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EE9900038A - Fluori sisaldavad 1,4-diasendatud piperidiini derivaadid - Google Patents

Fluori sisaldavad 1,4-diasendatud piperidiini derivaadid

Info

Publication number
EE9900038A
EE9900038A EEP199900038A EE9900038A EE9900038A EE 9900038 A EE9900038 A EE 9900038A EE P199900038 A EEP199900038 A EE P199900038A EE 9900038 A EE9900038 A EE 9900038A EE 9900038 A EE9900038 A EE 9900038A
Authority
EE
Estonia
Prior art keywords
fluoride
piperidine derivatives
disubstituted piperidine
disubstituted
derivatives
Prior art date
Application number
EEP199900038A
Other languages
English (en)
Inventor
Tsuchiya Yoshimi
Nomoto Takashi
Ohsawa Hirokazu
Kawakami Kumiko
Ohwaki Kenji
Nishikibe Masaru
Original Assignee
Banyu Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharmaceutical Co., Ltd. filed Critical Banyu Pharmaceutical Co., Ltd.
Publication of EE9900038A publication Critical patent/EE9900038A/et

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/46Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EEP199900038A 1996-08-01 1997-07-28 Fluori sisaldavad 1,4-diasendatud piperidiini derivaadid EE9900038A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP21943696 1996-08-01
JP5397997 1997-02-21
PCT/JP1997/002600 WO1998005641A1 (fr) 1996-08-01 1997-07-28 Derives de piperidine fluores a disubstitution en position 1,4

Publications (1)

Publication Number Publication Date
EE9900038A true EE9900038A (et) 1999-08-16

Family

ID=26394715

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900038A EE9900038A (et) 1996-08-01 1997-07-28 Fluori sisaldavad 1,4-diasendatud piperidiini derivaadid

Country Status (29)

Country Link
US (2) US5948792A (et)
EP (1) EP0930298B1 (et)
JP (1) JP3063164B2 (et)
KR (1) KR20000022214A (et)
CN (1) CN1226888A (et)
AR (3) AR008272A1 (et)
AT (1) ATE229941T1 (et)
AU (1) AU716050B2 (et)
BG (1) BG103114A (et)
BR (1) BR9711108A (et)
CA (1) CA2261680C (et)
CO (1) CO4960641A1 (et)
CZ (1) CZ33199A3 (et)
DE (1) DE69718026T2 (et)
EE (1) EE9900038A (et)
ES (1) ES2188961T3 (et)
HR (1) HRP970426A2 (et)
HU (1) HUP9902381A3 (et)
ID (1) ID17259A (et)
IL (1) IL127685A0 (et)
IS (1) IS4960A (et)
NO (1) NO990472L (et)
NZ (1) NZ333842A (et)
PE (1) PE92198A1 (et)
PL (1) PL331431A1 (et)
SK (1) SK12299A3 (et)
TR (2) TR199900204T2 (et)
WO (1) WO1998005641A1 (et)
YU (1) YU1299A (et)

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UA73543C2 (uk) 1999-12-07 2005-08-15 Тераванс, Інк. Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором
WO2001042212A1 (en) * 1999-12-07 2001-06-14 Theravance, Inc. Carbamate derivatives having muscarinic receptor antagonist activity
JP4782342B2 (ja) * 1999-12-17 2011-09-28 サノフィ−アベンティス フェノキシプロパノールアミン類、それらの製造方法およびそれらを含む医薬組成物
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US6469172B2 (en) 2000-03-08 2002-10-22 Merck & Co., Inc. Process for the preparation of chemical compounds
US6403584B1 (en) * 2000-06-22 2002-06-11 Merck & Co., Inc. Substituted nipecotyl derivatives as inhibitors of cell adhesion
EP1302458A4 (en) * 2000-07-11 2005-10-19 Banyu Pharma Co Ltd ESTERDERIVATE
CN1298717C (zh) 2000-12-22 2007-02-07 阿尔米雷尔普罗迪斯制药有限公司 奎宁环氨基甲酸酯衍生物及其作为m3拮抗剂的应用
HUP0303524A3 (en) 2000-12-28 2008-03-28 Almirall Ag Novel quinuclidine derivatives, process for their preparation and medicinal compositions containing the same and their use
DE10111843A1 (de) * 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von inflammatorischen Erkrankungen
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AU2002345266B2 (en) * 2002-07-08 2009-07-02 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
AU2002368152A1 (en) 2002-07-31 2004-02-25 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo (3.1.0)hexane derivatives useful as muscarinic receptor antagonists
US6583103B1 (en) 2002-08-09 2003-06-24 S.C. Johnson & Son, Inc. Two part cleaning formula resulting in an effervescent liquid
EP1545508A4 (en) 2002-08-09 2009-11-25 Ranbaxy Lab Ltd 3,6-DISUBSTITUTED AZABICYCLO ¬3.1.0 HEXANE DERIVATIVES AS USEFUL AS MUSCARINIC RECEPTOR AGONISTS
CN1688544A (zh) 2002-08-23 2005-10-26 兰贝克赛实验室有限公司 作为蕈毒碱受体拮抗剂的含氟代和磺酰氨基的3,6-二取代的氮杂双环(3.1.0)己烷衍生物
EP1562599A1 (en) * 2002-10-29 2005-08-17 Pharmacia & Upjohn Company LLC Quaternary ammonium compounds as muscarinic receptor antagonists
TWI295669B (en) 2002-10-30 2008-04-11 Theravance Inc Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
AU2002353286A1 (en) 2002-12-10 2004-06-30 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
EP1572173B1 (en) 2002-12-13 2010-04-28 Warner-Lambert Company LLC Alpha-2-delta ligand to treat lower urinary tract symptoms
EP1583741A1 (en) 2002-12-23 2005-10-12 Ranbaxy Laboratories, Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
ATE386738T1 (de) 2002-12-23 2008-03-15 Ranbaxy Lab Ltd Flavaxat-derivate als muscarin-rezeptor antagonisten
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
PE20040950A1 (es) 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
EP1618091A1 (en) 2003-04-09 2006-01-25 Ranbaxy Laboratories, Ltd. Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EP1615887A1 (en) * 2003-04-10 2006-01-18 Ranbaxy Laboratories, Ltd. Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EA009059B1 (ru) 2003-04-10 2007-10-26 Рэнбакси Лабораториз Лимитед Замещенные производные азабициклогексана в качестве антагонистов мускаринового рецептора
CN100436414C (zh) * 2003-04-11 2008-11-26 兰贝克赛实验室有限公司 作为毒蕈碱受体拮抗剂的氮杂双环衍生物
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Also Published As

Publication number Publication date
US5948792A (en) 1999-09-07
AR008272A1 (es) 1999-12-29
AR016877A2 (es) 2001-08-01
US6040449A (en) 2000-03-21
CA2261680A1 (en) 1998-02-12
ATE229941T1 (de) 2003-01-15
EP0930298B1 (en) 2002-12-18
BR9711108A (pt) 1999-08-17
AU716050B2 (en) 2000-02-17
SK12299A3 (en) 2000-05-16
PL331431A1 (en) 1999-07-19
HUP9902381A2 (hu) 1999-11-29
KR20000022214A (ko) 2000-04-25
NZ333842A (en) 2001-05-25
ID17259A (id) 1997-12-11
JP3063164B2 (ja) 2000-07-12
NO990472D0 (no) 1999-02-01
AR017021A1 (es) 2001-08-22
DE69718026T2 (de) 2003-07-10
CN1226888A (zh) 1999-08-25
ES2188961T3 (es) 2003-07-01
CO4960641A1 (es) 2000-09-25
AU3635197A (en) 1998-02-25
EP0930298A4 (en) 2000-06-07
TR200001482T2 (tr) 2000-11-21
HUP9902381A3 (en) 2000-06-28
PE92198A1 (es) 1999-01-09
CZ33199A3 (cs) 1999-07-14
IS4960A (is) 1999-01-29
IL127685A0 (en) 1999-10-28
EP0930298A1 (en) 1999-07-21
WO1998005641A1 (fr) 1998-02-12
DE69718026D1 (de) 2003-01-30
HRP970426A2 (en) 1998-08-31
NO990472L (no) 1999-02-01
CA2261680C (en) 2005-03-08
BG103114A (en) 1999-11-30
YU1299A (sh) 2002-03-18
TR199900204T2 (xx) 2000-01-21

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