T3 (es) | 2003-06-13 | 2004-06-08 | Composiciones oftálmicas que contienen una combinación sinérgica de dos polímeros |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09168920T Expired - Lifetime ES2415738T3 (es) | 2003-06-13 | 2004-06-08 | Composiciones oftálmicas que contienen una combinación sinérgica de dos polímeros |
Country Status (16)
Country | Link |
---|---|
US (1) | US7709012B2 (es) |
EP (5) | EP2116227B1 (es) |
JP (4) | JP4860475B2 (es) |
KR (5) | KR101131056B1 (es) |
CN (1) | CN100475192C (es) |
AU (2) | AU2004249137B2 (es) |
BR (1) | BRPI0411361B1 (es) |
CA (6) | CA2839847C (es) |
DK (1) | DK2116227T3 (es) |
ES (3) | ES2410505T3 (es) |
MX (1) | MXPA05013290A (es) |
PL (1) | PL2116227T3 (es) |
PT (1) | PT2116227E (es) |
SI (1) | SI2116227T1 (es) |
WO (1) | WO2004112836A2 (es) |
ZA (1) | ZA200509440B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8580851B2 (en) | 2002-08-21 | 2013-11-12 | Sucampo Ag | Ophthalmic solution |
US7947295B2 (en) * | 2003-06-13 | 2011-05-24 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
TWI336257B (en) * | 2003-06-13 | 2011-01-21 | Alcon Inc | Ophthalmic compositions containing a synergistic combination of three polymers |
US7759296B2 (en) * | 2003-06-19 | 2010-07-20 | Lubrizol Advanced Materials, Inc. | Cationic polymers and fixative application therefor |
KR20120005052A (ko) * | 2003-08-21 | 2012-01-13 | 수캄포 아게 | 안과용 조성물 |
EP2070518A2 (en) * | 2006-07-25 | 2009-06-17 | Osmotica Corp. | Ophthalmic solutions |
US20080057022A1 (en) * | 2006-08-30 | 2008-03-06 | Erning Xia | Ophthalmic Pharmaceutical Compositions and Uses Thereof |
US8138156B2 (en) * | 2006-10-18 | 2012-03-20 | Bausch & Lomb Incorporated | Ophthalmic compositions containing diglycine |
PL2109442T3 (pl) * | 2007-02-09 | 2014-07-31 | Novartis Ag | Kompozycje oftalmiczne zawierające synergistyczną kombinację trzech polimerów |
US8759321B2 (en) * | 2007-06-13 | 2014-06-24 | Bausch & Lomb Incorporated | Ophthalmic composition with hyaluronic acid and polymeric biguanide |
CN101784287B (zh) | 2007-06-26 | 2013-04-24 | 若素制药株式会社 | 水性组合物 |
KR101529093B1 (ko) | 2007-08-29 | 2015-06-16 | 와카모토 세이야꾸 가부시끼가이샤 | 라타노프로스트 함유 수성 의약 조성물 |
US8119112B2 (en) * | 2008-01-31 | 2012-02-21 | Bausch & Lomb Incorporated | Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid |
US9096819B2 (en) | 2008-01-31 | 2015-08-04 | Bausch & Lomb Incorporated | Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer |
CN101977630B (zh) * | 2008-03-07 | 2012-11-21 | 太阳医药高级研发有限公司 | 眼药组合物 |
US8629099B2 (en) * | 2008-03-25 | 2014-01-14 | Bausch & Lomb Incorporated | Ophthalmic compositions comprising a dipeptide |
US20100286010A1 (en) * | 2008-09-03 | 2010-11-11 | Erning Xia | Ophthalmic Compositions with Hyaluronic Acid |
US20100178317A1 (en) * | 2009-01-09 | 2010-07-15 | Burke Susan E | Lens Care Solutions with Hyaluronic Acid |
US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
WO2011018800A2 (en) * | 2009-08-13 | 2011-02-17 | Fdc Limited | A novel in-situ gel forming solution for ocular drug delivery |
CA2833591A1 (en) * | 2011-04-22 | 2012-10-26 | Alcon Research, Ltd. | Ophthalmic composition with a viscosity enhancement system having two different viscosity enhancing agents |
TWI652072B (zh) * | 2011-12-07 | 2019-03-01 | 歐樂根公司 | 使用鹽敏感性乳液系統對人類淚液膜進行高效脂質傳遞 |
US8324171B1 (en) | 2012-02-06 | 2012-12-04 | Bausch & Lomb Incorporated | Ophthalmic compositions containing diglycine |
US8664180B2 (en) | 2012-02-06 | 2014-03-04 | Bausch & Lomb Incorporated | Ophthalmic compositions containing diglycine |
UA113434C2 (uk) * | 2012-05-04 | 2017-01-25 | Алкон Рісерч, Лтд. | Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням |
EP3470059B1 (en) | 2015-01-26 | 2020-04-01 | Bausch & Lomb Incorporated | Ophthalmic suspension composition |
EP3310363A4 (en) * | 2015-06-18 | 2019-02-13 | Common Pharma, Inc | ANTIMICROBIAL FORMULATIONS |
JP6132968B1 (ja) * | 2016-01-29 | 2017-05-24 | 参天製薬株式会社 | ドルゾラミド、高分子およびホウ酸を含有する医薬組成物 |
TWI743107B (zh) | 2016-04-22 | 2021-10-21 | 日商樂敦製藥股份有限公司 | 容器與眼科組成物之組合 |
EP3446682B1 (en) * | 2016-04-22 | 2021-05-26 | Rohto Pharmaceutical Co., Ltd. | Ophthalmic composition |
US9867810B1 (en) | 2016-08-19 | 2018-01-16 | Orasis Pharmaceuticals Ltd. | Ophthalmic pharmaceutical compositions and uses relating thereto |
TWI833913B (zh) * | 2019-02-27 | 2024-03-01 | 日商參天製藥股份有限公司 | 含有迪夸弗索(diquafosol)或其鹽、乙烯系高分子及纖維素系高分子之眼科用組合物 |
WO2024180453A1 (en) * | 2023-02-28 | 2024-09-06 | Alcon Inc. | Dissolvable polymeric eye inserts with a non-ionic cellulose derivative |
WO2024180472A1 (en) * | 2023-02-28 | 2024-09-06 | Alcon Inc. | Ocular inserts |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3355336A (en) | 1966-08-18 | 1967-11-28 | Du Pont | Thickened water-bearing inorganic oxidizer salt explosive containing crosslinked galactomannan and polyacrylamide |
NL188266C (nl) | 1975-07-29 | 1992-05-18 | Merck & Co Inc | Werkwijze ter bereiding van een oogheelkundig inplantaat. |
US4039662A (en) | 1975-12-04 | 1977-08-02 | Alcon Laboratories, Inc. | Ophthalmic solution |
US4136173A (en) | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Mixed xanthan gum and locust beam gum therapeutic compositions |
DE3440352A1 (de) * | 1984-11-05 | 1986-05-07 | Dr. Thilo & Co GmbH, 8029 Sauerlach | Dry-eye-packung |
US5409904A (en) | 1984-11-13 | 1995-04-25 | Alcon Laboratories, Inc. | Hyaluronic acid compositions and methods |
FR2601385B1 (fr) * | 1986-07-09 | 1989-09-29 | Sucre Rech & Dev | Procede de preparation a partir de saccharose d'un melange de sucres a haute teneur en isomaltose par voie enzymatique et produits obtenus |
US4783488A (en) * | 1987-01-31 | 1988-11-08 | Bausch & Lomb Incorporated | Contact lens wetting solution |
US4767463A (en) | 1987-04-15 | 1988-08-30 | Union Carbide Corporation | Glycosaminoglycan and cationic polymer combinations |
US5188826A (en) | 1988-02-08 | 1993-02-23 | Insite Vision Incorporated | Topical ophthalmic suspensions |
US5368843A (en) | 1988-06-08 | 1994-11-29 | Lever Brothers Company, Division Of Conopco, Inc. | Thickening system |
US5204325A (en) * | 1988-12-15 | 1993-04-20 | Lindstrom Richard L | Viscoelastic solution |
US5075104A (en) | 1989-03-31 | 1991-12-24 | Alcon Laboratories, Inc. | Ophthalmic carboxy vinyl polymer gel for dry eye syndrome |
US5252318A (en) | 1990-06-15 | 1993-10-12 | Allergan, Inc. | Reversible gelation compositions and methods of use |
WO1992017174A1 (en) * | 1991-03-27 | 1992-10-15 | Senju Pharmaceutical Co., Ltd. | Process for preparing aqueous suspension |
JP2808378B2 (ja) * | 1991-03-27 | 1998-10-08 | 武田薬品工業株式会社 | 水性懸濁液剤の製造法 |
US5460834A (en) | 1991-12-13 | 1995-10-24 | Alcon Laboratories, Inc. | Combinations of polymers for use in physiological tear compositions |
WO1993017664A1 (en) * | 1992-03-02 | 1993-09-16 | Alcon Laboratories, Inc. | Combinations of cellulosic polymers and carboxy vinyl polymers and their use in pharmaceutical compositions |
US5340572A (en) * | 1993-02-08 | 1994-08-23 | Insite Vision Incorporated | Alkaline ophthalmic suspensions |
JP2787131B2 (ja) * | 1993-07-30 | 1998-08-13 | 千寿製薬株式会社 | 水性懸濁液剤 |
CN1085106A (zh) * | 1993-10-27 | 1994-04-13 | 吴亮 | 眼科手术用带有荧光的粘弹性物质 |
CA2134376C (en) * | 1993-12-20 | 2001-10-23 | Haresh G. Bhagat | Combinations of polymers for use in physiological tear compositions |
ES2116681T3 (es) | 1994-03-18 | 1998-07-16 | Senju Pharma Co | Preparaciones oftalmicas para reducir la presion intraocular. |
SE9401108D0 (sv) * | 1994-03-31 | 1994-03-31 | Leiras Oy | Ophthalmic composition I |
US5939485A (en) | 1995-06-19 | 1999-08-17 | Medlogic Global Corporation | Responsive polymer networks and methods of their use |
US5558876A (en) * | 1995-03-29 | 1996-09-24 | Alcon Laboratories, Inc. | Topical ophthalmic acidic drug formulations |
WO1998043643A1 (fr) * | 1997-04-01 | 1998-10-08 | Toa Medicine Co., Ltd. | Preparations d'une solution aqueuse d'acyclovir |
JP3361106B2 (ja) | 1997-07-29 | 2003-01-07 | アルコン ラボラトリーズ,インコーポレイテッド | ハードコンタクトレンズ・ケアのためのコンディショニング溶液 |
PT999825E (pt) | 1997-07-29 | 2004-02-27 | Alcon Lab Inc | Composicoes oftalmicas contendo polimeros de galactomanano e borato |
GB9718568D0 (en) * | 1997-09-03 | 1997-11-05 | Chauvin Pharmaceuticals Limite | Compositions |
DE69923987T2 (de) * | 1998-10-08 | 2006-11-02 | Karagoezian, Hampar L., San Juan Capistrano | Synergistische antimikrobielle, dermatologische und ophtahalmologische zubereitung, die ein chlorit und wasserstoffperoxid enthalten |
US6174859B1 (en) * | 1999-04-06 | 2001-01-16 | J & D Sciences, Inc. | Method of treatment |
US7084130B2 (en) * | 2001-12-11 | 2006-08-01 | Alcon, Inc. | Intraocular irrigating solution having improved flow characteristics |
ES2339745T3 (es) * | 2000-12-20 | 2010-05-25 | Alcon, Inc. | Solucion de irrigacion intraocular que tiene caracteristicas de fluidez mejoradas. |
AR035509A1 (es) | 2000-12-21 | 2004-06-02 | Alcon Inc | Solucion de lagrimas artificiales mejorada que contiene una combinacion de tres emolientes y el uso de dicha solucion para la fabricacion de un medicamento |
JP3455852B2 (ja) * | 2000-12-26 | 2003-10-14 | 株式会社オフテクス | 洗眼液組成物 |
WO2002060495A1 (en) * | 2001-01-09 | 2002-08-08 | Louis Johan Wagenaar | Procedure and composition of treatment and/or care of the eye |
JP2003137775A (ja) * | 2001-10-31 | 2003-05-14 | Menicon Co Ltd | 眼科用組成物 |
US7001615B1 (en) | 2001-12-07 | 2006-02-21 | Alcon, Inc. | Sustained release ophthalmic, otic and nasal suspension |
JP2003183157A (ja) * | 2001-12-19 | 2003-07-03 | Lion Corp | 眼科用組成物 |
US20040118414A1 (en) | 2002-12-20 | 2004-06-24 | Shah Mandar V | Surface modified viscoelastics for ocular surgery |
WO2003059391A2 (en) | 2001-12-21 | 2003-07-24 | Alcon, Inc. | Viscoelastics for ocular surgery |
US7128928B2 (en) | 2002-02-22 | 2006-10-31 | Pharmacia Corporation | Ophthalmic formulation with novel gum composition |
US20040137079A1 (en) * | 2003-01-08 | 2004-07-15 | Cook James N. | Contact lens and eye drop rewetter compositions and methods |
EP1624858B1 (en) | 2003-04-09 | 2018-06-06 | Rutgers, the State University of New Jersey | Novel encochleation methods |
US20040241151A1 (en) | 2003-05-27 | 2004-12-02 | Sca Hygiene Products Ab | Polymer matrix with lactic acid producing bacteria |
JP4694773B2 (ja) * | 2003-06-06 | 2011-06-08 | ロート製薬株式会社 | 粘膜適用液状組成物 |
US7914803B2 (en) * | 2003-06-13 | 2011-03-29 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of three polymers |
US7947295B2 (en) * | 2003-06-13 | 2011-05-24 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
TWI336257B (en) * | 2003-06-13 | 2011-01-21 | Alcon Inc | Ophthalmic compositions containing a synergistic combination of three polymers |
TWM258789U (en) * | 2004-06-09 | 2005-03-11 | Ming-Hsiang Yeh | Interactive toy |
US20060003964A1 (en) | 2004-06-30 | 2006-01-05 | Shah Mandar V | Dilution resistant viscoelastic compositions |
PL2109442T3 (pl) | 2007-02-09 | 2014-07-31 | Novartis Ag | Kompozycje oftalmiczne zawierające synergistyczną kombinację trzech polimerów |
-
2004
- 2004-06-06 CA CA2839847A patent/CA2839847C/en not_active Expired - Fee Related
- 2004-06-06 CA CA2839928A patent/CA2839928C/en not_active Expired - Fee Related
- 2004-06-06 KR KR1020117005797A patent/KR101131056B1/ko not_active IP Right Cessation
- 2004-06-06 PT PT91689208T patent/PT2116227E/pt unknown
- 2004-06-06 KR KR1020057023409A patent/KR101147046B1/ko not_active IP Right Cessation
- 2004-06-06 CA CA2527712A patent/CA2527712C/en not_active Expired - Fee Related
- 2004-06-06 KR KR1020117028334A patent/KR20110134525A/ko not_active Application Discontinuation
- 2004-06-06 CA CA2839898A patent/CA2839898C/en not_active Expired - Fee Related
- 2004-06-06 CN CNB2004800159648A patent/CN100475192C/zh not_active Expired - Lifetime
- 2004-06-06 KR KR1020127008027A patent/KR20120062846A/ko not_active Application Discontinuation
- 2004-06-06 CA CA2839930A patent/CA2839930C/en not_active Expired - Fee Related
- 2004-06-06 CA CA2839849A patent/CA2839849C/en not_active Expired - Fee Related
- 2004-06-06 JP JP2006533590A patent/JP4860475B2/ja not_active Expired - Lifetime
- 2004-06-06 KR KR1020117018563A patent/KR20110098863A/ko not_active Application Discontinuation
- 2004-06-06 AU AU2004249137A patent/AU2004249137B2/en not_active Ceased
- 2004-06-08 DK DK09168920.8T patent/DK2116227T3/da active
- 2004-06-08 ES ES11163662T patent/ES2410505T3/es not_active Expired - Lifetime
- 2004-06-08 ES ES12173896T patent/ES2570856T3/es not_active Expired - Lifetime
- 2004-06-08 ES ES09168920T patent/ES2415738T3/es not_active Expired - Lifetime
- 2004-06-08 EP EP09168920.8A patent/EP2116227B1/en not_active Expired - Lifetime
- 2004-06-08 WO PCT/US2004/018068 patent/WO2004112836A2/en active Application Filing
- 2004-06-08 MX MXPA05013290A patent/MXPA05013290A/es active IP Right Grant
- 2004-06-08 PL PL09168920T patent/PL2116227T3/pl unknown
- 2004-06-08 BR BRPI0411361A patent/BRPI0411361B1/pt not_active IP Right Cessation
- 2004-06-08 EP EP12173896.7A patent/EP2526929B1/en not_active Revoked
- 2004-06-08 SI SI200432047T patent/SI2116227T1/sl unknown
- 2004-06-08 EP EP11163662.7A patent/EP2361610B1/en not_active Expired - Lifetime
- 2004-06-08 EP EP04754624A patent/EP1631257A2/en not_active Withdrawn
- 2004-06-08 EP EP16153017.5A patent/EP3028692B1/en not_active Expired - Lifetime
- 2004-06-08 US US10/863,169 patent/US7709012B2/en active Active
- 2004-06-08 ZA ZA200509440A patent/ZA200509440B/en unknown
-
2010
- 2010-01-27 AU AU2010200297A patent/AU2010200297B2/en not_active Ceased
- 2010-11-11 JP JP2010253316A patent/JP2011026354A/ja active Pending
-
2011
- 2011-06-22 JP JP2011138663A patent/JP2011184463A/ja active Pending
-
2013
- 2013-02-22 JP JP2013032842A patent/JP2013100360A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2570856T3 (es) | Composiciones oftálmicas que contienen una combinación sinérgica de dos polímeros | |
AR047205A1 (es) | Composiciones oftalmicas que contienen una combinacion sinergica de tres polimeros | |
CO6331425A2 (es) | Composiciones que comprenden n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)6-metoxifenil)-1-(2,3-dihidroxiproxipropil)ciclopropan-1-sulfamida | |
AR048878A1 (es) | Composiciones topicas de metadona y metodos para usarlas | |
AR062046A1 (es) | Soluciones oftalmicas | |
AR045352A1 (es) | Forma de dosificacion a prueba de abuso | |
AR050616A1 (es) | Composiciones farmaceuticas para el tratamiento de trastornos hiperproliferativos. | |
CO6321225A2 (es) | Particulas portadoras sólidas para mejorar la procesabilidad de un agente farmacéutico | |
RS51569B (en) | COMPOSITIONS CONTAINING CRYSTAL TRANS - (+/-) - DELTA-9-TETRAHYDROCANABINOL | |
PE20110162A1 (es) | Yoduro de povidona, un nuevo conservante alternativo para composiciones oftalmicas | |
AR055095A1 (es) | Nuevos inhibidores macrociclicos de la replicacion del virus de la hepatitis c | |
AR070025A1 (es) | Uso de derivados de 1-amino-alquilciclohexano para el tratamiento del tinnitus coclear y composicion farmaceutica | |
NO20061840L (no) | Legemiddelbelegg som tilveiebringer hoy legemiddeltilsetning og fremgangsmater for a tilveiebringe samme | |
AR054227A1 (es) | Composicion de principios activos | |
BRPI0514474A (pt) | multiparticulados | |
BRPI0418251B8 (pt) | fosfonatos, monofosfonamidatos, bisfosfonamidatos, e, composição farmacêutica os compreendendo | |
BRPI0615292A8 (pt) | composições e métodos para preparação de fármacos de má solubilidade em água com estabilidade aumentada | |
BRPI0407583A (pt) | solução oftálmica lìmpida e estável | |
GT200600520A (es) | Agentes antibacterianos | |
BR0015416A (pt) | Composições contendo derivados do ácido hidroxieicosa tetraenóico e métodos de uso no tratamento de distúrbios de olhos secos | |
UY27929A1 (es) | Composiciones farmaceuticas de farmacos semiordenados y polimeros | |
WO2003066597A3 (en) | Guanidino compounds | |
CO5680387A2 (es) | Dentrifico quie contiene componente dual de bis-biguadina de estabilidad mejorada | |
AR057648A1 (es) | Composicion de metaflumizona para la administracion topica | |
BR0001201A (pt) | Composto ( poli ) tia-alcinóicos, composição cosmética, utilização de uma composição cosmética, utilização de um composto e composição farmacêutica |