Nothing Special   »   [go: up one dir, main page]

EA200600886A1 - Способ получения солей тиотропия, соли тиотропия, а также содержащие их лекарственные композиции - Google Patents

Способ получения солей тиотропия, соли тиотропия, а также содержащие их лекарственные композиции

Info

Publication number
EA200600886A1
EA200600886A1 EA200600886A EA200600886A EA200600886A1 EA 200600886 A1 EA200600886 A1 EA 200600886A1 EA 200600886 A EA200600886 A EA 200600886A EA 200600886 A EA200600886 A EA 200600886A EA 200600886 A1 EA200600886 A1 EA 200600886A1
Authority
EA
Eurasian Patent Office
Prior art keywords
salts
thiotropy
obtaining
dosage compositions
tiotropium
Prior art date
Application number
EA200600886A
Other languages
English (en)
Other versions
EA012326B1 (ru
Inventor
Рольф Банхольцер
Вальдемар Пфренгле
Петер Зигер
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200600886(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA200600886A1 publication Critical patent/EA200600886A1/ru
Publication of EA012326B1 publication Critical patent/EA012326B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В заявке описаны способ получения новых солей тиотропия формулы (I)в которой Х обозначает анион, эти новые соли тиотропия как таковые, содержащие их лекарственные композиции, а также их применение для получения лекарственного средства, предназначенного для лечения заболеваний дыхательных путей, прежде всего для лечения хронического обструктивного заболевания легких и астмы.
EA200600886A 2003-11-03 2004-10-29 Способ получения солей тиотропия, соли тиотропия, а также содержащие их лекарственные композиции EA012326B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03025075 2003-11-03
PCT/EP2004/012268 WO2005042526A1 (de) 2003-11-03 2004-10-29 Verfahren zur herstellung von tiotropiumsalze, tiotropiumsalze sowie arzneimitte lformulierungen diese enthaltend

Publications (2)

Publication Number Publication Date
EA200600886A1 true EA200600886A1 (ru) 2006-10-27
EA012326B1 EA012326B1 (ru) 2009-08-28

Family

ID=34530660

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600886A EA012326B1 (ru) 2003-11-03 2004-10-29 Способ получения солей тиотропия, соли тиотропия, а также содержащие их лекарственные композиции

Country Status (35)

Country Link
US (1) US8686148B2 (ru)
EP (3) EP2067779B9 (ru)
JP (1) JP5165244B2 (ru)
KR (1) KR20060117334A (ru)
CN (3) CN101407514B (ru)
AR (1) AR046317A1 (ru)
AT (1) ATE460414T1 (ru)
AU (1) AU2004285683C1 (ru)
BR (1) BRPI0416136A (ru)
CA (1) CA2544348A1 (ru)
CO (1) CO5690553A2 (ru)
CY (2) CY1110048T1 (ru)
DE (1) DE502004010885D1 (ru)
DK (2) DK1682541T3 (ru)
EA (1) EA012326B1 (ru)
ES (2) ES2422729T3 (ru)
HK (3) HK1099748A1 (ru)
HR (1) HRP20100149T1 (ru)
IL (1) IL175023A (ru)
ME (1) ME00361B (ru)
MX (1) MXPA06004697A (ru)
MY (1) MY143364A (ru)
NO (1) NO335814B1 (ru)
NZ (1) NZ547276A (ru)
PE (1) PE20050446A1 (ru)
PL (2) PL1682541T3 (ru)
PT (2) PT2067779E (ru)
RS (2) RS51758B (ru)
SG (1) SG137859A1 (ru)
SI (2) SI2067779T1 (ru)
TW (2) TWI435876B (ru)
UA (1) UA82413C2 (ru)
UY (1) UY28590A1 (ru)
WO (1) WO2005042526A1 (ru)
ZA (1) ZA200602342B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0416136A (pt) 2003-11-03 2007-01-02 Boehringer Ingelheim Int processo para a produção de sais de tiotrópio, sais de tiotrópio, bem como formulações de medicamentos contendo os mesmos
UA82414C2 (ru) * 2003-11-03 2008-04-10 Бёрингер Ингельхайм Интернациональ Гмбх Соли тиотропия, способ их получения, а также лекарственные композиции, которые их содержат
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
WO2006134021A2 (en) * 2005-06-15 2006-12-21 Boehringer Ingelheim International Gmbh Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
TW200738634A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt
MX2007009988A (es) 2005-12-19 2008-02-22 Sicor Inc Formas novedosas de bromuro de tiotropio y procesos para su preparacion.
CN101355937A (zh) * 2006-01-04 2009-01-28 贝林格尔·英格海姆国际有限公司 噻托铵盐在治疗中度持续性哮喘中的用途
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
CZ201241A3 (cs) 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
JP6042197B2 (ja) * 2012-12-11 2016-12-14 エア・ウォーター株式会社 肺障害治療剤

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2597329A (en) * 1947-08-06 1952-05-20 Merck & Co Inc Process for anion exchange of thiamin salts
US3551492A (en) * 1967-10-31 1970-12-29 Ciba Geigy Corp N,n'-diaminoalkoxy-benzyl-diamino-alkanes and the salts thereof
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
JPS6165885A (ja) 1984-09-07 1986-04-04 Tanabe Seiyaku Co Ltd 新規合成中間体及びその製法
AU591152B2 (en) 1985-07-30 1989-11-30 Glaxo Group Limited Devices for administering medicaments to patients
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
JP3302647B2 (ja) 1992-04-24 2002-07-15 小野薬品工業株式会社 フェニルアルカン酸エステルの塩酸塩、およびその製造方法
DE4318455A1 (de) 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
JP4023086B2 (ja) 1999-12-27 2007-12-19 和光純薬工業株式会社 スルホニウム塩化合物
US6908928B2 (en) * 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
SK287009B6 (sk) 2000-10-12 2009-09-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kryštalický monohydrát tiotropiumbromidu, spôsob jeho výroby, farmaceutický prostriedok s jeho obsahom a jeho použitie
UA75375C2 (en) 2000-10-12 2006-04-17 Boehringer Ingelheim Pharma Method for producing powdery preparations for inhaling
MEP40108A (en) 2000-10-12 2011-02-10 Boehringer Ingelheim Pharma Novel tiotropium-containing inhalation powder
CZ300794B6 (cs) * 2000-10-31 2009-08-12 Boehringer Ingelheim Pharma Gmbh And Co. Kg Farmaceutický prostredek a jeho použití jako inhalacní roztok
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020183292A1 (en) * 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
US20020193393A1 (en) * 2001-03-07 2002-12-19 Michel Pairet Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
DE10056104A1 (de) 2000-11-13 2002-05-23 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
DE10061877A1 (de) 2000-12-12 2002-06-13 Basf Ag Verfahren zur Herstellung wässriger Copolymerisatdispersionen von Copolymerisaten aus Kohlenmonoxid und wenigstens einer olefinisch ungesättigten Verbindung
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6506900B1 (en) * 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
DE10111843A1 (de) * 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von inflammatorischen Erkrankungen
US20020193394A1 (en) * 2001-03-13 2002-12-19 Bernd Disse Compounds for treating inflammatory diseases
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US6608055B2 (en) * 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
GB0203193D0 (en) 2002-02-11 2002-03-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
WO2003068233A1 (en) 2002-02-11 2003-08-21 Pfizer Limited Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases
US20030229227A1 (en) * 2002-03-16 2003-12-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
DK1494648T3 (da) 2002-04-04 2006-12-27 Boehringer Ingelheim Pharma Pulverpræparat til inhalation
UA80123C2 (en) 2002-04-09 2007-08-27 Boehringer Ingelheim Pharma Inhalation kit comprising inhalable powder of tiotropium
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
DE10216036A1 (de) 2002-04-11 2003-10-23 Boehringer Ingelheim Pharma Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz
US6908055B2 (en) * 2003-02-27 2005-06-21 Tandberg Data Asa System for extracting magnetic recording tape from a tape cartridge for engagement with a take-up reel
US20050030040A1 (en) * 2003-06-27 2005-02-10 Mitch Budniak Electrical testing device having voice annunciator
UA82414C2 (ru) 2003-11-03 2008-04-10 Бёрингер Ингельхайм Интернациональ Гмбх Соли тиотропия, способ их получения, а также лекарственные композиции, которые их содержат
BRPI0416136A (pt) 2003-11-03 2007-01-02 Boehringer Ingelheim Int processo para a produção de sais de tiotrópio, sais de tiotrópio, bem como formulações de medicamentos contendo os mesmos
US7968717B2 (en) * 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
SE0303270L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
WO2006134021A2 (en) * 2005-06-15 2006-12-21 Boehringer Ingelheim International Gmbh Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
CN102070630B (zh) 2013-04-17
US8686148B2 (en) 2014-04-01
CA2544348A1 (en) 2005-05-12
AU2004285683A1 (en) 2005-05-12
EP2067779A1 (de) 2009-06-10
CN101407514B (zh) 2013-05-29
EP2336126A1 (de) 2011-06-22
ES2422729T3 (es) 2013-09-13
IL175023A0 (en) 2006-08-20
ZA200602342B (en) 2007-06-27
HK1153409A1 (en) 2012-03-30
HK1099748A1 (en) 2007-08-24
EP2067779B9 (de) 2013-10-16
AR046317A1 (es) 2005-11-30
UA82413C2 (ru) 2008-04-10
PE20050446A1 (es) 2005-08-02
MXPA06004697A (es) 2006-07-05
PT1682541E (pt) 2010-04-14
SI1682541T1 (sl) 2010-06-30
KR20060117334A (ko) 2006-11-16
CY1110048T1 (el) 2015-01-14
PT2067779E (pt) 2013-07-25
JP2007509893A (ja) 2007-04-19
US20050131007A1 (en) 2005-06-16
JP5165244B2 (ja) 2013-03-21
EP2067779B1 (de) 2013-04-24
HK1129111A1 (en) 2009-11-20
TW201231465A (en) 2012-08-01
NO20061440L (no) 2006-07-12
DK2067779T3 (da) 2013-07-29
WO2005042526A1 (de) 2005-05-12
TWI363758B (en) 2012-05-11
UY28590A1 (es) 2005-06-30
ATE460414T1 (de) 2010-03-15
ES2342468T3 (es) 2010-07-07
NZ547276A (en) 2009-08-28
RS51758B (en) 2011-12-31
CN101407514A (zh) 2009-04-15
IL175023A (en) 2011-02-28
RS20060292A (en) 2008-08-07
DE502004010885D1 (de) 2010-04-22
SI2067779T1 (sl) 2013-08-30
PL2067779T3 (pl) 2013-09-30
TW200526653A (en) 2005-08-16
CN102070630A (zh) 2011-05-25
EP1682541B1 (de) 2010-03-10
AU2004285683C1 (en) 2011-09-08
AU2004285683B2 (en) 2011-04-21
EA012326B1 (ru) 2009-08-28
CN1882582A (zh) 2006-12-20
DK1682541T3 (da) 2010-06-28
PL1682541T3 (pl) 2010-08-31
MEP51308A (en) 2011-05-10
SG137859A1 (en) 2007-12-28
CY1114157T1 (el) 2016-08-31
ME00361B (me) 2011-10-10
HRP20100149T1 (hr) 2010-04-30
TWI435876B (zh) 2014-05-01
CO5690553A2 (es) 2006-10-31
CN100549010C (zh) 2009-10-14
MY143364A (en) 2011-04-29
EP1682541A1 (de) 2006-07-26
BRPI0416136A (pt) 2007-01-02
NO335814B1 (no) 2015-02-23

Similar Documents

Publication Publication Date Title
EA200500902A1 (ru) Порошковые лекарственные средства, содержащие соль тиотропия и ксинафоат салметерола
EA200200551A1 (ru) Новые содержащие тиотропий порошки для ингаляции
ATE330589T1 (de) Pharmazeutische zusammensetzung enthaltend resveratrol zur behandlung von entzündlichen erkrankungen der atemwege
EA200500715A1 (ru) Новые лекарственные средства для лечения хронического обструктивного заболевания лёгких
DE602005026007D1 (de) Opioide zur behandlung von chronisch-obstruktiver lungenerkrankung (copd)
CY1114157T1 (el) Αλατα του τιοτροπιου, μεθοδος για την παραγωγη τους και φαρμακευτικα σκευασματα που τα περιεχουν
ATE369353T1 (de) Medizinisch verwendbare arylethanolamin verbindungen
EA200401005A1 (ru) Дозированные ингаляторы под давлением, содержащие растворы бета-2-агонистов
EA200600854A1 (ru) Новые соли тиотропия, способ их получения, а также содержащие их лекарственные композиции
NO20032111L (no) Nye medikamentblandinger basert pa tiotropium-salter og pa salmeterol-salter
UA107578C2 (uk) Комбінована терапія при лікуванні діабету
EA200600853A1 (ru) Новый кристаллический ангидрат с антихолинергическим действием
EA200602016A1 (ru) ПОРОШКОВЫЕ КОМПОЗИЦИИ ДЛЯ ИНГАЛЯЦИИ, СОДЕРЖАЩИЕ ЭНАНТИОМЕРНОЧИСТЫЕ β-АГОНИСТЫ
NO20054767L (no) Sammensetninger omfattende apomorfin for inhalering i lunge
RU2010120806A (ru) Композиции для ингаляции, содержащие кислоту монтелукаст и ингибитор pde-4 или ингаляционный кортикостероид
EA200500864A1 (ru) Новый, содержащий тиотропий порошковый препарат для ингаляции
MXPA04002401A (es) Nuevos medicamentos para inhalacion.
JP2009506029A5 (ru)
DK1494648T3 (da) Pulverpræparat til inhalation
RU2010154194A (ru) Эфиры n-алкилкарбониламинокислот и n-алкилкарбониламинолактоны и их применение
DK1581224T3 (da) Tiotropiumholdig lægemiddelsammensætning til inhalation
WO2005007134A8 (de) Pulverformulierungen für die inhalation enthaltend ein neues anticholinergikum
RU2006120506A (ru) Способ лечения псориаза у детей
CY1113392T1 (el) Νεες κρυσταλλικες μορφες του βρωμιουχου τιοτροπιου

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM