DK3492601T3 - Hidtil ukendt protokol til fremstilling af sekvenseringsbiblioteker - Google Patents
Hidtil ukendt protokol til fremstilling af sekvenseringsbiblioteker Download PDFInfo
- Publication number
- DK3492601T3 DK3492601T3 DK18201917.4T DK18201917T DK3492601T3 DK 3492601 T3 DK3492601 T3 DK 3492601T3 DK 18201917 T DK18201917 T DK 18201917T DK 3492601 T3 DK3492601 T3 DK 3492601T3
- Authority
- DK
- Denmark
- Prior art keywords
- production
- hitherto unknown
- sequence libraries
- unknown protocol
- protocol
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B99/00—Subject matter not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6872—Methods for sequencing involving mass spectrometry
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/10—Ploidy or copy number detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2545/00—Reactions characterised by their quantitative nature
- C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
- C12Q2545/101—Reactions characterised by their quantitative nature the purpose being quantitative analysis with an internal standard/control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Theoretical Computer Science (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Primary Health Care (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Algebra (AREA)
- General Physics & Mathematics (AREA)
- Mathematical Analysis (AREA)
- Mathematical Optimization (AREA)
- Mathematical Physics (AREA)
- Pure & Applied Mathematics (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29635810P | 2010-01-19 | 2010-01-19 | |
US36083710P | 2010-07-01 | 2010-07-01 | |
US40701710P | 2010-10-26 | 2010-10-26 | |
US45584910P | 2010-10-26 | 2010-10-26 | |
EP17180803.3A EP3260555B1 (en) | 2010-01-19 | 2010-12-01 | Novel protocol for preparing sequencing libraries |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3492601T3 true DK3492601T3 (da) | 2022-04-04 |
Family
ID=44307118
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10830938.6T DK2366031T3 (da) | 2010-01-19 | 2010-12-01 | Fremgangsmåder til sekventering i prænatale diagnoser |
DK10830939.4T DK2376661T3 (da) | 2010-01-19 | 2010-12-01 | Simultan bestemmelse af aneuploidi og føtal fraktion |
DK18160303.6T DK3382037T3 (da) | 2010-01-19 | 2010-12-01 | Fremgangsmåder til bestemmelse af fraktionen af føtale nukleinsyrer i maternelle prøver |
DK10844163.5T DK2513339T3 (da) | 2010-01-19 | 2010-12-01 | Fremgangsmåde til bestemmelse af fraktion af føtal nukleinsyre i maternel-prøver |
DK17180803.3T DK3260555T3 (da) | 2010-01-19 | 2010-12-01 | Hidtil ukendt protokol til fremstilling af sekventeringsbiblioteker |
DK18201917.4T DK3492601T3 (da) | 2010-01-19 | 2010-12-01 | Hidtil ukendt protokol til fremstilling af sekvenseringsbiblioteker |
Family Applications Before (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10830938.6T DK2366031T3 (da) | 2010-01-19 | 2010-12-01 | Fremgangsmåder til sekventering i prænatale diagnoser |
DK10830939.4T DK2376661T3 (da) | 2010-01-19 | 2010-12-01 | Simultan bestemmelse af aneuploidi og føtal fraktion |
DK18160303.6T DK3382037T3 (da) | 2010-01-19 | 2010-12-01 | Fremgangsmåder til bestemmelse af fraktionen af føtale nukleinsyrer i maternelle prøver |
DK10844163.5T DK2513339T3 (da) | 2010-01-19 | 2010-12-01 | Fremgangsmåde til bestemmelse af fraktion af føtal nukleinsyre i maternel-prøver |
DK17180803.3T DK3260555T3 (da) | 2010-01-19 | 2010-12-01 | Hidtil ukendt protokol til fremstilling af sekventeringsbiblioteker |
Country Status (12)
Country | Link |
---|---|
US (12) | US20110224087A1 (da) |
EP (14) | EP4450645A3 (da) |
AU (4) | AU2010343276B2 (da) |
CA (4) | CA2786357C (da) |
CY (1) | CY1124494T1 (da) |
DK (6) | DK2366031T3 (da) |
ES (6) | ES2560929T3 (da) |
GB (5) | GB2479080B (da) |
HK (6) | HK1160185A1 (da) |
PL (4) | PL2366031T3 (da) |
TR (1) | TR201807917T4 (da) |
WO (3) | WO2011090557A1 (da) |
Families Citing this family (241)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2313143T3 (es) | 2005-04-06 | 2009-03-01 | Maurice Stroun | Metodo para el diagnostico de cancer mediante la deteccion de adn y arn circulantes. |
US10081839B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc | System and method for cleaning noisy genetic data and determining chromosome copy number |
US10083273B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
US8532930B2 (en) | 2005-11-26 | 2013-09-10 | Natera, Inc. | Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals |
CA2647793C (en) * | 2006-02-28 | 2016-07-05 | University Of Louisville Research Foundation | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
US20110033862A1 (en) * | 2008-02-19 | 2011-02-10 | Gene Security Network, Inc. | Methods for cell genotyping |
AU2009223671B2 (en) * | 2008-03-11 | 2014-11-27 | Sequenom, Inc. | Nucleic acid-based tests for prenatal gender determination |
US20110092763A1 (en) * | 2008-05-27 | 2011-04-21 | Gene Security Network, Inc. | Methods for Embryo Characterization and Comparison |
AU2009279734A1 (en) | 2008-08-04 | 2010-02-11 | Natera, Inc. | Methods for allele calling and ploidy calling |
US8962247B2 (en) | 2008-09-16 | 2015-02-24 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
EP2473638B1 (en) | 2009-09-30 | 2017-08-09 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
CN107312844B (zh) | 2009-11-06 | 2021-01-22 | 香港中文大学 | 基于大小的基因组分析 |
US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
EP3088532B1 (en) | 2009-12-22 | 2019-10-30 | Sequenom, Inc. | Processes and kits for identifying aneuploidy |
DK2366031T3 (da) * | 2010-01-19 | 2015-02-23 | Verinata Health Inc | Fremgangsmåder til sekventering i prænatale diagnoser |
EP2513341B1 (en) | 2010-01-19 | 2017-04-12 | Verinata Health, Inc | Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing |
US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
US20120100548A1 (en) | 2010-10-26 | 2012-04-26 | Verinata Health, Inc. | Method for determining copy number variations |
US9323888B2 (en) | 2010-01-19 | 2016-04-26 | Verinata Health, Inc. | Detecting and classifying copy number variation |
WO2011091063A1 (en) | 2010-01-19 | 2011-07-28 | Verinata Health, Inc. | Partition defined detection methods |
WO2011090556A1 (en) | 2010-01-19 | 2011-07-28 | Verinata Health, Inc. | Methods for determining fraction of fetal nucleic acid in maternal samples |
US9260745B2 (en) | 2010-01-19 | 2016-02-16 | Verinata Health, Inc. | Detecting and classifying copy number variation |
US20110312503A1 (en) | 2010-01-23 | 2011-12-22 | Artemis Health, Inc. | Methods of fetal abnormality detection |
US9090674B2 (en) * | 2010-05-17 | 2015-07-28 | The Board Of Regents Of The University Of Texas System | Rapid isolation of monoclonal antibodies from animals |
US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
WO2013052557A2 (en) * | 2011-10-03 | 2013-04-11 | Natera, Inc. | Methods for preimplantation genetic diagnosis by sequencing |
US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
CA2798758C (en) | 2010-05-18 | 2019-05-07 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US20130040375A1 (en) | 2011-08-08 | 2013-02-14 | Tandem Diagnotics, Inc. | Assay systems for genetic analysis |
US11203786B2 (en) | 2010-08-06 | 2021-12-21 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
US20130261003A1 (en) | 2010-08-06 | 2013-10-03 | Ariosa Diagnostics, In. | Ligation-based detection of genetic variants |
US11031095B2 (en) | 2010-08-06 | 2021-06-08 | Ariosa Diagnostics, Inc. | Assay systems for determination of fetal copy number variation |
US20140342940A1 (en) | 2011-01-25 | 2014-11-20 | Ariosa Diagnostics, Inc. | Detection of Target Nucleic Acids using Hybridization |
US10533223B2 (en) | 2010-08-06 | 2020-01-14 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
US10167508B2 (en) | 2010-08-06 | 2019-01-01 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
US8700338B2 (en) | 2011-01-25 | 2014-04-15 | Ariosa Diagnosis, Inc. | Risk calculation for evaluation of fetal aneuploidy |
US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
ES2523140T3 (es) | 2010-09-21 | 2014-11-21 | Population Genetics Technologies Ltd. | Aumento de la confianza en las identificaciones de alelos con el recuento molecular |
MY169852A (en) * | 2010-11-30 | 2019-05-17 | Univ Hong Kong Chinese | Detection of genetic or molecular aberrations associated with cancer |
JP6328934B2 (ja) | 2010-12-22 | 2018-05-23 | ナテラ, インコーポレイテッド | 非侵襲性出生前親子鑑定法 |
US10131947B2 (en) | 2011-01-25 | 2018-11-20 | Ariosa Diagnostics, Inc. | Noninvasive detection of fetal aneuploidy in egg donor pregnancies |
US9994897B2 (en) | 2013-03-08 | 2018-06-12 | Ariosa Diagnostics, Inc. | Non-invasive fetal sex determination |
US11270781B2 (en) | 2011-01-25 | 2022-03-08 | Ariosa Diagnostics, Inc. | Statistical analysis for non-invasive sex chromosome aneuploidy determination |
US8756020B2 (en) | 2011-01-25 | 2014-06-17 | Ariosa Diagnostics, Inc. | Enhanced risk probabilities using biomolecule estimations |
EP2673729B1 (en) | 2011-02-09 | 2018-10-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US9260753B2 (en) | 2011-03-24 | 2016-02-16 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
AU2012236200B2 (en) | 2011-03-30 | 2015-05-14 | Verinata Health, Inc. | Method for verifying bioassay samples |
PL3567124T3 (pl) | 2011-04-12 | 2022-04-19 | Verinata Health, Inc. | Rozdzielanie frakcji genomu z wykorzystaniem liczby polimorfizmu |
WO2012141712A1 (en) * | 2011-04-14 | 2012-10-18 | Verinata Health, Inc. | Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies |
GB2484764B (en) | 2011-04-14 | 2012-09-05 | Verinata Health Inc | Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies |
WO2014014498A1 (en) | 2012-07-20 | 2014-01-23 | Verinata Health, Inc. | Detecting and classifying copy number variation in a fetal genome |
US9411937B2 (en) * | 2011-04-15 | 2016-08-09 | Verinata Health, Inc. | Detecting and classifying copy number variation |
US20130059738A1 (en) * | 2011-04-28 | 2013-03-07 | Life Technologies Corporation | Methods and compositions for multiplex pcr |
CN106912197B (zh) | 2011-04-28 | 2022-01-25 | 生命技术公司 | 用于多重pcr的方法和组合物 |
US20130059762A1 (en) | 2011-04-28 | 2013-03-07 | Life Technologies Corporation | Methods and compositions for multiplex pcr |
AU2012249531B2 (en) | 2011-04-29 | 2017-06-29 | Sequenom, Inc. | Quantification of a minority nucleic acid species |
WO2012177792A2 (en) | 2011-06-24 | 2012-12-27 | Sequenom, Inc. | Methods and processes for non-invasive assessment of a genetic variation |
EP2563937A1 (en) * | 2011-07-26 | 2013-03-06 | Verinata Health, Inc | Method for determining the presence or absence of different aneuploidies in a sample |
US8712697B2 (en) | 2011-09-07 | 2014-04-29 | Ariosa Diagnostics, Inc. | Determination of copy number variations using binomial probability calculations |
CA2848304A1 (en) * | 2011-09-09 | 2013-03-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for sequencing a polynucleotide |
US20130110407A1 (en) * | 2011-09-16 | 2013-05-02 | Complete Genomics, Inc. | Determining variants in genome of a heterogeneous sample |
US9984198B2 (en) | 2011-10-06 | 2018-05-29 | Sequenom, Inc. | Reducing sequence read count error in assessment of complex genetic variations |
US9367663B2 (en) | 2011-10-06 | 2016-06-14 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
WO2013052913A2 (en) | 2011-10-06 | 2013-04-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US10196681B2 (en) | 2011-10-06 | 2019-02-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US20140242588A1 (en) | 2011-10-06 | 2014-08-28 | Sequenom, Inc | Methods and processes for non-invasive assessment of genetic variations |
US10424394B2 (en) | 2011-10-06 | 2019-09-24 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US8688388B2 (en) | 2011-10-11 | 2014-04-01 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
CA2851537C (en) | 2011-10-11 | 2020-12-29 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US9845552B2 (en) | 2011-10-27 | 2017-12-19 | Verinata Health, Inc. | Set membership testers for aligning nucleic acid samples |
JP6431769B2 (ja) | 2012-01-20 | 2018-11-28 | セクエノム, インコーポレイテッド | 実験条件を要因として含める診断プロセス |
ES2904816T3 (es) | 2012-02-27 | 2022-04-06 | Becton Dickinson Co | Composiciones para recuento molecular |
WO2013130512A2 (en) | 2012-02-27 | 2013-09-06 | The University Of North Carolina At Chapel Hill | Methods and uses for molecular tags |
WO2013128281A1 (en) | 2012-02-28 | 2013-09-06 | Population Genetics Technologies Ltd | Method for attaching a counter sequence to a nucleic acid sample |
EP3401399B1 (en) | 2012-03-02 | 2020-04-22 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
EP2831279B1 (en) | 2012-03-26 | 2023-05-03 | The Johns Hopkins University | Rapid aneuploidy detection |
CN103374518B (zh) * | 2012-04-12 | 2018-03-27 | 维里纳塔健康公司 | 拷贝数变异的检测和分类 |
DK2852680T3 (da) | 2012-05-21 | 2020-03-16 | Sequenom Inc | Fremgangsmåder og processer til ikke-invasiv evaluering af genetiske variationer |
US10504613B2 (en) | 2012-12-20 | 2019-12-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
US10289800B2 (en) | 2012-05-21 | 2019-05-14 | Ariosa Diagnostics, Inc. | Processes for calculating phased fetal genomic sequences |
CN104053787A (zh) * | 2012-05-23 | 2014-09-17 | 深圳华大基因医学有限公司 | 鉴定双胞胎类型的方法和系统 |
US11261494B2 (en) * | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
US10497461B2 (en) | 2012-06-22 | 2019-12-03 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
AU2013290102B2 (en) | 2012-07-13 | 2018-11-15 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
EP2875156A4 (en) | 2012-07-19 | 2016-02-24 | Ariosa Diagnostics Inc | DETECTION BASED ON MULTIPLEX SEQUENTIAL LIGATION OF GENETIC VARIANTS |
US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
WO2014039556A1 (en) | 2012-09-04 | 2014-03-13 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
CA2887094C (en) | 2012-10-04 | 2021-09-07 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
WO2014066635A1 (en) * | 2012-10-24 | 2014-05-01 | Complete Genomics, Inc. | Genome explorer system to process and present nucleotide variations in genome sequence data |
US10643738B2 (en) * | 2013-01-10 | 2020-05-05 | The Chinese University Of Hong Kong | Noninvasive prenatal molecular karyotyping from maternal plasma |
US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
KR102082025B1 (ko) | 2013-02-28 | 2020-02-26 | 더 차이니즈 유니버시티 오브 홍콩 | 대량 동시 rna 서열분석에 의한 모체 혈장 전사물 분석 |
EP2971100A1 (en) | 2013-03-13 | 2016-01-20 | Sequenom, Inc. | Primers for dna methylation analysis |
WO2014151511A2 (en) | 2013-03-15 | 2014-09-25 | Abbott Molecular Inc. | Systems and methods for detection of genomic copy number changes |
US20140278127A1 (en) * | 2013-03-15 | 2014-09-18 | Battelle Memorial Institute | Computer Files and Methods Supporting Forensic Analysis of Nucleotide Sequence Data |
EP2971097B1 (en) * | 2013-03-15 | 2018-08-01 | Verinata Health, Inc | Generating cell-free dna libraries directly from blood |
PL2981921T3 (pl) | 2013-04-03 | 2023-05-08 | Sequenom, Inc. | Metody i procesy nieinwazyjnej oceny zmienności genetycznych |
CN105555968B (zh) | 2013-05-24 | 2020-10-23 | 塞昆纳姆股份有限公司 | 遗传变异的非侵入性评估方法和过程 |
JP6521956B2 (ja) | 2013-06-17 | 2019-05-29 | ベリナタ ヘルス インコーポレイテッド | 性染色体におけるコピー数変異を判定するための方法 |
PL3011051T3 (pl) | 2013-06-21 | 2019-07-31 | Sequenom, Inc. | Sposób nieinwazyjnej oceny zmienności genetycznych |
ES2857908T3 (es) | 2013-08-28 | 2021-09-29 | Becton Dickinson Co | Análisis masivamente paralelo de células individuales |
GB201318369D0 (en) * | 2013-10-17 | 2013-12-04 | Univ Leuven Kath | Methods using BAF |
WO2015048535A1 (en) | 2013-09-27 | 2015-04-02 | Natera, Inc. | Prenatal diagnostic resting standards |
US10577655B2 (en) | 2013-09-27 | 2020-03-03 | Natera, Inc. | Cell free DNA diagnostic testing standards |
US10262755B2 (en) | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
EP3053071B1 (en) | 2013-10-04 | 2023-10-18 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
EP3055676A1 (en) | 2013-10-07 | 2016-08-17 | Cellular Research, Inc. | Methods and systems for digitally counting features on arrays |
EP3055427B1 (en) | 2013-10-07 | 2018-09-12 | Sequenom, Inc. | Methods and processes for non-invasive assessment of chromosome alterations |
EP3087204B1 (en) | 2013-12-28 | 2018-02-14 | Guardant Health, Inc. | Methods and systems for detecting genetic variants |
WO2015138774A1 (en) | 2014-03-13 | 2015-09-17 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
CA2945962C (en) | 2014-04-21 | 2023-08-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
EP3760739A1 (en) | 2014-07-30 | 2021-01-06 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
AU2015330734B2 (en) | 2014-10-10 | 2021-10-28 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US9859394B2 (en) | 2014-12-18 | 2018-01-02 | Agilome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
US10020300B2 (en) | 2014-12-18 | 2018-07-10 | Agilome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
US10006910B2 (en) | 2014-12-18 | 2018-06-26 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same |
US9857328B2 (en) | 2014-12-18 | 2018-01-02 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems and methods for manufacturing and using the same |
US9618474B2 (en) | 2014-12-18 | 2017-04-11 | Edico Genome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
EP3235010A4 (en) | 2014-12-18 | 2018-08-29 | Agilome, Inc. | Chemically-sensitive field effect transistor |
SG11201706529TA (en) | 2015-02-10 | 2017-09-28 | Univ Hong Kong Chinese | Detecting mutations for cancer screening and fetal analysis |
ES2824700T3 (es) | 2015-02-19 | 2021-05-13 | Becton Dickinson Co | Análisis unicelular de alto rendimiento que combina información proteómica y genómica |
KR101533792B1 (ko) * | 2015-02-24 | 2015-07-06 | 대한민국 | Ngs 기반 인간 객체의 상염색체 분석방법 |
WO2016138496A1 (en) | 2015-02-27 | 2016-09-01 | Cellular Research, Inc. | Spatially addressable molecular barcoding |
US11535882B2 (en) | 2015-03-30 | 2022-12-27 | Becton, Dickinson And Company | Methods and compositions for combinatorial barcoding |
EP3286326B1 (en) | 2015-04-23 | 2025-01-22 | Becton, Dickinson and Company | Method for whole transcriptome amplification |
US10844428B2 (en) * | 2015-04-28 | 2020-11-24 | Illumina, Inc. | Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS) |
EP3294906B1 (en) | 2015-05-11 | 2024-07-10 | Natera, Inc. | Methods for determining ploidy |
CA2986200A1 (en) | 2015-05-22 | 2016-12-01 | Nipd Genetics Public Company Limited | Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing |
US11124823B2 (en) | 2015-06-01 | 2021-09-21 | Becton, Dickinson And Company | Methods for RNA quantification |
EP3135770A1 (en) * | 2015-08-28 | 2017-03-01 | Latvian Biomedical Research and Study Centre | Set of oligonucleotides and method for detection of fetal dna fraction in maternal plasma |
US11302416B2 (en) | 2015-09-02 | 2022-04-12 | Guardant Health | Machine learning for somatic single nucleotide variant detection in cell-free tumor nucleic acid sequencing applications |
US10619186B2 (en) | 2015-09-11 | 2020-04-14 | Cellular Research, Inc. | Methods and compositions for library normalization |
US20180327844A1 (en) * | 2015-11-16 | 2018-11-15 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
EP3390668A4 (en) | 2015-12-17 | 2020-04-01 | Guardant Health, Inc. | METHODS OF DETERMINING THE NUMBER OF TUMOR GENE COPIES BY ACELLULAR DNA ANALYSIS |
US10982286B2 (en) | 2016-01-22 | 2021-04-20 | Mayo Foundation For Medical Education And Research | Algorithmic approach for determining the plasma genome abnormality PGA and the urine genome abnormality UGA scores based on cell free cfDNA copy number variations in plasma and urine |
JP7064665B2 (ja) | 2016-03-07 | 2022-05-11 | ファーザー フラナガンズ ボーイズ ホーム ドゥーイング ビジネス アズ ボーイズ タウン ナショナル リサーチ ホスピタル | 非侵襲的分子対照 |
CA3016360A1 (en) | 2016-04-15 | 2017-10-19 | Ucl Business Plc | Methods for lung cancer detection |
EP4269616A3 (en) | 2016-05-02 | 2024-02-14 | Becton, Dickinson and Company | Accurate molecular barcoding |
US10811539B2 (en) | 2016-05-16 | 2020-10-20 | Nanomedical Diagnostics, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
WO2017205691A1 (en) | 2016-05-26 | 2017-11-30 | Cellular Research, Inc. | Molecular label counting adjustment methods |
EP3464626B1 (en) | 2016-05-27 | 2022-04-06 | Sequenom, Inc. | Methods for detecting genetic variations |
US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
EP3491561A1 (en) | 2016-07-27 | 2019-06-05 | Sequenom, Inc. | Methods for non-invasive assessment of genomic instability |
CA3030890A1 (en) | 2016-07-27 | 2018-02-01 | Sequenom, Inc. | Genetic copy number alteration classifications |
AU2017328953B2 (en) * | 2016-09-15 | 2023-09-14 | Archerdx, Llc | Methods of nucleic acid sample preparation for analysis of cell-free DNA |
CA3037185A1 (en) | 2016-09-15 | 2018-03-22 | ArcherDX, Inc. | Methods of nucleic acid sample preparation |
KR102363716B1 (ko) | 2016-09-26 | 2022-02-18 | 셀룰러 리서치, 인크. | 바코딩된 올리고뉴클레오티드 서열을 갖는 시약을 이용한 단백질 발현의 측정 |
WO2018064486A1 (en) * | 2016-09-29 | 2018-04-05 | Counsyl, Inc. | Noninvasive prenatal screening using dynamic iterative depth optimization |
CN109642250B (zh) | 2016-09-30 | 2024-06-04 | 夸登特健康公司 | 用于无细胞核酸的多分辨率分析的方法 |
US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
WO2018085599A2 (en) * | 2016-11-02 | 2018-05-11 | ArcherDX, Inc. | Methods of nucleic acid sample preparation for immune repertoire sequencing |
SG11201903158RA (en) | 2016-11-08 | 2019-05-30 | Cellular Res Inc | Methods for cell label classification |
WO2018089378A1 (en) | 2016-11-08 | 2018-05-17 | Cellular Research, Inc. | Methods for expression profile classification |
US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
EP3568234B1 (en) | 2017-01-13 | 2023-09-06 | Cellular Research, Inc. | Hydrophilic coating of fluidic channels |
JP7051900B2 (ja) | 2017-01-18 | 2022-04-11 | イルミナ インコーポレイテッド | 不均一分子長を有するユニーク分子インデックスセットの生成およびエラー補正のための方法およびシステム |
EP3571614A1 (en) | 2017-01-20 | 2019-11-27 | Sequenom, Inc. | Methods for non-invasive assessment of copy number alterations |
CA3049682C (en) | 2017-01-20 | 2023-06-27 | Sequenom, Inc. | Methods for non-invasive assessment of genetic alterations |
CA3049455C (en) | 2017-01-20 | 2023-06-13 | Sequenom, Inc. | Sequencing adapter manufacture and use |
EP3574424A1 (en) | 2017-01-24 | 2019-12-04 | Sequenom, Inc. | Methods and processes for assessment of genetic variations |
MY197535A (en) | 2017-01-25 | 2023-06-21 | Univ Hong Kong Chinese | Diagnostic applications using nucleic acid fragments |
EP3577232A1 (en) | 2017-02-01 | 2019-12-11 | Cellular Research, Inc. | Selective amplification using blocking oligonucleotides |
WO2018156418A1 (en) | 2017-02-21 | 2018-08-30 | Natera, Inc. | Compositions, methods, and kits for isolating nucleic acids |
PT3596233T (pt) | 2017-03-17 | 2022-08-22 | Sequenom Inc | Métodos e processos para avaliação de mosaicismo genético |
JP7170711B2 (ja) * | 2017-04-18 | 2022-11-14 | アジレント・テクノロジーズ・ベルジャム・ナムローゼ・フェンノートシャップ | Dna分析のためのオフターゲット配列の使用 |
CA3059559A1 (en) | 2017-06-05 | 2018-12-13 | Becton, Dickinson And Company | Sample indexing for single cells |
EP3649258B1 (en) | 2017-07-07 | 2022-05-04 | Nipd Genetics Public Company Limited | Target-enriched multiplexed parallel analysis for assessment of fetal dna samples |
ES2924548T3 (es) | 2017-07-07 | 2022-10-07 | Nipd Genetics Public Company Ltd | Análisis paralelo multiplexado con enriquecimiento de blancos para la evaluación tumoral |
ES2925394T3 (es) | 2017-07-07 | 2022-10-17 | Nipd Genetics Public Company Ltd | Análisis paralelo multiplexado con enriquecimiento de blancos para la evaluación del riesgo de portar alteraciones genéticas |
PL3649257T3 (pl) | 2017-07-07 | 2022-07-18 | Nipd Genetics Public Company Limited | Wzbogacanie docelowych regionów genomowych do multipleksowej analizy równoległej |
LT3658689T (lt) | 2017-07-26 | 2021-06-25 | Trisomytest, S.R.O. | Neinvazinis prenatalinis vaisiaus chromosomos aneuploidijos nustatymo būdas iš motinos kraujo remiantis bajeso tinklu |
AU2018312117B2 (en) | 2017-08-04 | 2022-05-12 | Billiontoone, Inc. | Sequencing output determination and analysis with target-associated molecules in quantification associated with biological targets |
EP3662479A1 (en) | 2017-08-04 | 2020-06-10 | Trisomytest, s.r.o. | A method for non-invasive prenatal detection of fetal sex chromosomal abnormalities and fetal sex determination for singleton and twin pregnancies |
US11646100B2 (en) | 2017-08-04 | 2023-05-09 | Billiontoone, Inc. | Target-associated molecules for characterization associated with biological targets |
US11519024B2 (en) | 2017-08-04 | 2022-12-06 | Billiontoone, Inc. | Homologous genomic regions for characterization associated with biological targets |
US11447818B2 (en) | 2017-09-15 | 2022-09-20 | Illumina, Inc. | Universal short adapters with variable length non-random unique molecular identifiers |
CN108733982B (zh) * | 2017-09-26 | 2021-02-19 | 上海凡迪基因科技有限公司 | 孕妇nipt结果校正方法、装置及计算机可读存储介质、设备 |
WO2019084489A1 (en) | 2017-10-27 | 2019-05-02 | Juno Diagnostics, Inc. | DEVICES, SYSTEMS AND METHODS FOR ULTRA-LOW VOLUMES LIQUID BIOPSY |
JP2021506342A (ja) | 2017-12-14 | 2021-02-22 | ティーエーアイ ダイアグノスティックス インコーポレイテッドTai Diagnostics,Inc. | 移植のための移植片適合性の評価 |
CN111492068A (zh) | 2017-12-19 | 2020-08-04 | 贝克顿迪金森公司 | 与寡核苷酸相关联的颗粒 |
KR102031841B1 (ko) * | 2017-12-22 | 2019-10-15 | 테라젠지놈케어 주식회사 | 모체 시료 중 태아 분획을 결정하는 방법 |
DK3735470T3 (da) | 2018-01-05 | 2024-02-26 | Billiontoone Inc | Kvalitetskontroltemplates til sikring af validiteten af sekventeringsbaserede analyser |
WO2019195225A1 (en) | 2018-04-02 | 2019-10-10 | Illumina, Inc. | Compositions and methods for making controls for sequence-based genetic testing |
JP7573443B2 (ja) | 2018-04-14 | 2024-10-25 | ナテラ, インコーポレイテッド | 循環腫瘍dnaの個別化された検出を用いる癌検出およびモニタリングの方法 |
WO2019213237A1 (en) | 2018-05-03 | 2019-11-07 | Becton, Dickinson And Company | Molecular barcoding on opposite transcript ends |
AU2019262048A1 (en) | 2018-05-03 | 2020-11-12 | Becton, Dickinson And Company | High throughput multiomics sample analysis |
KR102447811B1 (ko) | 2018-05-17 | 2022-09-27 | 일루미나, 인코포레이티드 | 감소된 증폭 편향을 갖는 고속대량 단일 세포 서열분석 |
EP3833776A4 (en) | 2018-08-06 | 2022-04-27 | Billiontoone, Inc. | DILUTION MARKER FOR QUANTIFICATION OF BIOLOGICAL TARGETS |
JP2022511398A (ja) | 2018-10-01 | 2022-01-31 | ベクトン・ディキンソン・アンド・カンパニー | 5’転写物配列の決定 |
WO2020097315A1 (en) | 2018-11-08 | 2020-05-14 | Cellular Research, Inc. | Whole transcriptome analysis of single cells using random priming |
WO2020113577A1 (zh) * | 2018-12-07 | 2020-06-11 | 深圳华大生命科学研究院 | 一种靶基因文库的构建方法、检测装置及其应用 |
CN113195717A (zh) | 2018-12-13 | 2021-07-30 | 贝克顿迪金森公司 | 单细胞全转录组分析中的选择性延伸 |
WO2020150356A1 (en) | 2019-01-16 | 2020-07-23 | Becton, Dickinson And Company | Polymerase chain reaction normalization through primer titration |
EP4242322B1 (en) | 2019-01-23 | 2024-08-21 | Becton, Dickinson and Company | Oligonucleotides associated with antibodies |
AU2020216438A1 (en) | 2019-01-31 | 2021-07-29 | Guardant Health, Inc. | Compositions and methods for isolating cell-free DNA |
CN113454234A (zh) | 2019-02-14 | 2021-09-28 | 贝克顿迪金森公司 | 杂合体靶向和全转录物组扩增 |
US11965208B2 (en) | 2019-04-19 | 2024-04-23 | Becton, Dickinson And Company | Methods of associating phenotypical data and single cell sequencing data |
WO2020226528A1 (ru) * | 2019-05-08 | 2020-11-12 | Общество с ограниченной ответственностью "ГЕНОТЕК ИТ" | Способ определения кариотипа плода беременной женщины |
US11939622B2 (en) | 2019-07-22 | 2024-03-26 | Becton, Dickinson And Company | Single cell chromatin immunoprecipitation sequencing assay |
CN114269948B (zh) * | 2019-08-30 | 2025-01-28 | 香港中文大学 | 通过低深度基因组测序检测杂合性缺失的方法 |
WO2021087491A1 (en) | 2019-10-31 | 2021-05-06 | Sequenom, Inc. | Application of mosaicism ratio in multifetal gestations and personalized risk assessment |
CN114729350A (zh) | 2019-11-08 | 2022-07-08 | 贝克顿迪金森公司 | 使用随机引发获得用于免疫组库测序的全长v(d)j信息 |
CA3131748A1 (en) | 2019-11-22 | 2021-05-27 | Sarah E. SHULTZABERGER | Circulating rna signatures specific to preeclampsia |
WO2021146207A1 (en) | 2020-01-13 | 2021-07-22 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and rna |
CN115335520A (zh) | 2020-01-29 | 2022-11-11 | 贝克顿迪金森公司 | 用于通过测序对单细胞进行空间映射的条形码化的孔 |
EP4111168A1 (en) | 2020-02-25 | 2023-01-04 | Becton Dickinson and Company | Bi-specific probes to enable the use of single-cell samples as single color compensation control |
CN115605614A (zh) | 2020-05-14 | 2023-01-13 | 贝克顿迪金森公司(Us) | 用于免疫组库谱分析的引物 |
CN111534604B (zh) * | 2020-05-27 | 2024-01-23 | 广东华美众源生物科技有限公司 | 一种检测人常染色体dip-str遗传标记的荧光复合扩增试剂盒 |
CN115803445A (zh) | 2020-06-02 | 2023-03-14 | 贝克顿迪金森公司 | 用于5撇基因表达测定的寡核苷酸和珠 |
US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
US11377654B2 (en) | 2020-09-11 | 2022-07-05 | New England Biolabs, Inc. | Application of immobilized enzymes for nanopore library construction |
CN116635533A (zh) | 2020-11-20 | 2023-08-22 | 贝克顿迪金森公司 | 高表达的蛋白和低表达的蛋白的谱分析 |
AU2021391422A1 (en) | 2020-12-02 | 2022-11-03 | Illumina Software, Inc. | System and method for detection of genetic alterations |
AU2023240345A1 (en) | 2022-03-21 | 2024-10-10 | Billion Toone, Inc. | Molecule counting of methylated cell-free dna for treatment monitoring |
WO2024186778A1 (en) | 2023-03-03 | 2024-09-12 | Laboratory Corporation Of America Holdings | Methods and systems for positive cfdna screening on genetic variations using mosaicism ratio |
WO2024238593A1 (en) | 2023-05-15 | 2024-11-21 | Laboratory Corporation Of America Holdings | Machine-learning approaches to pan-cancer screening in whole genome sequencing |
CN117965744B (zh) * | 2023-12-12 | 2024-10-11 | 东莞博奥木华基因科技有限公司 | 一种基于多重pcr捕获技术检测胎儿样本倍性和母源细胞污染的试剂盒、引物和方法 |
Family Cites Families (105)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6270961B1 (en) | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
US5965362A (en) * | 1992-03-04 | 1999-10-12 | The Regents Of The University Of California | Comparative genomic hybridization (CGH) |
WO1994003638A1 (en) | 1992-07-30 | 1994-02-17 | Applied Biosystems, Inc. | Method of detecting aneuploidy by amplified short tandem repeats |
US5776737A (en) | 1994-12-22 | 1998-07-07 | Visible Genetics Inc. | Method and composition for internal identification of samples |
US6057103A (en) | 1995-07-18 | 2000-05-02 | Diversa Corporation | Screening for novel bioactivities |
AU735272B2 (en) | 1996-10-04 | 2001-07-05 | Intronn Llc | Sample collection devices and methods using markers and the use of such markers as controls in sample validation, laboratory evaluation and/or accreditation |
US20010051341A1 (en) | 1997-03-04 | 2001-12-13 | Isis Innovation Limited | Non-invasive prenatal diagnosis |
GB9704444D0 (en) | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
EP1591541B1 (en) | 1997-04-01 | 2012-02-15 | Illumina Cambridge Limited | Method of nucleic acid sequencing |
US5888740A (en) | 1997-09-19 | 1999-03-30 | Genaco Biomedical Products, Inc. | Detection of aneuploidy and gene deletion by PCR-based gene- dose co-amplification of chromosome specific sequences with synthetic sequences with synthetic internal controls |
AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
US6440706B1 (en) * | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
EP1290225A4 (en) | 2000-05-20 | 2004-09-15 | Univ Michigan | METHOD FOR PRODUCING A DNA BANK BY POSITIONAL REPRODUCTION |
AU2001273057A1 (en) | 2000-06-27 | 2002-01-08 | Fluidigm Corporation | A microfluidic design automation method and system |
CA2413158A1 (en) | 2000-06-30 | 2002-01-10 | Incyte Genomics, Inc. | Ecm-related tumor marker |
US20020142324A1 (en) * | 2000-09-22 | 2002-10-03 | Xun Wang | Fungal target genes and methods to identify those genes |
WO2002060582A2 (en) | 2000-11-16 | 2002-08-08 | Fluidigm Corporation | Microfluidic devices for introducing and dispensing fluids from microfluidic systems |
US6691042B2 (en) | 2001-07-02 | 2004-02-10 | Rosetta Inpharmatics Llc | Methods for generating differential profiles by combining data obtained in separate measurements |
US7226732B2 (en) | 2001-07-16 | 2007-06-05 | Cepheid | Methods, apparatus, and computer programs for verifying the integrity of a probe |
US6927028B2 (en) | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
US7893248B2 (en) | 2002-02-20 | 2011-02-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) |
KR20040102024A (ko) | 2002-03-01 | 2004-12-03 | 라브겐, 인코퍼레이티드 | 유전적 장애의 검출 방법 |
US6977162B2 (en) | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
US20030194704A1 (en) * | 2002-04-03 | 2003-10-16 | Penn Sharron Gaynor | Human genome-derived single exon nucleic acid probes useful for gene expression analysis two |
US7727720B2 (en) | 2002-05-08 | 2010-06-01 | Ravgen, Inc. | Methods for detection of genetic disorders |
AU2003277153A1 (en) | 2002-09-27 | 2004-04-19 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
US10229244B2 (en) | 2002-11-11 | 2019-03-12 | Affymetrix, Inc. | Methods for identifying DNA copy number changes using hidden markov model based estimations |
ES2329364T3 (es) | 2003-01-17 | 2009-11-25 | The Trustees Of Boston University | Analisis de haplotipos. |
EP1583846B1 (en) | 2003-01-17 | 2011-11-16 | The Chinese University Of Hong Kong | Circulating mrna as diagnostic markers for pregnancy-related disorders |
JP4480715B2 (ja) | 2003-01-29 | 2010-06-16 | 454 コーポレーション | 二重末端シーケンシング |
EP1599608A4 (en) * | 2003-03-05 | 2007-07-18 | Genetic Technologies Ltd | Identification of fetal DNA and fetal cell marker in maternal plasma or serum |
EP1606417A2 (en) | 2003-03-07 | 2005-12-21 | Rubicon Genomics Inc. | In vitro dna immortalization and whole genome amplification using libraries generated from randomly fragmented dna |
EP1649040A4 (en) | 2003-07-10 | 2007-07-18 | Third Wave Tech Inc | ANALYSIS FOR DIRECT MEASUREMENT OF A GENE ASSAY |
WO2005023091A2 (en) | 2003-09-05 | 2005-03-17 | The Trustees Of Boston University | Method for non-invasive prenatal diagnosis |
WO2005039389A2 (en) | 2003-10-22 | 2005-05-06 | 454 Corporation | Sequence-based karyotyping |
US7252946B2 (en) | 2004-01-27 | 2007-08-07 | Zoragen, Inc. | Nucleic acid detection |
US20100216153A1 (en) | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
US20100216151A1 (en) * | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
US20060046258A1 (en) * | 2004-02-27 | 2006-03-02 | Lapidus Stanley N | Applications of single molecule sequencing |
EP1765503A2 (en) | 2004-03-03 | 2007-03-28 | The General Hospital Corporation | System for delivering a diluted solution |
US20090117542A1 (en) | 2004-05-17 | 2009-05-07 | The Ohio State University Research Foundation | Unique short tandem repeats and methods of their use |
DE102004036285A1 (de) | 2004-07-27 | 2006-02-16 | Advalytix Ag | Verfahren zum Bestimmen der Häufigkeit von Sequenzen einer Probe |
TW200624106A (en) | 2004-09-07 | 2006-07-16 | Uni Charm Corp | Warming article |
JP2007327743A (ja) | 2004-09-07 | 2007-12-20 | Univ Of Tokyo | 遺伝子コピーの解析方法及び装置 |
US20060178835A1 (en) | 2005-02-10 | 2006-08-10 | Applera Corporation | Normalization methods for genotyping analysis |
JP5219516B2 (ja) | 2005-03-18 | 2013-06-26 | ザ チャイニーズ ユニバーシティー オブ ホンコン | 染色体異数性の検出方法 |
WO2006131928A2 (en) | 2005-06-08 | 2006-12-14 | Compugen Ltd. | Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis |
US20060286558A1 (en) * | 2005-06-15 | 2006-12-21 | Natalia Novoradovskaya | Normalization of samples for amplification reactions |
DE102005057988A1 (de) | 2005-08-04 | 2007-02-08 | Bosch Rexroth Ag | Axialkolbenmaschine |
ES2739484T3 (es) | 2006-02-02 | 2020-01-31 | Univ Leland Stanford Junior | Prueba genética fetal no invasiva mediante análisis digital |
US20100184043A1 (en) | 2006-02-28 | 2010-07-22 | University Of Louisville Research Foundation | Detecting Genetic Abnormalities |
CA2647793C (en) * | 2006-02-28 | 2016-07-05 | University Of Louisville Research Foundation | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
WO2007146105A2 (en) * | 2006-06-05 | 2007-12-21 | Cryo-Cell International, Inc. | Procurement, isolation and cryopreservation of fetal placental cells |
EP3425058A1 (en) | 2006-06-14 | 2019-01-09 | Verinata Health, Inc | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
EP2029779A4 (en) | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
EP2589668A1 (en) * | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
US20080050739A1 (en) * | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
EP2061801A4 (en) | 2006-06-14 | 2009-11-11 | Living Microsystems Inc | DIAGNOSIS OF FETAL ANOMALIES BY COMPARATIVE GENOMIC HYBRIDIZATION ANALYSIS |
EP3424598B1 (en) | 2006-06-14 | 2022-06-08 | Verinata Health, Inc. | Rare cell analysis using sample splitting and dna tags |
US20080113358A1 (en) | 2006-07-28 | 2008-05-15 | Ravi Kapur | Selection of cells using biomarkers |
WO2008015396A2 (en) | 2006-07-31 | 2008-02-07 | Solexa Limited | Method of library preparation avoiding the formation of adaptor dimers |
US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
EP2118298B1 (en) | 2007-02-08 | 2013-01-09 | Sequenom, Inc. | Nucleic acid-based tests for rhd typing |
SI2183693T2 (sl) | 2007-07-23 | 2019-02-28 | The Chinese University Of Hong Kong Technology Licenising Office | Diagnosticiranje fetalne kromosomske anevploidije z uporabo genomskega sekvenciranja |
US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
CA2701726A1 (en) | 2007-10-04 | 2009-04-09 | Halcyon Molecular | Sequencing nucleic acid polymers with electron microscopy |
SG190670A1 (en) * | 2008-02-01 | 2013-06-28 | Gen Hospital Corp | Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions |
AU2009223671B2 (en) * | 2008-03-11 | 2014-11-27 | Sequenom, Inc. | Nucleic acid-based tests for prenatal gender determination |
US20090299645A1 (en) | 2008-03-19 | 2009-12-03 | Brandon Colby | Genetic analysis |
WO2009120808A2 (en) * | 2008-03-26 | 2009-10-01 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
US20090270601A1 (en) * | 2008-04-21 | 2009-10-29 | Steven Albert Benner | Differential detection of single nucleotide polymorphisms |
EP2853601B1 (en) | 2008-07-18 | 2016-09-21 | TrovaGene, Inc. | Methods for PCR-based detection of "ultra short" nucleic acid sequences |
LT2562268T (lt) * | 2008-09-20 | 2017-04-25 | The Board Of Trustees Of The Leland Stanford Junior University | Neinvazinis fetalinės aneuploidijos diagnozavimas sekvenavimu |
US20100285537A1 (en) | 2009-04-02 | 2010-11-11 | Fluidigm Corporation | Selective tagging of short nucleic acid fragments and selective protection of target sequences from degradation |
WO2011056094A2 (ru) * | 2009-10-26 | 2011-05-12 | Общество С Ограниченной Ответственностью "Апoгeй" | Пожарный вентиль |
CA2778926C (en) | 2009-10-26 | 2018-03-27 | Lifecodexx Ag | Means and methods for non-invasive diagnosis of chromosomal aneuploidy |
ES2934941T3 (es) * | 2009-11-05 | 2023-02-28 | Univ Hong Kong Chinese | Análisis genómico fetal a partir de una muestra biológica materna |
JP2013510580A (ja) | 2009-11-12 | 2013-03-28 | エソテリックス ジェネティック ラボラトリーズ, エルエルシー | 遺伝子座のコピー数の分析 |
WO2011091063A1 (en) | 2010-01-19 | 2011-07-28 | Verinata Health, Inc. | Partition defined detection methods |
US9260745B2 (en) | 2010-01-19 | 2016-02-16 | Verinata Health, Inc. | Detecting and classifying copy number variation |
DK2366031T3 (da) | 2010-01-19 | 2015-02-23 | Verinata Health Inc | Fremgangsmåder til sekventering i prænatale diagnoser |
US9323888B2 (en) | 2010-01-19 | 2016-04-26 | Verinata Health, Inc. | Detecting and classifying copy number variation |
US20120237928A1 (en) | 2010-10-26 | 2012-09-20 | Verinata Health, Inc. | Method for determining copy number variations |
US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
US20120100548A1 (en) | 2010-10-26 | 2012-04-26 | Verinata Health, Inc. | Method for determining copy number variations |
US20120270739A1 (en) | 2010-01-19 | 2012-10-25 | Verinata Health, Inc. | Method for sample analysis of aneuploidies in maternal samples |
EP2513341B1 (en) | 2010-01-19 | 2017-04-12 | Verinata Health, Inc | Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing |
WO2011090556A1 (en) | 2010-01-19 | 2011-07-28 | Verinata Health, Inc. | Methods for determining fraction of fetal nucleic acid in maternal samples |
US20110312503A1 (en) | 2010-01-23 | 2011-12-22 | Artemis Health, Inc. | Methods of fetal abnormality detection |
CA2825984A1 (en) | 2010-02-25 | 2011-09-01 | Advanced Liquid Logic, Inc. | Method of making nucleic acid libraries |
WO2012012037A1 (en) * | 2010-07-19 | 2012-01-26 | New England Biolabs, Inc. | Oligonucleotide adaptors: compositions and methods of use |
US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
CN102409043B (zh) | 2010-09-21 | 2013-12-04 | 深圳华大基因科技服务有限公司 | 高通量低成本Fosmid文库构建的方法及其所使用标签和标签接头 |
MY169852A (en) | 2010-11-30 | 2019-05-17 | Univ Hong Kong Chinese | Detection of genetic or molecular aberrations associated with cancer |
US8877442B2 (en) | 2010-12-07 | 2014-11-04 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale |
CN102127818A (zh) | 2010-12-15 | 2011-07-20 | 张康 | 利用孕妇外周血建立胎儿dna文库的方法 |
AU2011348267A1 (en) | 2010-12-23 | 2013-08-01 | Sequenom, Inc. | Fetal genetic variation detection |
WO2012103031A2 (en) | 2011-01-25 | 2012-08-02 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
EP2673729B1 (en) | 2011-02-09 | 2018-10-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
PL3567124T3 (pl) | 2011-04-12 | 2022-04-19 | Verinata Health, Inc. | Rozdzielanie frakcji genomu z wykorzystaniem liczby polimorfizmu |
GB2484764B (en) | 2011-04-14 | 2012-09-05 | Verinata Health Inc | Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies |
US9411937B2 (en) | 2011-04-15 | 2016-08-09 | Verinata Health, Inc. | Detecting and classifying copy number variation |
WO2014014498A1 (en) | 2012-07-20 | 2014-01-23 | Verinata Health, Inc. | Detecting and classifying copy number variation in a fetal genome |
EP2563937A1 (en) | 2011-07-26 | 2013-03-06 | Verinata Health, Inc | Method for determining the presence or absence of different aneuploidies in a sample |
-
2010
- 2010-12-01 DK DK10830938.6T patent/DK2366031T3/da active
- 2010-12-01 EP EP24186817.3A patent/EP4450645A3/en active Pending
- 2010-12-01 EP EP10825822.9A patent/EP2370599B1/en active Active
- 2010-12-01 WO PCT/US2010/058609 patent/WO2011090557A1/en active Application Filing
- 2010-12-01 PL PL10830938T patent/PL2366031T3/pl unknown
- 2010-12-01 US US12/958,356 patent/US20110224087A1/en not_active Abandoned
- 2010-12-01 EP EP21157398.5A patent/EP3878973B1/en active Active
- 2010-12-01 GB GB1108794.7A patent/GB2479080B/en active Active
- 2010-12-01 TR TR2018/07917T patent/TR201807917T4/tr unknown
- 2010-12-01 CA CA2786357A patent/CA2786357C/en active Active
- 2010-12-01 PL PL17180803T patent/PL3260555T3/pl unknown
- 2010-12-01 EP EP18160303.6A patent/EP3382037B1/en active Active
- 2010-12-01 US US12/958,353 patent/US9657342B2/en active Active
- 2010-12-01 AU AU2010343276A patent/AU2010343276B2/en active Active
- 2010-12-01 ES ES10844163.5T patent/ES2560929T3/es active Active
- 2010-12-01 PL PL10830939T patent/PL2376661T3/pl unknown
- 2010-12-01 AU AU2010343279A patent/AU2010343279B2/en active Active
- 2010-12-01 ES ES10830938.6T patent/ES2534758T3/es active Active
- 2010-12-01 GB GB1118396.9A patent/GB2485644B/en active Active
- 2010-12-01 GB GB1118398.5A patent/GB2485645B/en active Active
- 2010-12-01 ES ES10830939.4T patent/ES2534986T3/es active Active
- 2010-12-01 DK DK10830939.4T patent/DK2376661T3/da active
- 2010-12-01 CA CA2786544A patent/CA2786544C/en active Active
- 2010-12-01 EP EP17180803.3A patent/EP3260555B1/en not_active Revoked
- 2010-12-01 US US12/958,352 patent/US20110245085A1/en not_active Abandoned
- 2010-12-01 EP EP10830938.6A patent/EP2366031B1/en active Active
- 2010-12-01 DK DK18160303.6T patent/DK3382037T3/da active
- 2010-12-01 DK DK10844163.5T patent/DK2513339T3/da active
- 2010-12-01 EP EP21213836.6A patent/EP4074838A1/en active Pending
- 2010-12-01 EP EP14192156.9A patent/EP2883965B8/en active Active
- 2010-12-01 ES ES18160303T patent/ES2870533T3/es active Active
- 2010-12-01 AU AU2010343277A patent/AU2010343277B2/en active Active
- 2010-12-01 EP EP14192160.1A patent/EP2848703A1/en not_active Withdrawn
- 2010-12-01 EP EP10844163.5A patent/EP2513339B1/en active Active
- 2010-12-01 GB GB1107268.3A patent/GB2479471B/en active Active
- 2010-12-01 EP EP14192165.0A patent/EP2848704B1/en active Active
- 2010-12-01 ES ES18201917T patent/ES2909841T3/es active Active
- 2010-12-01 CA CA2785718A patent/CA2785718C/en active Active
- 2010-12-01 CA CA2786351A patent/CA2786351C/en active Active
- 2010-12-01 WO PCT/US2010/058614 patent/WO2011090559A1/en active Application Filing
- 2010-12-01 EP EP18201917.4A patent/EP3492601B1/en active Active
- 2010-12-01 DK DK17180803.3T patent/DK3260555T3/da active
- 2010-12-01 EP EP15181244.3A patent/EP3006573B1/en active Active
- 2010-12-01 GB GB1108795.4A patent/GB2479476B/en active Active
- 2010-12-01 DK DK18201917.4T patent/DK3492601T3/da active
- 2010-12-01 PL PL18201917T patent/PL3492601T3/pl unknown
- 2010-12-01 WO PCT/US2010/058612 patent/WO2011090558A1/en active Application Filing
- 2010-12-01 ES ES17180803T patent/ES2704701T3/es active Active
- 2010-12-01 AU AU2010343278A patent/AU2010343278B2/en active Active
- 2010-12-01 EP EP10830939.4A patent/EP2376661B1/en active Active
-
2011
- 2011-12-21 US US13/333,832 patent/US20120094849A1/en not_active Abandoned
-
2012
- 2012-01-18 HK HK12100602.6A patent/HK1160185A1/xx unknown
- 2012-01-19 HK HK12110851.3A patent/HK1170269A1/xx unknown
- 2012-01-19 HK HK12100648.2A patent/HK1160186A1/xx unknown
- 2012-01-19 HK HK12110871.9A patent/HK1170270A1/xx unknown
- 2012-02-02 US US13/365,240 patent/US20120165203A1/en not_active Abandoned
- 2012-03-19 HK HK12102728.1A patent/HK1162197A1/xx unknown
-
2013
- 2013-04-17 HK HK13104694.6A patent/HK1177232A1/zh unknown
-
2017
- 2017-05-22 US US15/601,951 patent/US10941442B2/en active Active
- 2017-07-31 US US15/664,008 patent/US11130995B2/en active Active
- 2017-07-31 US US15/664,043 patent/US11286520B2/en active Active
-
2021
- 2021-03-05 US US17/193,279 patent/US11884975B2/en active Active
- 2021-05-17 CY CY20211100424T patent/CY1124494T1/el unknown
- 2021-09-02 US US17/465,163 patent/US11952623B2/en active Active
- 2021-12-17 US US17/554,195 patent/US20220106639A1/en active Pending
-
2023
- 2023-12-11 US US18/534,929 patent/US20240150828A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK3492601T3 (da) | Hidtil ukendt protokol til fremstilling af sekvenseringsbiblioteker | |
DK2539450T3 (da) | Fremgangsmåde til fremstilling af nukleinsyrebiblioteker | |
DK3053932T3 (da) | Hidtil ukendte ctla4-ig-immunoadhesiner | |
DK3329775T3 (da) | Fremgangsmåder til syntese af diarylthiohydantoin- og diarylhydantoinforbindelser | |
DK2736837T3 (da) | Fremgangsmåde til fremstilling af nanosiliciumtråde | |
DK2593449T3 (da) | Fremgangsmåde til syntese af benzothiadiazolforbindelse | |
DK3741883T3 (da) | Antistofbiblioteker | |
DK3351631T3 (da) | Fremgangsmåder til mærkning af dna-kodede biblioteker | |
DK2560683T4 (da) | Fremstilling af heteromultimeriske proteiner | |
DK2874506T3 (da) | Fremgangsmåde til fremstilling af enzymgranulater | |
DK2768796T3 (da) | Fremgangsmåde til fremstilling af quinolin-derivater | |
DK2526425T3 (da) | Fremgangsmåde til diagnosticering af endometriel receptivitet | |
DK3210978T3 (da) | Fremgangsmåde til fremstilling af acesulfamkalium | |
DK2580598T3 (da) | Massespektrometrisk måling af ss-laktamaseresisstens | |
DK2595948T3 (da) | Fremgangsmåde til fremstilling af ingenol-3-angelat | |
DK3299356T3 (da) | Fremgangsmåde til fremstilling af pleuromutiliner | |
DK2836460T3 (da) | Fremgangsmåde til fremstilling af graphen | |
DK2627656T3 (da) | Fremgangsmåde til fremstilling af dihydropteridinon og intermediater deraf | |
DK2618842T3 (da) | Hidtil ukendt immunstimulerende fremgangsmåde | |
DK2567019T3 (da) | Fremgangsmåde til coating af tekstiler | |
DK2616101T3 (da) | Fremgangsmåde til oprensning af pegyleret erythropoietin | |
DK2468877T3 (da) | Fremgangsmåde til fremstilling af enzymer | |
DK2542555T3 (da) | Fremgangsmåde til fremstilling af pyripyropenderivater | |
DK2920151T3 (da) | Fremgangsmåde til fremstilling af carboxamider | |
DK2454291T3 (da) | Fremgangsmåde til fremstilling af polyolefiner |