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EA201100564A1 - Антипролиферативные соединения - Google Patents

Антипролиферативные соединения

Info

Publication number
EA201100564A1
EA201100564A1 EA201100564A EA201100564A EA201100564A1 EA 201100564 A1 EA201100564 A1 EA 201100564A1 EA 201100564 A EA201100564 A EA 201100564A EA 201100564 A EA201100564 A EA 201100564A EA 201100564 A1 EA201100564 A1 EA 201100564A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antiproliferative compounds
treatment
compounds
antiproliferative
excessive
Prior art date
Application number
EA201100564A
Other languages
English (en)
Inventor
Штеффен Штойрер
Петер Эттмайер
Андреас Мантоулидис
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40019293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201100564(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201100564A1 publication Critical patent/EA201100564A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В заявке описаны соединения общей формулы (1)в которой группы R-R, X, X, Xи Lопределены в п.1 формулы изобретения, которые применимы для лечения заболеваний, характеризующихся чрезмерной или аномальной пролиферацией клеток, и их применение для такого лечения.
EA201100564A 2008-09-29 2009-09-28 Антипролиферативные соединения EA201100564A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08165437 2008-09-29
PCT/EP2009/062551 WO2010034838A2 (en) 2008-09-29 2009-09-28 New chemical compounds

Publications (1)

Publication Number Publication Date
EA201100564A1 true EA201100564A1 (ru) 2011-12-30

Family

ID=40019293

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100564A EA201100564A1 (ru) 2008-09-29 2009-09-28 Антипролиферативные соединения

Country Status (20)

Country Link
US (1) US8778929B2 (ru)
EP (1) EP2350052B1 (ru)
JP (1) JP5603869B2 (ru)
KR (1) KR20110063574A (ru)
CN (1) CN102227421A (ru)
AR (1) AR073700A1 (ru)
AU (1) AU2009295855A1 (ru)
BR (1) BRPI0920608A2 (ru)
CA (1) CA2738448A1 (ru)
CL (1) CL2011000691A1 (ru)
CO (1) CO6351739A2 (ru)
EA (1) EA201100564A1 (ru)
EC (1) ECSP11010930A (ru)
IL (1) IL211744A0 (ru)
MA (1) MA32656B1 (ru)
MX (1) MX2011003292A (ru)
PE (1) PE20110294A1 (ru)
TW (1) TW201018670A (ru)
UY (1) UY32146A (ru)
WO (1) WO2010034838A2 (ru)

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TW201014860A (en) 2008-09-08 2010-04-16 Boehringer Ingelheim Int New chemical compounds
EA201100564A1 (ru) 2008-09-29 2011-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Антипролиферативные соединения
EP2398797B1 (en) 2009-02-17 2013-11-06 Boehringer Ingelheim International GmbH Pyrimido[5,4-d]pyrimidine derivatives for the inhibition of tyrosine kinases
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Also Published As

Publication number Publication date
KR20110063574A (ko) 2011-06-10
AU2009295855A1 (en) 2010-04-01
JP5603869B2 (ja) 2014-10-08
CL2011000691A1 (es) 2011-07-29
MX2011003292A (es) 2011-04-21
MA32656B1 (fr) 2011-09-01
AR073700A1 (es) 2010-11-24
CA2738448A1 (en) 2010-04-01
TW201018670A (en) 2010-05-16
IL211744A0 (en) 2011-06-30
BRPI0920608A2 (pt) 2019-09-24
US8778929B2 (en) 2014-07-15
PE20110294A1 (es) 2011-05-26
ECSP11010930A (es) 2011-04-29
EP2350052A2 (en) 2011-08-03
JP2012504114A (ja) 2012-02-16
WO2010034838A3 (en) 2010-11-18
CN102227421A (zh) 2011-10-26
UY32146A (es) 2010-04-30
WO2010034838A2 (en) 2010-04-01
EP2350052B1 (en) 2014-08-13
US20110312939A1 (en) 2011-12-22
CO6351739A2 (es) 2011-12-20

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