EE05591B1 - Meetod bioloogiliselt aktiivse tstokiini valmistamiseks ja bioloogiliselt aktiivse tstokiini muteerunud prekursorit kodeeriv cDNA - Google Patents
Meetod bioloogiliselt aktiivse tstokiini valmistamiseks ja bioloogiliselt aktiivse tstokiini muteerunud prekursorit kodeeriv cDNAInfo
- Publication number
- EE05591B1 EE05591B1 EEP200100530A EEP200100530A EE05591B1 EE 05591 B1 EE05591 B1 EE 05591B1 EE P200100530 A EEP200100530 A EE P200100530A EE P200100530 A EEP200100530 A EE P200100530A EE 05591 B1 EE05591 B1 EE 05591B1
- Authority
- EE
- Estonia
- Prior art keywords
- toxin
- biologically active
- preparation
- cdna encoding
- mutated precursor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
- C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL12942799A IL129427A0 (en) | 1999-04-13 | 1999-04-13 | Preparation of biologically active molecules |
PCT/IL2000/000220 WO2000061768A2 (en) | 1999-04-13 | 2000-04-13 | Preparation of biologically active molecules |
Publications (2)
Publication Number | Publication Date |
---|---|
EE200100530A EE200100530A (et) | 2002-12-16 |
EE05591B1 true EE05591B1 (et) | 2012-10-15 |
Family
ID=11072700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200100530A EE05591B1 (et) | 1999-04-13 | 2000-04-13 | Meetod bioloogiliselt aktiivse tstokiini valmistamiseks ja bioloogiliselt aktiivse tstokiini muteerunud prekursorit kodeeriv cDNA |
Country Status (24)
Country | Link |
---|---|
US (1) | US7098002B1 (ko) |
EP (1) | EP1169460B1 (ko) |
JP (1) | JP4822587B2 (ko) |
KR (1) | KR100682185B1 (ko) |
CN (1) | CN1324140C (ko) |
AR (1) | AR023468A1 (ko) |
AT (1) | ATE326536T1 (ko) |
AU (1) | AU781342B2 (ko) |
BR (1) | BR0009782A (ko) |
CA (1) | CA2368994C (ko) |
DE (1) | DE60028022T2 (ko) |
DK (1) | DK1169460T3 (ko) |
EA (1) | EA006825B1 (ko) |
EE (1) | EE05591B1 (ko) |
ES (1) | ES2259287T3 (ko) |
HK (1) | HK1044351A1 (ko) |
IL (3) | IL129427A0 (ko) |
MX (1) | MXPA01010487A (ko) |
NO (1) | NO329525B1 (ko) |
PT (1) | PT1169460E (ko) |
SI (1) | SI1169460T1 (ko) |
UA (1) | UA73940C2 (ko) |
WO (1) | WO2000061768A2 (ko) |
ZA (1) | ZA200108364B (ko) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001029232A2 (en) * | 1999-10-20 | 2001-04-26 | Scios Inc. | Functional cloning of genes encoding proteins/enzymes involved in proteolytic cleavage |
US7273722B2 (en) | 2000-11-29 | 2007-09-25 | Allergan, Inc. | Neurotoxins with enhanced target specificity |
ATE315647T1 (de) | 2001-03-08 | 2006-02-15 | Ares Trading Sa | Interleukin -18 mutantenproteine, deren herstellung und verwendung |
IL142246A0 (en) * | 2001-03-26 | 2002-03-10 | Applied Research Systems | Method and kit for quantitation of polypeptides |
US7241593B2 (en) | 2002-02-11 | 2007-07-10 | Zymogenetics, Inc. | Materials and methods for preparing dimeric growth factors |
DE602004009292T2 (de) * | 2003-02-21 | 2009-03-19 | Biotecnol S.A. | Verwendung von caspasen zur herstellung von reifen rekombinanten fusionsproteinen |
WO2005017110A2 (en) * | 2003-08-06 | 2005-02-24 | University Of Maryland Biotechnology Institute | Engineered proteases for affinity purification and processing of fusion proteins |
MXPA06005837A (es) * | 2003-11-24 | 2007-01-26 | Novo Nordisk As | Proteinas de fusion y metodos de desdoblamiento de tales proteinas. |
CA2558811A1 (en) | 2004-03-08 | 2005-09-22 | Zymogenetics, Inc. | Dimeric fusion proteins and materials and methods for producing them |
WO2008008082A2 (en) * | 2005-09-19 | 2008-01-17 | Allergan, Inc. | Clostridial toxin activatable clostridial toxins |
JP5093783B2 (ja) * | 2006-04-20 | 2012-12-12 | クリングルファーマ株式会社 | Hgf前駆体蛋白質改変体及びその活性型蛋白質 |
DE102007008596B4 (de) * | 2007-02-15 | 2010-09-02 | Friedrich-Schiller-Universität Jena | Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung |
CA2697032C (en) | 2007-08-22 | 2021-09-14 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
WO2009044988A1 (en) * | 2007-10-01 | 2009-04-09 | Korea Research Institute Of Bioscience And Biotechnology | Method for large scale preparation of procaspases, which can be artificially activated, in e. coli expression system and their activation |
DE102009043743B4 (de) | 2009-03-13 | 2016-10-13 | Friedrich-Schiller-Universität Jena | Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung |
AU2010203353B2 (en) | 2009-01-12 | 2016-06-16 | Cytomx Therapeutics, Inc | Modified antibody compositions, methods of making and using thereof |
WO2010096838A2 (en) * | 2009-02-23 | 2010-08-26 | Cytomx Therapeutics, Llc | Proproteins and methods of use thereof |
CN103923897B (zh) * | 2013-01-11 | 2016-06-01 | 中国人民解放军军事医学科学院生物工程研究所 | caspase重组酶原及其编码基因与应用 |
CN103388001B (zh) * | 2013-07-16 | 2016-01-20 | 中国人民解放军第四军医大学 | 一种含凝血酶切割位点gst膜型表达载体及转染阳性细胞的方法 |
RU2711322C1 (ru) * | 2013-12-20 | 2020-01-16 | Ф. Хоффманн-Ля Рош Аг | Улучшенные способы получения рекомбинантного полипептида |
KR20180002636A (ko) | 2015-03-30 | 2018-01-08 | 그린라이트 바이오사이언시스, 아이엔씨. | 리보핵산의 무세포 생산 |
JP6691144B2 (ja) | 2015-06-24 | 2020-04-28 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 目的に合わせた親和性を有する抗トランスフェリンレセプター抗体 |
CR20180149A (es) | 2015-10-02 | 2018-04-05 | Hoffmann La Roche | Anticuerpos biespecíficos contra el cd20 humano y el receptor de transferrina humano y métodos de uso |
AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
MY195729A (en) | 2016-04-06 | 2023-02-07 | Greenlight Biosciences Inc | Cell-Free Production of Ribonucleic Acid |
EP3695002A1 (en) | 2017-10-11 | 2020-08-19 | GreenLight Biosciences, Inc. | Methods and compositions for nucleoside triphosphate and ribonucleic acid production |
KR20200080749A (ko) * | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | N-말단의 메티오닌이 절단된 목적 단백질 발현용 유전자 발현 카세트 및 이를 이용하여 n-말단의 메티오닌이 절단된 목적 단백질을 생산하는 방법 |
JP2022545643A (ja) * | 2019-08-13 | 2022-10-28 | キングス・カレッジ・ロンドン | Il-1スーパーファミリーのサイトカインの空間時間的に制限された活性が武装化された免疫応答性細胞 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05509320A (ja) * | 1990-06-25 | 1993-12-22 | オーエスアイ ファーマシューティカルズ,インコーポレイティド | 組織誘導型腫瘍成長抑制物質、その調製及び使用方法 |
US5824297A (en) * | 1990-06-25 | 1998-10-20 | Oncogene Science, Inc. | Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof |
DE69229252T2 (de) * | 1991-08-16 | 1999-12-16 | Merck & Co., Inc. | DNS, welche das Interleukin-1B-Vorläufer-Converting-Enzym kodiert |
US5476777A (en) * | 1991-12-31 | 1995-12-19 | Zymogenetics, Inc. | Methods for producing thrombin |
JPH06125784A (ja) * | 1992-01-17 | 1994-05-10 | Takeda Chem Ind Ltd | モノクローナル抗体,ハイブリドーマ,その製造法および用途 |
US6303369B1 (en) * | 1993-09-30 | 2001-10-16 | Carl Spana | Protein expression system |
JP2000502903A (ja) * | 1995-12-29 | 2000-03-14 | インサイト・ファーマスーティカルズ・インコーポレイテッド | インターフェロンγ誘導因子―2をコードする核酸 |
JP4059941B2 (ja) * | 1996-08-26 | 2008-03-12 | 社団法人芝蘭会 | Rho標的タンパク質p140mDia |
AT405516B (de) * | 1997-02-27 | 1999-09-27 | Immuno Ag | Faktor x-analoge mit modifizierter proteasespaltstelle |
JPH10327872A (ja) * | 1997-05-30 | 1998-12-15 | Otsuka Pharmaceut Co Ltd | Bcl−2相互作用蛋白遺伝子bis |
EP1013763B1 (en) * | 1997-08-07 | 2011-02-02 | Toray Industries, Inc. | Canine interleukin 18 production method |
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1999
- 1999-04-13 IL IL12942799A patent/IL129427A0/xx unknown
-
2000
- 2000-04-12 AR ARP000101692A patent/AR023468A1/es not_active Application Discontinuation
- 2000-04-13 US US09/958,914 patent/US7098002B1/en not_active Expired - Fee Related
- 2000-04-13 CA CA002368994A patent/CA2368994C/en not_active Expired - Fee Related
- 2000-04-13 UA UA2001117751A patent/UA73940C2/uk unknown
- 2000-04-13 PT PT00919108T patent/PT1169460E/pt unknown
- 2000-04-13 WO PCT/IL2000/000220 patent/WO2000061768A2/en active IP Right Grant
- 2000-04-13 EE EEP200100530A patent/EE05591B1/xx not_active IP Right Cessation
- 2000-04-13 DK DK00919108T patent/DK1169460T3/da active
- 2000-04-13 JP JP2000611691A patent/JP4822587B2/ja not_active Expired - Fee Related
- 2000-04-13 MX MXPA01010487A patent/MXPA01010487A/es active IP Right Grant
- 2000-04-13 EA EA200101078A patent/EA006825B1/ru not_active IP Right Cessation
- 2000-04-13 EP EP00919108A patent/EP1169460B1/en not_active Expired - Lifetime
- 2000-04-13 ES ES00919108T patent/ES2259287T3/es not_active Expired - Lifetime
- 2000-04-13 DE DE60028022T patent/DE60028022T2/de not_active Expired - Lifetime
- 2000-04-13 AU AU39851/00A patent/AU781342B2/en not_active Ceased
- 2000-04-13 BR BR0009782-9A patent/BR0009782A/pt active Search and Examination
- 2000-04-13 SI SI200030860T patent/SI1169460T1/sl unknown
- 2000-04-13 AT AT00919108T patent/ATE326536T1/de active
- 2000-04-13 IL IL14584200A patent/IL145842A0/xx active IP Right Grant
- 2000-04-13 CN CNB008080577A patent/CN1324140C/zh not_active Expired - Fee Related
- 2000-04-13 KR KR1020017012973A patent/KR100682185B1/ko not_active IP Right Cessation
-
2001
- 2001-10-10 IL IL145842A patent/IL145842A/en not_active IP Right Cessation
- 2001-10-11 ZA ZA200108364A patent/ZA200108364B/en unknown
- 2001-10-12 NO NO20014966A patent/NO329525B1/no not_active IP Right Cessation
-
2002
- 2002-08-15 HK HK02105972A patent/HK1044351A1/xx not_active IP Right Cessation
Also Published As
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HH1A | Change of representative | ||
MM4A | Lapsed by not paying the annual fees |
Effective date: 20170413 |