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EA199800378A1 - Новый способ получения фенилимидазолидиновых производных - Google Patents

Новый способ получения фенилимидазолидиновых производных

Info

Publication number
EA199800378A1
EA199800378A1 EA199800378A EA199800378A EA199800378A1 EA 199800378 A1 EA199800378 A1 EA 199800378A1 EA 199800378 A EA199800378 A EA 199800378A EA 199800378 A EA199800378 A EA 199800378A EA 199800378 A1 EA199800378 A1 EA 199800378A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
preparation
new process
hydrogen
alkyl
Prior art date
Application number
EA199800378A
Other languages
English (en)
Other versions
EA002658B1 (ru
Inventor
Рафаель Буше
Мишель Дельтиль
Даниель Гильмар
Филипп Макиевич
Original Assignee
Хехст Марион Руссель
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хехст Марион Руссель filed Critical Хехст Марион Руссель
Publication of EA199800378A1 publication Critical patent/EA199800378A1/ru
Publication of EA002658B1 publication Critical patent/EA002658B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение относится к способу получения соединений формулы (I)в которой Rи Rпредставляют собой, в частности, водород, циано, галоген или амино; Rпредставляет собой, в частности, водород или гидроксил алкил; Rи Rпредставляют собой, в частности, алкил, который может замещаться; X и Y представляют собой кислород или серу; отличающемуся тем, что получают продукт формулы (A), в которой W представляет собой атом галогена или производное гидантоина, которое участвует в различных реакциях с получением продуктов формулы (I), всех их изомеров и солей.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800378A 1995-11-16 1996-11-14 Способ получения фенилимидазолидиновых производных EA002658B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9513589A FR2741346B1 (fr) 1995-11-16 1995-11-16 Nouveau procede de preparation de derives phenylimidazolidine
PCT/FR1996/001794 WO1997018197A1 (fr) 1995-11-16 1996-11-14 Nouveau procede de preparation de derives phenylimidazolidine

Publications (2)

Publication Number Publication Date
EA199800378A1 true EA199800378A1 (ru) 1998-10-29
EA002658B1 EA002658B1 (ru) 2002-08-29

Family

ID=9484624

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800378A EA002658B1 (ru) 1995-11-16 1996-11-14 Способ получения фенилимидазолидиновых производных

Country Status (29)

Country Link
US (1) US6107488A (ru)
EP (1) EP0877738B1 (ru)
JP (1) JP2000500150A (ru)
KR (1) KR100466991B1 (ru)
CN (1) CN1131219C (ru)
AR (1) AR004965A1 (ru)
AT (1) ATE240300T1 (ru)
AU (1) AU718832B2 (ru)
BR (1) BR9611573A (ru)
CA (1) CA2235335A1 (ru)
CU (1) CU22890A3 (ru)
CZ (1) CZ144498A3 (ru)
DE (1) DE69628203T2 (ru)
DK (1) DK0877738T3 (ru)
EA (1) EA002658B1 (ru)
ES (1) ES2193271T3 (ru)
FR (1) FR2741346B1 (ru)
HU (1) HUP9904034A3 (ru)
IL (1) IL124382A0 (ru)
MX (1) MX9803730A (ru)
NO (1) NO316514B1 (ru)
PL (1) PL189697B1 (ru)
PT (1) PT877738E (ru)
SI (1) SI0877738T1 (ru)
TR (1) TR199800865T2 (ru)
TW (1) TW404942B (ru)
UA (1) UA67720C2 (ru)
WO (1) WO1997018197A1 (ru)
ZA (1) ZA969442B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1709193B1 (en) * 2003-12-19 2011-03-16 The Regents of The University of California Methods and materials for assessing prostate cancer therapies
AU2005232526B2 (en) * 2004-02-24 2011-06-23 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
FI2004181T6 (fi) 2006-03-27 2023-09-01 Androgeenireseptorin modulaattori eturauhassyövän ja androgeenireseptoriin liittyvien sairauksien hoitamiseksi
JP5350217B2 (ja) * 2006-03-29 2013-11-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ジアリールチオヒダントイン化合物
TW201716385A (zh) 2007-10-26 2017-05-16 加州大學董事會 二芳基乙內醯脲類化合物
EP2475366A1 (en) 2009-09-11 2012-07-18 Bayer Pharma Aktiengesellschaft Substituted (heteroarylmethyl) thiohydantoins as anticancer drugs
IN2012DN00777A (ru) 2009-09-15 2015-06-26 Mylan Group
KR101972719B1 (ko) 2010-02-16 2019-04-25 아라곤 파마슈티컬스, 인코포레이티드 안드로겐 수용체 조절제 및 이의 용도
BR112012030319A2 (pt) 2010-09-14 2016-08-09 Mylan Group copolímeros para composições de revestimentos sensíveis à radiação infravermelha próxima para placas de impressão litográfica térmicas de funcionamento positivo
EP3777845A1 (en) 2012-09-26 2021-02-17 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
CN111479560A (zh) 2017-10-16 2020-07-31 阿拉贡药品公司 用于治疗非转移性去势难治性前列腺癌的抗雄激素
CN108218784A (zh) * 2018-01-16 2018-06-29 吴江信凯医药科技有限公司 一种尼鲁米特的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4916937B1 (ru) * 1970-01-21 1974-04-25
JPS5136332B1 (ru) * 1970-12-09 1976-10-07
CH544491A (de) * 1971-03-16 1973-11-30 Ciba Geigy Ag Herbizides Mittel
MC1220A1 (fr) * 1977-10-28 1979-07-20 Hoffmann La Roche Nouveaux derives d'imidazolidine
JPS57197268A (en) * 1981-05-29 1982-12-03 Sumitomo Chem Co Ltd Substituted phenylhydantoin derivative, its preparation, and herbicide containing the same as active ingredient
JPS62298562A (ja) * 1986-06-17 1987-12-25 Nippon Kayaku Co Ltd ブロモアニリン類の製造法
FR2656302B1 (fr) * 1989-12-22 1992-05-07 Roussel Uclaf Nouveau procede de preparation de l'anandron et derives de l'anandron.
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.

Also Published As

Publication number Publication date
MX9803730A (es) 1998-11-30
ES2193271T3 (es) 2003-11-01
BR9611573A (pt) 1999-05-11
CZ144498A3 (cs) 1998-09-16
CA2235335A1 (fr) 1997-05-22
WO1997018197A1 (fr) 1997-05-22
CN1131219C (zh) 2003-12-17
AU718832B2 (en) 2000-04-20
DE69628203D1 (de) 2003-06-18
PL189697B1 (pl) 2005-09-30
CU22890A3 (es) 2004-01-23
IL124382A0 (en) 1998-12-06
US6107488A (en) 2000-08-22
ATE240300T1 (de) 2003-05-15
UA67720C2 (en) 2004-07-15
DE69628203T2 (de) 2004-02-05
JP2000500150A (ja) 2000-01-11
EP0877738A1 (fr) 1998-11-18
AU7577396A (en) 1997-06-05
NO982237D0 (no) 1998-05-15
EP0877738B1 (fr) 2003-05-14
ZA969442B (en) 1997-11-11
NO316514B1 (no) 2004-02-02
TR199800865T2 (xx) 1998-08-21
FR2741346B1 (fr) 1997-12-19
NO982237L (no) 1998-07-10
DK0877738T3 (da) 2003-09-08
HUP9904034A2 (hu) 2000-05-28
KR19990067639A (ko) 1999-08-25
PT877738E (pt) 2003-09-30
EA002658B1 (ru) 2002-08-29
CN1207732A (zh) 1999-02-10
FR2741346A1 (fr) 1997-05-23
TW404942B (en) 2000-09-11
KR100466991B1 (ko) 2005-04-06
HUP9904034A3 (en) 2001-08-28
PL326491A1 (en) 1998-09-28
AR004965A1 (es) 1999-04-07
SI0877738T1 (en) 2003-10-31

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Legal Events

Date Code Title Description
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU