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ES2167311T3 - Bancos de peptidos modificados resistentes a proteasas. - Google Patents

Bancos de peptidos modificados resistentes a proteasas.

Info

Publication number
ES2167311T3
ES2167311T3 ES91913414T ES91913414T ES2167311T3 ES 2167311 T3 ES2167311 T3 ES 2167311T3 ES 91913414 T ES91913414 T ES 91913414T ES 91913414 T ES91913414 T ES 91913414T ES 2167311 T3 ES2167311 T3 ES 2167311T3
Authority
ES
Spain
Prior art keywords
peptoids
designed
methods
libraries
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91913414T
Other languages
English (en)
Inventor
Paul A Bartlett
Daniel Santi
Reyna Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
University of California
Original Assignee
University of California
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, Chiron Corp filed Critical University of California
Application granted granted Critical
Publication of ES2167311T3 publication Critical patent/ES2167311T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE SUMINISTRAN PEPTOIDES QUE SON POLIMEROS QUE CONSTAN DE UNIDADES MONOMERAS EN LOS QUE LAS UNIDADES MONOMERAS INCLUYEN AL MENOS ALGUNOS AMINOACIDOS SUBSTITUTOS Y PUEDEN INCLUIR AMINOACIDOS CONVENCIONALES. LOS PEPTOIDES PUEDEN SINTETIZARSE EN GRAN NUMERO SUFICIENTE PARA SUMINISTRAR CATALOGOS DE PEPTOIDES QUE PUEDEN SER SELECCIONADOS PARA AISLAR LOS PEPTOIDES DE UNA ACTIVIDAD BIOLOGICA DESEADA. CIERTOS PEPTOIDES SE DESIGNAN PARA MIMETIZAR TANTO COMO SEA POSIBLE LA ACTIVIDAD DE PROTEINAS CONOCIDAS. OTROS PEPTOIDES SE DISEÑAN PARA TENER UNA MAYOR O UNA MENOR ACTIVIDAD QUE LAS PROTEINAS CONOCIDAS Y PUEDEN ESTAR DISEÑADOS DE FORMA QUE BLOQUEEN ZONAS RECEPTORAS CONOCIDAS Y / O EDUCIR UNA RESPUESTA INMUNOGENICA DESEADA Y POR LO TANTO ACTUAR COMO VACUNAS. SE HA DESCUBIERTO UNA GAMA DE DIFERENTES SUBSTITUTOS DEL AMINOACIDO, ASI COMO SUS METODOS DE SINTESIS Y METODOS PARA USAR TALES SUBSTITUTOS DEL AMINOACIDO EN LA SINTESIS DE PEPTOIDES Y CATALOGOS DE PEPTOIDES. TAMBIEN SE PRESENTAN METODOS PARA SELECCIONAR LOS CATALOGOS PARA OBTENER LOS PEPTOIDES DESEADOS DE UNA ACTIVIDAD BIOLOGICA PARTICULAR. LOS PEPTOIDES SE UNEN PREFERIBLEMENTE A DROGAS FARMACEUTICAMENTE ACTIVAS FORMANDO UN CONJUGADO QUE INCREMENTA LA AFINIDAD DE UNION A UNA ZONA RECEPTORA BIOLOGICA EN PARTICULAR.
ES91913414T 1990-06-14 1991-06-14 Bancos de peptidos modificados resistentes a proteasas. Expired - Lifetime ES2167311T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53833990A 1990-06-14 1990-06-14
US71582391A 1991-06-14 1991-06-14

Publications (1)

Publication Number Publication Date
ES2167311T3 true ES2167311T3 (es) 2002-05-16

Family

ID=27065784

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91913414T Expired - Lifetime ES2167311T3 (es) 1990-06-14 1991-06-14 Bancos de peptidos modificados resistentes a proteasas.

Country Status (11)

Country Link
EP (1) EP0535155B1 (es)
JP (1) JPH06504758A (es)
AT (1) ATE212641T1 (es)
AU (2) AU8286891A (es)
CA (1) CA2085118A1 (es)
DE (1) DE69132914T2 (es)
DK (1) DK0535155T3 (es)
ES (1) ES2167311T3 (es)
IE (1) IE66205B1 (es)
PT (1) PT97992B (es)
WO (1) WO1991019735A1 (es)

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ATE212641T1 (de) 2002-02-15
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EP0535155A4 (en) 1994-08-17
PT97992A (pt) 1992-04-30
DK0535155T3 (da) 2002-02-25
EP0535155A1 (en) 1993-04-07
IE66205B1 (en) 1995-12-13
EP0535155B1 (en) 2002-01-30
AU8286891A (en) 1992-01-07
AU3296495A (en) 1996-03-07
CA2085118A1 (en) 1991-12-15
WO1991019735A1 (en) 1991-12-26
AU683184B2 (en) 1997-10-30
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DE69132914T2 (de) 2002-09-19
JPH06504758A (ja) 1994-06-02

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