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EE05591B1 - Meetod bioloogiliselt aktiivse tstokiini valmistamiseks ja bioloogiliselt aktiivse tstokiini muteerunud prekursorit kodeeriv cDNA - Google Patents

Meetod bioloogiliselt aktiivse tstokiini valmistamiseks ja bioloogiliselt aktiivse tstokiini muteerunud prekursorit kodeeriv cDNA

Info

Publication number
EE05591B1
EE05591B1 EEP200100530A EEP200100530A EE05591B1 EE 05591 B1 EE05591 B1 EE 05591B1 EE P200100530 A EEP200100530 A EE P200100530A EE P200100530 A EEP200100530 A EE P200100530A EE 05591 B1 EE05591 B1 EE 05591B1
Authority
EE
Estonia
Prior art keywords
toxin
biologically active
preparation
cdna encoding
mutated precursor
Prior art date
Application number
EEP200100530A
Other languages
English (en)
Estonian (et)
Inventor
Rubinstein Menachem
Liu Bianling
Novick Daniela
Graber Pierre
Original Assignee
Yeda Research And Development Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research And Development Co. Ltd. filed Critical Yeda Research And Development Co. Ltd.
Publication of EE200100530A publication Critical patent/EE200100530A/xx
Publication of EE05591B1 publication Critical patent/EE05591B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472Cysteine endopeptidases (3.4.22)
    • C12N9/6475Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/545IL-1

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
EEP200100530A 1999-04-13 2000-04-13 Meetod bioloogiliselt aktiivse tstokiini valmistamiseks ja bioloogiliselt aktiivse tstokiini muteerunud prekursorit kodeeriv cDNA EE05591B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12942799A IL129427A0 (en) 1999-04-13 1999-04-13 Preparation of biologically active molecules
PCT/IL2000/000220 WO2000061768A2 (en) 1999-04-13 2000-04-13 Preparation of biologically active molecules

Publications (2)

Publication Number Publication Date
EE200100530A EE200100530A (et) 2002-12-16
EE05591B1 true EE05591B1 (et) 2012-10-15

Family

ID=11072700

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100530A EE05591B1 (et) 1999-04-13 2000-04-13 Meetod bioloogiliselt aktiivse tstokiini valmistamiseks ja bioloogiliselt aktiivse tstokiini muteerunud prekursorit kodeeriv cDNA

Country Status (24)

Country Link
US (1) US7098002B1 (ko)
EP (1) EP1169460B1 (ko)
JP (1) JP4822587B2 (ko)
KR (1) KR100682185B1 (ko)
CN (1) CN1324140C (ko)
AR (1) AR023468A1 (ko)
AT (1) ATE326536T1 (ko)
AU (1) AU781342B2 (ko)
BR (1) BR0009782A (ko)
CA (1) CA2368994C (ko)
DE (1) DE60028022T2 (ko)
DK (1) DK1169460T3 (ko)
EA (1) EA006825B1 (ko)
EE (1) EE05591B1 (ko)
ES (1) ES2259287T3 (ko)
HK (1) HK1044351A1 (ko)
IL (3) IL129427A0 (ko)
MX (1) MXPA01010487A (ko)
NO (1) NO329525B1 (ko)
PT (1) PT1169460E (ko)
SI (1) SI1169460T1 (ko)
UA (1) UA73940C2 (ko)
WO (1) WO2000061768A2 (ko)
ZA (1) ZA200108364B (ko)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001029232A2 (en) * 1999-10-20 2001-04-26 Scios Inc. Functional cloning of genes encoding proteins/enzymes involved in proteolytic cleavage
US7273722B2 (en) 2000-11-29 2007-09-25 Allergan, Inc. Neurotoxins with enhanced target specificity
ATE315647T1 (de) 2001-03-08 2006-02-15 Ares Trading Sa Interleukin -18 mutantenproteine, deren herstellung und verwendung
IL142246A0 (en) * 2001-03-26 2002-03-10 Applied Research Systems Method and kit for quantitation of polypeptides
US7241593B2 (en) 2002-02-11 2007-07-10 Zymogenetics, Inc. Materials and methods for preparing dimeric growth factors
DE602004009292T2 (de) * 2003-02-21 2009-03-19 Biotecnol S.A. Verwendung von caspasen zur herstellung von reifen rekombinanten fusionsproteinen
WO2005017110A2 (en) * 2003-08-06 2005-02-24 University Of Maryland Biotechnology Institute Engineered proteases for affinity purification and processing of fusion proteins
MXPA06005837A (es) * 2003-11-24 2007-01-26 Novo Nordisk As Proteinas de fusion y metodos de desdoblamiento de tales proteinas.
CA2558811A1 (en) 2004-03-08 2005-09-22 Zymogenetics, Inc. Dimeric fusion proteins and materials and methods for producing them
WO2008008082A2 (en) * 2005-09-19 2008-01-17 Allergan, Inc. Clostridial toxin activatable clostridial toxins
JP5093783B2 (ja) * 2006-04-20 2012-12-12 クリングルファーマ株式会社 Hgf前駆体蛋白質改変体及びその活性型蛋白質
DE102007008596B4 (de) * 2007-02-15 2010-09-02 Friedrich-Schiller-Universität Jena Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung
CA2697032C (en) 2007-08-22 2021-09-14 The Regents Of The University Of California Activatable binding polypeptides and methods of identification and use thereof
WO2009044988A1 (en) * 2007-10-01 2009-04-09 Korea Research Institute Of Bioscience And Biotechnology Method for large scale preparation of procaspases, which can be artificially activated, in e. coli expression system and their activation
DE102009043743B4 (de) 2009-03-13 2016-10-13 Friedrich-Schiller-Universität Jena Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung
AU2010203353B2 (en) 2009-01-12 2016-06-16 Cytomx Therapeutics, Inc Modified antibody compositions, methods of making and using thereof
WO2010096838A2 (en) * 2009-02-23 2010-08-26 Cytomx Therapeutics, Llc Proproteins and methods of use thereof
CN103923897B (zh) * 2013-01-11 2016-06-01 中国人民解放军军事医学科学院生物工程研究所 caspase重组酶原及其编码基因与应用
CN103388001B (zh) * 2013-07-16 2016-01-20 中国人民解放军第四军医大学 一种含凝血酶切割位点gst膜型表达载体及转染阳性细胞的方法
RU2711322C1 (ru) * 2013-12-20 2020-01-16 Ф. Хоффманн-Ля Рош Аг Улучшенные способы получения рекомбинантного полипептида
KR20180002636A (ko) 2015-03-30 2018-01-08 그린라이트 바이오사이언시스, 아이엔씨. 리보핵산의 무세포 생산
JP6691144B2 (ja) 2015-06-24 2020-04-28 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 目的に合わせた親和性を有する抗トランスフェリンレセプター抗体
CR20180149A (es) 2015-10-02 2018-04-05 Hoffmann La Roche Anticuerpos biespecíficos contra el cd20 humano y el receptor de transferrina humano y métodos de uso
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
MY195729A (en) 2016-04-06 2023-02-07 Greenlight Biosciences Inc Cell-Free Production of Ribonucleic Acid
EP3695002A1 (en) 2017-10-11 2020-08-19 GreenLight Biosciences, Inc. Methods and compositions for nucleoside triphosphate and ribonucleic acid production
KR20200080749A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 N-말단의 메티오닌이 절단된 목적 단백질 발현용 유전자 발현 카세트 및 이를 이용하여 n-말단의 메티오닌이 절단된 목적 단백질을 생산하는 방법
JP2022545643A (ja) * 2019-08-13 2022-10-28 キングス・カレッジ・ロンドン Il-1スーパーファミリーのサイトカインの空間時間的に制限された活性が武装化された免疫応答性細胞

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05509320A (ja) * 1990-06-25 1993-12-22 オーエスアイ ファーマシューティカルズ,インコーポレイティド 組織誘導型腫瘍成長抑制物質、その調製及び使用方法
US5824297A (en) * 1990-06-25 1998-10-20 Oncogene Science, Inc. Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
DE69229252T2 (de) * 1991-08-16 1999-12-16 Merck & Co., Inc. DNS, welche das Interleukin-1B-Vorläufer-Converting-Enzym kodiert
US5476777A (en) * 1991-12-31 1995-12-19 Zymogenetics, Inc. Methods for producing thrombin
JPH06125784A (ja) * 1992-01-17 1994-05-10 Takeda Chem Ind Ltd モノクローナル抗体,ハイブリドーマ,その製造法および用途
US6303369B1 (en) * 1993-09-30 2001-10-16 Carl Spana Protein expression system
JP2000502903A (ja) * 1995-12-29 2000-03-14 インサイト・ファーマスーティカルズ・インコーポレイテッド インターフェロンγ誘導因子―2をコードする核酸
JP4059941B2 (ja) * 1996-08-26 2008-03-12 社団法人芝蘭会 Rho標的タンパク質p140mDia
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
JPH10327872A (ja) * 1997-05-30 1998-12-15 Otsuka Pharmaceut Co Ltd Bcl−2相互作用蛋白遺伝子bis
EP1013763B1 (en) * 1997-08-07 2011-02-02 Toray Industries, Inc. Canine interleukin 18 production method

Also Published As

Publication number Publication date
WO2000061768A2 (en) 2000-10-19
AU3985100A (en) 2000-11-14
IL145842A (en) 2008-06-05
EA006825B1 (ru) 2006-04-28
NO329525B1 (no) 2010-11-01
ZA200108364B (en) 2002-10-11
CA2368994A1 (en) 2000-10-19
KR100682185B1 (ko) 2007-02-12
US7098002B1 (en) 2006-08-29
AU781342B2 (en) 2005-05-19
IL145842A0 (en) 2002-07-25
CN1353761A (zh) 2002-06-12
MXPA01010487A (es) 2002-05-06
PT1169460E (pt) 2006-07-31
WO2000061768A3 (en) 2001-02-08
HK1044351A1 (en) 2002-10-18
JP2002541813A (ja) 2002-12-10
EE200100530A (et) 2002-12-16
BR0009782A (pt) 2002-01-08
DE60028022T2 (de) 2006-09-28
KR20020007365A (ko) 2002-01-26
EP1169460B1 (en) 2006-05-17
EP1169460A2 (en) 2002-01-09
ATE326536T1 (de) 2006-06-15
SI1169460T1 (sl) 2006-08-31
CA2368994C (en) 2010-03-09
EA200101078A1 (ru) 2002-04-25
AR023468A1 (es) 2002-09-04
NO20014966L (no) 2001-12-11
UA73940C2 (uk) 2005-10-17
DE60028022D1 (de) 2006-06-22
ES2259287T3 (es) 2006-10-01
IL129427A0 (en) 2000-02-17
NO20014966D0 (no) 2001-10-12
DK1169460T3 (da) 2006-09-18
CN1324140C (zh) 2007-07-04
JP4822587B2 (ja) 2011-11-24

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Effective date: 20170413