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EA201691492A1 - Диарильные макроциклы в качестве модуляторов протеинкиназ - Google Patents

Диарильные макроциклы в качестве модуляторов протеинкиназ

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Publication number
EA201691492A1
EA201691492A1 EA201691492A EA201691492A EA201691492A1 EA 201691492 A1 EA201691492 A1 EA 201691492A1 EA 201691492 A EA201691492 A EA 201691492A EA 201691492 A EA201691492 A EA 201691492A EA 201691492 A1 EA201691492 A1 EA 201691492A1
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EA
Eurasian Patent Office
Prior art keywords
diarylic
proteinkinase
modulators
macro cycles
macro
Prior art date
Application number
EA201691492A
Other languages
English (en)
Other versions
EA031863B1 (ru
Inventor
Цзинжун Джин Цуй
Ишань Ли
Эван В. Роджерс
Даюн Чжай
Original Assignee
ТиПи ТЕРАПЬЮТИКС, ИНК.
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Application filed by ТиПи ТЕРАПЬЮТИКС, ИНК. filed Critical ТиПи ТЕРАПЬЮТИКС, ИНК.
Publication of EA201691492A1 publication Critical patent/EA201691492A1/ru
Publication of EA031863B1 publication Critical patent/EA031863B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)

Abstract

Данное изобретение относится к определенным диарильным макроциклическим соединениям, фармацевтическим композициям, содержащим их, и к способам их применения, включая способы лечения рака, боли, неврологических заболеваний, аутоимунных заболеваний и воспаления.
EA201691492A 2014-01-24 2015-01-23 Диарильные макроциклы в качестве модуляторов протеинкиназ EA031863B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461931506P 2014-01-24 2014-01-24
US201462049326P 2014-09-11 2014-09-11
US201562106301P 2015-01-22 2015-01-22
PCT/US2015/012597 WO2015112806A2 (en) 2014-01-24 2015-01-23 Diaryl macrocycles as modulators of protein kinases

Publications (2)

Publication Number Publication Date
EA201691492A1 true EA201691492A1 (ru) 2017-06-30
EA031863B1 EA031863B1 (ru) 2019-03-29

Family

ID=53682127

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201892241A EA201892241A1 (ru) 2014-01-24 2015-01-23 Диарильные макроциклы в качестве модуляторов протеинкиназ
EA201691492A EA031863B1 (ru) 2014-01-24 2015-01-23 Диарильные макроциклы в качестве модуляторов протеинкиназ

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201892241A EA201892241A1 (ru) 2014-01-24 2015-01-23 Диарильные макроциклы в качестве модуляторов протеинкиназ

Country Status (32)

Country Link
US (6) US9714258B2 (ru)
EP (6) EP4338739A3 (ru)
JP (5) JP6490713B2 (ru)
KR (1) KR102402179B1 (ru)
CN (3) CN110317213B (ru)
AP (1) AP2016009383A0 (ru)
AU (2) AU2015209239B2 (ru)
CA (1) CA2936079C (ru)
CL (1) CL2016001876A1 (ru)
CY (1) CY1121850T1 (ru)
DK (3) DK3097107T3 (ru)
EA (2) EA201892241A1 (ru)
ES (3) ES2976459T3 (ru)
FI (1) FI3636649T3 (ru)
HK (1) HK1231407A1 (ru)
HR (3) HRP20240503T1 (ru)
HU (3) HUE066590T2 (ru)
IL (2) IL246860B (ru)
LT (3) LT3636649T (ru)
MX (2) MX2016009588A (ru)
MY (1) MY193524A (ru)
NZ (2) NZ722375A (ru)
PE (1) PE20160931A1 (ru)
PH (1) PH12016501463A1 (ru)
PL (3) PL3572416T3 (ru)
PT (3) PT3097107T (ru)
RS (3) RS63829B1 (ru)
SG (2) SG11201605929RA (ru)
SI (3) SI3097107T1 (ru)
UA (1) UA121206C2 (ru)
WO (1) WO2015112806A2 (ru)
ZA (2) ZA201604654B (ru)

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