EE04433B1 - 3-spiroindolin-2-ooni derivaadid kui vasopressiini- ja/või oksütotsiiniretseptorite ligandid, nendevalmistamismeetod, neid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine ravimite valmistamiseks - Google Patents

3-spiroindolin-2-ooni derivaadid kui vasopressiini- ja/või oksütotsiiniretseptorite ligandid, nendevalmistamismeetod, neid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine ravimite valmistamiseks

Info

Publication number: EE04433B1
Authority: EE; Estonia
Prior art keywords: preparation; spiroindolin; vasopressin; medicaments; ligands
Prior art date: 1995-10-24

Application number

EE9800151A

Other languages

English (en)

Estonian (et)

Other versions

EE9800151A (et

Inventor

Foulon Lo�c

Garcia Georges

Serradeil-Le Gal Claudine

Valette Grard

Original Assignee

Sanofi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-24

Filing date

1996-10-24

Publication date

2005-02-15

1996-10-24 Application filed by Sanofi filed Critical Sanofi

1998-12-15 Publication of EE9800151A publication Critical patent/EE9800151A/xx

2005-02-15 Publication of EE04433B1 publication Critical patent/EE04433B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Addiction (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Emergency Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Vascular Medicine (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EE9800151A 1995-10-24 1996-10-24 3-spiroindolin-2-ooni derivaadid kui vasopressiini- ja/või oksütotsiiniretseptorite ligandid, nendevalmistamismeetod, neid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine ravimite valmistamiseks EE04433B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9512533A FR2740136B1 (fr)	1995-10-24	1995-10-24	Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant
PCT/FR1996/001666 WO1997015556A1 (fr)	1995-10-24	1996-10-24	Derives 3-spiro-indolin-2-one comme ligands des recepteurs de la vasopressine et/ou de l'ocytocine

Publications (2)

Publication Number	Publication Date
EE9800151A EE9800151A (et)	1998-12-15
EE04433B1 true EE04433B1 (et)	2005-02-15

Family

ID=9483867

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800151A EE04433B1 (et)	1995-10-24	1996-10-24	3-spiroindolin-2-ooni derivaadid kui vasopressiini- ja/või oksütotsiiniretseptorite ligandid, nendevalmistamismeetod, neid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine ravimite valmistamiseks

Country Status (31)

Country	Link
US (2)	US5994350A (xx)
EP (1)	EP0873309B1 (xx)
JP (2)	JP3274471B2 (xx)
KR (1)	KR100298925B1 (xx)
CN (1)	CN1106384C (xx)
AR (1)	AR004225A1 (xx)
AT (1)	ATE229940T1 (xx)
AU (1)	AU715841B2 (xx)
BR (1)	BR9611198A (xx)
CZ (1)	CZ295585B6 (xx)
DE (1)	DE69625517T2 (xx)
DK (1)	DK0873309T3 (xx)
EE (1)	EE04433B1 (xx)
ES (1)	ES2191769T3 (xx)
FR (1)	FR2740136B1 (xx)
HK (1)	HK1016596A1 (xx)
HU (1)	HUP9900331A3 (xx)
IL (1)	IL124002A (xx)
IN (1)	IN185328B (xx)
IS (1)	IS1949B (xx)
MY (1)	MY115864A (xx)
NO (1)	NO310974B1 (xx)
NZ (1)	NZ320352A (xx)
PL (1)	PL187093B1 (xx)
RU (1)	RU2167864C2 (xx)
SK (1)	SK284546B6 (xx)
TR (1)	TR199800719T2 (xx)
TW (1)	TW474917B (xx)
UA (1)	UA59345C2 (xx)
WO (1)	WO1997015556A1 (xx)
ZA (1)	ZA968945B (xx)

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FR2778103A1 (fr) *	1998-04-29	1999-11-05	Sanofi Sa	Compositions pharmaceutiques contenant en association un antagoniste v1a de l'arginine-vasopressine et un antagoniste des recepteurs at1 de l'angiotensine ii
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HU225150B1 (en) *	1999-07-15	2006-07-28	Sanofi Aventis	Novel process for producing 2-methoxy-4-(t-butylaminocarbonyl)-benzenesulfonyl chloride
HU225703B1 (en) *	1999-07-15	2007-06-28	Sanofi Aventis	Process for producing spiro[cis-4-(betha-hydroxy-ethyloxi)-cyclohexane-[3h]indole]-2'[1'h]-one derivatives
HUP9902376A3 (en)	1999-07-15	2002-11-28	Sanofi Aventis	Process for producing n-(1,1-dimethyl)-4-[[s'-ethoxi-4-cis-[2-(4-morpholino)-ethoxi]-2'-oxospiro[cyclohexane-1,3'-[3h]indole]-1'(2'h)yl]-sulfonyl]-3-methoxybenzamide and its salts
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WO2002044179A1 (fr) *	2000-11-28	2002-06-06	Yamanouchi Pharmaceutical Co., Ltd.	Dérivés de 1,4,5,6-tétrahydroimidazo[4,5-d]diazépine ou sels de ces derniers
AU2002231098A1 (en) *	2000-12-15	2002-06-24	Emory University	Nonpeptide agonists and antagonists of vasopressin receptors
US7498332B2 (en)	2001-02-14	2009-03-03	Duke University	Therapy for cerebral vasospasm
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AU2005249794A1 (en)	2004-06-04	2005-12-15	Teva Pharmaceutical Industries, Ltd.	Pharmaceutical composition containing irbesartan
FR2874920B1 (fr) *	2004-09-09	2006-10-20	Sanofi Aventis Sa	Derives de 3-spiro-indolin-2-one comme ligand des recepteurs de la vasopressine
FR2874921B1 (fr) *	2004-09-09	2006-10-20	Sanofi Aventis Sa	Derives de 3-spiro-indolin-2-one, leur preparation et leur application en therapeutique
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CA2593044A1 (en) *	2004-12-31	2006-07-13	Abbott Gmbh & Co. Kg	Substituted oxindole derivatives, medicaments containing said derivatives and use thereof
DE102005014936A1 (de) *	2005-03-24	2006-12-14	Abbott Gmbh & Co. Kg	Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
AR056968A1 (es)	2005-04-11	2007-11-07	Xenon Pharmaceuticals Inc	Compuestos espiro-oxindol y composiciones farmacéuticas
MY145694A (en)	2005-04-11	2012-03-30	Xenon Pharmaceuticals Inc	Spiroheterocyclic compounds and their uses as therapeutic agents
AR056317A1 (es) *	2005-04-20	2007-10-03	Xenon Pharmaceuticals Inc	Compuestos de oxindol y composicion farmaceutica
EP2076514A1 (en) *	2006-10-12	2009-07-08	Xenon Pharmaceuticals Inc.	Spiro (furo ý3, 2-c¨pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
AR063280A1 (es) *	2006-10-12	2009-01-21	Xenon Pharmaceuticals Inc	Uso de compuestos de espiro-oxindol como agentes terapeuticos
BRPI0719166A2 (pt) *	2006-10-12	2014-06-03	Xenon Pharmaceuticals Inc	Derivados de espiro-oxindol tricíclicos e seus usos como agentes terapêuticos
FR2927625B1 (fr)	2008-02-19	2010-03-12	Sanofi Aventis	Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique
US7723372B2 (en) *	2008-03-19	2010-05-25	Hoffman-La Roche Inc.	Spiroindolinone derivatives
FR2930249B1 (fr)	2008-04-21	2010-05-14	Sanofi Aventis	Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique.
JP5570172B2 (ja) *	2008-10-08	2014-08-13	持田製薬株式会社	喫煙による循環機能不全の予防／改善または治療剤
US8101647B2 (en)	2008-10-17	2012-01-24	Xenon Pharmaceuticals Inc.	Spiro-oxindole compounds and their use as therapeutic agents
EP2350090B1 (en)	2008-10-17	2015-06-03	Xenon Pharmaceuticals Inc.	Spiro-oxindole compounds and their use as therapeutic agents
AR077252A1 (es)	2009-06-29	2011-08-10	Xenon Pharmaceuticals Inc	Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
WO2011047173A2 (en) *	2009-10-14	2011-04-21	Xenon Pharmaceuticals Inc.	Pharmaceutical compositions for oral administration
AU2010306768B2 (en)	2009-10-14	2016-08-04	Xenon Pharmaceuticals Inc.	Synthetic methods for spiro-oxindole compounds
US8088815B2 (en)	2009-12-02	2012-01-03	Hoffman-La Roche Inc.	Spiroindolinone pyrrolidines
US8288431B2 (en)	2010-02-17	2012-10-16	Hoffmann-La Roche Inc.	Substituted spiroindolinones
CA2788440A1 (en)	2010-02-26	2011-09-01	Xenon Pharmaceuticals Inc.	Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
US8217044B2 (en)	2010-04-28	2012-07-10	Hoffmann-La Roche Inc.	Spiroindolinone pyrrolidines
MD4202C1 (ro) *	2012-03-21	2013-09-30	Институт Химии Академии Наук Молдовы	Procedeu de obţinere a derivaţilor carbometoxi ai spiro[ciclopropan-oxindolilor]
MD4201C1 (ro) *	2012-03-21	2013-09-30	Институт Химии Академии Наук Молдовы	Procedeu de obţinere a derivaţilor carbonitrilici ai spiro[ciclopropan-oxindolilor]
JP6285969B2 (ja) *	2013-03-08	2018-02-28	ウォックハートリミテッド	（２ｓ，５ｒ）−７−オキソ−６−スルホオキシ−２−［（（３ｒ）−ピペリジン−３−カルボニル）−ヒドラジノカルボニル］−１，６−ジアザ−ビシクロ［３．２．１］オクタンの調製のためのプロセス
TW201636017A (zh)	2015-02-05	2016-10-16	梯瓦製藥國際有限責任公司	以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法
HU231206B1 (hu)	2017-12-15	2021-10-28	Richter Gedeon Nyrt.	Triazolobenzazepinek
TW201938171A (zh)	2017-12-15	2019-10-01	匈牙利商羅特格登公司	作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物

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Publication number	Priority date	Publication date	Assignee	Title
FR2686878B1 (fr) *	1992-01-30	1995-06-30	Sanofi Elf	Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant.
US5663431A (en) *	1992-01-30	1997-09-02	Sanofi	1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
FR2708605A1 (fr) *	1993-07-30	1995-02-10	Sanofi Sa	Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
US5686624A (en) *	1992-01-30	1997-11-11	Sanofi	1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
FR2708606B1 (fr) *	1993-07-30	1995-10-27	Sanofi Sa	Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.

1995
- 1995-10-24 FR FR9512533A patent/FR2740136B1/fr not_active Expired - Fee Related
1996
- 1996-10-22 TW TW085112955A patent/TW474917B/zh not_active IP Right Cessation
- 1996-10-23 AR ARP960104863A patent/AR004225A1/es active IP Right Grant
- 1996-10-23 MY MYPI96004404A patent/MY115864A/en unknown
- 1996-10-23 IN IN2288DE1996 patent/IN185328B/en unknown
- 1996-10-24 JP JP51636397A patent/JP3274471B2/ja not_active Expired - Fee Related
- 1996-10-24 KR KR1019980702996A patent/KR100298925B1/ko not_active IP Right Cessation
- 1996-10-24 SK SK490-98A patent/SK284546B6/sk not_active IP Right Cessation
- 1996-10-24 RU RU98109945/04A patent/RU2167864C2/ru not_active IP Right Cessation
- 1996-10-24 BR BR9611198A patent/BR9611198A/pt not_active IP Right Cessation
- 1996-10-24 US US09/051,900 patent/US5994350A/en not_active Expired - Lifetime
- 1996-10-24 DE DE69625517T patent/DE69625517T2/de not_active Expired - Lifetime
- 1996-10-24 CZ CZ19981267A patent/CZ295585B6/cs not_active IP Right Cessation
- 1996-10-24 EP EP96934967A patent/EP0873309B1/fr not_active Expired - Lifetime
- 1996-10-24 AT AT96934967T patent/ATE229940T1/de active
- 1996-10-24 CN CN96198579A patent/CN1106384C/zh not_active Expired - Fee Related
- 1996-10-24 NZ NZ320352A patent/NZ320352A/xx not_active IP Right Cessation
- 1996-10-24 EE EE9800151A patent/EE04433B1/xx not_active IP Right Cessation
- 1996-10-24 UA UA98042064A patent/UA59345C2/uk unknown
- 1996-10-24 WO PCT/FR1996/001666 patent/WO1997015556A1/fr active IP Right Grant
- 1996-10-24 PL PL96326555A patent/PL187093B1/pl not_active IP Right Cessation
- 1996-10-24 TR TR1998/00719T patent/TR199800719T2/xx unknown
- 1996-10-24 IL IL12400296A patent/IL124002A/en not_active IP Right Cessation
- 1996-10-24 AU AU73080/96A patent/AU715841B2/en not_active Ceased
- 1996-10-24 ZA ZA968945A patent/ZA968945B/xx unknown
- 1996-10-24 ES ES96934967T patent/ES2191769T3/es not_active Expired - Lifetime
- 1996-10-24 HU HU9900331A patent/HUP9900331A3/hu unknown
- 1996-10-24 DK DK96934967T patent/DK0873309T3/da active
1998
- 1998-04-14 IS IS4714A patent/IS1949B/is unknown
- 1998-04-23 NO NO19981817A patent/NO310974B1/no not_active IP Right Cessation
1999
- 1999-04-14 HK HK99101588A patent/HK1016596A1/xx not_active IP Right Cessation
- 1999-10-12 US US09/417,190 patent/US6046341A/en not_active Expired - Lifetime
2001
- 2001-03-16 JP JP2001075467A patent/JP2001302631A/ja active Pending

Also Published As

Publication number	Publication date
TW474917B (en)	2002-02-01
FR2740136A1 (fr)	1997-04-25
RU2167864C2 (ru)	2001-05-27
US5994350A (en)	1999-11-30
NO981817L (no)	1998-04-23
HUP9900331A2 (hu)	1999-05-28
PL326555A1 (en)	1998-09-28
IS4714A (is)	1998-04-14
EP0873309A1 (fr)	1998-10-28
ES2191769T3 (es)	2003-09-16
MX9803269A (es)	1998-09-30
AU715841B2 (en)	2000-02-10
KR100298925B1 (ko)	2001-09-06
UA59345C2 (uk)	2003-09-15
CZ126798A3 (cs)	1998-08-12
IN185328B (xx)	2000-12-30
EE9800151A (et)	1998-12-15
NO310974B1 (no)	2001-09-24
CN1106384C (zh)	2003-04-23
KR19990067056A (ko)	1999-08-16
HK1016596A1 (en)	1999-11-05
JPH11509232A (ja)	1999-08-17
FR2740136B1 (fr)	1998-01-09
DE69625517T2 (de)	2003-09-11
IL124002A (en)	2002-11-10
WO1997015556A1 (fr)	1997-05-01
ZA968945B (en)	1997-05-29
BR9611198A (pt)	1999-04-06
DK0873309T3 (da)	2003-03-17
ATE229940T1 (de)	2003-01-15
SK49098A3 (en)	1998-09-09
MY115864A (en)	2003-09-30
EP0873309B1 (fr)	2002-12-18
CZ295585B6 (cs)	2005-08-17
NO981817D0 (no)	1998-04-23
HUP9900331A3 (en)	1999-11-29
JP3274471B2 (ja)	2002-04-15
TR199800719T2 (xx)	1998-08-21
AU7308096A (en)	1997-05-15
SK284546B6 (sk)	2005-06-02
CN1202886A (zh)	1998-12-23
DE69625517D1 (de)	2003-01-30
NZ320352A (en)	2000-01-28
IS1949B (is)	2004-10-13
PL187093B1 (pl)	2004-05-31
JP2001302631A (ja)	2001-10-31
AR004225A1 (es)	1998-11-04
US6046341A (en)	2000-04-04

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2013-06-17	MM4A	Lapsed by not paying the annual fees	Effective date: 20121024