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GEP20001968B - Arilthio Compounds as Antibacterial and Antiviral Agents - Google Patents

Arilthio Compounds as Antibacterial and Antiviral Agents

Info

Publication number
GEP20001968B
GEP20001968B GEAP19922651A GEAP1992002651A GEP20001968B GE P20001968 B GEP20001968 B GE P20001968B GE AP19922651 A GEAP19922651 A GE AP19922651A GE AP1992002651 A GEAP1992002651 A GE AP1992002651A GE P20001968 B GEP20001968 B GE P20001968B
Authority
GE
Georgia
Prior art keywords
arilthio
antibacterial
compounds
antiviral agents
chemistry
Prior art date
Application number
GEAP19922651A
Inventor
Grigorio Tarzia
Harry Finch
Aldo Feriani
David Gordon Trist
Original Assignee
Glaxo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Spa filed Critical Glaxo Spa
Publication of GEP20001968B publication Critical patent/GEP20001968B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1. Technical Result Reducing of toxicity and increase of aggresive antagonistic properties. 2. Essence A novel 1,5-benzodiazepine derivatives of the formula (I) where R1, R2 , R3 R4 and m are presented in the description, method of its production and pharmaceutical compositions comprising them. 3. Field of Application Chemistry, in particular organic chemistry and medicine. 8 ind. cl., and 7 dep. cl.
GEAP19922651A 1992-01-21 1992-01-21 Arilthio Compounds as Antibacterial and Antiviral Agents GEP20001968B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929201180A GB9201180D0 (en) 1992-01-21 1992-01-21 Chemical compounds

Publications (1)

Publication Number Publication Date
GEP20001968B true GEP20001968B (en) 2000-03-05

Family

ID=10708914

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP19922651A GEP20001968B (en) 1992-01-21 1992-01-21 Arilthio Compounds as Antibacterial and Antiviral Agents

Country Status (29)

Country Link
US (2) US5580895A (en)
JP (1) JP3253723B2 (en)
KR (1) KR100263625B1 (en)
CN (1) CN1049217C (en)
AP (1) AP369A (en)
AU (2) AU3450193A (en)
BG (1) BG61876B1 (en)
CA (1) CA2087672C (en)
CZ (1) CZ283950B6 (en)
FI (1) FI111632B (en)
GB (1) GB9201180D0 (en)
GE (1) GEP20001968B (en)
HU (2) HU221297B1 (en)
IL (1) IL104447A (en)
IS (1) IS3970A (en)
MX (1) MX9300261A (en)
MY (1) MY131307A (en)
NO (1) NO305952B1 (en)
NZ (1) NZ245715A (en)
OA (1) OA09964A (en)
PH (1) PH30894A (en)
PL (1) PL175340B1 (en)
RO (1) RO114128B1 (en)
RU (1) RU2124009C1 (en)
SK (1) SK280173B6 (en)
TW (1) TW226013B (en)
UA (1) UA29416C2 (en)
WO (1) WO1993014074A1 (en)
ZA (1) ZA93375B (en)

Families Citing this family (45)

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Publication number Priority date Publication date Assignee Title
GB9225492D0 (en) * 1992-12-05 1993-01-27 Glaxo Group Ltd Amine derivatives
CN1120845A (en) * 1993-04-15 1996-04-17 格拉克索有限公司 1,5 benzodiazepine derivatives having CCK and/or gastrin antagonistic activity
GB9307833D0 (en) * 1993-04-15 1993-06-02 Glaxo Inc Modulators of cholecystokinin and gastrin
GB9308431D0 (en) * 1993-04-23 1993-06-09 Glaxo Spa Chemical compounds
GB9308421D0 (en) * 1993-04-23 1993-06-09 Glaxo Spa Chemical compounds
GB9315018D0 (en) * 1993-07-20 1993-09-01 Glaxo Spa Chemical compounds
GB2280182A (en) * 1993-07-20 1995-01-25 Glaxo Spa Benzodiazepine derivatives
GB9314977D0 (en) * 1993-07-20 1993-09-01 Glaxo Spa Chemical compounds
GB9314981D0 (en) * 1993-07-20 1993-09-01 Glaxo Spa Chemical compounds
TW369529B (en) * 1994-04-14 1999-09-11 Glaxo Inc 5-heterocyclo-1,5-benzodiazepine derivatives, pharmaceutical composition comprising the same and process for the preparation thereof
US5739129A (en) * 1994-04-14 1998-04-14 Glaxo Wellcome Inc. CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
PE27497A1 (en) * 1994-04-15 1997-08-07 Glaxo Inc DERIVATIVES OF 1,5 BENZODIAZEPINA
GB9420748D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
US5780464A (en) * 1994-10-14 1998-07-14 Glaxo Wellcome Inc. Enteric coated compositions of 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity
IL124808A0 (en) 1995-12-11 1999-01-26 New England Medical Center Inc Assay for and uses of peptide hormone receptor ligands
US5750353A (en) * 1995-12-11 1998-05-12 New England Medical Center Hospitals, Inc. Assay for non-peptide agonists to peptide hormone receptors
ES2206754T3 (en) * 1996-12-10 2004-05-16 Zeria Pharmaceutical Co., Ltd. DERIVATIVES OF 1,5 - BENZODIAZEPINA.
KR20050100615A (en) * 2003-01-14 2005-10-19 싸이토키네틱스, 인코포레이티드 Compounds, compositions and methods
GB0307918D0 (en) * 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
WO2005049024A2 (en) * 2003-11-18 2005-06-02 Boehringer Ingelheim International Gmbh Solid pharmaceutical preparation form
CN101035525A (en) 2004-06-17 2007-09-12 赛特凯恩蒂克公司 Substituted urea derivatives for treating cardiac diseases
US7538223B2 (en) 2005-08-04 2009-05-26 Cytokinetics, Inc. Compounds, compositions and methods
US20070161617A1 (en) 2005-12-15 2007-07-12 Morgan Bradley P Certain chemical entities, compositions and methods
US7825120B2 (en) 2005-12-15 2010-11-02 Cytokinetics, Inc. Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
WO2007078815A2 (en) 2005-12-16 2007-07-12 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
JP5178526B2 (en) 2005-12-19 2013-04-10 サイトキネティクス・インコーポレーテッド Compounds, compositions and methods
CU20090172A7 (en) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos TRICYCLIC AND TETRACYCLIC SYSTEMS WITH ACTIVITY ON THE CENTRAL AND VASCULAR NERVOUS SYSTEM
JP6014904B2 (en) 2011-07-29 2016-10-26 国立大学法人徳島大学 ERAP1-derived peptides and uses thereof
CN103435562B (en) * 2013-08-26 2016-02-24 华东理工大学 6-replaces Benzodiazepine-2,4-cyclohexadione compounds and uses thereof
KR102667914B1 (en) 2015-07-22 2024-05-21 이난타 파마슈티칼스, 인코포레이티드 Benzodiazepine derivatives as RSV inhibitors
EP3402799B1 (en) 2016-01-15 2022-05-04 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
WO2018152413A1 (en) 2017-02-16 2018-08-23 Enanta Pharmaceuticals, Inc. Processes for the preparation of benzodiazepine derivatives
US10752598B2 (en) * 2017-06-07 2020-08-25 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as RSV inhibitors
WO2019006291A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
US11091501B2 (en) 2017-06-30 2021-08-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
EP3687543B1 (en) 2017-09-29 2024-03-20 Enanta Pharmaceuticals, Inc. Combinations of pharmaceutical agents as rsv inhibitors
US10647711B2 (en) 2017-11-13 2020-05-12 Enanta Pharmaceuticals, Inc. Azepin-2-one derivatives as RSV inhibitors
US10975094B2 (en) 2018-04-11 2021-04-13 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
JP7525855B2 (en) 2018-11-30 2024-07-31 国立大学法人徳島大学 Breast cancer therapeutic agent containing PHB2-derived peptide that inhibits BIG3-PHB2 interaction
MX2021011144A (en) 2019-03-18 2022-01-18 Enanta Pharm Inc Benzodiazepine derivatives as rsv inhibitors.
WO2020210246A1 (en) 2019-04-09 2020-10-15 Enanta Pharmaceuticals, Inc, Heterocyclic compounds as rsv inhibitors
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
UY39032A (en) 2020-01-24 2021-07-30 Enanta Pharm Inc HETEROCYCLIC COMPOUNDS AS ANTIVIRAL AGENTS
US11534439B2 (en) 2020-07-07 2022-12-27 Enanta Pharmaceuticals, Inc. Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
WO2022086840A1 (en) 2020-10-19 2022-04-28 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641280B1 (en) * 1988-12-29 1994-01-21 Roussel Uclaf NOVEL 2,4-DIOXO 2,3,4,5-TETRAHYDRO 1H-1,5-BENZODIAZEPINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS

Also Published As

Publication number Publication date
CZ173694A3 (en) 1995-09-13
NO305952B1 (en) 1999-08-23
RO114128B1 (en) 1999-01-29
US5637697A (en) 1997-06-10
ZA93375B (en) 1994-07-18
RU94037768A (en) 1996-08-10
MY131307A (en) 2007-08-30
AP369A (en) 1994-11-06
TW226013B (en) 1994-07-01
SK280173B6 (en) 1999-09-10
FI943421A (en) 1994-07-19
US5580895A (en) 1996-12-03
CN1049217C (en) 2000-02-09
AU3450193A (en) 1993-08-03
HU221297B1 (en) 2002-09-28
CA2087672C (en) 2003-08-05
AU661749B2 (en) 1995-08-03
OA09964A (en) 1995-12-11
NO942720L (en) 1994-07-20
UA29416C2 (en) 2000-11-15
WO1993014074A1 (en) 1993-07-22
IL104447A0 (en) 1993-05-13
GB9201180D0 (en) 1992-03-11
BG98881A (en) 1995-03-31
CN1074678A (en) 1993-07-28
SK86494A3 (en) 1995-03-08
AU3193593A (en) 1993-07-22
AP9300478A0 (en) 1993-01-31
PL175340B1 (en) 1998-12-31
PH30894A (en) 1997-12-23
NZ245715A (en) 1995-07-26
KR100263625B1 (en) 2000-11-01
FI943421A0 (en) 1994-07-19
MX9300261A (en) 1994-03-31
RU2124009C1 (en) 1998-12-27
HU9402150D0 (en) 1994-09-28
IS3970A (en) 1993-07-22
JPH07118244A (en) 1995-05-09
CA2087672A1 (en) 1993-07-22
NO942720D0 (en) 1994-07-20
JP3253723B2 (en) 2002-02-04
BG61876B1 (en) 1998-08-31
CZ283950B6 (en) 1998-07-15
FI111632B (en) 2003-08-29
HU211295A9 (en) 1995-11-28
IL104447A (en) 1998-02-22
HUT67375A (en) 1995-03-28

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