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EA202090839A1 - Новые платформы для костимуляции, новые конструкции car и другие улучшения для адаптивной клеточной терапии - Google Patents

Новые платформы для костимуляции, новые конструкции car и другие улучшения для адаптивной клеточной терапии

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Publication number
EA202090839A1
EA202090839A1 EA202090839A EA202090839A EA202090839A1 EA 202090839 A1 EA202090839 A1 EA 202090839A1 EA 202090839 A EA202090839 A EA 202090839A EA 202090839 A EA202090839 A EA 202090839A EA 202090839 A1 EA202090839 A1 EA 202090839A1
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EA
Eurasian Patent Office
Prior art keywords
new
costimulation
platforms
cellular therapy
car designs
Prior art date
Application number
EA202090839A
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English (en)
Inventor
Прит М. Чаудхари
Original Assignee
Юниверсити Оф Саутерн Калифорния
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Publication of EA202090839A1 publication Critical patent/EA202090839A1/ru

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Abstract

Изобретение предоставляет композиции и способ, которые способствуют адаптивной клеточной терапии. Данное изобретение предоставляет полинуклеотиды, векторы, системы и клетки, содержащие химерные антигенные рецепторы (CAR), синтетические иммунные рецепторы (SIR) и т.п., в сочетании со специфическими активаторами активности NF-B, таким образом, улучшая клеточную пролиферацию, экспрессию и снижая апоптоз, что улучшает персистенцию клеток при адаптивной клеточной терапии.
EA202090839A 2017-09-27 2018-09-27 Новые платформы для костимуляции, новые конструкции car и другие улучшения для адаптивной клеточной терапии EA202090839A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762564249P 2017-09-27 2017-09-27
PCT/US2018/053247 WO2019067805A1 (en) 2017-09-27 2018-09-27 NEW PLATFORMS FOR CO-STIMULATION, NEW CAR DESIGNS AND OTHER IMPROVEMENTS FOR ADOPTIVE CELL THERAPY

Publications (1)

Publication Number Publication Date
EA202090839A1 true EA202090839A1 (ru) 2021-02-04

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EA202090839A EA202090839A1 (ru) 2017-09-27 2018-09-27 Новые платформы для костимуляции, новые конструкции car и другие улучшения для адаптивной клеточной терапии

Country Status (14)

Country Link
US (1) US20230140802A1 (ru)
EP (1) EP3687553A4 (ru)
JP (2) JP2021500861A (ru)
KR (1) KR20200071079A (ru)
CN (1) CN111629734A (ru)
AU (1) AU2018338647A1 (ru)
BR (1) BR112020005938A2 (ru)
CA (1) CA3075806A1 (ru)
EA (1) EA202090839A1 (ru)
IL (1) IL273201A (ru)
MX (1) MX2020004185A (ru)
SG (1) SG11202002321YA (ru)
WO (1) WO2019067805A1 (ru)
ZA (2) ZA202002046B (ru)

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AU2018338647A1 (en) 2020-05-07
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EP3687553A1 (en) 2020-08-05
BR112020005938A2 (pt) 2020-11-17
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