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EA201891211A1 - Ингибиторы cxcr2 - Google Patents

Ингибиторы cxcr2

Info

Publication number
EA201891211A1
EA201891211A1 EA201891211A EA201891211A EA201891211A1 EA 201891211 A1 EA201891211 A1 EA 201891211A1 EA 201891211 A EA201891211 A EA 201891211A EA 201891211 A EA201891211 A EA 201891211A EA 201891211 A1 EA201891211 A1 EA 201891211A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cxcr2 inhibitors
cxcr2
inhibitors
compounds
Prior art date
Application number
EA201891211A
Other languages
English (en)
Other versions
EA035417B1 (ru
Inventor
Си Чэнь
Дин Р. Драголи
Джунфа Фан
Ярослав КАЛИСИАК
Манмохан Редди Лелети
Виенгкхам Малатонг
Джеффри МакМэхон
Хироко Танака
Цзюй Ян
Чао Юй
Пэнли Чжан
Венкат Мали
Original Assignee
Кемосентрикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кемосентрикс, Инк. filed Critical Кемосентрикс, Инк.
Publication of EA201891211A1 publication Critical patent/EA201891211A1/ru
Publication of EA035417B1 publication Critical patent/EA035417B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Описаны соединения в качестве ингибиторов CXCR2, имеющие структуру
EA201891211A 2015-11-19 2016-11-17 Ингибиторы cxcr2 EA035417B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562257529P 2015-11-19 2015-11-19
PCT/US2016/062427 WO2017087610A1 (en) 2015-11-19 2016-11-17 Inhibitors of cxcr2

Publications (2)

Publication Number Publication Date
EA201891211A1 true EA201891211A1 (ru) 2018-12-28
EA035417B1 EA035417B1 (ru) 2020-06-10

Family

ID=58717757

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891211A EA035417B1 (ru) 2015-11-19 2016-11-17 Ингибиторы cxcr2

Country Status (19)

Country Link
US (4) US9809581B2 (ru)
EP (1) EP3377059B1 (ru)
JP (1) JP6901479B2 (ru)
CN (1) CN108601766B (ru)
AR (1) AR106757A1 (ru)
AU (1) AU2016355654B2 (ru)
BR (1) BR112018010118B1 (ru)
CA (1) CA3005737C (ru)
DK (1) DK3377059T3 (ru)
EA (1) EA035417B1 (ru)
ES (1) ES2841912T3 (ru)
IL (1) IL259354B (ru)
MX (1) MX2018006148A (ru)
PL (1) PL3377059T3 (ru)
PT (1) PT3377059T (ru)
SG (1) SG11201804136SA (ru)
TW (1) TWI724056B (ru)
WO (1) WO2017087610A1 (ru)
ZA (1) ZA201803436B (ru)

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TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
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CN112274511B (zh) * 2019-07-22 2024-04-02 正大天晴药业集团股份有限公司 用于治疗移植物抗宿主病的喹啉衍生物
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CN113018438B (zh) * 2019-12-24 2022-06-17 四川大学 Cxcr2抑制剂在制备治疗鼻咽癌的药物中的用途
CN114929225B (zh) * 2020-01-19 2024-06-28 正大天晴药业集团股份有限公司 用于治疗类风湿性关节炎的喹啉衍生物
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Publication number Publication date
AU2016355654A1 (en) 2018-06-14
BR112018010118B1 (pt) 2023-10-31
MX2018006148A (es) 2019-06-12
US20220009911A1 (en) 2022-01-13
US20170144996A1 (en) 2017-05-25
EP3377059A4 (en) 2019-03-20
WO2017087610A1 (en) 2017-05-26
IL259354A (en) 2018-07-31
SG11201804136SA (en) 2018-06-28
EP3377059B1 (en) 2020-10-21
TW201720816A (zh) 2017-06-16
BR112018010118A2 (pt) 2018-11-21
US10370363B2 (en) 2019-08-06
KR20180100556A (ko) 2018-09-11
US20180170916A1 (en) 2018-06-21
US9809581B2 (en) 2017-11-07
EP3377059A1 (en) 2018-09-26
AR106757A1 (es) 2018-02-14
ES2841912T3 (es) 2021-07-12
US11040960B2 (en) 2021-06-22
CA3005737A1 (en) 2017-05-26
CN108601766A (zh) 2018-09-28
IL259354B (en) 2021-05-31
US20200140418A1 (en) 2020-05-07
PT3377059T (pt) 2021-01-11
CN108601766B (zh) 2022-05-13
NZ742819A (en) 2024-03-22
JP2018534329A (ja) 2018-11-22
DK3377059T3 (da) 2021-01-11
CA3005737C (en) 2023-09-12
EA035417B1 (ru) 2020-06-10
AU2016355654B2 (en) 2021-09-30
TWI724056B (zh) 2021-04-11
ZA201803436B (en) 2021-01-27
PL3377059T3 (pl) 2021-05-17
US11945805B2 (en) 2024-04-02
JP6901479B2 (ja) 2021-07-14

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