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EA201592269A1 - Способы и композиции для снижения иммуносупрессии опухолевыми клетками - Google Patents

Способы и композиции для снижения иммуносупрессии опухолевыми клетками

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Publication number
EA201592269A1
EA201592269A1 EA201592269A EA201592269A EA201592269A1 EA 201592269 A1 EA201592269 A1 EA 201592269A1 EA 201592269 A EA201592269 A EA 201592269A EA 201592269 A EA201592269 A EA 201592269A EA 201592269 A1 EA201592269 A1 EA 201592269A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
compositions
immunosupression
reducing
tumor cells
Prior art date
Application number
EA201592269A
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English (en)
Other versions
EA035475B1 (ru
Inventor
Кай В. Вучерпфенниг
Гленн Дранофф
Пэнхой Чжоу
Доналд Шэффер
Нир Хакохен
Харви И. Кэнтор
Диана Альварес Ариас
Original Assignee
Дана-Фарбер Кэнсер Инститьют, Инк.
ДЗЕ ДЖЕНЕРАЛ ХОСПИТАЛ КОРПОРЕЙШН д/б/а МАССАЧУСЕТС ДЖЕНЕРАЛ ХОСПИТАЛ
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Application filed by Дана-Фарбер Кэнсер Инститьют, Инк., ДЗЕ ДЖЕНЕРАЛ ХОСПИТАЛ КОРПОРЕЙШН д/б/а МАССАЧУСЕТС ДЖЕНЕРАЛ ХОСПИТАЛ filed Critical Дана-Фарбер Кэнсер Инститьют, Инк.
Publication of EA201592269A1 publication Critical patent/EA201592269A1/ru
Publication of EA035475B1 publication Critical patent/EA035475B1/ru

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Abstract

Настоящее изобретение отчасти относится к способам обнаружения мишеней для иммунотерапии in vivo, к терапевтическим композициям (например, мшРНК, иммунореактивные клетки, экспрессирующие мшРНК и/или химерные рецепторы антигенов (CAR)) и к способам их применения.
EA201592269A 2013-06-10 2014-06-10 Способы и композиции для снижения иммуносупрессии опухолевыми клетками EA035475B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361833298P 2013-06-10 2013-06-10
US201361921303P 2013-12-27 2013-12-27
US201461929821P 2014-01-21 2014-01-21
PCT/US2014/041739 WO2014201021A2 (en) 2013-06-10 2014-06-10 Methods and compositions for reducing immunosupression by tumor cells

Publications (2)

Publication Number Publication Date
EA201592269A1 true EA201592269A1 (ru) 2016-05-31
EA035475B1 EA035475B1 (ru) 2020-06-23

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EA201592269A EA035475B1 (ru) 2013-06-10 2014-06-10 Способы и композиции для снижения иммуносупрессии опухолевыми клетками

Country Status (11)

Country Link
US (4) US9944931B2 (ru)
EP (2) EP3008173B1 (ru)
JP (3) JP6546160B2 (ru)
KR (3) KR20230005422A (ru)
CN (1) CN105431524B (ru)
AU (2) AU2014278323B2 (ru)
CA (2) CA2912389C (ru)
EA (1) EA035475B1 (ru)
ES (1) ES2897579T3 (ru)
MX (2) MX2015016963A (ru)
WO (1) WO2014201021A2 (ru)

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AU2017248121B2 (en) * 2016-04-08 2022-07-21 Adaptimmune Limited T cell receptors
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