ES2061398A1 - Procedimiento de obtencion de n-acetil homocisteina tiolactona a partir del dl-homocistina por metodos electroquimicos. - Google Patents
Procedimiento de obtencion de n-acetil homocisteina tiolactona a partir del dl-homocistina por metodos electroquimicos.Info
- Publication number
- ES2061398A1 ES2061398A1 ES09300403A ES9300403A ES2061398A1 ES 2061398 A1 ES2061398 A1 ES 2061398A1 ES 09300403 A ES09300403 A ES 09300403A ES 9300403 A ES9300403 A ES 9300403A ES 2061398 A1 ES2061398 A1 ES 2061398A1
- Authority
- ES
- Spain
- Prior art keywords
- homocystine
- obtaining
- catholyte
- electrochemical methods
- homocysteine thiolactone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B3/00—Electrolytic production of organic compounds
- C25B3/20—Processes
- C25B3/25—Reduction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE N-ACETIL HOMOCISTEINA TIOLACTONA, DE FORMULA (I), A PARTIR DE DL-HOMOCISTINA POR METODOS ELECTROQUIMICOS. UNA SOLUCION ACUOSA DE DL-HOMOCISTINA Y UN ACIDO MINERAL SE SOMETE A ELECTROLISIS EN UNA CELULA ELECTROLITICA, CON SEPARACION DE CATOLITO Y ANOLITO. EL CATOLITO ESTA FORMADO POR LA MENCIONADA SOLUCION, Y EL ANOLITO ES UNA SOLUCION SALINA CUALQUIERA. LOS ELECTRODOS PUEDEN SER PLANOS, TRIDIMENSIONALES, FORMANDO LECHO COMPACTO O FLUIDIZADO. LA TENSION DE CORRIENTE ESTA COMPRENDIDA ENTRE 10 MA/CM2 Y 2 A/CM2; LA TEMPERATURA ESTA COMPRENDIDA ENTRE 0 Y 90 C. LA SOLUCION OBTENIDA EN EL CATOLITO SE CONCENTRA, SE SECA Y SE ACETILA PARA OBTENER EL COMPUESTO (I), CON UN ALTO GRADO DE PUREZA. EL COMPUESTO DE LA INVENCION PUEDE UTILIZARSE PARA LA TERAPIA DE ENFERMEDADES HEPATICAS Y COMO MUCOLITICO.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09300403A ES2061398B1 (es) | 1993-03-02 | 1993-03-02 | Procedimiento de obtencion de n-acetil homocisteina tiolactona a partir del dl-homocistina por metodos electroquimicos. |
EP94870038A EP0618312A1 (en) | 1993-03-02 | 1994-03-01 | Process for obtaining n-acetyl homocysteine thiolactone from DL-homocystine by electrochemical methods |
JP6031639A JPH072837A (ja) | 1993-03-02 | 1994-03-01 | Dl−ホモシスチンから電気化学的方法によりn−アセチルホモシステインチオラクトンを調製する方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09300403A ES2061398B1 (es) | 1993-03-02 | 1993-03-02 | Procedimiento de obtencion de n-acetil homocisteina tiolactona a partir del dl-homocistina por metodos electroquimicos. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2061398A1 true ES2061398A1 (es) | 1994-12-01 |
ES2061398B1 ES2061398B1 (es) | 1996-02-16 |
Family
ID=8280946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09300403A Expired - Fee Related ES2061398B1 (es) | 1993-03-02 | 1993-03-02 | Procedimiento de obtencion de n-acetil homocisteina tiolactona a partir del dl-homocistina por metodos electroquimicos. |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0618312A1 (es) |
JP (1) | JPH072837A (es) |
ES (1) | ES2061398B1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998059242A1 (en) * | 1997-06-23 | 1998-12-30 | Nexstar Pharmaceuticals, Inc. | Homocysteine assay |
CN109943860B (zh) * | 2019-04-26 | 2019-12-31 | 武汉本杰明医药股份有限公司 | Dl-高半胱氨酸硫内酯盐酸盐的合成方法 |
KR102384780B1 (ko) | 2020-02-27 | 2022-04-11 | (주) 파마젠 | 호모시스테인 티오락톤 또는 셀레노락톤의 제조방법 |
CN111909374B (zh) * | 2020-07-23 | 2022-03-29 | 河北工业大学 | 一种具有自修复性能的锂电池粘结剂的制备方法及其应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2147468A5 (en) * | 1971-07-28 | 1973-03-09 | Fuveau Sa | N-acetyl homocysteine thiolactone - by demethylating methionine with hydriodic acid and acetic anhydride, then acetylating |
ES8708134A1 (es) * | 1985-02-22 | 1987-09-16 | Chiesi Farma Spa | Un procedimiento para la preparacion de derivados de homocisteina-tiolactona |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1134683B (de) * | 1961-03-16 | 1962-08-16 | Degussa | Verfahren zur Herstellung von N-Acylhomocysteinthiolacton |
FR2129877B1 (es) * | 1971-03-18 | 1974-08-02 | Fuveau Sa | |
FR2265355B1 (es) * | 1974-03-28 | 1977-11-04 | Blum Jean | |
JPH0273984A (ja) * | 1988-09-08 | 1990-03-13 | Nippon Rikagaku Yakuhin Kk | 遊離ホモシスティンの製造法 |
DE3903420A1 (de) * | 1989-02-06 | 1990-08-09 | Hoechst Ag | Verfahren zur herstellung von thiophenderivaten |
-
1993
- 1993-03-02 ES ES09300403A patent/ES2061398B1/es not_active Expired - Fee Related
-
1994
- 1994-03-01 EP EP94870038A patent/EP0618312A1/en not_active Withdrawn
- 1994-03-01 JP JP6031639A patent/JPH072837A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2147468A5 (en) * | 1971-07-28 | 1973-03-09 | Fuveau Sa | N-acetyl homocysteine thiolactone - by demethylating methionine with hydriodic acid and acetic anhydride, then acetylating |
ES8708134A1 (es) * | 1985-02-22 | 1987-09-16 | Chiesi Farma Spa | Un procedimiento para la preparacion de derivados de homocisteina-tiolactona |
Also Published As
Publication number | Publication date |
---|---|
EP0618312A1 (en) | 1994-10-05 |
JPH072837A (ja) | 1995-01-06 |
ES2061398B1 (es) | 1996-02-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC2A | Transfer of patent | ||
FD1A | Patent lapsed |
Effective date: 20101018 |