DOP2018000287A - Método para producir derivado de difenilmetano - Google Patents
Método para producir derivado de difenilmetanoInfo
- Publication number
- DOP2018000287A DOP2018000287A DO2018000287A DO2018000287A DOP2018000287A DO P2018000287 A DOP2018000287 A DO P2018000287A DO 2018000287 A DO2018000287 A DO 2018000287A DO 2018000287 A DO2018000287 A DO 2018000287A DO P2018000287 A DOP2018000287 A DO P2018000287A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- difenylmethane
- producing
- synthesis route
- synthesis
- linear
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B51/00—Introduction of protecting groups or activating groups, not provided for in the preceding groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a un método mejorado para producir un derivado de difenilmetano que es eficaz como inhibidor del cotransportador de glucosa dependiente de sodio (SGLT), el método se lleva a cabo por medio de un método de síntesis convergente en el cual cada grupo principal se sintetiza por separado y luego se acopla. Como tal, en comparación con un método de síntesis lineal descrito en documentos existentes, la ruta de síntesis es compacta y el rendimiento puede aumentarse, y los factores de riesgo inherentes a la ruta de síntesis lineal pueden reducirse. Además, la forma cristalina del compuesto producido de acuerdo con el método tiene excelentes características fisicoquímicas y, por lo tanto, puede utilizarse de manera efectiva en campos como la fabricación farmacéutica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20160075910 | 2016-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2018000287A true DOP2018000287A (es) | 2019-03-31 |
Family
ID=60664449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2018000287A DOP2018000287A (es) | 2016-06-17 | 2018-12-17 | Método para producir derivado de difenilmetano |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US10640496B2 (es) |
| EP (2) | EP3473621B1 (es) |
| JP (4) | JP6763978B2 (es) |
| KR (2) | KR102233229B1 (es) |
| CN (2) | CN113651803B (es) |
| AU (1) | AU2017285813B2 (es) |
| BR (1) | BR112018076243A2 (es) |
| CA (2) | CA3081033C (es) |
| CL (1) | CL2018003645A1 (es) |
| CO (1) | CO2018014018A2 (es) |
| DK (2) | DK3473621T3 (es) |
| DO (1) | DOP2018000287A (es) |
| EC (1) | ECSP19000185A (es) |
| ES (2) | ES2898336T3 (es) |
| HR (1) | HRP20211670T8 (es) |
| HU (1) | HUE056428T2 (es) |
| MA (2) | MA44545B2 (es) |
| MX (2) | MX2018015647A (es) |
| MY (1) | MY203941A (es) |
| NZ (1) | NZ749398A (es) |
| PE (2) | PE20240590A1 (es) |
| PH (1) | PH12018550206A1 (es) |
| PL (2) | PL3663292T3 (es) |
| PT (2) | PT3473621T (es) |
| RS (1) | RS62550B1 (es) |
| SA (2) | SA518400666B1 (es) |
| SG (2) | SG11201811154QA (es) |
| SI (1) | SI3663292T1 (es) |
| TN (1) | TN2018000437A1 (es) |
| WO (1) | WO2017217792A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102011054773A1 (de) | 2011-10-25 | 2013-04-25 | Vb Autobatterie Gmbh & Co. Kgaa | Anschlusspol für einen Akkumulator, Akkumulatorgehäuse und Maschine zur Herstellung eines Anschlusspols |
| KR102307475B1 (ko) | 2018-08-13 | 2021-09-30 | 주식회사 대웅제약 | Sglt 저해제의 합성에 유용한 중간체의 제조 |
| CN112341416A (zh) * | 2019-08-09 | 2021-02-09 | 天津津艺医药科技发展有限责任公司 | 一种制备苯并含氧脂杂环衍生物的方法 |
| EP4112612A4 (en) | 2020-02-27 | 2024-04-03 | Daewoong Pharmaceutical Co., Ltd. | USEFUL INTERMEDIATE FOR SYNTHESIS OF SGLT INHIBITOR AND METHOD FOR PREPARING SGLT INHIBITOR USING SAME |
| MX2023002828A (es) | 2020-09-10 | 2023-03-17 | Daewoong Pharmaceutical Co Ltd | Metodo de sintesis para la preparacion de un intermedio de inhibidores de sglt. |
| CN112094253B (zh) * | 2020-09-10 | 2023-01-10 | 株式会社大熊制药 | 用于制备sglt抑制剂中间体的合成方法 |
| CN113200860B (zh) * | 2021-04-29 | 2024-07-30 | 爱斯特（成都）生物制药股份有限公司 | 一种sglt2抑制剂中间体的制备方法 |
| CN113801010A (zh) * | 2021-11-18 | 2021-12-17 | 山东诚创蓝海医药科技有限公司 | 一种5-溴-2-氯苯甲酸的制备方法 |
| CN113912487B (zh) * | 2021-11-23 | 2024-05-28 | 山东研峰新材料科技有限公司 | 一种2,5-双卤代苯甲酸的合成方法 |
| KR20230110001A (ko) | 2022-01-14 | 2023-07-21 | 주식회사 대웅제약 | Ssglt 저해제의 합성에 유용한 중간체의 제조 방법 |
| KR20240044194A (ko) * | 2022-09-28 | 2024-04-04 | 주식회사 대웅제약 | 이나보글리플로진의 신규한 공결정 |
| KR20240044190A (ko) * | 2022-09-28 | 2024-04-04 | 주식회사 대웅제약 | 이나보글리플로진의 신규한 결정형 및 이의 제조방법 |
| WO2024136385A1 (ko) | 2022-12-21 | 2024-06-27 | 주식회사 대웅테라퓨틱스 | 이나보글리플로진을 포함하는 점안제 형태의 약학 조성물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4966907A (en) * | 1988-08-12 | 1990-10-30 | Merck & Co., Inc. | 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis |
| PL1651658T5 (pl) * | 2003-08-01 | 2020-11-30 | Mitsubishi Tanabe Pharma Corporation | Nowe związki o działaniu inhibitującym transporter zależny od sodu |
| BRPI0813840A2 (pt) | 2007-07-26 | 2017-06-06 | Lexicon Pharmaceuticals Inc | métodos e compostos úteis para a preparação de inibidores de cotransportador 2 de glicose de sódio |
| KR20110041495A (ko) | 2008-07-30 | 2011-04-21 | 페레르 인터내쇼날 에스.에이. | 1,6-디하이드로-2ｈ-3-옥사-6-아자-ａｓ-인다세네 화합물 |
| US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
| WO2012041898A1 (en) * | 2010-09-29 | 2012-04-05 | Celon Pharma Sp. Z O.O. | Combination of sglt2 inhibitor and a sugar compound for the treatment of diabetes |
| EP2714032B1 (en) | 2011-06-01 | 2019-01-16 | Green Cross Corporation | Novel diphenylmethane derivatives as sglt2 inhibitors |
| US9340521B2 (en) * | 2013-03-18 | 2016-05-17 | Green Cross Corporation | Method for dual inhibition of SGLT1 and SGLT2 using diphenylmethane derivatives |
| FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
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2017
- 2017-06-15 WO PCT/KR2017/006271 patent/WO2017217792A1/ko active Application Filing
- 2017-06-15 SI SI201730944T patent/SI3663292T1/sl unknown
- 2017-06-15 DK DK17813615.6T patent/DK3473621T3/da active
- 2017-06-15 HR HRP20211670TT patent/HRP20211670T8/hr unknown
- 2017-06-15 DK DK20152959.1T patent/DK3663292T3/da active
- 2017-06-15 KR KR1020170075799A patent/KR102233229B1/ko active Protection Beyond IP Right Term
- 2017-06-15 MX MX2018015647A patent/MX2018015647A/es unknown
- 2017-06-15 SG SG11201811154QA patent/SG11201811154QA/en unknown
- 2017-06-15 EP EP17813615.6A patent/EP3473621B1/en active Active
- 2017-06-15 PT PT17813615T patent/PT3473621T/pt unknown
- 2017-06-15 PE PE2023002240A patent/PE20240590A1/es unknown
- 2017-06-15 AU AU2017285813A patent/AU2017285813B2/en active Active
- 2017-06-15 CN CN202110860586.9A patent/CN113651803B/zh active Active
- 2017-06-15 CN CN201780036968.1A patent/CN109311861B/zh active Active
- 2017-06-15 CA CA3081033A patent/CA3081033C/en active Active
- 2017-06-15 BR BR112018076243-1A patent/BR112018076243A2/pt active Search and Examination
- 2017-06-15 SG SG10201911782RA patent/SG10201911782RA/en unknown
- 2017-06-15 PL PL20152959T patent/PL3663292T3/pl unknown
- 2017-06-15 MX MX2021008988A patent/MX2021008988A/es unknown
- 2017-06-15 US US16/310,005 patent/US10640496B2/en active Active
- 2017-06-15 JP JP2018565754A patent/JP6763978B2/ja active Active
- 2017-06-15 HU HUE20152959A patent/HUE056428T2/hu unknown
- 2017-06-15 EP EP20152959.1A patent/EP3663292B1/en active Active
- 2017-06-15 MA MA44545A patent/MA44545B2/fr unknown
- 2017-06-15 RS RS20211297A patent/RS62550B1/sr unknown
- 2017-06-15 MY MYPI2018002498A patent/MY203941A/en unknown
- 2017-06-15 PT PT201529591T patent/PT3663292T/pt unknown
- 2017-06-15 TN TNP/2018/000437A patent/TN2018000437A1/en unknown
- 2017-06-15 PE PE2018003162A patent/PE20190467A1/es unknown
- 2017-06-15 MA MA50774A patent/MA50774B1/fr unknown
- 2017-06-15 PL PL17813615T patent/PL3473621T3/pl unknown
- 2017-06-15 NZ NZ749398A patent/NZ749398A/en unknown
- 2017-06-15 ES ES20152959T patent/ES2898336T3/es active Active
- 2017-06-15 ES ES17813615T patent/ES2891825T3/es active Active
- 2017-06-15 CA CA3026756A patent/CA3026756C/en active Active
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2018
- 2018-12-15 SA SA518400666A patent/SA518400666B1/ar unknown
- 2018-12-15 SA SA521422474A patent/SA521422474B1/ar unknown
- 2018-12-17 PH PH12018550206A patent/PH12018550206A1/en unknown
- 2018-12-17 DO DO2018000287A patent/DOP2018000287A/es unknown
- 2018-12-17 CL CL2018003645A patent/CL2018003645A1/es unknown
- 2018-12-21 CO CONC2018/0014018A patent/CO2018014018A2/es unknown
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2019
- 2019-01-04 EC ECSENADI2019185A patent/ECSP19000185A/es unknown
- 2019-08-30 US US16/557,180 patent/US10889574B2/en active Active
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2020
- 2020-04-06 JP JP2020068458A patent/JP7352509B2/ja active Active
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2021
- 2021-03-22 KR KR1020210036824A patent/KR102379584B1/ko active IP Right Grant
- 2021-06-21 JP JP2021102648A patent/JP2021152054A/ja active Pending
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2023
- 2023-07-06 JP JP2023111632A patent/JP2023145481A/ja active Pending
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