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EA201990238A1 - ФОСФОРСОДЕРЖАЩИЕ ПРОЛЕКАРСТВА СТИМУЛЯТОРОВ sGC - Google Patents

ФОСФОРСОДЕРЖАЩИЕ ПРОЛЕКАРСТВА СТИМУЛЯТОРОВ sGC

Info

Publication number
EA201990238A1
EA201990238A1 EA201990238A EA201990238A EA201990238A1 EA 201990238 A1 EA201990238 A1 EA 201990238A1 EA 201990238 A EA201990238 A EA 201990238A EA 201990238 A EA201990238 A EA 201990238A EA 201990238 A1 EA201990238 A1 EA 201990238A1
Authority
EA
Eurasian Patent Office
Prior art keywords
stimulants
phosphorus
sgc
formula
pharmaceutically acceptable
Prior art date
Application number
EA201990238A
Other languages
English (en)
Other versions
EA039683B1 (ru
Inventor
Джеймс Эдвард Шеппек
Пол Аллан Ренхауэ
Ара Мермериан
Тимоти Клод Барден
Глен Роберт Ренни
Раджеш Р. Ийенгар
Такаси Накаи
Original Assignee
Сайклерион Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сайклерион Терапьютикс, Инк. filed Critical Сайклерион Терапьютикс, Инк.
Publication of EA201990238A1 publication Critical patent/EA201990238A1/ru
Publication of EA039683B1 publication Critical patent/EA039683B1/ru

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
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Abstract

Настоящая заявка на патент раскрывает соединения формулы I, показанной ниже, или их фармацевтически приемлемые соли, где J, n, R, R, R, R, R, m и X определены в настоящем документе.
EA201990238A 2016-07-07 2017-07-06 ФОСФОРСОДЕРЖАЩИЕ ПРОЛЕКАРСТВА СТИМУЛЯТОРОВ sGC EA039683B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662359419P 2016-07-07 2016-07-07
PCT/US2017/040809 WO2018009596A1 (en) 2016-07-07 2017-07-06 Phosphorus prodrugs of sgc stimulators

Publications (2)

Publication Number Publication Date
EA201990238A1 true EA201990238A1 (ru) 2019-07-31
EA039683B1 EA039683B1 (ru) 2022-02-28

Family

ID=59351139

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201990238A EA039683B1 (ru) 2016-07-07 2017-07-06 ФОСФОРСОДЕРЖАЩИЕ ПРОЛЕКАРСТВА СТИМУЛЯТОРОВ sGC

Country Status (13)

Country Link
US (3) US10927136B2 (ru)
EP (1) EP3481837B1 (ru)
JP (2) JP7016853B2 (ru)
KR (1) KR102513343B1 (ru)
CN (2) CN109476686B (ru)
AU (2) AU2017291826B2 (ru)
BR (1) BR112019000290B1 (ru)
CA (1) CA3029374A1 (ru)
EA (1) EA039683B1 (ru)
IL (1) IL263993B2 (ru)
MA (1) MA45592A (ru)
MX (2) MX2019000103A (ru)
WO (1) WO2018009596A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA45592A (fr) * 2016-07-07 2019-05-15 Ironwood Pharmaceuticals Inc Promédicaments à base de phosphore de stimulateurs de sgc
EP3820476A1 (en) 2018-07-11 2021-05-19 Cyclerion Therapeutics, Inc. Use of sgc stimulators for the treatment of mitochonrial disorders
CN114377149B (zh) * 2021-12-14 2023-11-10 西北工业大学 一种Mn基可降解MOF纳米反应器及其制备方法和应用
US12065408B2 (en) * 2022-11-07 2024-08-20 Virginia Commonwealth Univeristy Benzaldehyde compounds with direct polymer destabilizing effects to treat sickle cell disease
CN116478309B (zh) * 2023-05-19 2024-05-17 青海大学 锁阳精多糖、锁阳多糖化合物及制备方法和应用

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