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ES2188344B1 - Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos. - Google Patents

Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.

Info

Publication number
ES2188344B1
ES2188344B1 ES200002914A ES200002914A ES2188344B1 ES 2188344 B1 ES2188344 B1 ES 2188344B1 ES 200002914 A ES200002914 A ES 200002914A ES 200002914 A ES200002914 A ES 200002914A ES 2188344 B1 ES2188344 B1 ES 2188344B1
Authority
ES
Spain
Prior art keywords
obtaining
procedure
compounds derived
benzotiophene
themselves
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200002914A
Other languages
English (en)
Other versions
ES2188344A1 (es
Inventor
Juan Carlos Del Castillo Nieto
Berta Lasheras Aldaz
Antonio Monge Vega
Marisabel Mourelle Mancini
Joaquin Del Rio Zambrana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Vita SA
Original Assignee
Laboratorios Vita SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200002914A priority Critical patent/ES2188344B1/es
Application filed by Laboratorios Vita SA filed Critical Laboratorios Vita SA
Priority to EEP200300245A priority patent/EE200300245A/xx
Priority to PL01362982A priority patent/PL362982A1/xx
Priority to CNA018196004A priority patent/CN1478088A/zh
Priority to CZ20031398A priority patent/CZ20031398A3/cs
Priority to EP01983737A priority patent/EP1337528B1/en
Priority to KR10-2003-7007272A priority patent/KR20030066689A/ko
Priority to APAP/P/2003/002801A priority patent/AP2003002801A0/en
Priority to EA200300519A priority patent/EA200300519A1/ru
Priority to SI200130192T priority patent/SI1337528T1/xx
Priority to IL15596601A priority patent/IL155966A0/xx
Priority to ES01983737T priority patent/ES2225623T3/es
Priority to JP2002546540A priority patent/JP2004514719A/ja
Priority to DE60104717T priority patent/DE60104717T2/de
Priority to SK620-2003A priority patent/SK6202003A3/sk
Priority to PT01983737T priority patent/PT1337528E/pt
Priority to PCT/IB2001/002211 priority patent/WO2002044170A2/en
Priority to GE5158A priority patent/GEP20043366B/en
Priority to CA002429892A priority patent/CA2429892A1/en
Priority to AT01983737T priority patent/ATE272634T1/de
Priority to NZ525950A priority patent/NZ525950A/en
Priority to TR2004/02779T priority patent/TR200402779T4/xx
Priority to AU2002215157A priority patent/AU2002215157A1/en
Priority to OA1200300144A priority patent/OA12536A/en
Priority to US10/432,697 priority patent/US20040034219A1/en
Priority to HU0303568A priority patent/HUP0303568A3/hu
Priority to BR0115708-6A priority patent/BR0115708A/pt
Priority to MXPA03004875A priority patent/MXPA03004875A/es
Priority to PE2001001181A priority patent/PE20020692A1/es
Priority to ARP010105490A priority patent/AR034009A1/es
Priority to ZA200303858A priority patent/ZA200303858B/en
Priority to MA27164A priority patent/MA26963A1/fr
Priority to HR20030407A priority patent/HRP20030407A2/hr
Priority to IS6824A priority patent/IS6824A/is
Priority to NO20032332A priority patent/NO20032332D0/no
Priority to BG107851A priority patent/BG107851A/bg
Publication of ES2188344A1 publication Critical patent/ES2188344A1/es
Application granted granted Critical
Publication of ES2188344B1 publication Critical patent/ES2188344B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Thin Film Transistor (AREA)

Abstract

Compuestos derivados de benzotiofeno, su procedimiento de obtención y utilización de los mismos. La presente invención proporciona nuevos derivados de benzotiofeno de fórmula general (I) así como un procedimiento para su obtención, las correspondientes composiciones y su utilización para la fabricación de un medicamento destinado al tratamiento de trastornos neurológicos. Estos nuevos compuestos se comportan como inhibidores de la receptación de serotonina y muestran elevada afinidad hacia el receptor 5-HT1A.
ES200002914A 2000-11-29 2000-11-29 Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos. Expired - Fee Related ES2188344B1 (es)

Priority Applications (36)

Application Number Priority Date Filing Date Title
ES200002914A ES2188344B1 (es) 2000-11-29 2000-11-29 Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.
NZ525950A NZ525950A (en) 2000-11-29 2001-11-19 Benzothiophene derivative compounds, process of preparation and use thereof as serotonin reuptake inhibitors with affinity to the 5-HT1A receptor to treat neurological disorders such as psychosis, depression, anxiety and panic attacks
CNA018196004A CN1478088A (zh) 2000-11-29 2001-11-19 苯并噻吩衍生物、其制备方法以及应用
CZ20031398A CZ20031398A3 (cs) 2000-11-29 2001-11-19 Deriváty benzothiofenových sloučenin, způsob jejich přípravy a jejich použití
EP01983737A EP1337528B1 (en) 2000-11-29 2001-11-19 Benzothiophene derivative compounds, process of preparation and use thereof
KR10-2003-7007272A KR20030066689A (ko) 2000-11-29 2001-11-19 벤조티오펜 유도체 화합물, 이의 제조방법 및 용도
AT01983737T ATE272634T1 (de) 2000-11-29 2001-11-19 Benzothiophenderivate, verhahren zu ihrer herstellung und ihre verwendung
EA200300519A EA200300519A1 (ru) 2000-11-29 2001-11-19 Соединения производных бензотиофена, способ их получения и применения
SI200130192T SI1337528T1 (en) 2000-11-29 2001-11-19 Benzothiophene derivative compounds, process of preparation and use thereof
IL15596601A IL155966A0 (en) 2000-11-29 2001-11-19 Benzothiophene derivative compounds, process of preparation and use thereof
ES01983737T ES2225623T3 (es) 2000-11-29 2001-11-19 Compuestos derivados de benzotiofeno, su procedimdiento de obtencion y utilizacion de los mismos.
JP2002546540A JP2004514719A (ja) 2000-11-29 2001-11-19 ベンゾチオフェン誘導体化合物、その製造方法および使用
DE60104717T DE60104717T2 (de) 2000-11-29 2001-11-19 Benzothiophenderivate, verhahren zu ihrer herstellung und ihre verwendung
PL01362982A PL362982A1 (en) 2000-11-29 2001-11-19 Benzothiophene derivative compounds, process for the preparation and use thereof
PT01983737T PT1337528E (pt) 2000-11-29 2001-11-19 Compostos derivados de benzotiofeno, processo de preparacao e a sua utilizacao
PCT/IB2001/002211 WO2002044170A2 (en) 2000-11-29 2001-11-19 Benzothiophene derivative compounds, process of preparation and use thereof
GE5158A GEP20043366B (en) 2000-11-29 2001-11-19 Benzothiophene Derivative Compounds Process of Preparation and Use Thereof
TR2004/02779T TR200402779T4 (tr) 2000-11-29 2001-11-19 Benzotiyofen türevi bileşikler, bunların hazırlama yöntemleri ve kullanımları.
EEP200300245A EE200300245A (et) 2000-11-29 2001-11-19 Bensotiofeeni derivaadid, nende valmistamise meetod ja kasutamine
APAP/P/2003/002801A AP2003002801A0 (en) 2000-11-29 2001-11-19 Benzothiophene derivative compounds, process of preparation and use thereof
CA002429892A CA2429892A1 (en) 2000-11-29 2001-11-19 Benzothiophene derivative compounds, process of preparation and use thereof
AU2002215157A AU2002215157A1 (en) 2000-11-29 2001-11-19 Benzothiophene derivative compounds, process of preparation and use thereof
OA1200300144A OA12536A (en) 2000-11-29 2001-11-19 Benzothiophene derivative compounds, process of preparation and use thereof.
US10/432,697 US20040034219A1 (en) 2000-11-29 2001-11-19 Benzothiophene derivative compounds process of preparation and use thereof
HU0303568A HUP0303568A3 (en) 2000-11-29 2001-11-19 Benzothiophene derivatives, process for their preparation and use thereof
BR0115708-6A BR0115708A (pt) 2000-11-29 2001-11-19 Compostos derivados de benzotiofeno, seu processo de obten-ção e uso dos mesmos
MXPA03004875A MXPA03004875A (es) 2000-11-29 2001-11-19 Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.
SK620-2003A SK6202003A3 (en) 2000-11-29 2001-11-19 Benzothiophene derivative compounds, process of the preparation and use thereof
PE2001001181A PE20020692A1 (es) 2000-11-29 2001-11-26 Compuestos derivados de benzotiofeno y su procedimiento de obtencion
ARP010105490A AR034009A1 (es) 2000-11-29 2001-11-27 Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos
ZA200303858A ZA200303858B (en) 2000-11-29 2003-05-19 Benzothiophene derivative compounds, process of preparation and use thereof.
MA27164A MA26963A1 (fr) 2000-11-29 2003-05-19 Composes derives de benzothiophene, procede de leur preparation et leur utilisation.
HR20030407A HRP20030407A2 (en) 2000-11-29 2003-05-20 Benzothiophene derivative compounds, process of preparation and use thereof
NO20032332A NO20032332D0 (no) 2000-11-29 2003-05-22 Benzodiazepinderivatforbindelser, fremgangsmåte til fremstilling og anvendelse derav
IS6824A IS6824A (is) 2000-11-29 2003-05-22 Bensóþíófenafleiðuefnasambönd, aðferð við að framleiða og nota þau
BG107851A BG107851A (bg) 2000-11-29 2003-05-27 Съединения, производни на бензотиофена, метод за тяхното получаване и използването им

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200002914A ES2188344B1 (es) 2000-11-29 2000-11-29 Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.

Publications (2)

Publication Number Publication Date
ES2188344A1 ES2188344A1 (es) 2003-06-16
ES2188344B1 true ES2188344B1 (es) 2004-09-16

Family

ID=8495887

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200002914A Expired - Fee Related ES2188344B1 (es) 2000-11-29 2000-11-29 Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.
ES01983737T Expired - Lifetime ES2225623T3 (es) 2000-11-29 2001-11-19 Compuestos derivados de benzotiofeno, su procedimdiento de obtencion y utilizacion de los mismos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES01983737T Expired - Lifetime ES2225623T3 (es) 2000-11-29 2001-11-19 Compuestos derivados de benzotiofeno, su procedimdiento de obtencion y utilizacion de los mismos.

Country Status (35)

Country Link
US (1) US20040034219A1 (es)
EP (1) EP1337528B1 (es)
JP (1) JP2004514719A (es)
KR (1) KR20030066689A (es)
CN (1) CN1478088A (es)
AP (1) AP2003002801A0 (es)
AR (1) AR034009A1 (es)
AT (1) ATE272634T1 (es)
AU (1) AU2002215157A1 (es)
BG (1) BG107851A (es)
BR (1) BR0115708A (es)
CA (1) CA2429892A1 (es)
CZ (1) CZ20031398A3 (es)
DE (1) DE60104717T2 (es)
EA (1) EA200300519A1 (es)
EE (1) EE200300245A (es)
ES (2) ES2188344B1 (es)
GE (1) GEP20043366B (es)
HR (1) HRP20030407A2 (es)
HU (1) HUP0303568A3 (es)
IL (1) IL155966A0 (es)
IS (1) IS6824A (es)
MA (1) MA26963A1 (es)
MX (1) MXPA03004875A (es)
NO (1) NO20032332D0 (es)
NZ (1) NZ525950A (es)
OA (1) OA12536A (es)
PE (1) PE20020692A1 (es)
PL (1) PL362982A1 (es)
PT (1) PT1337528E (es)
SI (1) SI1337528T1 (es)
SK (1) SK6202003A3 (es)
TR (1) TR200402779T4 (es)
WO (1) WO2002044170A2 (es)
ZA (1) ZA200303858B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60231507D1 (de) 2001-07-20 2010-07-01 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
SI1497266T1 (sl) 2002-03-27 2008-10-31 Glaxo Group Ltd Derivati kinolina in njihova uporaba kot ligandi 5-ht6
NZ541009A (en) 2003-01-13 2007-09-28 Dynogen Pharmaceuticals Inc Method of treating nausea, vomiting, retching or any combination thereof
US7276603B2 (en) 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
NZ544331A (en) 2003-07-22 2010-03-26 Arena Pharm Inc Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
DE102004023635A1 (de) * 2004-05-10 2006-04-13 Grünenthal GmbH Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023506A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023632A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Substituierte Cyclohexylcarbonsäure-Derivate
DE102004023501A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023508A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Säurederivate substituierter Cyclohexyl-1,4-diamine
DE102004023522A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023507A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexylessigsäure-Derivate
US7881267B2 (en) * 2004-06-04 2011-02-01 Hewlett-Packard Development Company, L.P. Portable computing device for wireless communications and method of operation
DE102004063797A1 (de) * 2004-12-30 2006-07-13 Schwarz Pharma Ag Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
EP2254564A1 (en) 2007-12-12 2010-12-01 Glaxo Group Limited Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
US20110021538A1 (en) 2008-04-02 2011-01-27 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
CN101619056B (zh) * 2008-07-02 2013-07-17 石药集团中奇制药技术（石家庄）有限公司 苯并噻吩烷醇哌嗪衍生物及其作为抗抑郁症药物的应用
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
WO2015014256A1 (en) 2013-07-29 2015-02-05 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
RU2017145976A (ru) 2015-06-12 2019-07-15 Аксовант Сайенсиз Гмбх Производные диарил- и арилгетероарилмочевины, применимые для профилактики и лечения нарушения поведения во время REM-фазы сна
AU2016291673A1 (en) 2015-07-15 2018-01-25 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease

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US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
ZA929008B (en) * 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
US5658909A (en) * 1994-11-17 1997-08-19 Molecular Geriatrics Corporation Certain substituted 1-aryl-3-piperazin-1'-yl propanones to treat Alzheimer's Disease
US5693804A (en) * 1994-11-17 1997-12-02 Molecular Geriatrics Corporation Substituted 1-aryl-3-piperazin-1'-yl propanones
ES2128266B1 (es) * 1997-07-08 2000-01-16 Vita Invest Sa Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes.

Also Published As

Publication number Publication date
NO20032332L (no) 2003-05-22
CN1478088A (zh) 2004-02-25
EP1337528B1 (en) 2004-08-04
WO2002044170A2 (en) 2002-06-06
TR200402779T4 (tr) 2004-11-22
AU2002215157A1 (en) 2002-06-11
AP2003002801A0 (en) 2003-06-30
WO2002044170A3 (en) 2002-09-06
JP2004514719A (ja) 2004-05-20
BR0115708A (pt) 2004-02-03
KR20030066689A (ko) 2003-08-09
EP1337528A2 (en) 2003-08-27
DE60104717T2 (de) 2006-04-06
BG107851A (bg) 2004-06-30
CZ20031398A3 (cs) 2004-01-14
GEP20043366B (en) 2004-04-13
EA200300519A1 (ru) 2003-12-25
EE200300245A (et) 2003-08-15
HUP0303568A3 (en) 2005-02-28
US20040034219A1 (en) 2004-02-19
HRP20030407A2 (en) 2004-08-31
PL362982A1 (en) 2004-11-02
HUP0303568A2 (hu) 2004-03-01
ZA200303858B (en) 2004-05-19
NO20032332D0 (no) 2003-05-22
IL155966A0 (en) 2003-12-23
SK6202003A3 (en) 2004-05-04
ES2188344A1 (es) 2003-06-16
MXPA03004875A (es) 2005-02-14
NZ525950A (en) 2004-11-26
CA2429892A1 (en) 2002-06-06
PE20020692A1 (es) 2002-09-02
IS6824A (is) 2003-05-22
AR034009A1 (es) 2004-01-21
ES2225623T3 (es) 2005-03-16
SI1337528T1 (en) 2005-02-28
OA12536A (en) 2006-06-05
PT1337528E (pt) 2004-11-30
MA26963A1 (fr) 2004-12-20
DE60104717D1 (de) 2004-09-09
ATE272634T1 (de) 2004-08-15

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