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ECSP066975A - Derivados de fenol y tiofenol 3-o 4-monosustituidos utiles como ligandos de h3 - Google Patents

Derivados de fenol y tiofenol 3-o 4-monosustituidos utiles como ligandos de h3

Info

Publication number
ECSP066975A
ECSP066975A EC2006006975A ECSP066975A ECSP066975A EC SP066975 A ECSP066975 A EC SP066975A EC 2006006975 A EC2006006975 A EC 2006006975A EC SP066975 A ECSP066975 A EC SP066975A EC SP066975 A ECSP066975 A EC SP066975A
Authority
EC
Ecuador
Prior art keywords
phenol
useful
monosustitutes
ligandos
derivatives
Prior art date
Application number
EC2006006975A
Other languages
English (en)
Inventor
Henry Jacobelli
Patrick Bernardelli
Fabrice Vergne
Andrew Michael Cronin
Alexis Denis
Stephen Martin Denton
Mark Ian Kemp
Edwige Lorthiois
Fiona Rousseau
Delphine Serradeil-Civit
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04291187A external-priority patent/EP1593679A1/en
Priority claimed from GB0504564A external-priority patent/GB0504564D0/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of ECSP066975A publication Critical patent/ECSP066975A/es

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    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06—Radicals substituted by oxygen atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Abstract

La invención se refiere a derivados de fenol y tiofenol 3- ó 4-monosustituidos de fórmula (1) y a procedimientos para la preparación de, a intermedios usados en la preparación de, a composiciones que contienen y a los usos de tales derivados. Tales derivados de fenol y tiofenol 3- ó 4-monosustituidos son ligados H3 y son útiles en numerosas enfermedades, trastornos y afecciones, en particular enfermedades, trastornos y afecciones inflamatorias, alérgicas y respiratorias.
EC2006006975A 2004-05-07 2006-11-08 Derivados de fenol y tiofenol 3-o 4-monosustituidos utiles como ligandos de h3 ECSP066975A (es)

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EP04291187A EP1593679A1 (en) 2004-05-07 2004-05-07 3- Or 4-monosubstituted phenol derivatives useful as H3 ligands
GB0504564A GB0504564D0 (en) 2005-03-04 2005-03-04 New compounds

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Families Citing this family (25)

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MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
CZ2006427A3 (cs) 2003-12-29 2006-11-15 Sepracor Inc. Pyrrolové a pyrazolové inhibitory DAAO
JP2006213674A (ja) * 2005-02-07 2006-08-17 Ube Ind Ltd ４−ホルミルテトラヒドロピラン化合物の製法
CN101553217A (zh) 2005-07-06 2009-10-07 塞普拉科公司 艾司佐匹克隆与反式4－(3,4－二氯苯基)－1,2,3,4－四氢－n－甲基－1－萘胺或反式4－(3,4－二氯苯基)－1,2,3,4－四氢－1－萘胺的组合以及治疗绝经期和心境障碍、焦虑症和认知障碍的方法
WO2007045989A1 (en) * 2005-10-20 2007-04-26 Pfizer Limited Pyridyl derivatives useful as h3 ligands
CA2636275C (en) 2006-01-06 2013-02-12 Sepracor Inc. Tetralone-based monoamine reuptake inhibitors
BRPI0706365A2 (pt) 2006-01-06 2011-03-22 Sepracor Inc Cicloalquilaminas como inibidores da recaptação de monoamina
PT2013835E (pt) 2006-03-31 2016-01-06 Sunovion Pharmaceuticals Inc Preparação de amidas and aminas quirais
AU2007236115A1 (en) 2006-04-11 2007-10-18 Novartis Ag Organic compounds
US9108948B2 (en) * 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
NZ611323A (en) * 2006-06-23 2014-10-31 Abbvie Bahamas Ltd Cyclopropyl amine derivatives as histamin h3 receptor modulators
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
BRPI0718874A2 (pt) * 2006-12-22 2015-06-23 Novartis Ag Compostos orgânicos
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
BRPI0811639A2 (pt) 2007-05-31 2014-09-30 Sepracor Inc Cicloaquilaminas fenil substituídas como inibidores da recaptação de monoamina
TW201039822A (en) 2009-02-06 2010-11-16 Taisho Pharmaceutical Co Ltd Dihydroquinolinone derivatives
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
WO2011153359A1 (en) 2010-06-04 2011-12-08 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
WO2012037258A1 (en) 2010-09-16 2012-03-22 Abbott Laboratories Processes for preparing 1,2-substituted cyclopropyl derivatives
MX337469B (es) * 2011-10-26 2016-03-02 Pfizer Ltd Derivados de (4-fenilimidazol-2-il)etilamina utiles como moduladores de canal de sodio.
WO2014095534A1 (en) * 2012-12-19 2014-06-26 Basf Se New substituted triazoles and imidazoles and their use as fungicides
US9365511B2 (en) * 2013-01-09 2016-06-14 Arena Pharmaceuticals, Inc. Biphenyl-ethyl-pyrrolidine derivatives as histamine H3 receptor modulators for the treatment of cognitive disorders
TWI663159B (zh) * 2013-12-10 2019-06-21 美商健臻公司 原肌球蛋白相關之激酶（ｔｒｋ）抑制劑
TWI696621B (zh) 2014-12-18 2020-06-21 美商健臻公司 原肌球蛋白相關激酶（ｔｒｋ）抑制劑之醫藥調配物
CN113336715B (zh) * 2021-08-04 2021-11-23 山东海利尔化工有限公司 一种含二氧戊环的三唑类化合物及其中间体的制备方法

Family Cites Families (5)

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DE3024836A1 (de) * 1980-07-01 1982-01-28 A. Nattermann & Cie GmbH, 5000 Köln (3-alkylamino-2-hydroxy-propoxy)-benzylnitrile, verfahren zu deren herstellung und diese als wirkstof enthaltende arzneimittel
DK368687A (da) * 1986-11-21 1988-05-22 Cheminova As Aminoalkylerede hydroxyforbindelser og deres anvendelse som fungicider
WO2002006223A1 (en) * 2000-07-13 2002-01-24 Abbott Laboratories 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
DK1311482T3 (da) * 2000-08-08 2007-05-07 Ortho Mcneil Pharm Inc Ikke-imidazolaryloxypiperidiner som H3-receptorligander
AU2002254114A1 (en) * 2001-03-23 2002-10-08 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses

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ATE472540T1 (de) 2010-07-15
CY1110735T1 (el) 2015-06-10
EA011161B1 (ru) 2009-02-27
RS51403B (en) 2011-02-28
WO2005108384A1 (en) 2005-11-17
CN1950351B (zh) 2012-01-18
PE20060237A1 (es) 2006-04-01
NL1028968C2 (nl) 2006-04-03
ES2346665T3 (es) 2010-10-19
MXPA06012819A (es) 2007-01-26
SV2006002107A (es) 2006-06-26
AU2005240846A1 (en) 2005-11-17
UY28883A1 (es) 2005-12-30
AP2006003772A0 (en) 2006-10-31
AR048939A1 (es) 2006-06-14
JP2008050365A (ja) 2008-03-06
IL178433A0 (en) 2007-02-11
PL1747210T3 (pl) 2010-11-30
BRPI0510664B1 (pt) 2020-04-07
NZ550769A (en) 2010-06-25
DK1747210T3 (da) 2010-09-27
KR100843848B1 (ko) 2008-07-03
KR20060133091A (ko) 2006-12-22
HK1100823A1 (en) 2007-09-28
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