DK562376A - Fremgangsmade til fremstilling af ergolinderivater - Google Patents

Fremgangsmade til fremstilling af ergolinderivater

Info

Publication number: DK562376A
Authority: DK; Denmark
Prior art keywords: preparing; procedure; ergolin; derivatives; ergolin derivatives
Prior art date: 1975-12-23

Application number

DK562376A

Other languages

English (en)

Other versions

DK146205C (da

DK146205B (da

Inventor

P Stuetz

T Fehr

P Stadler

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-12-23

Filing date

1976-12-14

Publication date

1977-06-24

1975-12-23 Priority claimed from CH1668075A external-priority patent/CH620441A5/de

1976-12-14 Application filed by Sandoz Ag filed Critical Sandoz Ag

1977-06-24 Publication of DK562376A publication Critical patent/DK562376A/da

1983-07-25 Publication of DK146205B publication Critical patent/DK146205B/da

1983-12-27 Application granted granted Critical

1983-12-27 Publication of DK146205C publication Critical patent/DK146205C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK562376A 1975-12-23 1976-12-14 Analogifremgangsmaade til fremstilling af 8alfa-ergolin-i-derivater DK146205C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
CH1668075A CH620441A5 (en)	1975-12-23	1975-12-23	Process for the preparation of novel ergoline compounds
CH1668075		1975-12-23
CH618876		1976-05-18
CH618876		1976-05-18

Publications (3)

Publication Number	Publication Date
DK562376A true DK562376A (da)	1977-06-24
DK146205B DK146205B (da)	1983-07-25
DK146205C DK146205C (da)	1983-12-27

Family

ID=25699142

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK562376A DK146205C (da)	1975-12-23	1976-12-14	Analogifremgangsmaade til fremstilling af 8alfa-ergolin-i-derivater
DK554179A DK554179A (da)	1975-12-23	1979-12-21	Fremgangsmaade til fremstilling af ergolinderivater

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK554179A DK554179A (da)	1975-12-23	1979-12-21	Fremgangsmaade til fremstilling af ergolinderivater

Country Status (20)

Country	Link
US (1)	US4348391A (da)
JP (1)	JPS5278900A (da)
AU (1)	AU514288B2 (da)
CA (1)	CA1092100A (da)
DE (1)	DE2656344A1 (da)
DK (2)	DK146205C (da)
ES (1)	ES454442A1 (da)
FI (1)	FI763587A (da)
FR (1)	FR2336135A1 (da)
GB (1)	GB1567484A (da)
HK (1)	HK3483A (da)
IE (1)	IE44242B1 (da)
IL (1)	IL51133A (da)
MY (1)	MY8400060A (da)
NL (1)	NL7614018A (da)
NZ (1)	NZ182934A (da)
PH (1)	PH14035A (da)
PT (1)	PT66006B (da)
SE (1)	SE432253B (da)
SG (1)	SG63382G (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH654838A5 (fr) *	1980-07-25	1986-03-14	Sandoz Ag	Ergolinderivate, verfahren zu deren herstellung, diese enthaltende pharmazeutische zusammensetzungen.
BE889713A (fr) *	1980-07-25	1982-01-25	Sandoz Sa	Nouveaux derives de l'ergoline, leur preparation et leur application comme medicaments
CH644606A5 (de) *	1980-09-23	1984-08-15	Sandoz Ag	Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3101535A1 (de) *	1981-01-14	1982-08-12	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
GB2112382B (en) *	1981-11-06	1985-03-06	Erba Farmitalia	Ergoline derivatives
DE3151912A1 (de) *	1981-12-23	1983-06-30	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3216870A1 (de) *	1982-05-03	1983-11-03	Schering AG, 1000 Berlin und 4709 Bergkamen	Pharmazeutische zubereitungen mit zytostatischer wirkung
HU196399B (en) *	1983-02-16	1988-11-28	Sandoz Ag	Process for producing ergoline derivatives and pharmaceutical compositions comprising such compounds
CH652719A5 (en) *	1983-02-16	1985-11-29	Sandoz Ag	Ergoline derivatives, their preparation and use
CH664568A5 (de) *	1984-01-12	1988-03-15	Sandoz Ag	8-alpha-acylaminoergoline.
US4675322A (en) *	1984-12-10	1987-06-23	Eli Lilly And Company	1-Substituted-6-n-propyl-8β-methylthio-methylergolines
CH666035A5 (de) *	1984-12-24	1988-06-30	Sandoz Ag	8-alpha-acylaminoergolene.
HU193317B (en) *	1985-06-12	1987-09-28	Richter Gedeon Vegyeszet	Process for producing 2-bromo-alpha-ergochristin
US4801712A (en) *	1985-06-24	1989-01-31	Eli Lilly And Company	2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
DE3535929A1 (de) *	1985-10-04	1987-04-09	Schering Ag	1,2-disubstituierte ergolinderivate
HU196598B (en) *	1986-04-25	1988-12-28	Richter Gedeon Vegyeszet	Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
GB8615471D0 (en) *	1986-06-25	1986-07-30	Erba Farmitalia	T-butyl ergoline derivatives
US4798834A (en) *	1987-08-31	1989-01-17	Eli Lilly And Company	Optionally substituted (3β-9,10-didehydro-2,3-dihydro ergoline as serotonergic function enhancement
AT392945B (de) *	1988-06-27	1991-07-10	Gerhard Mader Ges M B H Ing	Lager- und transportbehaelter fuer schuettgueter und lose materialien
IT1232692B (it) *	1989-08-04	1992-03-04	Poli Ind Chimica Spa	Derivati ergolinici con attivita' dopaminergica
AU2635599A (en) *	1999-03-17	2000-10-04	Eugen Eigenmann	Use of prolactin inhibitors for the treatment of fertility problems in animal species

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3270020A (en) *		1966-08-30		Dihydro ergocornine
US3245996A (en) *		1966-04-12		Cyanoethyl lysergol
US3232943A (en) *		1966-02-01		Cyanoethyl ergolene and ergoline derivatives
US3185695A (en) *		1965-05-25		Dbwethyl-ergoline ii derivatives
US2533698A (en) *		1950-12-12		Urethanes containing the lysergic
US3218323A (en) *		1965-11-16		Esters of i,g-dimethyl-b-ergolenyl carbamic acid
CH415658A (de) *	1962-06-18	1966-06-30	Sandoz Ag	Verfahren zur Herstellung von neuen Urethanen
BE712054A (da) *	1967-03-16	1968-07-15
US3920664A (en) *	1972-07-21	1975-11-18	Lilly Co Eli	D-2-halo-6-alkyl-8-substituted ergolines and related compounds
US3880856A (en) *	1973-06-29	1975-04-29	Lilly Co Eli	Ergoline dimers
CS171480B1 (da) *	1974-03-19	1976-10-29
CH605936A5 (en) *	1974-07-19	1978-10-13	Sandoz Ag	8-Alpha-(Amino-or cyanomethyl)-ergoline derivs
GB1517973A (en) *	1974-07-19	1978-07-19	Sandoz Ltd	6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
US3904757A (en) *	1974-08-08	1975-09-09	Lilly Co Eli	Treatment of parkinsonism
US3922347A (en) *	1974-12-19	1975-11-25	Lilly Co Eli	Method of inhibiting prolactin secretion with 8-acylaminoergolenes

1976
- 1976-12-13 DE DE19762656344 patent/DE2656344A1/de active Granted
- 1976-12-14 DK DK562376A patent/DK146205C/da not_active IP Right Cessation
- 1976-12-14 FI FI763587A patent/FI763587A/fi not_active Application Discontinuation
- 1976-12-15 SE SE7614085A patent/SE432253B/xx not_active IP Right Cessation
- 1976-12-17 NL NL7614018A patent/NL7614018A/xx not_active Application Discontinuation
- 1976-12-21 PH PH19276A patent/PH14035A/en unknown
- 1976-12-21 GB GB53303/76A patent/GB1567484A/en not_active Expired
- 1976-12-21 ES ES454442A patent/ES454442A1/es not_active Expired
- 1976-12-21 AU AU20793/76A patent/AU514288B2/en not_active Expired
- 1976-12-21 IL IL51133A patent/IL51133A/xx unknown
- 1976-12-21 CA CA268,415A patent/CA1092100A/en not_active Expired
- 1976-12-21 NZ NZ182934A patent/NZ182934A/xx unknown
- 1976-12-21 IE IE2803/76A patent/IE44242B1/en unknown
- 1976-12-22 FR FR7638697A patent/FR2336135A1/fr active Granted
- 1976-12-22 JP JP51153514A patent/JPS5278900A/ja active Granted
- 1976-12-22 PT PT66006A patent/PT66006B/pt unknown
1979
- 1979-12-21 DK DK554179A patent/DK554179A/da unknown
1980
- 1980-09-22 US US06/189,068 patent/US4348391A/en not_active Expired - Lifetime
1982
- 1982-12-23 SG SG633/82A patent/SG63382G/en unknown
1983
- 1983-01-20 HK HK34/83A patent/HK3483A/xx unknown
1984
- 1984-12-30 MY MY60/84A patent/MY8400060A/xx unknown

Also Published As

Publication number	Publication date
SE432253B (sv)	1984-03-26
ES454442A1 (es)	1978-03-01
DK146205C (da)	1983-12-27
SG63382G (en)	1983-09-09
GB1567484A (en)	1980-05-14
DE2656344A1 (de)	1977-07-07
PT66006A (fr)	1977-01-01
CA1092100A (en)	1980-12-23
MY8400060A (en)	1984-12-31
PH14035A (en)	1980-12-12
HK3483A (en)	1983-01-20
PT66006B (fr)	1978-07-06
JPS6133031B2 (da)	1986-07-31
FI763587A (da)	1977-06-24
IE44242B1 (en)	1981-09-23
AU2079376A (en)	1978-06-29
DE2656344C2 (da)	1990-11-08
NZ182934A (en)	1978-12-18
IL51133A0 (en)	1977-02-28
FR2336135A1 (fr)	1977-07-22
FR2336135B1 (da)	1980-03-07
DK554179A (da)	1979-12-21
JPS5278900A (en)	1977-07-02
SE7614085L (sv)	1977-06-24
DK146205B (da)	1983-07-25
IL51133A (en)	1981-11-30
NL7614018A (nl)	1977-06-27
AU514288B2 (en)	1981-02-05
US4348391A (en)	1982-09-07

Publication	Publication Date	Title
DK494876A (da)	1977-05-08	Fremgangsmade til fremstilling af piperidinderivater
DK298176A (da)	1977-01-03	Fremgangsmade til fremstilling af 1,4-dihydropyrinderivater
DK365176A (da)	1977-02-14	Fremgangsmade til fremstilling af pyrrolidinderivater
DK518176A (da)	1977-05-19	Fremgangsmade til fremstilling af polyprenylderivater
DK145228C (da)	1983-02-28	Analogifremgangsmaade til fremstilling af 3-amino-4-deoxo-4-iminorifamycinderivater
DK562376A (da)	1977-06-24	Fremgangsmade til fremstilling af ergolinderivater
DK462376A (da)	1977-04-17	Fremgangsmade til fremstilling af 5-halogenpyrimidinderivater
DK155002C (da)	1989-06-12	Analogifremgangsmaade til fremstilling af salicylanilidderivater
DK243176A (da)	1976-12-04	Fremgangsmade til fremstilling af polycliske forbindelser
DK517776A (da)	1977-05-19	Fremgangsmade til femstilling af heterocycliske forbindelser
DK415676A (da)	1977-04-09	Fremgangsmade til fremstilling af pilocarpiniumsalte
DK29376A (da)	1976-07-28	Fremgangsmade til fremstilling af 1-aryloxy-3-n-substituerede aminopropanderivater
DK164476A (da)	1976-10-22	Fremgangsmade til fremstilling af piperazinylpyrazinforbindelser
DK497976A (da)	1977-05-06	Fremgangsmade til fremstilling af alaninderivater
DK360576A (da)	1977-02-13	Fremgangsmade til fremstilling af pyridinderivater
DK117677A (da)	1977-09-19	Fremgangsmade til fremstilling af piperidinderivater
DK324776A (da)	1977-01-29	Fremgangsmade til fremstilling af 3-cyanoimino-3-aminopropionitriler
DK139267B (da)	1979-01-22	Fremgangsmaade til fremstilling af 4-androsten3,17-dionderivater
DK329577A (da)	1978-01-23	Fremgangsmade til fremstilling af derivater af phenoxyhydroxypropylamin
DK494976A (da)	1977-05-08	Fremgangsmade til fremstilling af purinderivater
DK305876A (da)	1977-01-09	Fremgangsmade til fremstilling af l-pyroglutamyl-l-prolinamid
DK97376A (da)	1976-09-09	Fremgangsmade til fremstilling af histidinderivater
DK155598C (da)	1989-09-25	Fremgangsmaade til fremstilling af ethylchlorthioformiat
DK143137C (da)	1981-11-09	Fremgangsmaade til fremstilling af phosphitchlorider
DK143281C (da)	1981-12-07	Fremgangsmaade til fremstilling af phosphitchlorider

Legal Events

Date	Code	Title	Description
1992-08-24	PBP	Patent lapsed