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ES2554245T3 - Formulaciones parasiticidas inyectables de levamisol y lactonas macrocíclicas - Google Patents

Formulaciones parasiticidas inyectables de levamisol y lactonas macrocíclicas Download PDF

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Publication number
ES2554245T3
ES2554245T3 ES11731566.3T ES11731566T ES2554245T3 ES 2554245 T3 ES2554245 T3 ES 2554245T3 ES 11731566 T ES11731566 T ES 11731566T ES 2554245 T3 ES2554245 T3 ES 2554245T3
Authority
ES
Spain
Prior art keywords
levamisole
macrocyclic lactones
surfactant
effective amount
parasiticidal formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11731566.3T
Other languages
English (en)
Inventor
Robert Holmes
Majid Razzak
Alan Johnson
Jitendra Goswami
Atul Awasthi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Animal Health USA Inc
Original Assignee
Merial Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44342950&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2554245(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merial Inc filed Critical Merial Inc
Application granted granted Critical
Publication of ES2554245T3 publication Critical patent/ES2554245T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una formulación farmacéuticamente o veterinariamente aceptable adaptada para ser inyectada en un animal, formulación que comprende; a. una cantidad eficaz de un levamisol; b. una cantidad eficaz de al menos una lactona macrocíclica; c. un sistema farmacéuticamente aceptable de disolventes y tensioactivos en la que el sistema proporciona estabilidad durante el almacenamiento aceptable para tanto el levamisol como la lactona macrocíclica y en la que el sistema proporciona una viscosidad que es adecuada para inyección; en la que el sistema comprende al menos un tensioactivo, en el que el tensioactivo es CREMOPHOR EL, y un disolvente orgánico miscible en agua que es dimetilacetamida (DMA).
ES11731566.3T 2010-05-12 2011-05-12 Formulaciones parasiticidas inyectables de levamisol y lactonas macrocíclicas Active ES2554245T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33388210P 2010-05-12 2010-05-12
US333882P 2010-05-12
PCT/US2011/036321 WO2011143479A1 (en) 2010-05-12 2011-05-12 Injectable parasiticidal formulations of levamisole and macrocyclic lactones

Publications (1)

Publication Number Publication Date
ES2554245T3 true ES2554245T3 (es) 2015-12-17

Family

ID=44342950

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11731566.3T Active ES2554245T3 (es) 2010-05-12 2011-05-12 Formulaciones parasiticidas inyectables de levamisol y lactonas macrocíclicas

Country Status (13)

Country Link
US (1) US20110281920A1 (es)
EP (1) EP2568980B1 (es)
AR (1) AR081187A1 (es)
AU (1) AU2011252987B2 (es)
DK (1) DK2568980T3 (es)
ES (1) ES2554245T3 (es)
HR (1) HRP20160103T1 (es)
HU (1) HUE028600T2 (es)
NZ (1) NZ603699A (es)
PL (1) PL2568980T3 (es)
PT (1) PT2568980E (es)
SI (1) SI2568980T1 (es)
WO (1) WO2011143479A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010101389C4 (en) * 2010-12-08 2017-03-02 Jurox Pty Ltd Anthelmintic formulation
UA113179C2 (xx) 2011-06-23 2016-12-26 Антипаразитарна композиція, яка містить макроциклічний лактон і левамізол, і спосіб лікування паразитарної інфестації
NZ594610A (en) * 2011-08-16 2013-03-28 Virbac New Zealand Ltd Injectable Anthelmintic Formulations cotaining levamisole and one or more macrocyclic lactones for controlling internal parasites in ruminants
US20140045885A1 (en) * 2012-08-10 2014-02-13 Siobhan P. Ellison Decoquinate, 4-hydroxyquinolones and napthoquinones combined with levamisole, Imidazothiazole, for the prevention and treatment of sarcocystosis and equine protozoal myeloencephalitis caused by Sarcocystis and Neospora and other apicomplexan protozoans.
RU2527329C2 (ru) * 2012-10-25 2014-08-27 Государственное научное учреждение Курский научно-исследовательский институт агропромышленного производства Россельхозакадемии Способ получения комплексного иммунометаболического препарата с антиинфекционной активностью
WO2014098623A1 (en) * 2012-12-20 2014-06-26 Alleva Animal Health Limited Injectable eprinomectin formulation and anthelmintic use thereof
ES2846820T3 (es) 2013-04-12 2021-07-29 Zoetis Services Llc Composición de lactonas macrocíclicas, levamisol, un aminoazúcar y un agente antiparasitario adicional
BR102013031277B1 (pt) * 2013-12-05 2018-10-02 Ouro Fino Participacoes E Empreendimentos S A processo para preparar uma suspensão anti-helmíntica e suspensão anti-helmíntica injetável
AU2016200283B2 (en) * 2015-02-21 2016-10-13 Al Hanbali, Othman Abdul Rahim DR LEVIA: A New Injectable Parasiticidal Veterinary Formulation of Levamisole HCI and Ivermectin Solution
WO2018038623A1 (en) * 2016-08-23 2018-03-01 Donaghys Limited Improvements in parasite treatments

Family Cites Families (35)

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SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4096271A (en) * 1977-08-03 1978-06-20 American Cyanamid Company Slow release injectable formulations of tetramisole and derivatives in benzyl benzoate
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4389397A (en) * 1980-08-04 1983-06-21 Merck & Co., Inc. Solubilization of ivermectin in water
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
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NZ232422A (en) 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
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Also Published As

Publication number Publication date
AR081187A1 (es) 2012-07-04
SI2568980T1 (sl) 2016-02-29
EP2568980B1 (en) 2015-11-11
HRP20160103T1 (hr) 2016-02-26
PT2568980E (pt) 2016-03-15
WO2011143479A1 (en) 2011-11-17
US20110281920A1 (en) 2011-11-17
NZ603699A (en) 2013-08-30
PL2568980T3 (pl) 2016-05-31
AU2011252987B2 (en) 2013-05-02
AU2011252987A1 (en) 2012-12-13
HUE028600T2 (en) 2016-12-28
EP2568980A1 (en) 2013-03-20
DK2568980T3 (en) 2015-11-30

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