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BR112022012684A2 - Compostos cíclicos e métodos de uso dos mesmos - Google Patents

Compostos cíclicos e métodos de uso dos mesmos

Info

Publication number
BR112022012684A2
BR112022012684A2 BR112022012684A BR112022012684A BR112022012684A2 BR 112022012684 A2 BR112022012684 A2 BR 112022012684A2 BR 112022012684 A BR112022012684 A BR 112022012684A BR 112022012684 A BR112022012684 A BR 112022012684A BR 112022012684 A2 BR112022012684 A2 BR 112022012684A2
Authority
BR
Brazil
Prior art keywords
methods
compounds
cyclic compounds
formula
pharmaceutically acceptable
Prior art date
Application number
BR112022012684A
Other languages
English (en)
Inventor
FENG Shulu
LAWRENZ Morgan
Krilov Goran
Placzek Andrew
Nie Zhe
TRZOSS Lynnie
Trzoss Michael
Tang Haifeng
Rachel Lagiakos H
Original Assignee
Schroedinger Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schroedinger Inc filed Critical Schroedinger Inc
Publication of BR112022012684A2 publication Critical patent/BR112022012684A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPOSTOS CÍCLICOS E MÉTODOS PARA USÁ-LOS. O presente pedido refere-se a compostos de Fórmula (I), conforme definido neste documento, e seus sais farmaceuticamente aceitáveis. O presente pedido também descreve uma composição farmacêutica compreendendo um composto de Fórmula (I), e seus sais farmaceuticamente aceitáveis, e métodos de utilização dos compostos e composições para o tratamento de doenças, tais como câncer, distúrbios autoimunes e distúrbios inflamatórios.
BR112022012684A 2019-12-27 2020-12-24 Compostos cíclicos e métodos de uso dos mesmos BR112022012684A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962954262P 2019-12-27 2019-12-27
US202063040582P 2020-06-18 2020-06-18
US202063119521P 2020-11-30 2020-11-30
PCT/US2020/066999 WO2021134004A1 (en) 2019-12-27 2020-12-24 Cyclic compounds and methods of using same

Publications (1)

Publication Number Publication Date
BR112022012684A2 true BR112022012684A2 (pt) 2023-03-07

Family

ID=74206185

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022012684A BR112022012684A2 (pt) 2019-12-27 2020-12-24 Compostos cíclicos e métodos de uso dos mesmos

Country Status (13)

Country Link
US (1) US20240018157A1 (pt)
EP (1) EP4081526A1 (pt)
JP (2) JP2023509886A (pt)
KR (1) KR20220123023A (pt)
CN (1) CN114945571A (pt)
AU (1) AU2020413333A1 (pt)
BR (1) BR112022012684A2 (pt)
CA (1) CA3161339A1 (pt)
CL (1) CL2022001741A1 (pt)
IL (1) IL294214A (pt)
MX (1) MX2022007171A (pt)
TW (1) TW202136270A (pt)
WO (1) WO2021134004A1 (pt)

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WO2023051759A1 (zh) * 2021-09-30 2023-04-06 上海拓界生物医药科技有限公司 三环化合物及其制备方法
TW202342032A (zh) 2022-02-02 2023-11-01 日商小野藥品工業股份有限公司 含有ｍａｌｔ１抑制劑作為有效成分的癌治療劑
WO2024020534A2 (en) * 2022-07-22 2024-01-25 Schrödinger, Inc. Cyclic compounds and methods of using same
WO2024133859A1 (en) * 2022-12-23 2024-06-27 Janssen Pharmaceutica Nv Malt1 inhibitors

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Also Published As

Publication number Publication date
AU2020413333A1 (en) 2022-06-16
IL294214A (en) 2022-08-01
WO2021134004A1 (en) 2021-07-01
CL2022001741A1 (es) 2023-01-27
TW202136270A (zh) 2021-10-01
JP2023509886A (ja) 2023-03-10
US20240018157A1 (en) 2024-01-18
MX2022007171A (es) 2022-08-22
CN114945571A (zh) 2022-08-26
EP4081526A1 (en) 2022-11-02
KR20220123023A (ko) 2022-09-05
CA3161339A1 (en) 2021-07-01
JP2024023699A (ja) 2024-02-21

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