EP1962777A1

EP1962777A1 - Improved long-term effect of antiperspirants

Info

Publication number: EP1962777A1
Application number: EP06807392A
Authority: EP
Inventors: Lara Terstegen; Katrin Wilke; Stefan Biel; Roger Wepf
Original assignee: Beiersdorf AG
Current assignee: Beiersdorf AG
Priority date: 2005-12-16
Filing date: 2006-10-19
Publication date: 2008-09-03
Also published as: WO2007071474A1; DE102005060788A1

Abstract

The invention relates to the use of aluminum-based antiperspirant substances in cosmetic preparations to improve filaggrin expression in sweat gland pores of humans. The preparation increasing the antiperspirant effect comprises aluminum-based antiperspirant substances, preferably aluminum chlorohydrates, and one or several organic solvents that are selected among the group encompassing 1,1'-oxydi-2-propanol, hexyl salicylate, and/or methylethyl tetradecanoate.

Description

Improved long-term effect of antiperspirants

The invention relates to the use of aluminum-based antiperspirant active in cosmetic preparations for increasing filaggrin expression in the sweat gland Ausfganges of humans and the use of aluminum-based antiperspirant active ingredients for the preparation of preparations for application to the human skin to increase filaggrin expression in the sweat glands - Execution.

It is believed that the sweat reduction of aluminum-containing antiperspirant active agents i.a. Whether this obstruction is caused by denaturation of the keratin or by clotting of corneocytes in the sweat gland duct (Shelley WB and Hurley HJ, Acta Derm. Venereol (1975) 55: 241-60). or by the generation of an ACH / AZG gel (Reller HH and Luedders WL, in: Advances in Modern Toxicology, Dermatoxicology and Pharmacology, FN Marzulli and HI Maibach, Eds. Hemisphere Publishing Company, Washington and London (1977) Vol. 4: 1 -5) formed by neutralization in the sweat gland duct is still open.

The thus obtained and known constipation is effective only in the short term. Heavy sweating or armpit cleaning as part of the normal body cleansing routine relieve the constipation and thus the antiperspirant effect. However, the resulting need to apply antiperspirant (AT) products at least once a day may cause skin irritation, especially after shaving or in or on previously damaged areas of the skin.

It would be desirable to provide a new methodology of using cosmetic preparations that enriches the prior art and helps to avoid its disadvantages.

It would be particularly advantageous to provide a cosmetic and / or dermatological antiperspirant formulation having an enhanced antiperspirant effect, and in particular one which contributes to the stabilization and / or maintenance of the antiperspirant effect of an antiperspirant after sweating and / or skin cleansing. The invention encompasses the use of aluminum-based antiperspirant active substances in cosmetic formulations according to claim 1 or for its preparation according to claim 2. In particular, a cosmetic preparation comprising aluminum-based antiperspirant active ingredients and at least one organic solvent selected from group 1 dissolves, 1 '-Oxydi-2-propanol, Hexylsalicilat and / or methyl ethyl tetradecanoate the tasks set.

The subject of the subclaims are advantageous embodiments of the use or preparation according to the invention.

Surprisingly, it has been found that the use of cosmetic formulations with aluminum-based antiperspirant active ingredients, preferably aluminum chloroadrate (ACH), increases filaggrin expression in the sweat glands. This process according to the invention of the, in particular ACH, -induced expression of filaggrin results in that the cross-sectional area of the outlet is reduced by up to 50%, so that the blockage of the outlet can be reached faster and more easily. In addition to the blockage of the Ausführganges by the aluminum salts creates a "natural constipation" of the output with abgeschilferen corneocytes, which in contrast to the blockage by aluminum-based antiperspirant active ingredients alone is not to remove by heavy sweating nor by normal body cleansing.

Due to this special use of aluminum-based AT agents, the antiperspirant effect of cosmetic preparations, in particular antiperspirants, comprising these aluminum-based AT agents, preferably aluminum chlorohydrates, is enhanced on account of the synergistic blockage processes described above.

The preparations according to the invention lead to the stabilization and / or maintenance of the antiperspirant effect of an antiperspirant even after sweating and / or skin cleansing.

Due to the increased production of keratinized corneocytes in the outlet, a blockage of the skin's own material is produced here in addition to the ACH-based blockage of the excretions, which also continues after the discontinuation of the AT product and its maximum duration is limited only by the natural regeneration time of the horny layer (about 14 days), which is a very positive long-term effect. A 50% reduction is expected in about 7 days. That is, by the use according to the invention, the antiperspirant effect of an aluminum-based antiperspirant active ingredient in cosmetic preparations is stabilized or maintained for up to 14 days, in particular up to 7 days (1 week).

It has been found in detail that the axillary administration of aluminum-containing antiperspirants, preferably ACH, in deo / AT formulations by addition of small amounts of organic solvents leads to a greatly increased keratinization rate of the cells of the sweat gland duct. As a result, more horny corneocytes are released, which are released into the duct as part of the natural desquamation, clogging the duct from the inside and preventing the flow of sweat. This additional clogging mechanism is insensitive to increased sweating and / or purging, thus providing an additional long-term antiperspirant (AT) effect (see Figure 1), as previously described.

Figure 1 shows a comparison of filaggrin expression and cornification of ACH-treated and untreated executions marked by stars in the figures in two subjects. In each case the marking of filaggrin is shown as well as the entire epidermis for a better overview. On the left the filaggrin expression of ACH-treated executions and on the right the filaggrin expression of untreated acrosyringia of the same subjects are shown.

The use of the preparations according to the invention comprising small amounts of organic solvents for increasing the expression of filaggrin in the sweat gland process of human beings and for enhancing the antiperspirant effect of cosmetic preparations, in particular antiperspirants, is therefore predestined.

Particularly advantageous is therefore the combination of AT active agents such as aluminum salts, preferably ACH, preferably in the range of 10 wt.% To 25 wt.%, Based on the total mass of the preparation, with small amounts of organic solvents, those complexing components in the ACH on the Skin stabilize the filaggrin expression especially stimulate. The organic solvents are preferably selected from the group 1, 1'-oxydi-2-propanol, hexyl salicilate and / or methyl ethyl tetradecanoate,

The combination of the preparation according to the invention, based on emulsion, containing at least one organic solvent, preferably 1, 1'-oxydi-2-propanol, hexyl salicilate and / or methyl ethyl tetradecanoate, with a roll-on packaging shows also astonishing advantages over the AT agents of the prior art Technology. The organic solvents affect the emulsion structure after application to the skin and may be e.g. cause a faster breakdown of the emulsion or an improved release of ACH from the emulsion.

The solvents thus do not act as plasticizers or solubilizers but as so-called "emulsion breakers", which results in an improved release of the antiperspirant active substance and thus leads to the advantageous properties described above, such as increasing filaggrin expression, increased keratinization rate, enhancement of anti-perspirant activity. Transpirantwirkung and improved long-term antiperspirant effect.

The organic solvents are also wetting aids, which improve the application, for example, of an emulsion to the spherical surface of a roll-on packaging, so that more product is applied with the same application time than with an AT agent without the organic solvent.

The combination of the preparations according to the invention with a roll-on packaging is thus extremely effective and easy to use.

The combination of ACH, preferably in the range from 10% by weight to 25% by weight, based on the total mass of the preparation, has shown to be particularly advantageous with organic solvents, the solvent or solvents being selected from group 1, 1 '-Oxydi-2-propanol, preferably in a proportion of 0.01 wt.% To 0.5 wt.%, Hexylsalicilat, preferably in the range of 0.01 wt.% To 0.1 wt.% And / or Methylethyltetradecanoat , preferably in the range from 0.001% by weight to 0.01% by weight, in each case based on the total mass of the preparations. Preference is given to choose 1, 1 '-Oxydi-2-propanol as the solvent. Preference is given to choosing hexyl salicylate as solvent. Preference is given to choosing methyl ethyl tetradecanoate as solvent. Preference is given to choose 1, 1 '-Oxydi-2-propanol and Hexylsalicilat as the solvent. Preference is given to choosing 1, 1'-oxydi-2-propanol and methyl ethyltetradecanoate as solvent.

Preference is given to choose 1, 1 '-Oxydi-2-propanol, Methylethyltetradecanoat and Hexylsalicilat as the solvent. Preference is given to selecting hexyl salicylate and methyl ethyl tetradecanoate as solvent.

It is therefore preferred to combine one or two of the organic solvents 1, 1'-oxydi-2-propanol, hexyl salicylate and / or methyl ethyl tetradecanoate in combination with the other solvent (s).

As a small amount of organic solvent, a weight fraction of up to 1, 5 wt.%, Particularly up to 1 wt.%, In particular up to 0.5 wt.%, Based on the total mass of the preparation to understand.

The combination of aluminum-based antiperspirant active ingredients with a small amount, ie of up to 1, 5 wt.%, Particularly up to 1 wt.%, In particular up to 0.5 wt.% Of organic solvents, in particular selected from the group 1, 1 '- oxydi-2-propanol, Hexylsalicilat and / or Methylethyltetradecanoat, in cosmetic preparations, in particular based on O / W emulsions, leads to an increase in filaggrin expression in the sweat gland Ausfganges of man, this in turn to a Enhancing the antiperspirant effect of the cosmetic preparation leads.

Such a preparation, preferably based on emulsion, in particular as OVW emulsion, comprising aluminum-based antiperspirant active ingredients, in particular ACH, and small amounts, ie of up to 1, 5 wt.%, Particularly up to 0.5 wt.% Of organic Solvents, in particular selected from the group 1, 1 '-Oxydi-2-propanol, Hexylsalicilat and / or Methylethyltetradecanoat, is therefore particularly preferably according to the invention. The described process, the greatly increased keratinization rate of the cells of the sweat gland duct, can be achieved even better in aqueous systems by adjusting the spreading behavior of the product such that the average decrease in the contact angle after application to the skin is> 1 ° χs ^{' 1} ( see Figure 2), as the formulations of the invention allow. Figure 2 shows the investigation of the spreading behavior of two AT products according to the invention with pure ACH solution (ACH concentration in each case 10%). The spreading behavior of the products can thus be adjusted so that the mean decrease in the contact angle after application to the skin is> 1 ° χs ^-1 . An improvement of the process in emulsions (preferably oil in water, O / W) can also be achieved if, in addition to oil droplets, pronounced lamellar lipid phases are present in the emulsion, as shown in FIG. 3 and how the formulations according to the invention make this possible. FIG. 3 shows the investigation of the emulsion structure of an AT product according to the invention based on an O / W system. In addition to isolated oil droplets, in contrast to products of the prior art, extended lamellar phases can also be observed, which form a continuous structure.

A cosmetic preparation, preferably based on an O / W system, comprising not only aluminum-based antiperspirant active ingredients but also lamellar lipid phases, is preferred according to the invention.

Filaggrin is a protein or rather a group of isoform proteins that are formed during the process of keratinization in the stratum granulosum from profilaggrin. The gene coding for profilaggrin is known and sequenced. It is located on the short arm of chromosome 21, among other genes that code for proteins that are important for the cornification process. The expression of these genes may also be regulated together. Profilaggrin and filaggrin are histidine-rich cationic proteins. The latter binds to various intermediate filaments such as cytokeratin, vimentin and desmin. Filaggrin is a keratin-associated filament protein that is only expressed in differentiated keratinocytes during terminal differentiation of the cells by proteolysis and dephosphorylations in the mature Filaggrinform processed.

It is likewise surprising and preferred according to the invention that the cosmetic preparations according to the invention, applied to the skin, lead to pore-refining pore refining and to an improved skin appearance.

For this purpose, by means of the SAFIR system, which brings the ingredients of hair follicles (pores, microcomedones, etc.) to fluoresce (shine), the skin before and after treatment with the preparations of the invention considered. It turned out that the area of these fluorescent spots became smaller after the treatment, so the pores had narrowed.

The consumer also understands by 'pore-refining', the diminishing or disappearance of so-called 'senile comedones' or 'blackheads' or 'blackheads' that show up as black spots on the face. If the pores are not stunted by these pigment structures, they are usually barely visible and are not recognized as a cosmetic problem.

Here, too, the application of formulations according to the invention is shown to be skin-enhancing.

As the aluminum-based antiperspirant active, it is advantageous to use acidic aluminum salts in aqueous solution. In this case, the concentration ranges described relate to the so-called active contents of the antiperspirant complexes, in the case of the aluminum compounds to anhydrous complexes. Preference is also beyond the use of so-called. Activated Aluminiumchlorohydraten. The following list of advantageous antiperspirant active agents should in no way be limiting:

Aluminum salts of the empirical empirical formula [Al ₂ (OH) _n Cl _n ] (at m + n = 6):

- Aluminum Chloroydrat [Al ₂ (OH) ₅ Cl] x H ₂ O.

Standard aluminum complexes: Locron L, Locron LIC, Locron LIF (Clariant), Chlorhydrol (Reheis), ACH-303 (Summit), Aloxicoll L (Giulini).

Activated aluminum complexes: Reach 501 (Reheis), Aloxicoll 51 L - Aluminum sesquichlorohydrate [Al ₂ (OH) ₄₅ Cli ₁₅ ] x H ₂ O

Standard Aluminum Complexes: Aloxicoll 31 L (Giulini), Westchlor 186 (Westwood Chemicals)

Activated Aluminum Complexes: Reach 301 (Reheis)

Aluminum dichlorohydrate [Al ₂ (OH) ₄ Cl ₂ ] x H ₂ O

Aluminum-zirconium salts, such as, for example, Al-Zr-tetrachlorohydrex glycine (35% aq. Sol.), Are suitable aluminum-based antiperspirant active substances according to the invention. The antiperspirant active ingredients are used in the formulations according to the invention in an amount of 1% by weight to 35% by weight, preferably from 1% by weight to 30% by weight, in particular 10% by weight to 25% by weight, based in each case on Total mass of the preparation used.

The combination of cosmetic preparations with ACH, preferably in the range from 10% by weight to 25% by weight, based on the total mass of the preparation, is particularly advantageous.

Advantageously, preparations according to the invention may also be added with deodorants. The usual cosmetic deodorants are based on different active principles. By using antimicrobial substances in cosmetic deodorants, the bacterial flora on the skin can be reduced. Ideally, only the odor causing microorganisms should be effectively reduced. The sweat flow itself is not affected, in the ideal case, only the microbial decomposition of the sweat is temporarily stopped. The combination of astringents with antimicrobial substances in one and the same composition is also common.

All active ingredients commonly used for deodorants can be used to advantage, for example odor maskers such as the common perfume ingredients, odor absorbers, for example the layer silicates described in DE 40 09 347, of these in particular montmorillonite, kaolinite, INt, beidellite, nontronite, saponite, hectorite, bentonite , Smectite, furthermore, for example, zinc salts of ricinoleic acid. Germ-inhibiting agents are also suitable for incorporation into the preparations according to the invention. Advantageous substances are, for example, 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Irgasan), 1, 6-di- (4-chlorophenylbiguanido) hexane (chlorhexidine), 3,4,4'-trichlorocarbanilide, quaternary ammonium compounds , Clove oil, mint oil, thyme oil, triethyl citrate, farnesol (3,7,1 1-trimethyl-2,6,10-dodecatriene-1-ol) and in DE 37 40 186, DE 39 38 140, DE 42 04 321 DE 42 29 707, DE 42 29 737, DE 42 37 081, DE 43 09 372, DE 43 24 219 described effective agents. Also, sodium bicarbonate is advantageous to use.

The preparations according to the invention reduce the sweat flow (measured according to FDA guidelines) by 50-80%. A somewhat reduced sweat flow reduction can also be observed after heavy sweating or body cleansing, without the product being applied again beforehand. In particular, this welding flux reduction has been observed in cosmetic preparations comprising one or more organic solvents, especially if these are selected from the group 1, 1 '-Oxydi-2-propanol, Hexylsalicilat and / or methyl ethyltetradecanoat.

Emulsions are often used as cosmetic or medical preparations. Emulsions are generally understood to mean heterogeneous systems which consist of two liquids that are immiscible or only slightly miscible with one another, which are usually referred to as phases. In emulsions, one of the two liquid phases is dispersed in the form of very fine droplets in the other liquid. In addition to the formation of micellar phases (ie phases in which the inner phase is dispersed in the form of drops in the outer phase), it is also possible to form bicontinuous structures in which no independent liquid droplets are observed, but continuous, lamellar structures of the inner phase, passing through the surrounding phase (see Lagaly G, Schulz O and Zimehl R, Dispersions and Emulsions, Steinkopff Verlag, Darmstadt (1997)).

Depending on how an emulsion is built up inside and how the ratio of the lamellar phase to micellar phases is represented, this also influences the contact angle that this emulsion forms when applied to technical or biological surfaces and how this contact angle changes over time. The spreading behavior of the product according to the invention can be adjusted so that the average decrease in the contact angle after application to the skin is> 1 ° χs ^{' 1} . This is essentially due to the lamellar emulsion structure which is achieved according to the invention.

If the two liquids are water and oil and oil droplets are finely distributed in water, then it is an oil-in-water emulsion (O / W emulsion, eg milk). The basic character of an O / W emulsion is characterized by the water. A water-in-oil emulsion (W / O emulsion, eg butter) is the reverse principle, with the basic character being determined by the oil. According to the invention, in particular W / O, O / W or W / O / W emulsions are relevant.

Advantageously, the preparation of the invention is based on O / W emulsions. Preference is given to O / W microemulsions, in particular microemulsion gels, as described in WO 9815255 and WO 9628132 are claimed; The disclosures made therein are hereby explicitly incorporated in the disclosure of the present invention.

Particularly advantageous is the preparation of emulsion systems, which in addition to micellar phases also have pronounced lamellar phase portions. In addition, it is particularly advantageous to prepare emulsion systems whose contact angle on skin decreases by> 1 ° ^' s ^{' 1} directly after application, so that optimum distribution of the product is ensured.

The penetration depth of aluminum into the humane armpit skin was determined on cryostat sections of axillary punches on the one hand by means of morine staining and subsequent fluorescence microscopy (for Morin staining see Quatrale RP, Coble DW et al., J. Soc.Coact.Chem. (1981), 32: 107-136). on the other hand examined in cryo-scanning electron microscope with attached EDX-Detekor (for EDX detection on frozen biological samples see Tobler M, Zierold K et al., Pancreas (1992) 7: 686-97). Filaggrin expression was assessed by immunofluorescent labeling on cryostat and plastic sections of axillary biopsies. The increased differentiation of the epidermis was detected on ultrathin sections in the transmission electron microscope.

Examination of human axillary skin with regard to the distribution of aluminum by means of morine detection after three weeks of treatment with cosmetic formulations according to the present invention shows that in 75% of the examinations investigated a positive aluminum signal is detectable. This was limited in the majority of cases to the area of the stratum corneum and only occasionally found deeper in the lumen of the sweat gland duct. Filaggrin expression in the region of the epidermal sweat gland duct of ACH-treated armpits is massively increased in comparison to untreated armpits, as could be demonstrated by confocal immunofluorescence microscopy (for immunostaining see Wilke K, Wepf R et al., Skin Pharmacol. Physiol. 2006) 19: 38-49). This increased expression of filaggrin is limited to the area of the execution and not to be found in the area of the surrounding epidermis. It indicates increased keratinization in the duct, which could then also be demonstrated by transmission electron microscopy on the same specimens (for correlative detection in CLSM and TEM see Biel SS, Kawaschinski K et al., J. Microsc. (2003) 212: 91-99) and thus impressively demonstrates the use according to the invention.

To detect lamellar phases in the cosmetic formulations, they were frozen by means of the high-pressure freezing technique and subsequently imaged by short freeze-etching and tungsten vapor deposition in a cryo-scanning electron microscope (for illustration see Wiesner S, Biel, SS et al., Microscopy and Microanalysis (2003) 9 Suppl. 3: 510-51 1).

The cosmetic and dermatological preparations according to the invention may comprise cosmetic adjuvants such as are conventionally used in such preparations, e.g. Preservatives, bactericides, UV filters, antioxidants, water-soluble vitamins, minerals, suspended solid particles, perfumes, foaming inhibitors, dyes, pigments that have a coloring effect, thickeners, moisturizing and / or moisturizing substances or other common ingredients a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers or silicone derivatives.

In addition to aluminum-based antiperspirant active ingredients, preferably ACH (50% aq. Sol.) And / or Al-Zr-tetrachlorohydrex glycine (35% aq. Sol.), The preparations according to the invention preferably also comprise 2-octyldodecanol, avocado oil and / or chitosan ,

The preparations furthermore preferably comprise glycerol monoisostearate, polyoxyethylene 20-cetyl stearyl ether, polyethylene glycol 21 stearyl ether, polypropylene glycol 15 stearyl ether, polyethylene glycol 2-stearyl ether and / or polyoxyethylene 20-isocetyl ether.

The preparations are preferably produced and used in an optically appealing transparent manner.

Examples

Preparations as transparent microemulsions and microemulsion gels

Ingredients Chemical 1 Name [wt.%] [Wt.%] [Wt.%] [Wt.%] [Wt.%]

Example formulations of transparent alcoholic roll-on

Example formulations translucent microemulsions and microemulsion gels

Example formulations steareth system / macroemulsion

Sample Recipes Deo Cream - Macro Emulsion

Claims

claims

1. Use of aluminum-based antiperspirant active ingredients in cosmetic preparations for increasing the filaggrin expression in the sweat gland Ausfganges of humans.

2. Use of aluminum-based antiperspirant active ingredients for the preparation of preparations for application to the human skin to increase filaggrin expression in the sweat glands of humans.

Use according to any one of the preceding claims for blocking the sweat gland passageway by increased secreted corneocytes in combination with the aluminum-based antiperspirant active.

4. Use according to one of the preceding claims for enhancing the antiperspirant effect of cosmetic preparations, in particular antiperspirants.

5. Use according to one of the preceding claims for stabilizing and / or maintaining the antiperspirant effect of an antiperspirant after sweating and / or skin cleansing.

6. Use according to one of the preceding claims for stabilizing and / or maintaining the antiperspirant effect of an antiperspirant for up to 14 days, in particular 7 days.

7. Use according to one of the preceding claims, characterized in that the aluminum-based Antitranspirantwirkstoffe, preferably Aluminiumchlorohydrate, to a proportion of 1 wt.% To 35 wt.%, Preferably from 1 wt.% To 30 wt.%, In particular 10 % By weight to 25% by weight, in each case based on the total weight of the preparation.

8. Use according to one of the preceding claims, characterized in that the preparation contains small amounts of one or more organic solvents.

9. Use according to claim 8, characterized in that the organic solvent or solvents are selected from the group 1, 1'-oxydi-2-propanol, hexyl salicylate and / or methyl ethyl tetradecanoate.

10. Use according to claim 9, characterized in that 1, 1 '-Oxydi-2-propanol in the range of 0.01 wt.% To 0.5 wt.%, Based on the total mass of the preparation, the preparation added becomes.

1 1. Use according to claim 9 or 10, characterized in that Hexylsalicilat in the range of 0.01 wt.% To 0.1 wt.%, Based on the total mass of the preparation, the preparation is added.

12. Use according to claim 9, 10 or 1 1, characterized in that Methylethyltetradecanoat in the range of 0.001 wt.% To 0.01 wt.%, Based on the total mass of the preparation, the preparation is added.

13. Use according to any one of claims 8 to 12, characterized in that one or two of the organic solvents 1, 1 '-Oxydi-2-propanol, Hexylsalicilat and / or Methylethyltetradecanoat be combined in combination with the other or the other solvents.

14. Use according to any one of claims 8 to 13 for increasing the keratinization rate of the cells of the sweat gland duct.

15. Use according to one of the preceding claims, characterized in that the preparation is an emulsion or for producing an emulsion, in particular as W / O, O / W or W / O / W emulsion.

16. Use according to one of the preceding claims, characterized in that the contact angle of the preparation on skin directly after application by> 1 ° χs ^{' 1} decreases.

17. A cosmetic preparation for increasing the antiperspirant activity comprising at least one aluminum-based antiperspirant active, preferably aluminum chlorohydrate, and one or more organic solvents selected from the group 1, 1 '-Oxydi-2-propanol, Hexylsalicilat and / or Methylethyltetradecanoat.

18. A preparation according to claim 17, characterized in that 1, 1 '-Oxydi-2-propanol in a proportion of 0.01 wt.% To 0.5 wt.%, Hexylsalicilat in the range of

0.01 wt.% To 0.1 wt.% And / or Methylethyltetradecanoat in the range of 0.001 wt.% To 0.01 wt.%, Each based on the total mass of the preparations added.

19. A preparation according to claim 17 or 18, characterized in that the preparation is based on an emulsion, preferably an O / W emulsion.

20. Preparation according to one of claims 17 to 19, characterized in that the preparation is a microemulsion or a microemulsion gel.

21. Preparation according to one of claims 19 or 20, characterized in that lamellar lipid phases are present in the emulsion.

22. Preparation according to one of claims 17 to 21, characterized in that the spreading behavior of the preparation has a mean decrease in the contact angle after the

Application to the skin of equal to or more than 1 ° χs ^{' 1} has.

23. Preparation or its use according to one of the preceding claims, characterized in that the preparation is transparent.

24. Preparation or its use according to one of the preceding claims in combination with a roll-on packaging, characterized in that the preparation tion based on an emulsion and at least one organic solvent selected from 1, 1 '-Oxydi-2-propanol, Hexylsalicilat and / or Methylethyltetradecanoat comprises.

25. A preparation or its use according to any one of the preceding claims comprising as Antitrantpirant active ingredient ACH (50% aq., Lsg.) And / or Al-Zr-Tetrachloro- hydrex glycine (35% aq., Lsg.) And 2-octyldodecanol, avocado oil and / or chitosan.

26. Preparation or its use according to one of the preceding claims for pore refinement of the skin and / or improvement of the skin appearance.