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EA200701758A1 - Замещённые арильные производные 1,4-пиразина - Google Patents

Замещённые арильные производные 1,4-пиразина

Info

Publication number
EA200701758A1
EA200701758A1 EA200701758A EA200701758A EA200701758A1 EA 200701758 A1 EA200701758 A1 EA 200701758A1 EA 200701758 A EA200701758 A EA 200701758A EA 200701758 A EA200701758 A EA 200701758A EA 200701758 A1 EA200701758 A1 EA 200701758A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrazine
aryl derivatives
replaced aryl
diseases associated
disorders
Prior art date
Application number
EA200701758A
Other languages
English (en)
Other versions
EA012874B1 (ru
Inventor
Патрик Роберт Верхоуст
Роберт Луис Хоффман
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200701758A1 publication Critical patent/EA200701758A1/ru
Publication of EA012874B1 publication Critical patent/EA012874B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)

Abstract

Изобретение относится к описанным соединениям формулы (I), а также их фармацевтически приемлемым солям, которые действуют в качестве антагонистов CRFи полезны в лечении расстройств и заболеваний, ассоциирующихся с рецепторами CRF, включая расстройства и заболевания, связанные с центральной нервной системой (ЦНС).
EA200701758A 2005-03-17 2006-03-06 Замещённые арильные производные 1,4-пиразина EA012874B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66291705P 2005-03-17 2005-03-17
PCT/IB2006/000564 WO2006114666A1 (en) 2005-03-17 2006-03-06 SUBSTITUTED ARYL 1,4-PYRAZlNE DERIVATIVES

Publications (2)

Publication Number Publication Date
EA200701758A1 true EA200701758A1 (ru) 2008-02-28
EA012874B1 EA012874B1 (ru) 2009-12-30

Family

ID=36617394

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701758A EA012874B1 (ru) 2005-03-17 2006-03-06 Замещённые арильные производные 1,4-пиразина

Country Status (26)

Country Link
US (1) US20060211710A1 (ru)
EP (1) EP1871763A1 (ru)
JP (1) JP2008533124A (ru)
KR (1) KR20070113294A (ru)
CN (1) CN101160304A (ru)
AP (1) AP2007004174A0 (ru)
AR (1) AR056279A1 (ru)
AU (1) AU2006238976A1 (ru)
BR (1) BRPI0606284A2 (ru)
CA (1) CA2601600C (ru)
CR (1) CR9436A (ru)
DO (1) DOP2006000056A (ru)
EA (1) EA012874B1 (ru)
GT (1) GT200600116A (ru)
IL (1) IL185997A0 (ru)
MA (1) MA29336B1 (ru)
MX (1) MX2007011423A (ru)
NL (1) NL1031384C2 (ru)
NO (1) NO20075209L (ru)
PE (1) PE20061108A1 (ru)
TN (1) TNSN07355A1 (ru)
TW (1) TWI315670B (ru)
UA (1) UA86873C2 (ru)
UY (1) UY29418A1 (ru)
WO (1) WO2006114666A1 (ru)
ZA (1) ZA200707933B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2543484C2 (ru) * 2009-10-30 2015-03-10 Янссен Фармацевтика Нв Пиразины для использования в качестве модуляторов дельта-опиоидных рецепторов

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0525068D0 (en) 2005-12-08 2006-01-18 Novartis Ag Organic compounds
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
WO2011092290A1 (en) 2010-02-01 2011-08-04 Novartis Ag Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
US8835444B2 (en) 2010-02-02 2014-09-16 Novartis Ag Cyclohexyl amide derivatives as CRF receptor antagonists
JP2022062287A (ja) * 2019-02-27 2022-04-20 住友化学株式会社 ピリジルピラジン化合物の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5883105A (en) * 1996-04-03 1999-03-16 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5872136A (en) * 1996-04-03 1999-02-16 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US5880140A (en) * 1996-04-03 1999-03-09 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
PA8467401A1 (es) * 1998-02-17 2000-09-29 Pfizer Prod Inc Procedimiento para tratar la insuficiencia cardiaca
EP1218360B1 (en) * 1999-10-07 2008-05-28 Amgen Inc., Triazine kinase inhibitors
IL139197A0 (en) * 1999-10-29 2001-11-25 Pfizer Prod Inc Use of corticotropin releasing factor antagonists and related compositions
CN1231473C (zh) * 2000-02-16 2005-12-14 神经能质公司 取代的芳基吡嗪
ES2333586T3 (es) * 2001-11-21 2010-02-24 PHARMACIA & UPJOHN COMPANY LLC Derivados de aril 1,4-pirazina sustituidos.
US6992087B2 (en) * 2001-11-21 2006-01-31 Pfizer Inc Substituted aryl 1,4-pyrazine derivatives
WO2003091225A1 (en) * 2002-04-26 2003-11-06 Pharmacia & Upjohn Company Substituted pyrazine derivatives
CA2494975A1 (en) * 2002-09-12 2004-03-25 Pharmacia & Upjohn Company Llc Substituted 1,4-pyrazine derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2543484C2 (ru) * 2009-10-30 2015-03-10 Янссен Фармацевтика Нв Пиразины для использования в качестве модуляторов дельта-опиоидных рецепторов

Also Published As

Publication number Publication date
JP2008533124A (ja) 2008-08-21
CA2601600A1 (en) 2006-11-02
WO2006114666A8 (en) 2008-04-03
MA29336B1 (fr) 2008-03-03
TWI315670B (en) 2009-10-11
MX2007011423A (es) 2007-10-12
ZA200707933B (en) 2009-08-26
NL1031384C2 (nl) 2007-01-23
NO20075209L (no) 2007-10-11
GT200600116A (es) 2006-11-09
AP2007004174A0 (en) 2007-10-31
NL1031384A1 (nl) 2006-09-20
CN101160304A (zh) 2008-04-09
EP1871763A1 (en) 2008-01-02
US20060211710A1 (en) 2006-09-21
BRPI0606284A2 (pt) 2009-06-09
CR9436A (es) 2007-11-23
KR20070113294A (ko) 2007-11-28
DOP2006000056A (es) 2006-08-30
TNSN07355A1 (fr) 2008-12-31
WO2006114666A1 (en) 2006-11-02
UY29418A1 (es) 2006-10-31
AR056279A1 (es) 2007-10-03
IL185997A0 (en) 2008-01-20
AU2006238976A1 (en) 2006-11-02
CA2601600C (en) 2010-09-14
PE20061108A1 (es) 2006-10-13
EA012874B1 (ru) 2009-12-30
UA86873C2 (en) 2009-05-25
TW200700067A (en) 2007-01-01

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