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EA201590849A1 - Композиции, способы и применения для лечения диабета и связанных состояний посредством контроля уровня глюкозы крови - Google Patents

Композиции, способы и применения для лечения диабета и связанных состояний посредством контроля уровня глюкозы крови

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Publication number
EA201590849A1
EA201590849A1 EA201590849A EA201590849A EA201590849A1 EA 201590849 A1 EA201590849 A1 EA 201590849A1 EA 201590849 A EA201590849 A EA 201590849A EA 201590849 A EA201590849 A EA 201590849A EA 201590849 A1 EA201590849 A1 EA 201590849A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions
methods
diabetes
blood glucose
control
Prior art date
Application number
EA201590849A
Other languages
English (en)
Other versions
EA031798B1 (ru
Inventor
Даниель Коэн
Илья Чумаков
Сергей Набирошкин
Родольф Аж
Original Assignee
Фарнекст
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фарнекст filed Critical Фарнекст
Publication of EA201590849A1 publication Critical patent/EA201590849A1/ru
Publication of EA031798B1 publication Critical patent/EA031798B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Настоящее изобретение относится к композициям и способам для регуляции гликемии у млекопитающего, нуждающегося в этом. Настоящее изобретение относится к композициям и способам для лечения заболевания диабета и связанных расстройств. В частности, настоящее изобретение относится к новой терапии или комбинированной терапии диабета и связанных расстройств на основе композиций, контролирующих уровень глюкозы крови.
EA201590849A 2012-10-30 2013-10-30 Применение ифенпродила для лечения диабета EA031798B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261720156P 2012-10-30 2012-10-30
EP12306354.7A EP2727587A1 (en) 2012-10-30 2012-10-30 Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level
PCT/EP2013/072728 WO2014068007A1 (en) 2012-10-30 2013-10-30 Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level

Publications (2)

Publication Number Publication Date
EA201590849A1 true EA201590849A1 (ru) 2015-11-30
EA031798B1 EA031798B1 (ru) 2019-02-28

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EA201590849A EA031798B1 (ru) 2012-10-30 2013-10-30 Применение ифенпродила для лечения диабета

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Country Link
US (2) US10092554B2 (ru)
EP (3) EP2727587A1 (ru)
JP (2) JP6387010B2 (ru)
KR (1) KR20150081323A (ru)
CN (2) CN104981240B (ru)
AU (2) AU2013340826B2 (ru)
BR (1) BR112015009702A2 (ru)
CA (1) CA2888576C (ru)
EA (1) EA031798B1 (ru)
ES (2) ES2757846T3 (ru)
HK (1) HK1214168A1 (ru)
IL (1) IL238283A0 (ru)
MX (1) MX2015005368A (ru)
NZ (1) NZ707139A (ru)
SG (2) SG10201801695XA (ru)
WO (1) WO2014068007A1 (ru)
ZA (1) ZA201503110B (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA031331B9 (ru) * 2012-03-01 2019-02-28 Фарнекст Комбинация акампросата, баклофена и рилузола для лечения амиотрофического бокового склероза и родственного заболевания
EP2890370B1 (en) 2012-08-31 2019-10-09 The Regents of the University of California Agents useful for treating obesity, diabetes and related disorders
US9897565B1 (en) 2012-09-11 2018-02-20 Aseko, Inc. System and method for optimizing insulin dosages for diabetic subjects
US9171343B1 (en) 2012-09-11 2015-10-27 Aseko, Inc. Means and method for improved glycemic control for diabetic patients
CN105188692A (zh) * 2013-03-29 2015-12-23 国立大学法人熊本大学 2型糖尿病治疗剂
PT2981269T (pt) 2013-04-04 2023-10-10 Boehringer Ingelheim Vetmedica Gmbh Tratamento de distúrbios metabólicos em animais equinos
EP3062782A1 (en) * 2013-10-30 2016-09-07 Pharnext Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level
BR112016011564B1 (pt) 2013-12-17 2021-02-09 Boehringer Ingelheim Vetmedica Gmbh usos de inibidores de sglt2 ou formas farmaceuticamente aceitáveis dos mesmos para o tratamento de distúrbios metabólicos em animais felinos
EP4234012A3 (en) 2014-01-23 2023-09-20 Boehringer Ingelheim Vetmedica GmbH Sglt2 inhibitors for treatment of metabolic disorders in canine animals
US9898585B2 (en) 2014-01-31 2018-02-20 Aseko, Inc. Method and system for insulin management
US9486580B2 (en) 2014-01-31 2016-11-08 Aseko, Inc. Insulin management
KR20160111013A (ko) 2014-02-11 2016-09-23 파넥스트 신경질환의 치료를 위한 바클로펜, 아캄프로세이트 및 중쇄 트리-글리세리드의 조합
MX2016012705A (es) 2014-04-01 2016-12-16 Boehringer Ingelheim Vetmedica Gmbh Tratamiento de trastornos metabolicos en animales equinos.
US9839644B2 (en) 2014-09-09 2017-12-12 ARKAY Therapeutics, LLC Formulations and methods for treatment of metabolic syndrome
NZ728804A (en) * 2014-09-25 2022-10-28 Boehringer Ingelheim Vetmedica Gmbh Combination treatment of sglt2 inhibitors and dopamine agonists for preventing metabolic disorders in equine animals
JP6989262B2 (ja) 2014-10-27 2022-01-05 アセコー インコーポレイテッド 皮下外来患者管理
US11081226B2 (en) 2014-10-27 2021-08-03 Aseko, Inc. Method and controller for administering recommended insulin dosages to a patient
CN104434952B (zh) * 2014-12-08 2017-10-24 成都恒瑞制药有限公司 一种治疗糖尿病的药物组合物及其制备方法
CN105055413A (zh) * 2015-07-23 2015-11-18 上海市第六人民医院 一种小檗碱和瑞格列奈的药物组合物
US9886556B2 (en) 2015-08-20 2018-02-06 Aseko, Inc. Diabetes management therapy advisor
KR102659761B1 (ko) 2015-08-27 2024-04-24 베링거잉겔하임베트메디카게엠베하 Sglt-2 억제제를 포함하는 액상 약제학적 조성물
CA3136665A1 (en) * 2019-04-12 2020-10-15 Sdg, Inc. Lipid-based nanoparticles and use of same in optimized insulin dosing regimens
CN115397414A (zh) * 2020-02-07 2022-11-25 株式会社纽若梵提 包含利美尼定的用于治疗脆性x染色体综合征的组合物
JP2023544401A (ja) * 2020-10-01 2023-10-23 ザ・ジョンズ・ホプキンス・ユニバーシティ Ｂｃｇベースのワクチン組成物およびその使用方法
CN112294827B (zh) * 2020-11-12 2021-12-24 四川大学华西医院 5-胆甾烯 -3β-醇硫酸酯盐的用途
EP4100022A4 (en) 2021-04-09 2023-08-09 Peking University ARNSI, MEDICAL COMPOSITIONS AND METHODS FOR TREATING DIABETES USING THE SAME
WO2022225984A1 (en) * 2021-04-19 2022-10-27 Spruce Health Sciences Inc. Nutritional supplement for regulating blood sugar

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2314719A1 (fr) * 1975-04-11 1977-01-14 Roussel Uclaf Nouveau medicament notamment diuretique
IT1157365B (it) * 1977-10-24 1987-02-11 Sandoz Ag Medicamenti per trattare l'obesita' o ridurre il peso del corpo
US5019591A (en) * 1989-02-17 1991-05-28 Pennsylvania Research Corporation Method for treating retinopathy and other small vessel disorders associated with diabetes
JPH059114A (ja) * 1990-08-29 1993-01-19 Takeda Chem Ind Ltd 糖尿病性合併症の予防・治療剤
US20030095925A1 (en) * 1997-10-01 2003-05-22 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders
JP4821037B2 (ja) 2000-08-25 2011-11-24 富士通株式会社 ラマン増幅を用いた光増幅器およびラマン励起光源
SI1385548T1 (sl) * 2001-01-26 2007-10-31 Schering Corp Kombinacije zaviralca(-ev) absorpcije sterola s kardiovaskularnim(-i) sredstvom(-i) za zdravljenje vaskularnih obolenj
US20030162754A1 (en) * 2001-12-17 2003-08-28 Tufts University Use of GABA and GABAB agonists
WO2003063846A2 (en) * 2002-01-30 2003-08-07 Pharmacia Corporation Aldosterone receptor antagonist and alpha-adrenergic modulating agent combination therapy for prevention or treatment of cardiovascular conditions
AU2003251734A1 (en) * 2002-07-25 2004-02-16 Pharmacia Italia S.P.A. Nicergoline, mmdl and mdl for the treatment of neurodegenerative disorders of the retina and optic nerve
EP1725226A2 (en) * 2004-03-17 2006-11-29 Sosei R&D Ltd. The treatment of inflammatory disorders and pain using beta-aminoalcohols
MX2007014088A (es) * 2005-05-10 2008-02-07 Fournier Lab Sa Uso novedoso de los agonistas del receptor x hepatico.
EP1884513A4 (en) * 2005-05-23 2010-04-28 Japan Tobacco Inc PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME
GB2432526A (en) * 2005-11-24 2007-05-30 Arakis Ltd Use of ifenprodil for the treatment of ophthalmic diseases
US20090181976A1 (en) * 2006-02-28 2009-07-16 Buschmann Helmut H Use of Compounds Binding to the Sigma Receptor for the Treatment of Metabolic Syndrome
EP1829534A1 (en) * 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Use of compounds binding to the sigma receptor for the treatment of metabolic syndrome
US20080213362A1 (en) * 2007-02-02 2008-09-04 Lawrence Solomon Compositions and methods using torsemide
WO2008112167A1 (en) * 2007-03-09 2008-09-18 Indigene Pharmaceuticals Inc. Combination of metformin r-(+) lipoate and antihypertensive agents for the treatment of diabetic hyperglycemia and diabetic complications
WO2008141189A1 (en) * 2007-05-09 2008-11-20 Elixir Pharmaceuticals, Inc. Ghrelin modulating compounds and combinations thereof
CA2697057A1 (en) * 2007-08-22 2009-02-26 Gilead Colorado, Inc. Therapy for complications of diabetes
JP5685550B2 (ja) * 2009-02-13 2015-03-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｓｇｌｔ２阻害剤、ｄｐｐ−ｉｖ阻害剤、更に必要により抗糖尿病薬を含む医薬組成物及びその使用
UA115968C2 (uk) * 2011-03-01 2018-01-25 Фарнекст Нові композиції для лікування неврологічних захворювань
JP2014531454A (ja) * 2011-09-21 2014-11-27 ギリアード サイエンシーズ， インコーポレイテッド グルカゴン分泌を減少させるナトリウムチャネルブロッカー
EA029157B1 (ru) * 2012-07-18 2018-02-28 Фарнекст Терапия макулярной дегенерации на основе баклофена и акампросата

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