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ES2153054T3 - Procedimiento para la transformacion de grupos hidroxilo en los correspondientes compuestos fluorados. - Google Patents

Procedimiento para la transformacion de grupos hidroxilo en los correspondientes compuestos fluorados.

Info

Publication number
ES2153054T3
ES2153054T3 ES95937846T ES95937846T ES2153054T3 ES 2153054 T3 ES2153054 T3 ES 2153054T3 ES 95937846 T ES95937846 T ES 95937846T ES 95937846 T ES95937846 T ES 95937846T ES 2153054 T3 ES2153054 T3 ES 2153054T3
Authority
ES
Spain
Prior art keywords
pct
compounds
fluorated
transformation
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95937846T
Other languages
English (en)
Inventor
Helmut Vorbruggen
Barbel Bennua-Skalmowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2153054T3 publication Critical patent/ES2153054T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0007—Androstane derivatives not substituted in position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0062—Estrane derivatives substituted in position 17 alfa not substituted in position 17 beta

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE DESCRIBE UN NUEVO PROCEDIMIENTO PARA LA CONVERSION DE GRUPOS HIDROXILO EN LOS CORRESPONDIENTES COMPUESTOS CON FLUOR, HACIENDO REACCIONAR ALCOHOLES PRIMARIOS Y SECUNDARIOS CON FLUORURO DE PERFLUOROBUTANOSULFONILO O SUS HOMOLOGOS MAS GRANDES, COMO EL FLUORURO DE PERFLUOROOCTANOSULFONILO, EN PRESENCIA DE 2-3 EQUIVALENTES DE BASES ORGANICAS FUERTES EN DISOLVENTES ORGANICOS PUROS.
ES95937846T 1994-10-26 1995-10-25 Procedimiento para la transformacion de grupos hidroxilo en los correspondientes compuestos fluorados. Expired - Lifetime ES2153054T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4439488A DE4439488C1 (de) 1994-10-26 1994-10-26 Verfahren zur Umwandlung von Hydroxylgruppen in die entsprechenden Fluorverbindungen

Publications (1)

Publication Number Publication Date
ES2153054T3 true ES2153054T3 (es) 2001-02-16

Family

ID=6532527

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95937846T Expired - Lifetime ES2153054T3 (es) 1994-10-26 1995-10-25 Procedimiento para la transformacion de grupos hidroxilo en los correspondientes compuestos fluorados.

Country Status (12)

Country Link
US (1) US5760255A (es)
EP (1) EP0735992B1 (es)
JP (1) JP3807680B2 (es)
AT (1) ATE198464T1 (es)
AU (1) AU3869795A (es)
CA (1) CA2179753C (es)
DE (2) DE4439488C1 (es)
ES (1) ES2153054T3 (es)
HU (1) HU9601762D0 (es)
MX (1) MX9602422A (es)
PT (1) PT735992E (es)
WO (1) WO1996013474A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1045587C (zh) * 1996-07-18 1999-10-13 中国科学院上海有机化学研究所 一种官能化(z,e)-共轭双烯化合物,高选择性,高效的合成方法及用途
US6090937A (en) * 1998-03-17 2000-07-18 Ajinomoto Co., Inc. Methods for producing nucleoside derivatives and intermediates therefor
US6248889B1 (en) 1998-11-20 2001-06-19 3M Innovative Properties Company Process for converting an alcohol to the corresponding fluoride
WO2006018991A1 (ja) * 2004-08-18 2006-02-23 Central Glass Company, Limited 光学活性α－フルオロカルボン酸エステル誘導体の製造方法
JP5186722B2 (ja) 2005-03-18 2013-04-24 セントラル硝子株式会社 スルフリルフルオリドを用いるフッ素化反応
JP4940790B2 (ja) * 2006-06-30 2012-05-30 セントラル硝子株式会社 脱ヒドロキシフッ素化剤
WO2008122611A1 (en) * 2007-04-05 2008-10-16 Solvay (Société Anonyme) Process for the manufacture of fluorinated compounds
EP2744771B1 (en) * 2011-08-19 2020-10-21 The Trustees of Princeton University C-halogen bond formation
CN102432514B (zh) * 2011-12-26 2014-05-07 兰州博实生化科技有限责任公司 1-叔丁氧羰基-3-氟氮杂环丁烷的合成方法
KR102699048B1 (ko) 2015-03-31 2024-08-26 칸토 덴카 코교 가부시키가이샤 불소화알칸의 제조 방법, 아미딘 염기의 분리, 회수 방법, 및 회수 아미딘 염기의 사용 방법
JP2019214513A (ja) * 2016-10-05 2019-12-19 関東電化工業株式会社 フッ素化化合物の製造方法
CN113683648A (zh) * 2021-08-26 2021-11-23 上海皓鸿生物医药科技有限公司 一种2’-氟-2’-脱氧尿苷的合成方法及其中间体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914265A (en) * 1972-12-11 1975-10-21 Du Pont Dialkylaminosulfur trifluorides as fluorinating agents

Also Published As

Publication number Publication date
JPH09507503A (ja) 1997-07-29
AU3869795A (en) 1996-05-23
HU9601762D0 (en) 1996-09-30
CA2179753C (en) 2007-06-26
DE59508939D1 (de) 2001-02-08
EP0735992A1 (de) 1996-10-09
WO1996013474A1 (de) 1996-05-09
US5760255A (en) 1998-06-02
PT735992E (pt) 2001-04-30
MX9602422A (es) 1997-05-31
EP0735992B1 (de) 2001-01-03
DE4439488C1 (de) 1996-03-21
CA2179753A1 (en) 1996-05-09
ATE198464T1 (de) 2001-01-15
JP3807680B2 (ja) 2006-08-09

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