Nothing Special   »   [go: up one dir, main page]

ES2058024B1 - Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico. - Google Patents

Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.

Info

Publication number
ES2058024B1
ES2058024B1 ES09202260A ES9202260A ES2058024B1 ES 2058024 B1 ES2058024 B1 ES 2058024B1 ES 09202260 A ES09202260 A ES 09202260A ES 9202260 A ES9202260 A ES 9202260A ES 2058024 B1 ES2058024 B1 ES 2058024B1
Authority
ES
Spain
Prior art keywords
analgesic
derivative
arilpropionic
new
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES09202260A
Other languages
English (en)
Other versions
ES2058024A1 (es
Inventor
Germano Carganico
Casellas David Mauleon
Perez M Luisa Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Menarini SA
Original Assignee
Laboratorios Menarini SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini SA filed Critical Laboratorios Menarini SA
Priority to ES09202260A priority Critical patent/ES2058024B1/es
Priority to UA95058442A priority patent/UA44233C2/uk
Priority to HU9501375A priority patent/HU217973B/hu
Priority to RO95-00865A priority patent/RO118712B1/ro
Priority to MD96-0285A priority patent/MD921G2/ro
Priority to AU54210/94A priority patent/AU674040B2/en
Priority to KR1019950701827A priority patent/KR100284838B1/ko
Priority to ES93924604T priority patent/ES2081780T3/es
Priority to AT93924604T priority patent/ATE153649T1/de
Priority to DE69311130T priority patent/DE69311130T2/de
Priority to JP51169794A priority patent/JP3778516B2/ja
Priority to US08/428,231 priority patent/US5554789A/en
Priority to RU95112575A priority patent/RU2128160C1/ru
Priority to BR9307408A priority patent/BR9307408A/pt
Priority to NZ257557A priority patent/NZ257557A/en
Priority to DE0668851T priority patent/DE668851T1/de
Priority to PCT/EP1993/003127 priority patent/WO1994011332A1/en
Priority to HU9802850A priority patent/HU219975B/hu
Priority to SK603-95A priority patent/SK280550B6/sk
Priority to EP93924604A priority patent/EP0668851B1/en
Priority to CZ19951149A priority patent/CZ286621B6/cs
Priority to PL93308466A priority patent/PL175265B1/pl
Priority to CA002149013A priority patent/CA2149013C/en
Priority to DK93924604.7T priority patent/DK0668851T3/da
Publication of ES2058024A1 publication Critical patent/ES2058024A1/es
Application granted granted Critical
Publication of ES2058024B1 publication Critical patent/ES2058024B1/es
Priority to BG99609A priority patent/BG61723B1/bg
Priority to NO951790A priority patent/NO304306B1/no
Priority to FI952230A priority patent/FI108637B/fi
Priority to UY24179A priority patent/UY24179A1/es
Priority to GR960300012T priority patent/GR960300012T1/el
Priority to GR970401991T priority patent/GR3024344T3/el
Priority to HK98105382A priority patent/HK1006306A1/xx
Priority to NO2006007C priority patent/NO2006007I1/no
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

NUEVO DERIVADO ARILPROPIONICO, PROCEDIMIENTO DE FABRICACION DEL MISMO Y SU UTILIZACION COMO ANALGESICO. EL NUEVO DERIVADO ARILPROPIONICO, CONSISTE EN LA SAL DE TROMETAMINA DEL ACIDO (+)-(S)-2-3-(3-BENZOILFENIL) PROPIONICO, DE FORMULA I. FORMULA EL PROCEDIMIENTO PARA SU PREPARACION COMPRENDE LA REACCION EN CONDICIONES EQUIMOLARES DEL ACIDO (+)-(S)-2-3-(3-BENZOILFENIL) PROPIONICO (III). FORMULA CON LA TROMETAMINA, HSI2 SCNC (CHSI2 SCOH)SI3 SC EN UN DISOLVENTE POLAR O MEZCLA DE DISOLVENTES POLARES, A UNA TEMPERATURA COMPRENDIDA ENTRE 0G Y REFLUJO DE DISOLVENTE Y DURANTE UN PERIODO COMPRENDIDO ENTRE 1 Y 24 HORAS. ESTE COMPUESTO EXHIBE UNA ELEVADA ACCION COMO ANALGESICO EN TERAPIA HUMANA.
ES09202260A 1992-11-10 1992-11-10 Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico. Expired - Lifetime ES2058024B1 (es)

Priority Applications (32)

Application Number Priority Date Filing Date Title
ES09202260A ES2058024B1 (es) 1992-11-10 1992-11-10 Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.
UA95058442A UA44233C2 (uk) 1992-11-10 1993-09-11 (+)-(s)-2-(3-бензоїлфеніл) сіль трометаміну пропіонової кислоти, спосіб її одержання, фармацевтична композиція та спосіб одержання знеболюючого та протизапального медпрепарату
EP93924604A EP0668851B1 (en) 1992-11-10 1993-11-09 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent
MD96-0285A MD921G2 (ro) 1992-11-10 1993-11-09 Derivaţi arilpropionici, procedeu de obţinere a lor şi compoziţie farmaceutică pe baza lor
RO95-00865A RO118712B1 (ro) 1992-11-10 1993-11-09 Derivat arilpropionic, procedeu de obtinere si utilizare a acestuia ca agent analgezic
KR1019950701827A KR100284838B1 (ko) 1992-11-10 1993-11-09 새로운 아릴프로피온 유도체, 그 제조방법 및 진통제로서의 이용방법
CZ19951149A CZ286621B6 (cs) 1992-11-10 1993-11-09 Tromethaminová sůl (+)-(S)-2-(3-benzoylfenyl)propionové kyseliny, způsob její výroby a farmaceutický prostředek s jejím obsahem
AT93924604T ATE153649T1 (de) 1992-11-10 1993-11-09 Arylpropionsäurederivat, verfahren zu seiner herstellung und seine verwendung als analgetikum
DE69311130T DE69311130T2 (de) 1992-11-10 1993-11-09 Arylpropionsäurederivat, verfahren zu seiner herstellung und seine verwendung als analgetikum
JP51169794A JP3778516B2 (ja) 1992-11-10 1993-11-09 新規なアリールプロピオン酸誘導体、その製造方法及び鎮痛薬としてのその用途
US08/428,231 US5554789A (en) 1992-11-10 1993-11-09 Arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent
RU95112575A RU2128160C1 (ru) 1992-11-10 1993-11-09 Трометаминная соль (+)-(s)-2-(3-бензоилфенил)пропионовой кислоты, способ ее получения, фармацевтическая композиция
BR9307408A BR9307408A (pt) 1992-11-10 1993-11-09 Novo derivado arilpropi nico processo para a prepara-Æo do mesmo e seu uso como agente analgesico
NZ257557A NZ257557A (en) 1992-11-10 1993-11-09 Tromethamine salt of (+)-(s)-2-(3-benzoyl phenyl)propionic acid and pharmaceutical compositions, preparation and the use thereof as an analgesic agent
DE0668851T DE668851T1 (de) 1992-11-10 1993-11-09 Arylpropionsäurederivat, verfahren zu seiner herstellung und seine verwendung als analgetikum.
PCT/EP1993/003127 WO1994011332A1 (en) 1992-11-10 1993-11-09 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent
HU9501375A HU217973B (hu) 1992-11-10 1993-11-09 Eljárás ketoprofén trometamin-só és ezt tartalmazó gyógyszerkészítmények előállítására
HU9802850A HU219975B (hu) 1992-11-10 1993-11-09 (+)-(S)-Ketoprofén trometamin só és ezt tartalmazó gyógyszerkészítmények
AU54210/94A AU674040B2 (en) 1992-11-10 1993-11-09 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent
ES93924604T ES2081780T3 (es) 1992-11-10 1993-11-09 Nuevo derivado arilpropionico, procedimiento para su preparacion y su utilizacion como agente analgesico.
PL93308466A PL175265B1 (pl) 1992-11-10 1993-11-09 Nowa pochodna arylopropionowa sól trometaminowa kwasu (+)-S-2-(3-benzoilofenylo)propionowego, sposób jej wytwarzania i kompozycja farmaceutyczna
CA002149013A CA2149013C (en) 1992-11-10 1993-11-09 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent
DK93924604.7T DK0668851T3 (da) 1992-11-10 1993-11-09 Hidtil ukendt arylpropionsyrederivat, fremgangsmåde til fremstilling heraf og anvendelse heraf som analgetisk middel
SK603-95A SK280550B6 (sk) 1992-11-10 1993-11-09 Trometamín (+)-(s)-2(3-benzoylfenyl)propionát, spô
BG99609A BG61723B1 (bg) 1992-11-10 1995-05-02 Ново арилпропионово производство, метод за неговотополучаване и използването му като аналгетично средство
NO951790A NO304306B1 (no) 1992-11-10 1995-05-08 Nytt arylpropionsyrederivat, farmas°ytisk blanding inneholdende dette, og anvendelse av det nye derivat ved fremstilling av et medikament
FI952230A FI108637B (fi) 1992-11-10 1995-05-09 Menetelmä lääkeaineena käyttökelpoisen (+)-(S)-2-(3-bentsoyylifenyyli)propaanihapon trometamiinisuolan valmistamiseksi
UY24179A UY24179A1 (es) 1992-11-10 1996-03-14 Procedimiento para la obtención de la sal de trometamina del acido (+)-(s)-2-(3-benzoilfenil)-propionico
GR960300012T GR960300012T1 (en) 1992-11-10 1996-03-31 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent.
GR970401991T GR3024344T3 (en) 1992-11-10 1997-07-31 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent.
HK98105382A HK1006306A1 (en) 1992-11-10 1998-06-16 A novel arylpropionic derivative a process for the preparation and the use thereof as an analgesic agent
NO2006007C NO2006007I1 (no) 1992-11-10 2006-07-31 (+)-(S)-2-(3-benzoylfenyl)-propionsyre-trometaminsalt(deksketoprofentrometamol)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09202260A ES2058024B1 (es) 1992-11-10 1992-11-10 Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.

Publications (2)

Publication Number Publication Date
ES2058024A1 ES2058024A1 (es) 1994-10-16
ES2058024B1 true ES2058024B1 (es) 1995-05-01

Family

ID=8278730

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09202260A Expired - Lifetime ES2058024B1 (es) 1992-11-10 1992-11-10 Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.
ES93924604T Expired - Lifetime ES2081780T3 (es) 1992-11-10 1993-11-09 Nuevo derivado arilpropionico, procedimiento para su preparacion y su utilizacion como agente analgesico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES93924604T Expired - Lifetime ES2081780T3 (es) 1992-11-10 1993-11-09 Nuevo derivado arilpropionico, procedimiento para su preparacion y su utilizacion como agente analgesico.

Country Status (27)

Country Link
US (1) US5554789A (es)
EP (1) EP0668851B1 (es)
JP (1) JP3778516B2 (es)
KR (1) KR100284838B1 (es)
AT (1) ATE153649T1 (es)
AU (1) AU674040B2 (es)
BG (1) BG61723B1 (es)
BR (1) BR9307408A (es)
CA (1) CA2149013C (es)
CZ (1) CZ286621B6 (es)
DE (2) DE668851T1 (es)
DK (1) DK0668851T3 (es)
ES (2) ES2058024B1 (es)
FI (1) FI108637B (es)
GR (2) GR960300012T1 (es)
HK (1) HK1006306A1 (es)
HU (2) HU217973B (es)
MD (1) MD921G2 (es)
NO (2) NO304306B1 (es)
NZ (1) NZ257557A (es)
PL (1) PL175265B1 (es)
RO (1) RO118712B1 (es)
RU (1) RU2128160C1 (es)
SK (1) SK280550B6 (es)
UA (1) UA44233C2 (es)
UY (1) UY24179A1 (es)
WO (1) WO1994011332A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2124196B1 (es) * 1997-06-04 1999-12-01 Menarini Lab Procedimiento para la fabricacion de una forma farmaceutica semisolida conteniendo dexketoprofeno trometamol y su utilizacion en el tratamiento topico de la inflamacion.
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
US20080051411A1 (en) * 2002-12-17 2008-02-28 Cink Russell D Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof
RU2356549C2 (ru) * 2002-12-17 2009-05-27 Эббетт ГмбХ унд Ко.КГ Композиция, включающая фенофибриновую кислоту, ее физиологически приемлемую соль или производное
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
EP1739072A1 (en) * 2005-06-15 2007-01-03 Laboratorios Menarini S.A. Polymorphic forms of dexketoprofen trometamol, preparation and pharmaceutical compositions thereof
CA2663377A1 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
TWI364413B (en) * 2008-07-25 2012-05-21 Univ Nat Central Racemic ibuprofen amine salt and synthesis method thereof
AU2009309575B2 (en) 2008-10-31 2015-02-26 C-A-I-R Biosciences Gmbh Choline and tromethamine salt of Licofelone
EP2398500B1 (en) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Glutathione-based drug delivery system
IL255113B (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them
ES2350670B1 (es) * 2009-06-10 2011-12-07 Polichem, S.L. Composicion veterinaria de ketoprofeno
CN101928214B (zh) * 2009-06-19 2012-12-19 黄石世星药业有限责任公司 右旋酮洛芬氨丁三醇的一种合成方法
WO2011001213A1 (en) * 2009-06-30 2011-01-06 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi A process for preparing dexketoprofen trometamol form a and form b crystals
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102557976B (zh) * 2010-12-15 2015-06-10 辽宁盛京制药有限公司 溴芬酸有机盐及其制备方法、其组合物及用途
TR201104864A2 (tr) 2011-05-18 2012-12-21 Bi̇lgi̇ç Mahmut Deksketoprofen içeren suda çözünebilir formülasyonlar.
TR201205317A2 (tr) 2011-05-18 2012-12-21 B�Lg�� Mahmut Deksketoprofen içeren efervesan formülasyonlar.
CN102381986A (zh) * 2011-07-25 2012-03-21 南京特丰药业股份有限公司 一种右旋布洛芬氨丁三醇盐及其口服溶液的制备方法
WO2013022410A2 (en) * 2011-08-08 2013-02-14 Mahmut Bilgic Production method for effervescent formulations comprising dexketoprofen
WO2013095315A1 (en) 2011-12-19 2013-06-27 Mahmut Bilgic Formulations comprising dexketoprofen (particle size 300-2500 micrometer)
WO2013100877A1 (en) 2011-12-27 2013-07-04 Mahmut Bilgic Dexketoprofen formulations
EP2671569B1 (en) 2012-06-06 2015-09-16 Galenicum Health S.L. Stable pharmaceutical compositions with fast onset
EP2759293A1 (en) 2013-01-25 2014-07-30 Laboratorios Lesvi, S.L. Pharmaceutical compositions of (+)-(s)-2-(3-benzoylphenyl)propionic acid tromethamine salt
EP2764875A1 (en) 2013-02-06 2014-08-13 Galenicum Health S.L. Process for preparing a stable pharmaceutical composition comprising dexketoprofen trometamol
ITMI20130210A1 (it) 2013-02-14 2014-08-15 Menarini Lab Composizioni farmaceutiche contenenti dexketoprofene e tramadolo
TR201616365A1 (tr) 2016-11-14 2018-05-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Deksketoprofen ve eletri̇ptanin oral farmasöti̇k kompozi̇syonlari
AU2017364349A1 (en) * 2016-11-28 2019-07-11 Sarin PARAYIL Novel organic crystalline salt of haloacetic acid
TR201618765A2 (tr) 2016-12-16 2018-07-23 Imuneks Farma Ilac Sanayi Ve Ticaret Anonim Sirketi Ağrı ve enflamasyonun tedavisi için steroid olmayan anti-enflamatuvar ilaçlar ve H2 reseptörü antagonisti kombinasyonları.
KR102552315B1 (ko) * 2020-11-11 2023-07-06 대원제약주식회사 펠루비프로펜 신규 염을 주성분으로 하며 위장장애 부작용이 저감된 약학적 조성물
KR102462607B1 (ko) * 2020-11-11 2022-11-03 대원제약주식회사 펠루비프로펜 신규 염을 주성분으로 하는 안정성이 증가된 약학적 조성물
WO2023182869A1 (en) * 2022-03-25 2023-09-28 Ildong Pharmaceutical Co., Ltd. Novel salt of glp-1 receptor agonist compound, preparation method thereof and pharmaceutical composition comprising thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US427996A (en) * 1890-05-13 houg-hton
FR1201726A (fr) * 1959-06-20 1960-01-05 Procédé d'obtention de dérivés flavoniques à partir des feuilles de certains végétaux
FR1546478A (fr) * 1967-01-27 1968-11-22 Rhone Poulenc Sa Nouveaux dérivés de l'acide benzoyl-3 phénylacétique et leur préparation
BR6915470D0 (pt) * 1969-03-24 1973-03-13 Syntex Corp Processo para preparar derivados de acido 2-(6'substituido 2'naftil)propionico e de seus sais
GB1408853A (en) * 1972-03-17 1975-10-08 Upjohn Co Medical process and treatment
US3821289A (en) * 1972-07-03 1974-06-28 Rorer Inc William H Tetrahydronaphthylalkanoic acids and their derivatives
GB1497044A (en) * 1974-03-07 1978-01-05 Prodotti Antibiotici Spa Salts of phenyl-alkanoic acids
US4097674A (en) * 1975-03-17 1978-06-27 Syntex Corporation 2-Naphthylacetic acid derivatives
FR2319340A1 (fr) * 1975-07-28 1977-02-25 Roussel Uclaf Nouveau sel de l'acide a-methyl benzoyl-5 thiophene-2 acetique, procede de preparation et application a titre de medicament
ES455698A1 (es) * 1977-02-07 1978-01-01 Invest Tecnica Aplicada Procedimiento para la preparacion de un nuevo derivado buta-nolaminico.
GR68102B (es) * 1978-08-08 1981-10-30 Fujisawa Pharmaceutical Co
HU185926B (en) * 1979-09-27 1985-04-28 Agostne Kahan Process for preparing water soluble derivatives of non-steroid antiinflammatory compositions and pharmaceutical compositins containing such derivatives
DE3328401A1 (de) * 1983-08-05 1985-02-21 Merckle GmbH, 7902 Blaubeuren Injizierbare loesung zur behandlung von entzuendungen
CH664563A5 (it) * 1985-04-19 1988-03-15 Seuref Ag Composti con attivita antiflogistica, antipiretica, analgesica, loro preparazione e composizioni farmaceutiche che li contengono.
EP0227078A1 (en) * 1985-12-20 1987-07-01 Wisconsin Alumni Research Foundation Process for preparing (S)-alpha-methylarylacetic acids
IT1207994B (it) * 1986-01-03 1989-06-01 Therapicon Srl Sali idrosulubili di composti adattivita' antiinfiammatoria ed analgesica, loro preparazione ed utilizzo in composizioni farmaceutiche.
WO1989005798A1 (en) * 1987-12-18 1989-06-29 Ciba-Geigy Ag TROMETHAMINE SALT OF 1-METHYL-beta-OXO-alpha-(PHENYLCARBAMOYL)-2-PYRROLEPROPIONITRILE
US4960892A (en) * 1988-06-10 1990-10-02 American Home Products Corporation Naphthalenepropionic acid derivatives as anti-inflammatory/anti-allergic agents
US4868214A (en) * 1987-11-17 1989-09-19 Analgesic Associates Onset-hastened/enhanced analgesia

Also Published As

Publication number Publication date
ES2081780T3 (es) 1997-07-01
AU674040B2 (en) 1996-12-05
CA2149013C (en) 2004-08-10
ATE153649T1 (de) 1997-06-15
AU5421094A (en) 1994-06-08
HU9802850D0 (en) 1999-02-01
EP0668851A1 (en) 1995-08-30
BG61723B1 (bg) 1998-04-30
HU9501375D0 (en) 1995-06-28
BR9307408A (pt) 1999-08-24
GR3024344T3 (en) 1997-10-31
FI108637B (fi) 2002-02-28
NO951790L (no) 1995-07-06
CZ114995A3 (en) 1995-10-18
RU95112575A (ru) 1997-06-20
DE69311130D1 (de) 1997-07-03
RO118712B1 (ro) 2003-09-30
MD921G2 (ro) 1998-10-31
HUT71903A (en) 1996-02-28
FI952230A0 (fi) 1995-05-09
SK60395A3 (en) 1995-09-13
RU2128160C1 (ru) 1999-03-27
PL175265B1 (pl) 1998-12-31
NO2006007I1 (no) 2006-08-14
JP3778516B2 (ja) 2006-05-24
PL308466A1 (en) 1995-07-24
UA44233C2 (uk) 2002-02-15
NO304306B1 (no) 1998-11-30
BG99609A (bg) 1996-01-31
JPH08503203A (ja) 1996-04-09
CZ286621B6 (cs) 2000-05-17
SK280550B6 (sk) 2000-03-13
KR100284838B1 (ko) 2001-04-02
ES2081780T1 (es) 1996-03-16
NZ257557A (en) 1996-01-26
US5554789A (en) 1996-09-10
WO1994011332A1 (en) 1994-05-26
DK0668851T3 (da) 1997-12-22
UY24179A1 (es) 1996-09-03
GR960300012T1 (en) 1996-03-31
FI952230A (fi) 1995-05-09
EP0668851B1 (en) 1997-05-28
ES2058024A1 (es) 1994-10-16
HU219975B (hu) 2001-10-28
NO951790D0 (no) 1995-05-08
HK1006306A1 (en) 1999-02-19
DE69311130T2 (de) 1997-09-18
HU217973B (hu) 2000-05-28
DE668851T1 (de) 1996-10-10
CA2149013A1 (en) 1994-05-26

Similar Documents

Publication Publication Date Title
ES2058024B1 (es) Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.
NO308794B1 (no) Farmakologisk aktive pyridin-derivater, preparater inneholdende forbindelsene samt forbindelsenes anvendelse
AU3202595A (en) 1,2-substituted imidazolyl compounds for the treatment of inflammation
NZ337211A (en) Method of treating inflammatory, HIV diseases by using peptidyl boronic acid ester and acid compounds as proteasome inhibitors
TR199802060T2 (xx) Aminoisokinolinler ve aminopiridin t�revlerinin iltihap �nleyiciler olarak kullan�m�.
DE69415018D1 (de) Oralanzuwendende flüssige arzneizubereitung enthaltend 2-(4-isobutylphenyl)propionsäure
ES2095148T3 (es) Nuevo procedimiento para la preparacion de beta-carbolinas.
AU7470098A (en) Antithrombotic agents
DK0627916T3 (da) Farmaceutisk præparat, anvendeligt som analgetikum og indeholdende (R)-2-(3-benzoylphenyl)propionsyre
DE69328205D1 (de) Rektale Flunisolid-Zubereitung zur Behandlung entzündlicher Darmerkrankungen
DE68920022D1 (de) Indolessigsäure-derivate, verfahren zur herstellung sowie arzneimittel, die diese als aktive mittel enthalten.
AU1434201A (en) Antithrombotic agents
ATE268768T1 (de) Antithrombosemittel
ATE221068T1 (de) Anellierte beta-carboline

Legal Events

Date Code Title Description
GC2A Exploitation certificate registered application with search report

Effective date: 19970210