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EA200970765A1 - 2-аминопиримидиновые модуляторы рецептора hгистамина - Google Patents

2-аминопиримидиновые модуляторы рецептора hгистамина

Info

Publication number
EA200970765A1
EA200970765A1 EA200970765A EA200970765A EA200970765A1 EA 200970765 A1 EA200970765 A1 EA 200970765A1 EA 200970765 A EA200970765 A EA 200970765A EA 200970765 A EA200970765 A EA 200970765A EA 200970765 A1 EA200970765 A1 EA 200970765A1
Authority
EA
Eurasian Patent Office
Prior art keywords
receptor
aminopyrimidine
modulators
histagamine
compounds
Prior art date
Application number
EA200970765A
Other languages
English (en)
Other versions
EA016133B1 (ru
Inventor
Хой Цай
Франк Чавез
Джеймс П. Эдвардс
Энн Е. Фитцджералд
Цзин Лю
Неелакандха С. Мани
Даниэль К. Винер
Мишель К. Риззолио
Брэд М. Савалль
Дебора М. Смит
Дженнифер Д. Венэйбл
Дзяньмэй Вэй
Рональд Л. Волин
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200970765A1 publication Critical patent/EA200970765A1/ru
Publication of EA016133B1 publication Critical patent/EA016133B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D498/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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  • Chemical & Material Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
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  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Описаны соединения 2-аминопиримидина, которые могут быть использованы в качестве модуляторов рецептора Н. Такие соединения могут использоваться в фармацевтических композициях и способах лечения заболеваний, нарушений и состояний, опосредуемых активностью рецептора Н, таких как аллергия, астма, аутоиммунные заболевания и зуд.
EA200970765A 2007-02-14 2008-02-14 2-аминопиримидиновые модуляторы рецептора нгистамина, способ их получения, фармацевтические композиции и способ их применения для модуляции рецептора hгистамина EA016133B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88979807P 2007-02-14 2007-02-14
PCT/US2008/001950 WO2008100565A1 (en) 2007-02-14 2008-02-14 2-aminopyrimidine modulators of the histamine h4 receptor

Publications (2)

Publication Number Publication Date
EA200970765A1 true EA200970765A1 (ru) 2009-12-30
EA016133B1 EA016133B1 (ru) 2012-02-28

Family

ID=39686377

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970765A EA016133B1 (ru) 2007-02-14 2008-02-14 2-аминопиримидиновые модуляторы рецептора нгистамина, способ их получения, фармацевтические композиции и способ их применения для модуляции рецептора hгистамина

Country Status (23)

Country Link
US (6) US7923451B2 (ru)
EP (2) EP2599386A1 (ru)
JP (1) JP5281586B2 (ru)
KR (1) KR20090110877A (ru)
CN (1) CN101668423B (ru)
AR (1) AR065354A1 (ru)
AU (1) AU2008216727B2 (ru)
BR (1) BRPI0807815A2 (ru)
CA (1) CA2678077A1 (ru)
CL (1) CL2008000467A1 (ru)
CO (1) CO6210771A2 (ru)
CR (1) CR11027A (ru)
EA (1) EA016133B1 (ru)
EC (1) ECSP099582A (ru)
GT (1) GT200900231A (ru)
IL (1) IL200335A0 (ru)
MX (1) MX2009008787A (ru)
NI (1) NI200900159A (ru)
NZ (1) NZ578977A (ru)
PE (1) PE20081776A1 (ru)
TW (1) TW200904437A (ru)
UY (1) UY30917A1 (ru)
WO (1) WO2008100565A1 (ru)

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US9944649B2 (en) 2014-05-01 2018-04-17 Novartis Ag Compounds and compositions as toll-like receptor 7 agonists
SG11201609981RA (en) 2014-06-04 2016-12-29 Thomas Helledays Stiftelse För Medicinsk Forskning Mth1 inhibitors for treatment of inflammatory and autoimmune conditions
AU2015268961B9 (en) 2014-06-04 2019-10-10 Thomas Helledays Stiftelse For Medicinsk Forskning MTH1 inhibitors for treatment of cancer
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