ES2123812T3 - Derivados 1,5-benzodiazepina utiles como antagonistas de las cck o de la gastrina. - Google Patents
Derivados 1,5-benzodiazepina utiles como antagonistas de las cck o de la gastrina.Info
- Publication number
- ES2123812T3 ES2123812T3 ES94924257T ES94924257T ES2123812T3 ES 2123812 T3 ES2123812 T3 ES 2123812T3 ES 94924257 T ES94924257 T ES 94924257T ES 94924257 T ES94924257 T ES 94924257T ES 2123812 T3 ES2123812 T3 ES 2123812T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- sup
- alkyl
- cycloalkyl
- united
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
COMPUESTOS DE FORMULA (I) EN DONDE R 1 REPRESENTA UN GRUPO FENILO, C{SUB, 3-7}CICLOALQUILO, C{SUB, 7-11}CICLOALQUILO UNIDO, C{SUB, 7-11}CICLOALQUILO UNIDO, O C{SUB, 1-6}ALQUILO; EL MENCIONADO GRUPO ALQUILO PUEDE ESTAR SUSTITUIDO POR UN GRUPO HIDROXI, FENILO, C{SUB, 1-6}ALKOXICARBONILO, C{SUB, 37}CICLOALQUILO, O C{SUB, 7-11}CICLOALQUILO UNIDO; R{SUP, 2} REPRESENTA UN GRUPO FENILO OPCIONALMENTE SUSTITUIDO POR 1 O 2 SUSTITUYENTES SELECCIONADOS DE HALOGENO, C{SUB, 1-4}ALQUILO, C{SUB, 1-4}ALQUILTIO, CIANO, NITRO, TRIFLUOMETILO, TRIFLUOMETOXI,(()CH{SUB, 2}())NR{SUP,4} U O(()CH{SUB, 2}())PR{SUP,4}, EN DONDE R{SUP,4} REPRESENTA HIDROXI, C{SUB, 14}ALCOXI, CO{SUB, 2}R{SUP,5} O NR{SUP,6}R{SUP,7}; N ES CERO O 1; P ES UN ENTERO DE 1 A 4; R{SUP,3} REPRESENTA EL GRUPO ALKNR{SUP,8}R{SUP,9}; R{SUP,5} REPRESENTA HIDROGENO O C{SUB, 14}ALQUILO; R{SUP,6} REPRESENTA HIDROGENO O C{SUB, 1-4}ALQUILO; R{SUP,7} REPRESENTA HIDROGENO, C{SUB, 1-4}ALQUILO, ACILO O C{SUB, 2-6}ALQUILO SUSTITUIDO POR UNO O MAS GRUPOS HIDROXI, CARBOXILO Y/O AMINO O R{SUP,6} Y R{SUP,7} JUNTO CON EL ATOMO DE HIDROGENO AL QUE ESTAN UNIDOS FORMAN UN ANILLO HETEROCICLICO SATURADO 5-7 QUE CONTIENE UN HETEROATOMO ADICIONAL SELECCIONADO DE OXIGENO, AZUFRE O NITROGENO Y/O PUEDE ESTAR SUSTITUIDO POR 1 O 2 GRUPOS C{SUB, 1-4}ALQUILO O HIDROXI. R{SUP,8} Y R{SUP,9} INDEPENDIENTEMENTE REPRESENTAN HIDROGENO, C{SUB, 1-4}ALQUILO O C{SUB, 2-6}ALQUILO SUSTITUIDO POR UNO O MAS GRUPOS HIDROXI, CARBOXILO Y/O AMINO O R{SUP,8} Y R{SUP,9} JUNTO CON EL ATOMO DE NITROGENO AL QUE ESTAN UNIDOS FORMAN UN ANILLO HETEROCICLICO SATURADO 5-7 QUE CONTIENE UN HETEROATOMO ADICIONAL SELECCIONADO DE OXIGENO, AZUFRE O NITROGENO Y/O PUEDE SER SUSTITUIDO POR 1 O 2 GRUPOS C{SUB, 1-4}ALQUILO, O HIDROXI; ALK REPRESENTA UNA CADENA DE C{SUB, 2-6}ALQUILENO RECTA O RAMIFICADA OPCIONALMENTE SUSTITUIDA POR UN GRUPO HIDROXILO; R{SUP,10} REPRESENTA HIDROGENO O UN ATOMO HALOGENO; M ES CERO, 1 O 2; X ES OXIGENO O NH; Y SALES Y/O ESTERES METABOLICAMENTE LABILES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS SON ANTAGONISTAS DE GASTRINA Y CCK.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939314981A GB9314981D0 (en) | 1993-07-20 | 1993-07-20 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2123812T3 true ES2123812T3 (es) | 1999-01-16 |
Family
ID=10739096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94924257T Expired - Lifetime ES2123812T3 (es) | 1993-07-20 | 1994-07-18 | Derivados 1,5-benzodiazepina utiles como antagonistas de las cck o de la gastrina. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US5716953A (es) |
| EP (1) | EP0710230B1 (es) |
| JP (1) | JP3587849B2 (es) |
| KR (1) | KR100347287B1 (es) |
| CN (1) | CN1050835C (es) |
| AP (1) | AP492A (es) |
| AT (1) | ATE171167T1 (es) |
| AU (1) | AU687858B2 (es) |
| CA (1) | CA2167308A1 (es) |
| CO (1) | CO4290299A1 (es) |
| CZ (1) | CZ290472B6 (es) |
| DE (1) | DE69413405T2 (es) |
| DK (1) | DK0710230T3 (es) |
| EC (1) | ECSP941120A (es) |
| ES (1) | ES2123812T3 (es) |
| FI (1) | FI960223A (es) |
| GB (1) | GB9314981D0 (es) |
| HR (1) | HRP940411B1 (es) |
| HU (1) | HU222439B1 (es) |
| IL (1) | IL110366A (es) |
| IS (1) | IS4190A (es) |
| MY (1) | MY118638A (es) |
| NO (1) | NO313288B1 (es) |
| NZ (1) | NZ271075A (es) |
| PE (1) | PE8295A1 (es) |
| PL (1) | PL175609B1 (es) |
| RU (1) | RU2135485C1 (es) |
| SI (1) | SI0710230T1 (es) |
| SV (1) | SV1994000031A (es) |
| TW (1) | TW290542B (es) |
| WO (1) | WO1995003285A1 (es) |
| ZA (1) | ZA945238B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5739129A (en) * | 1994-04-14 | 1998-04-14 | Glaxo Wellcome Inc. | CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines |
| PE27497A1 (es) * | 1994-04-15 | 1997-08-07 | Glaxo Inc | Derivados de 1,5 benzodiazepina |
| AU3459497A (en) * | 1996-07-12 | 1998-02-09 | Chugai Seiyaku Kabushiki Kaisha | Cancer cell proliferation inhibitors |
| US6683075B1 (en) | 1996-12-23 | 2004-01-27 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use |
| US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US20030190307A1 (en) | 1996-12-24 | 2003-10-09 | Biogen, Inc. | Stable liquid interferon formulations |
| US6569851B1 (en) * | 1998-06-22 | 2003-05-27 | Elan Pharmaceutials, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6958330B1 (en) | 1998-06-22 | 2005-10-25 | Elan Pharmaceuticals, Inc. | Polycyclic α-amino-ε-caprolactams and related compounds |
| HUP0203294A3 (en) | 1999-10-15 | 2003-03-28 | Hoffmann La Roche | Benzodiazepine derivatives, process for their preparation, pharmaceutical compositions containing them and their use |
| US20050192265A1 (en) * | 2003-03-20 | 2005-09-01 | Thompson Richard C. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds |
| US8430925B2 (en) * | 2004-02-27 | 2013-04-30 | Cardiacmd, Inc. | Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same |
| CA2684760A1 (en) * | 2007-04-19 | 2008-10-30 | F. Hoffmann-La Roche Ag | Dihydro-benzo[b][1,4]diazepin-2-one sulfonamide derivatives |
| RU2540464C2 (ru) * | 2012-05-28 | 2015-02-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации | Водорастворимое производное амида салициловой кислоты, обладающее транквилизирующей, ноотропной и анальгезирующей активностью |
| CN103435562B (zh) * | 2013-08-26 | 2016-02-24 | 华东理工大学 | 6-取代苯并二氮卓-2,4-二酮类化合物及其用途 |
| RU2702359C1 (ru) * | 2019-06-04 | 2019-10-08 | Федеральное государственное бюджетное научное учреждение Уфимский федеральный исследовательский центр Российской академии наук | Способ получения 2,2,4-триалкил-2,3-дигидро-1Н-1,5-бензодиазепинов |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2641280B1 (fr) * | 1988-12-29 | 1994-01-21 | Roussel Uclaf | Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments |
| CA2068355A1 (en) * | 1991-05-14 | 1992-11-15 | Mark S. Chambers | Benzodiazephine derivatives, compositions containing them and their use in therapy |
| GEP20001968B (en) * | 1992-01-21 | 2000-03-05 | Glaxo Spa | Arilthio Compounds as Antibacterial and Antiviral Agents |
| GB9201181D0 (en) * | 1992-01-21 | 1992-03-11 | Glaxo Spa | Chemical compounds |
| GB9225492D0 (en) * | 1992-12-05 | 1993-01-27 | Glaxo Group Ltd | Amine derivatives |
-
1993
- 1993-07-20 GB GB939314981A patent/GB9314981D0/en active Pending
-
1994
- 1994-07-15 IS IS4190A patent/IS4190A/is unknown
- 1994-07-18 HR HR940411A patent/HRP940411B1/xx not_active IP Right Cessation
- 1994-07-18 EC EC1994001120A patent/ECSP941120A/es unknown
- 1994-07-18 ZA ZA945238A patent/ZA945238B/xx unknown
- 1994-07-18 AP APAP/P/1994/000657A patent/AP492A/en active
- 1994-07-18 KR KR1019960700279A patent/KR100347287B1/ko not_active IP Right Cessation
- 1994-07-18 AT AT94924257T patent/ATE171167T1/de not_active IP Right Cessation
- 1994-07-18 EP EP94924257A patent/EP0710230B1/en not_active Expired - Lifetime
- 1994-07-18 RU RU96102670A patent/RU2135485C1/ru not_active IP Right Cessation
- 1994-07-18 HU HU9600124A patent/HU222439B1/hu not_active IP Right Cessation
- 1994-07-18 PE PE1994246888A patent/PE8295A1/es not_active Application Discontinuation
- 1994-07-18 DK DK94924257T patent/DK0710230T3/da active
- 1994-07-18 NZ NZ271075A patent/NZ271075A/en unknown
- 1994-07-18 SI SI9430207T patent/SI0710230T1/xx not_active IP Right Cessation
- 1994-07-18 PL PL94312659A patent/PL175609B1/pl not_active IP Right Cessation
- 1994-07-18 CZ CZ1996173A patent/CZ290472B6/cs not_active IP Right Cessation
- 1994-07-18 CA CA002167308A patent/CA2167308A1/en not_active Abandoned
- 1994-07-18 DE DE69413405T patent/DE69413405T2/de not_active Expired - Fee Related
- 1994-07-18 CN CN94193283A patent/CN1050835C/zh not_active Expired - Fee Related
- 1994-07-18 ES ES94924257T patent/ES2123812T3/es not_active Expired - Lifetime
- 1994-07-18 AU AU74589/94A patent/AU687858B2/en not_active Ceased
- 1994-07-18 CO CO94031454A patent/CO4290299A1/es unknown
- 1994-07-18 JP JP50492695A patent/JP3587849B2/ja not_active Expired - Fee Related
- 1994-07-18 WO PCT/EP1994/002353 patent/WO1995003285A1/en active IP Right Grant
- 1994-07-18 MY MYPI94001865A patent/MY118638A/en unknown
- 1994-07-18 US US08/578,535 patent/US5716953A/en not_active Expired - Fee Related
- 1994-07-19 SV SV1994000031A patent/SV1994000031A/es active IP Right Grant
- 1994-07-19 IL IL11036694A patent/IL110366A/en not_active IP Right Cessation
- 1994-07-22 TW TW083106738A patent/TW290542B/zh active
-
1996
- 1996-01-17 FI FI960223A patent/FI960223A/fi unknown
- 1996-01-19 NO NO19960237A patent/NO313288B1/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2123812T3 (es) | Derivados 1,5-benzodiazepina utiles como antagonistas de las cck o de la gastrina. | |
| FI954105A (fi) | Uusia 4-aminopyridiinejä, niiden valmistusmenetelmä sekä näitä yhdisteitä sisältäviä lääkkeitä | |
| ES2055056T3 (es) | Derivados de pirimidopirimidina. | |
| ES2036551T3 (es) | Compuestos heterociclicos. | |
| FI942635A (fi) | Piperatsiinijohdannaiset 5HT1A-antagonisteina | |
| ES2127912T3 (es) | Benzoderivados condensados. | |
| ES2054872T3 (es) | Nuevos derivados de acido bencimidazolin-2-oxo-1-carboxilico utiles como antagonistas de los receptores 5-ht. | |
| PE10290A1 (es) | Procedimiento de preparacion de derivados de benzotriazol | |
| ES8600305A1 (es) | Procedimiento de preparar compuestos beta-lactamicos | |
| AU540766B2 (en) | Nonapeptide and decapeptide analogs of lhrh | |
| MY123467A (en) | Preparation of sterically hindered amine ethers | |
| AR010195A1 (es) | Antagonistas de vasopresina de benzacepina triciclicos y procedimiento para su preparacion. | |
| CO4340623A1 (es) | Derivados de indolina, metodo de preparacion y uso | |
| ES2168121T3 (es) | Derivados de acido 3-amino-2-mercaptobenzoico y procedimientos para su preparacion. | |
| ES2164881T3 (es) | Derivados de 6-carboxamido dihidropirano. | |
| ES2038766T3 (es) | 4-aril-5-carbamoil-1,4-dihidropiridinas. | |
| MX9301045A (es) | Procedimiento para preparar antagonistas receptores de fibrinogeno. | |
| ES2112483T3 (es) | 4-aril-4-hidroxi-tetrahidropiranos y 3-aril-3-hidroxi-tetrahidrofuranos como inhibidores de 5-lipoxigenasa. | |
| CO4970746A1 (es) | Nuevos compuestos sustituidos de benzoisotiazol para tratamiento de estados mediados por la quimioquina | |
| ES2164990T3 (es) | Agonistas de receptores muscarinicos. | |
| ES2159943T3 (es) | Neuvos derivados de piridina y composiciones farmaceuticas que los contienen. | |
| AR012553A1 (es) | Una composicion que posee propiedades antivirales, en base a 7h-benz (de) antracenos y las composiciones farmaceuticas que los contienen conjuntamentecon derivados de la benzantrona | |
| ES2143630T3 (es) | Derivados azabicicloalquilos de imidazo(1,5-a)indol-3-ona utilizados como antagonistas de 5ht3. | |
| ES2145306T3 (es) | Nitro-benzamidas utiles como agentes anti-arritmicos. | |
| ES2155898T3 (es) | Derivados de azepina tetraciclica sustituidos, que presentan una afinidad por los receptores 5-ht2. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 710230 Country of ref document: ES |