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EA202191656A1 - Анти-il-36 антитела и способы их применения - Google Patents

Анти-il-36 антитела и способы их применения

Info

Publication number
EA202191656A1
EA202191656A1 EA202191656A EA202191656A EA202191656A1 EA 202191656 A1 EA202191656 A1 EA 202191656A1 EA 202191656 A EA202191656 A EA 202191656A EA 202191656 A EA202191656 A EA 202191656A EA 202191656 A1 EA202191656 A1 EA 202191656A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibodies
methods
application
proteins
binding
Prior art date
Application number
EA202191656A
Other languages
English (en)
Inventor
Цзинвэй Вивиан Ли
Жермена Фу-Келли
Луиза Шарф
Тина Тай
Ашка Пател
Шашанк Бхарилл
Эрик Эдвард Каррер
Original Assignee
23Эндми, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 23Эндми, Инк. filed Critical 23Эндми, Инк.
Publication of EA202191656A1 publication Critical patent/EA202191656A1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/245IL-1
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515Complete light chain, i.e. VL + CL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

В заявке описывают связывающие белки, например антитела и антигенсвязывающие фрагменты, которые специфически связываются с цитокинами IL-36 человека, а именно IL-36, IL-36 и/или IL-36, и блокируют стимулируемые IL-36 сигнальные пути. Также описывают композиции, содержащие такие белки, и способы получения и применения таких связывающих белков.
EA202191656A 2018-12-21 2019-12-19 Анти-il-36 антитела и способы их применения EA202191656A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862784316P 2018-12-21 2018-12-21
PCT/US2019/067435 WO2020132220A1 (en) 2018-12-21 2019-12-19 Anti-il-36 antibodies and methods of use thereof

Publications (1)

Publication Number Publication Date
EA202191656A1 true EA202191656A1 (ru) 2021-10-26

Family

ID=69187940

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202191656A EA202191656A1 (ru) 2018-12-21 2019-12-19 Анти-il-36 антитела и способы их применения

Country Status (19)

Country Link
US (2) US11884719B2 (ru)
EP (1) EP3898673A1 (ru)
JP (1) JP2022514950A (ru)
KR (1) KR20210107721A (ru)
CN (1) CN113454113A (ru)
AR (1) AR123405A1 (ru)
AU (1) AU2019405782A1 (ru)
BR (1) BR112021010374A2 (ru)
CA (1) CA3120474A1 (ru)
CL (1) CL2021001615A1 (ru)
CO (1) CO2021007882A2 (ru)
EA (1) EA202191656A1 (ru)
IL (1) IL283884A (ru)
MX (1) MX2021007589A (ru)
PE (1) PE20211295A1 (ru)
SG (1) SG11202106100VA (ru)
TW (1) TW202035460A (ru)
WO (1) WO2020132220A1 (ru)
ZA (1) ZA202103311B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ736535A (en) 2015-04-15 2024-08-30 Anaptysbio Inc Antibodies directed against interleukin 36 receptor (il-36r)
CA3183475A1 (en) * 2020-06-22 2021-12-30 Thomas Huber Anti-il-36 antibodies and methods of use thereof
WO2022150644A1 (en) * 2021-01-08 2022-07-14 Anaptysbio, Inc. Anti-interleukin 36 receptor (il-36r) therapy for acne
US20240084021A1 (en) * 2021-01-08 2024-03-14 Anaptysbio, Inc. Anti-interleukin 36 receptor (il-36r) therapy for hidradenitis suppurativa

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Also Published As

Publication number Publication date
WO2020132220A1 (en) 2020-06-25
BR112021010374A2 (pt) 2021-08-24
EP3898673A1 (en) 2021-10-27
MX2021007589A (es) 2021-12-10
AU2019405782A1 (en) 2021-06-17
CA3120474A1 (en) 2020-06-25
CO2021007882A2 (es) 2021-06-21
US11884719B2 (en) 2024-01-30
US20200199217A1 (en) 2020-06-25
PE20211295A1 (es) 2021-07-20
CN113454113A (zh) 2021-09-28
KR20210107721A (ko) 2021-09-01
ZA202103311B (en) 2022-10-26
SG11202106100VA (en) 2021-07-29
WO2020132220A9 (en) 2020-09-10
JP2022514950A (ja) 2022-02-16
CL2021001615A1 (es) 2021-11-26
US20240132582A1 (en) 2024-04-25
IL283884A (en) 2021-07-29
TW202035460A (zh) 2020-10-01
AR123405A1 (es) 2022-11-30

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