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EA200300663A1 - Антагонисты cxcr3 - Google Patents

Антагонисты cxcr3

Info

Publication number
EA200300663A1
EA200300663A1 EA200300663A EA200300663A EA200300663A1 EA 200300663 A1 EA200300663 A1 EA 200300663A1 EA 200300663 A EA200300663 A EA 200300663A EA 200300663 A EA200300663 A EA 200300663A EA 200300663 A1 EA200300663 A1 EA 200300663A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inflammatory
diseases
applicable
treatment
compounds
Prior art date
Application number
EA200300663A
Other languages
English (en)
Other versions
EA007538B1 (ru
Inventor
Джулио К. Медина
Майкл Дж. Джонсон
Ан-Ронг Ли
Дживен Лиу
Алан Кси Хуанг
Лиушенг Жу
Эндрю П. Маркус
Original Assignee
Туларик Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Туларик Инк. filed Critical Туларик Инк.
Publication of EA200300663A1 publication Critical patent/EA200300663A1/ru
Publication of EA007538B1 publication Critical patent/EA007538B1/ru

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    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P17/00Drugs for dermatological disorders
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
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    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Pulmonology (AREA)
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  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Предложены соединения, композиции и способы, которые применимы при лечении воспалительных и иммунных состояний и заболеваний. В частности, изобретение относится к соединениям, которые модулируют экспрессию и/или функцию рецептора хемокина. Предложенные способы применимы для лечения воспалительных и иммунорегуляторных расстройств и заболеваний, таких как рассеянный склероз, ревматоидный артрит и диабет типа I.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300663A 2000-12-11 2001-12-11 Антагонисты cxcr3 EA007538B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25524100P 2000-12-11 2000-12-11
US29649901P 2001-06-06 2001-06-06
PCT/US2001/047850 WO2002083143A1 (en) 2000-12-11 2001-12-11 Cxcr3 antagonists

Publications (2)

Publication Number Publication Date
EA200300663A1 true EA200300663A1 (ru) 2004-06-24
EA007538B1 EA007538B1 (ru) 2006-10-27

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EA200300663A EA007538B1 (ru) 2000-12-11 2001-12-11 Антагонисты cxcr3

Country Status (19)

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US (3) US6964967B2 (ru)
EP (1) EP1343505A1 (ru)
JP (1) JP4259877B2 (ru)
KR (1) KR100883184B1 (ru)
CN (1) CN1575177A (ru)
AU (1) AU2001297717B2 (ru)
BR (1) BR0116096A (ru)
CA (1) CA2431553A1 (ru)
CZ (1) CZ20031910A3 (ru)
EA (1) EA007538B1 (ru)
HU (1) HUP0500880A2 (ru)
IL (2) IL156304A0 (ru)
MX (1) MXPA03005152A (ru)
NO (1) NO325450B1 (ru)
NZ (1) NZ526622A (ru)
PL (1) PL366311A1 (ru)
SK (1) SK8752003A3 (ru)
WO (1) WO2002083143A1 (ru)
ZA (1) ZA200304342B (ru)

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IL156304A (en) 2009-02-11
CZ20031910A3 (cs) 2003-12-17
ZA200304342B (en) 2005-08-31
NO325450B1 (no) 2008-05-05
AU2001297717B2 (en) 2006-02-23
BR0116096A (pt) 2005-10-18
US20020169159A1 (en) 2002-11-14
KR100883184B1 (ko) 2009-02-12
CN1575177A (zh) 2005-02-02
US6964967B2 (en) 2005-11-15
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CA2431553A1 (en) 2002-10-24
US7053215B2 (en) 2006-05-30

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