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EA201071089A1 - Производные хиназолина как модуляторы raf-киназы и способы их применения - Google Patents

Производные хиназолина как модуляторы raf-киназы и способы их применения

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Publication number
EA201071089A1
EA201071089A1 EA201071089A EA201071089A EA201071089A1 EA 201071089 A1 EA201071089 A1 EA 201071089A1 EA 201071089 A EA201071089 A EA 201071089A EA 201071089 A EA201071089 A EA 201071089A EA 201071089 A1 EA201071089 A1 EA 201071089A1
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EA
Eurasian Patent Office
Prior art keywords
methods
raf
hinazolin
derivatives
application
Prior art date
Application number
EA201071089A
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English (en)
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EA019350B1 (ru
Inventor
Санни Абрахам
Шрипад С. Бхагват
Брайан Т. Кэмпбелл
Ци Чао
Раффаэлла Фараони
Марк У. Холладэй
Эндилий Г. Лай
Мартин У. Роуботтом
Эдуардо Сетти
Келли Г. Спрэнкл
Original Assignee
Эмбит Байосайенсиз Корпорейшн
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Application filed by Эмбит Байосайенсиз Корпорейшн filed Critical Эмбит Байосайенсиз Корпорейшн
Publication of EA201071089A1 publication Critical patent/EA201071089A1/ru
Publication of EA019350B1 publication Critical patent/EA019350B1/ru

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    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
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    • A61K31/33Heterocyclic compounds
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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Abstract

Обеспечиваются соединения, композиции и способы для модулирования активности RAF-киназ, включая BRAF-киназу, и для лечения, предупреждения или уменьшения одного или большего числа симптомов болезней или нарушений, опосредованных RAF-киназами.
EA201071089A 2008-03-17 2009-03-17 Производные хиназолина как модуляторы raf-киназы и способы их применения EA019350B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6976308P 2008-03-17 2008-03-17
US11050808P 2008-10-31 2008-10-31
PCT/US2009/001659 WO2009117080A1 (en) 2008-03-17 2009-03-17 Quinazoline derivatives as raf kinase modulators and methods of use thereof

Publications (2)

Publication Number Publication Date
EA201071089A1 true EA201071089A1 (ru) 2011-04-29
EA019350B1 EA019350B1 (ru) 2014-03-31

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Application Number Title Priority Date Filing Date
EA201071089A EA019350B1 (ru) 2008-03-17 2009-03-17 Производные хиназолина как модуляторы raf-киназы и способы их применения

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Country Link
US (5) US8618289B2 (ru)
EP (3) EP2947072B1 (ru)
JP (1) JP5542793B2 (ru)
KR (2) KR101713501B1 (ru)
CN (2) CN106146484A (ru)
AU (1) AU2009226136B2 (ru)
BR (1) BRPI0906186A2 (ru)
CA (2) CA2972138A1 (ru)
DK (2) DK2268623T3 (ru)
EA (1) EA019350B1 (ru)
ES (2) ES2610989T3 (ru)
HK (2) HK1151525A1 (ru)
HU (2) HUE025197T2 (ru)
IL (1) IL207793A (ru)
MX (1) MX2010010172A (ru)
MY (1) MY161576A (ru)
NZ (1) NZ587907A (ru)
PL (2) PL2268623T3 (ru)
PT (2) PT2268623E (ru)
SG (2) SG10201608813PA (ru)
SI (2) SI2268623T1 (ru)
WO (1) WO2009117080A1 (ru)
ZA (1) ZA201006524B (ru)

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